SIMILAR PATTERNS OF AMINO ACIDS FOR 1A52_B_ESTB2_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dkp PHYTASE

(Escherichia
coli) 		PF00328
(His_Phos_2) 		5 ALA A 214
LEU A 249
LEU A 247
ILE A 237
LEU A 170
 None
 1.29A 1a52B-1dkpA:
undetectable		 1a52B-1dkpA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gz5 ALPHA-TREHALOSE-PHOS
PHATE SYNTHASE

(Escherichia
coli) 		PF00982
(Glyco_transf_20) 		5 ALA A  11
GLU A  15
LEU A  28
ILE A 225
HIS A 154
 None
None
None
IMD  A 902 ( 4.3A)
IMD  A 902 (-3.9A)
 1.44A 1a52B-1gz5A:
undetectable		 1a52B-1gz5A:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hfe PROTEIN (FE-ONLY
HYDROGENASE
(E.C.1.18.99.1)
(LARGER SUBUNIT))

(Desulfovibrio
vulgaris) 		PF02906
(Fe_hyd_lg_C)
PF13237
(Fer4_10) 		5 MET L 219
LEU L 210
ILE L 103
HIS L 141
LEU L 285
 None
 1.30A 1a52B-1hfeL:
undetectable		 1a52B-1hfeL:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jv1 GLCNAC1P
URIDYLTRANSFERASE
ISOFORM 1: AGX1

(Homo sapiens) 		PF01704
(UDPGP) 		5 MET A 171
ALA A 109
LEU A 107
LEU A 106
ILE A 192
 None
 1.33A 1a52B-1jv1A:
0.0		 1a52B-1jv1A:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nig HYPOTHETICAL PROTEIN
TA1238

(Thermoplasma
acidophilum) 		PF09155
(DUF1940) 		5 ALA A  32
LEU A  36
LEU A 102
ILE A 142
LEU A  51
 None
 1.40A 1a52B-1nigA:
0.0		 1a52B-1nigA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nkl NK-LYSIN

(Sus scrofa) 		PF05184
(SapB_1) 		5 MET A  49
GLU A  24
LEU A  61
ILE A  69
LEU A  14
 None
 0.94A 1a52B-1nklA:
undetectable		 1a52B-1nklA:
15.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1pcg ESTROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 MET A 342
GLU A 353
LEU A 387
LEU A 391
ARG A 394
 None
EST  A   1 (-2.8A)
EST  A   1 (-4.0A)
EST  A   1 ( 3.9A)
EST  A   1 (-3.7A)
 1.41A 1a52B-1pcgA:
34.7		 1a52B-1pcgA:
98.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1pcg ESTROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		10 MET A 343
ALA A 350
GLU A 353
LEU A 387
MET A 388
LEU A 391
ARG A 394
ILE A 424
HIS A 524
LEU A 525
 EST  A   1 ( 4.0A)
EST  A   1 ( 3.7A)
EST  A   1 (-2.8A)
EST  A   1 (-4.0A)
None
EST  A   1 ( 3.9A)
EST  A   1 (-3.7A)
EST  A   1 ( 4.5A)
EST  A   1 (-3.8A)
EST  A   1 (-3.6A)
 0.29A 1a52B-1pcgA:
34.7		 1a52B-1pcgA:
98.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sgv TRNA PSEUDOURIDINE
SYNTHASE B

(Mycobacterium
tuberculosis) 		PF01509
(TruB_N)
PF09142
(TruB_C)
PF16198
(TruB_C_2) 		5 ALA A 231
LEU A 226
LEU A 224
ILE A  51
LEU A  63
 None
 1.10A 1a52B-1sgvA:
undetectable		 1a52B-1sgvA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ugo BCL2-ASSOCIATED
ATHANOGENE 5

(Mus musculus) 		PF02179
(BAG) 		5 ALA A  79
GLU A  83
LEU A  57
LEU A  53
LEU A  20
 None
 1.11A 1a52B-1ugoA:
undetectable		 1a52B-1ugoA:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vjz ENDOGLUCANASE

(Thermotoga
maritima) 		PF00150
(Cellulase) 		5 ALA A  88
LEU A  85
ILE A 175
HIS A 153
LEU A 156
 None
 1.45A 1a52B-1vjzA:
undetectable		 1a52B-1vjzA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vlc 3-ISOPROPYLMALATE
DEHYDROGENASE

(Thermotoga
maritima) 		PF00180
(Iso_dh) 		5 MET A  97
GLU A 271
LEU A  69
ILE A  60
LEU A  53
 None
 1.43A 1a52B-1vlcA:
undetectable		 1a52B-1vlcA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1we1 HEME OXYGENASE 1

(Synechocystis
sp. PCC 6803) 		PF01126
(Heme_oxygenase) 		5 MET A 175
GLU A 118
LEU A 119
LEU A 120
LEU A   9
 None
 1.44A 1a52B-1we1A:
2.7		 1a52B-1we1A:
21.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1xls RETINOIC ACID
RECEPTOR RXR-ALPHA

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 ALA A 272
LEU A 309
ARG A 316
ILE A 345
LEU A 436
 9CR  A 801 (-3.5A)
9CR  A 801 (-4.2A)
9CR  A 801 (-2.6A)
9CR  A 801 ( 4.5A)
9CR  A 801 (-4.7A)
 1.02A 1a52B-1xlsA:
23.7		 1a52B-1xlsA:
31.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bdq COPPER HOMEOSTASIS
PROTEIN CUTC

(Streptococcus
agalactiae) 		PF03932
(CutC) 		5 ALA A 115
MET A  78
ARG A  76
ILE A  97
LEU A 121
 None
 1.44A 1a52B-2bdqA:
undetectable		 1a52B-2bdqA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bv7 GLYCOLIPID TRANSFER
PROTEIN

(Bos taurus) 		PF08718
(GLTP) 		5 ALA A  90
GLU A  77
LEU A  74
ILE A  18
LEU A  24
 None
 1.29A 1a52B-2bv7A:
undetectable		 1a52B-2bv7A:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ckh SENTRIN-SPECIFIC
PROTEASE 1

(Homo sapiens) 		PF02902
(Peptidase_C48) 		5 MET A 604
ALA A 610
LEU A 478
MET A 477
ILE A 637
 None
 1.29A 1a52B-2ckhA:
undetectable		 1a52B-2ckhA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cy7 CYSTEINE PROTEASE
APG4B

(Homo sapiens) 		PF03416
(Peptidase_C54) 		5 ALA A  86
LEU A 164
LEU A 222
ILE A 168
LEU A 152
 None
 1.18A 1a52B-2cy7A:
undetectable		 1a52B-2cy7A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dt8 DEGV FAMILY PROTEIN

(Thermus
thermophilus) 		PF02645
(DegV) 		5 ALA A 174
LEU A 188
LEU A 190
ILE A 264
HIS A 267
 None
None
None
PLM  A 701 ( 4.5A)
PLM  A 701 (-3.7A)
 1.37A 1a52B-2dt8A:
undetectable		 1a52B-2dt8A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g7l TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR

(Streptomyces
coelicolor) 		PF00440
(TetR_N)
PF02909
(TetR_C) 		5 ALA A  28
LEU A  66
ARG A  21
HIS A 107
LEU A  37
 None
 1.46A 1a52B-2g7lA:
undetectable		 1a52B-2g7lA:
26.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2gpv ESTROGEN-RELATED
RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 ALA A 272
GLU A 275
LEU A 309
ARG A 316
HIS A 434
 OHT  A 500 (-3.5A)
OHT  A 500 (-2.6A)
OHT  A 500 ( 4.0A)
OHT  A 500 (-3.8A)
OHT  A 500 ( 4.7A)
 0.64A 1a52B-2gpvA:
27.5		 1a52B-2gpvA:
36.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hx0 PUTATIVE DNA-BINDING
PROTEIN

(Salmonella
enterica) 		PF03479
(DUF296) 		5 ALA A  40
GLU A 117
LEU A  37
ARG A 141
LEU A  28
 None
 1.23A 1a52B-2hx0A:
undetectable		 1a52B-2hx0A:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ije GUANINE
NUCLEOTIDE-RELEASING
PROTEIN

(Mus musculus) 		PF00617
(RasGEF) 		5 ALA S1117
GLU S1120
LEU S1035
LEU S1038
ILE S1227
 None
 1.46A 1a52B-2ijeS:
undetectable		 1a52B-2ijeS:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j4r EXOPOLYPHOSPHATASE

(Aquifex
aeolicus) 		PF02541
(Ppx-GppA) 		5 ALA A  96
GLU A  97
LEU A 100
ILE A  64
LEU A  45
 None
 1.38A 1a52B-2j4rA:
undetectable		 1a52B-2j4rA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j5g ALR4455 PROTEIN

(Nostoc sp. PCC
7120) 		PF00378
(ECH_1) 		5 LEU D 103
LEU D 104
ARG D 221
ILE D 236
HIS D 156
 None
 1.40A 1a52B-2j5gD:
undetectable		 1a52B-2j5gD:
21.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ocf ESTROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		10 MET A 343
ALA A 350
GLU A 353
LEU A 387
MET A 388
LEU A 391
ARG A 394
ILE A 424
HIS A 524
LEU A 525
 EST  A 596 (-4.8A)
EST  A 596 ( 3.9A)
EST  A 596 (-2.7A)
EST  A 596 ( 4.2A)
None
EST  A 596 ( 4.6A)
EST  A 596 (-4.0A)
EST  A 596 ( 4.7A)
EST  A 596 (-4.2A)
EST  A 596 (-3.6A)
 0.51A 1a52B-2ocfA:
33.3		 1a52B-2ocfA:
99.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ozk URIDYLATE-SPECIFIC
ENDORIBONUCLEASE

(Severe acute
respiratory
syndrome-related
coronavirus) 		PF06471
(NSP11) 		5 MET A 218
GLU A 210
ARG A 198
ILE A 235
LEU A 227
 None
 1.46A 1a52B-2ozkA:
undetectable		 1a52B-2ozkA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pjq UNCHARACTERIZED
PROTEIN LP_2664

(Lactobacillus
plantarum) 		PF01966
(HD) 		5 ALA A  37
LEU A  52
LEU A  50
ILE A  97
HIS A  58
 None
 0.97A 1a52B-2pjqA:
undetectable		 1a52B-2pjqA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qgo PUTATIVE FE-S
BIOSYNTHESIS PROTEIN

(Lactobacillus
acidophilus) 		PF01521
(Fe-S_biosyn) 		5 ALA A  12
LEU A  97
LEU A  99
ILE A  74
LEU A  22
 None
 1.42A 1a52B-2qgoA:
undetectable		 1a52B-2qgoA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qma DIAMINOBUTYRATE-PYRU
VATE TRANSAMINASE
AND
L-2,4-DIAMINOBUTYRAT
E DECARBOXYLASE

(Vibrio
parahaemolyticus) 		PF00282
(Pyridoxal_deC) 		5 ALA A 722
LEU A 636
LEU A 638
ILE A 652
LEU A 664
 None
 1.33A 1a52B-2qmaA:
undetectable		 1a52B-2qmaA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rg2 CHOLOYLGLYCINE
HYDROLASE

(Clostridium
perfringens) 		PF02275
(CBAH) 		5 MET A  57
ALA A  79
LEU A  81
LEU A 142
ILE A  22
 None
None
CSO  A   2 ( 4.0A)
EDO  A 333 ( 4.5A)
None
 1.27A 1a52B-2rg2A:
undetectable		 1a52B-2rg2A:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x1m METHIONYL-TRNA
SYNTHETASE

(Mycolicibacterium
smegmatis) 		PF09334
(tRNA-synt_1g) 		5 ALA A 276
LEU A 175
LEU A 178
ILE A 289
HIS A 260
 None
 1.38A 1a52B-2x1mA:
undetectable		 1a52B-2x1mA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x4f MYOSIN LIGHT CHAIN
KINASE FAMILY MEMBER
4

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A 293
MET A 286
ILE A 350
HIS A 358
LEU A 361
 None
 1.16A 1a52B-2x4fA:
undetectable		 1a52B-2x4fA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xym RNA-DIRECTED RNA
POLYMERASE

(Hepacivirus C) 		PF00998
(RdRP_3) 		5 ALA A  88
LEU A  83
LEU A  82
ILE A 253
LEU A 285
 None
 1.26A 1a52B-2xymA:
undetectable		 1a52B-2xymA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bhw UNCHARACTERIZED
PROTEIN

(Magnetospirillum
magneticum) 		PF08849
(DUF1819) 		5 GLU A 158
LEU A  15
LEU A  17
ILE A  23
LEU A  60
 None
 1.38A 1a52B-3bhwA:
undetectable		 1a52B-3bhwA:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d6b GLUTARYL-COA
DEHYDROGENASE

(Burkholderia
pseudomallei) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		5 MET A 299
ALA A 338
LEU A 367
LEU A 364
ILE A 271
 None
 1.39A 1a52B-3d6bA:
undetectable		 1a52B-3d6bA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dbi SUGAR-BINDING
TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY

(Escherichia
coli) 		PF13377
(Peripla_BP_3) 		5 ALA A 172
GLU A 175
LEU A 327
ILE A 295
HIS A 165
 None
 1.34A 1a52B-3dbiA:
undetectable		 1a52B-3dbiA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dka DINB-LIKE PROTEIN

(Bacillus
subtilis) 		PF05163
(DinB) 		5 LEU A 120
LEU A 121
ILE A  92
HIS A  53
LEU A  54
 None
 1.38A 1a52B-3dkaA:
undetectable		 1a52B-3dkaA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dmy PROTEIN FDRA

(Escherichia
coli) 		PF00549
(Ligase_CoA)
PF02629
(CoA_binding) 		5 LEU A 226
MET A 171
ILE A 180
HIS A 222
LEU A 247
 None
 1.45A 1a52B-3dmyA:
undetectable		 1a52B-3dmyA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ego PROBABLE
2-DEHYDROPANTOATE
2-REDUCTASE

(Bacillus
subtilis) 		PF02558
(ApbA)
PF08546
(ApbA_C) 		5 ALA A 217
GLU A 216
LEU A 280
LEU A 283
LEU A 180
 None
 1.31A 1a52B-3egoA:
undetectable		 1a52B-3egoA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3goa 3-KETOACYL-COA
THIOLASE

(Salmonella
enterica) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		5 ALA A 246
LEU A  34
MET A  35
LEU A  38
ILE A  53
 None
 1.07A 1a52B-3goaA:
undetectable		 1a52B-3goaA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gxa OUTER MEMBRANE
LIPOPROTEIN GNA1946

(Neisseria
meningitidis) 		PF03180
(Lipoprotein_9) 		5 ALA A 241
LEU A  88
LEU A  93
ILE A  45
LEU A 252
 None
 1.38A 1a52B-3gxaA:
undetectable		 1a52B-3gxaA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ir1 OUTER MEMBRANE
LIPOPROTEIN GNA1946

(Neisseria
meningitidis) 		PF03180
(Lipoprotein_9) 		5 ALA A 241
LEU A  88
LEU A  93
ILE A  45
LEU A 252
 None
 1.39A 1a52B-3ir1A:
undetectable		 1a52B-3ir1A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3is6 PUTATIVE PERMEASE
PROTEIN, ABC
TRANSPORTER

(Porphyromonas
gingivalis) 		PF12704
(MacB_PCD) 		5 ALA A 158
MET A 200
LEU A 152
ILE A 181
LEU A 111
 None
 1.23A 1a52B-3is6A:
undetectable		 1a52B-3is6A:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kye ROADBLOCK/LC7
DOMAIN, ROBL_LC7

(Streptomyces
avermitilis) 		PF03259
(Robl_LC7) 		5 LEU A  16
MET A  17
LEU A  20
ARG A  23
LEU A 128
 None
 1.22A 1a52B-3kyeA:
undetectable		 1a52B-3kyeA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l0z PUTATIVE
NICOTINATE-NUCLEOTID
E-DIMETHYLBENZIMIDAZ
OLE
PHOSPHORIBOSYLTRANSF
ERASE

(Methanocaldococcus
jannaschii) 		PF02277
(DBI_PRT) 		5 ALA A 244
LEU A 163
LEU A 160
ILE A 118
LEU A 209
 None
 1.46A 1a52B-3l0zA:
undetectable		 1a52B-3l0zA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l2z BIRA BIFUNCTIONAL
PROTEIN

(Mycobacterium
tuberculosis) 		PF02237
(BPL_C)
PF03099
(BPL_LplA_LipB) 		5 ALA A 105
LEU A 153
LEU A 143
ILE A  83
LEU A 190
 None
 1.33A 1a52B-3l2zA:
undetectable		 1a52B-3l2zA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ln3 DIHYDRODIOL
DEHYDROGENASE

(Mus musculus) 		PF00248
(Aldo_ket_red) 		5 ALA A 218
LEU A 260
ILE A  16
HIS A  48
LEU A  19
 NAD  A 327 (-4.9A)
None
None
None
None
 1.44A 1a52B-3ln3A:
undetectable		 1a52B-3ln3A:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nc3 CYTOCHROME P450 CYPX

(Bacillus
subtilis) 		PF00067
(p450) 		5 ALA A 162
LEU A 232
LEU A 228
ARG A  67
ILE A 154
 None
GOL  A 407 ( 4.8A)
None
None
None
 1.34A 1a52B-3nc3A:
2.5		 1a52B-3nc3A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nzp ARGININE
DECARBOXYLASE

(Campylobacter
jejuni) 		PF02784
(Orn_Arg_deC_N) 		5 ALA A 251
GLU A 250
LEU A 186
ILE A 238
LEU A 271
 None
 1.24A 1a52B-3nzpA:
undetectable		 1a52B-3nzpA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o7j OHCU DECARBOXYLASE

(Klebsiella
pneumoniae) 		PF09349
(OHCU_decarbox) 		5 GLU A 161
LEU A 158
ARG A  49
HIS A  80
LEU A  83
 None
 1.34A 1a52B-3o7jA:
undetectable		 1a52B-3o7jA:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q0g ENOYL-COA HYDRATASE
ECHA8

(Mycobacterium
tuberculosis) 		PF00378
(ECH_1) 		5 ALA A 170
GLU A 169
LEU A 158
ARG A 163
LEU A 119
 None
 1.43A 1a52B-3q0gA:
undetectable		 1a52B-3q0gA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3syj ADHESION AND
PENETRATION PROTEIN
AUTOTRANSPORTER

(Haemophilus
influenzae) 		PF02395
(Peptidase_S6)
PF03212
(Pertactin) 		5 ALA A 622
GLU A 110
LEU A 203
ARG A  81
ILE A 236
 None
 1.34A 1a52B-3syjA:
undetectable		 1a52B-3syjA:
12.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t3o METAL DEPENDENT
HYDROLASE

(Thermus
thermophilus) 		PF07521
(RMMBL)
PF12706
(Lactamase_B_2) 		5 ALA A 103
GLU A 128
LEU A 278
ILE A 244
HIS A 245
 None
 1.43A 1a52B-3t3oA:
undetectable		 1a52B-3t3oA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tp9 BETA-LACTAMASE AND
RHODANESE DOMAIN
PROTEIN

(Alicyclobacillus
acidocaldarius) 		PF00581
(Rhodanese)
PF00753
(Lactamase_B) 		5 MET A 250
GLU A  67
LEU A 261
LEU A 264
ILE A 347
 None
 1.45A 1a52B-3tp9A:
undetectable		 1a52B-3tp9A:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tsd INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Bacillus
anthracis) 		PF00478
(IMPDH)
PF00571
(CBS) 		5 ALA A 356
LEU A 321
LEU A  11
ILE A 461
LEU A  18
 None
 1.35A 1a52B-3tsdA:
undetectable		 1a52B-3tsdA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tzt GLYCOSYL TRANSFERASE
FAMILY 8

(Anaerococcus
prevotii) 		PF01501
(Glyco_transf_8) 		5 ALA A   4
LEU A 118
ARG A  31
ILE A 122
LEU A 163
 EDO  A 302 (-4.5A)
EDO  A 302 (-4.3A)
None
None
None
 1.35A 1a52B-3tztA:
undetectable		 1a52B-3tztA:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v8v RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE L

(Escherichia
coli) 		PF01170
(UPF0020)
PF02926
(THUMP)
PF10672
(Methyltrans_SAM) 		5 ALA A   6
LEU A  16
LEU A  12
HIS A 160
LEU A 159
 None
 1.37A 1a52B-3v8vA:
undetectable		 1a52B-3v8vA:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vis ESTERASE

(Thermobifida
alba) 		PF12740
(Chlorophyllase2) 		5 ALA A 160
LEU A 147
LEU A 143
ARG A 182
ILE A  81
 None
 1.16A 1a52B-3visA:
undetectable		 1a52B-3visA:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w0k BIFUNCTIONAL
ENDOMANNANASE/ENDOGL
UCANASE

(Caldanaerobius
polysaccharolyticus) 		PF00150
(Cellulase) 		5 ALA A  86
LEU A  83
ILE A 173
HIS A 151
LEU A 154
 None
 1.37A 1a52B-3w0kA:
undetectable		 1a52B-3w0kA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ars HISTIDINE ACID
PHOSPHATASE

(Hafnia alvei) 		PF00328
(His_Phos_2) 		5 ALA A 217
LEU A 252
LEU A 250
ILE A 240
LEU A 172
 None
 1.43A 1a52B-4arsA:
undetectable		 1a52B-4arsA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dqd EXTRACELLULAR
LIGAND-BINDING
RECEPTOR

(Rhodopseudomonas
palustris) 		PF13458
(Peripla_BP_6) 		5 MET A 114
ALA A 106
LEU A  82
LEU A  81
ILE A  27
 None
 1.26A 1a52B-4dqdA:
undetectable		 1a52B-4dqdA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eei ADENYLOSUCCINATE
LYASE

(Francisella
tularensis) 		PF00206
(Lyase_1) 		5 ALA A  33
GLU A  32
LEU A  28
ARG A  48
ILE A  97
 None
 1.43A 1a52B-4eeiA:
3.0		 1a52B-4eeiA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hzu ENERGY-COUPLING
FACTOR TRANSPORTER
TRANSMEMBRANE
PROTEIN ECFT
PREDICTED MEMBRANE
PROTEIN

(Lactobacillus
brevis) 		PF02361
(CbiQ)
PF07155
(ECF-ribofla_trS) 		5 ALA T 175
GLU T 174
LEU T 208
ARG T 215
LEU S  39
 None
 1.32A 1a52B-4hzuT:
undetectable		 1a52B-4hzuT:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jrn RHOPTRY KINASE
FAMILY PROTEIN

(Toxoplasma
gondii) 		PF14531
(Kinase-like) 		5 ALA A 269
LEU A 278
MET A 356
ARG A 250
LEU A 258
 None
None
ANP  A 601 (-3.3A)
None
ANP  A 601 ( 4.6A)
 1.46A 1a52B-4jrnA:
undetectable		 1a52B-4jrnA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k2p T-LYMPHOMA INVASION
AND
METASTASIS-INDUCING
PROTEIN 1

(Homo sapiens) 		PF00169
(PH) 		5 ALA A 643
GLU A 612
LEU A 665
ARG A 669
ILE A 656
 None
 1.32A 1a52B-4k2pA:
undetectable		 1a52B-4k2pA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kc5 RHIE PROTEIN

(Paraburkholderia
rhizoxinica) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 LEU A3257
MET A3258
ILE A3292
HIS A3404
LEU A3405
 None
 1.32A 1a52B-4kc5A:
undetectable		 1a52B-4kc5A:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n1j NACHT, LRR AND PYD
DOMAINS-CONTAINING
PROTEIN 14

(Homo sapiens) 		PF02758
(PYRIN) 		5 ALA A  53
GLU A  49
LEU A  61
ILE A  78
LEU A  19
 None
 1.46A 1a52B-4n1jA:
undetectable		 1a52B-4n1jA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n1j NACHT, LRR AND PYD
DOMAINS-CONTAINING
PROTEIN 14

(Homo sapiens) 		PF02758
(PYRIN) 		6 ALA A  53
GLU A  49
LEU A  61
MET A  62
ILE A  78
LEU A  27
 None
 1.38A 1a52B-4n1jA:
undetectable		 1a52B-4n1jA:
18.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4n1y ESTROGEN RECEPTOR

(Crassostrea
gigas) 		PF00104
(Hormone_recep) 		5 ALA A 287
GLU A 290
LEU A 324
ARG A 331
ILE A 361
 None
 0.54A 1a52B-4n1yA:
28.3		 1a52B-4n1yA:
38.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4n1y ESTROGEN RECEPTOR

(Crassostrea
gigas) 		PF00104
(Hormone_recep) 		5 ALA A 287
GLU A 290
LEU A 324
LEU A 325
LEU A 470
 None
 1.33A 1a52B-4n1yA:
28.3		 1a52B-4n1yA:
38.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n2x DL-2-HALOACID
DEHALOGENASE

(Methylobacterium
sp. CPA1) 		PF10778
(DehI) 		5 ALA A  68
GLU A  69
ARG A  76
ILE A 124
LEU A  59
 None
 1.44A 1a52B-4n2xA:
2.3		 1a52B-4n2xA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o1o RIBONUCLEASE L

(Sus scrofa) 		PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A)
PF12796
(Ank_2)
PF13857
(Ank_5) 		5 LEU A 108
LEU A 106
ILE A  96
HIS A  62
LEU A  61
 None
 1.21A 1a52B-4o1oA:
undetectable		 1a52B-4o1oA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4po0 SERUM ALBUMIN

(Oryctolagus
cuniculus) 		PF00273
(Serum_albumin) 		5 ALA A 151
LEU A 250
LEU A 251
ILE A  20
LEU A 139
 None
 1.33A 1a52B-4po0A:
undetectable		 1a52B-4po0A:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q5n GLUTHATIONE
S-TRANSFERASE BLO T
8 ISOFORM

(Blomia
tropicalis) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		5 MET A  90
GLU A 105
LEU A 171
HIS A  24
LEU A  21
 None
 1.33A 1a52B-4q5nA:
undetectable		 1a52B-4q5nA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4quk DIHYDROFLAVONOL-4-RE
DUCTASE

(Medicago
truncatula) 		PF01370
(Epimerase) 		5 ALA A 235
LEU A  26
LEU A  27
HIS A  49
LEU A 200
 None
 1.30A 1a52B-4qukA:
undetectable		 1a52B-4qukA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uoo LIPOTEICHOIC ACID
SYNTHASE

(Listeria
monocytogenes) 		PF00884
(Sulfatase) 		5 ALA A 338
LEU A 536
LEU A 314
ILE A 516
LEU A 543
 None
 1.19A 1a52B-4uooA:
undetectable		 1a52B-4uooA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z4l CELLOBIOSE
2-EPIMERASE

(Caldicellulosiruptor
saccharolyticus) 		PF07221
(GlcNAc_2-epim) 		5 ALA A  63
GLU A 125
ARG A 198
ILE A 385
LEU A  14
 None
 1.27A 1a52B-4z4lA:
undetectable		 1a52B-4z4lA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zu9 ELONGATION FACTOR
SELB

(Aquifex
aeolicus) 		PF00009
(GTP_EFTU)
PF09107
(SelB-wing_3) 		5 ALA A   7
LEU A   5
LEU A  57
ILE A 171
HIS A 110
 None
 1.45A 1a52B-4zu9A:
undetectable		 1a52B-4zu9A:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bt1 HAT1-INTERACTING
FACTOR 1

(Saccharomyces
cerevisiae) 		no annotation 5 ALA A 282
GLU A 283
LEU A 263
LEU A 260
ARG A 304
 None
 1.40A 1a52B-5bt1A:
undetectable		 1a52B-5bt1A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cwl DESIGNED HELICAL
REPEAT PROTEIN

(synthetic
construct) 		no annotation 5 ALA A 100
GLU A  97
LEU A 137
ILE A 168
LEU A 119
 None
 1.36A 1a52B-5cwlA:
undetectable		 1a52B-5cwlA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dbx STE20/SPS1-RELATED
PROLINE-ALANINE-RICH
PROTEIN KINASE

(Mus musculus) 		PF00069
(Pkinase) 		5 MET A 268
ALA A 275
LEU A 278
ILE A 220
LEU A 189
 None
 1.40A 1a52B-5dbxA:
undetectable		 1a52B-5dbxA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e4y HOMOSERINE
O-ACETYLTRANSFERASE

(Pseudomonas
veronii) 		PF00561
(Abhydrolase_1) 		5 LEU A 336
MET A 332
LEU A 333
ARG A  72
HIS A 322
 None
 1.25A 1a52B-5e4yA:
undetectable		 1a52B-5e4yA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hdt SISTER CHROMATID
COHESION PROTEIN
PDS5 HOMOLOG B

(Homo sapiens) 		no annotation 5 ALA A 735
LEU A 776
ILE A 747
HIS A 715
LEU A 714
 None
 1.47A 1a52B-5hdtA:
undetectable		 1a52B-5hdtA:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jw7 E3 UBIQUITIN-PROTEIN
LIGASE SOPA
E3 UBIQUITIN-PROTEIN
LIGASE TRIM56

(Homo sapiens;
Salmonella
enterica) 		PF13445
(zf-RING_UBOX)
PF13599
(Pentapeptide_4)
PF13981
(SopA) 		5 ALA A 341
GLU B  26
ARG A 296
ILE A 324
LEU A 382
 None
 1.46A 1a52B-5jw7A:
undetectable		 1a52B-5jw7A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lcx (-)-ISOPIPERITENONE
REDUCTASE

(Mentha x
piperita) 		PF00106
(adh_short) 		5 ALA A 164
LEU A 168
ILE A  33
HIS A  63
LEU A  65
 None
 1.46A 1a52B-5lcxA:
undetectable		 1a52B-5lcxA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n4l CERULOPLASMIN

(Rattus
norvegicus) 		no annotation 5 ALA A 277
LEU A 316
MET A 315
ILE A  26
LEU A 328
 None
None
None
None
CU  A1103 (-4.4A)
 1.40A 1a52B-5n4lA:
undetectable		 1a52B-5n4lA:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nkm PROTEIN SMG-8
PROTEIN SMG-9

(Caenorhabditis
elegans) 		PF10220
(Smg8_Smg9)
no annotation 		5 ALA D 185
LEU D 181
ILE E 172
HIS D 352
LEU D 351
 EDO  D 402 (-4.0A)
None
None
None
None
 1.30A 1a52B-5nkmD:
undetectable		 1a52B-5nkmD:
24.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5toa ESTROGEN RECEPTOR
BETA

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 ALA A 302
GLU A 305
ARG A 346
ILE A 373
LEU A 476
 EST  A 601 ( 3.9A)
EST  A 601 (-2.4A)
EST  A 601 (-4.1A)
None
EST  A 601 (-3.5A)
 1.01A 1a52B-5toaA:
30.7		 1a52B-5toaA:
57.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5toa ESTROGEN RECEPTOR
BETA

(Homo sapiens) 		PF00104
(Hormone_recep) 		10 MET A 295
ALA A 302
GLU A 305
LEU A 339
MET A 340
LEU A 343
ARG A 346
ILE A 376
HIS A 475
LEU A 476
 EST  A 601 ( 4.4A)
EST  A 601 ( 3.9A)
EST  A 601 (-2.4A)
EST  A 601 (-3.9A)
EST  A 601 ( 4.8A)
EST  A 601 ( 4.4A)
EST  A 601 (-4.1A)
EST  A 601 ( 4.4A)
EST  A 601 (-4.4A)
EST  A 601 (-3.5A)
 0.39A 1a52B-5toaA:
30.7		 1a52B-5toaA:
57.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5toa ESTROGEN RECEPTOR
BETA

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 MET A 295
LEU A 354
ILE A 376
HIS A 475
LEU A 476
 EST  A 601 ( 4.4A)
None
EST  A 601 ( 4.4A)
EST  A 601 (-4.4A)
EST  A 601 (-3.5A)
 1.35A 1a52B-5toaA:
30.7		 1a52B-5toaA:
57.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vrd BIFUNCTIONAL
COENZYME PQQ
SYNTHESIS PROTEIN
C/D

(Methylobacterium
extorquens) 		no annotation 5 ALA D 153
LEU D 156
ARG D  91
HIS D  19
LEU D  22
 None
 1.25A 1a52B-5vrdD:
2.0		 1a52B-5vrdD:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vws CYTOCHROME P450

(Thermobispora
bispora) 		PF00067
(p450) 		5 ALA A 178
GLU A 181
LEU A 150
HIS A 232
LEU A 229
 None
 1.21A 1a52B-5vwsA:
2.5		 1a52B-5vwsA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vy3 PROTEASOME SUBUNIT
ALPHA

(Thermoplasma
acidophilum) 		no annotation 5 MET A 120
ALA A  92
LEU A 112
ILE A 157
LEU A 136
 None
 1.23A 1a52B-5vy3A:
undetectable		 1a52B-5vy3A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w7a ACYLOXYACYL
HYDROLASE LARGE
SUBUNIT

(Oryctolagus
cuniculus) 		no annotation 5 ALA B 488
LEU B 415
LEU B 501
ILE B 364
HIS B 412
 None
 1.40A 1a52B-5w7aB:
undetectable		 1a52B-5w7aB:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x87 BESTROPHIN

(Klebsiella
pneumoniae) 		no annotation 5 ALA A  82
GLU A  81
LEU A  85
ARG A 201
LEU A 272
 None
 1.39A 1a52B-5x87A:
undetectable		 1a52B-5x87A:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6amn HEAT SHOCK PROTEIN
104

(Saccharomyces
cerevisiae) 		no annotation 5 ALA A  38
GLU A  41
LEU A  21
ILE A  76
LEU A  30
 None
 1.42A 1a52B-6amnA:
undetectable		 1a52B-6amnA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cf8 LYTIC
TRANSGLYCOSYLASE

(Campylobacter
jejuni) 		no annotation 5 ALA A 403
LEU A 404
MET A 432
ILE A 417
HIS A 445
 None
 1.44A 1a52B-6cf8A:
undetectable		 1a52B-6cf8A:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dll P-HYDROXYBENZOATE
HYDROXYLASE

(Pseudomonas
putida) 		no annotation 5 ALA A  59
GLU A  58
LEU A  20
ARG A 311
LEU A 109
 None
 1.43A 1a52B-6dllA:
undetectable		 1a52B-6dllA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fhs RUVB-LIKE HELICASE

(Chaetomium
thermophilum) 		no annotation 5 ALA A 380
GLU A 383
LEU A 411
LEU A 408
ILE A 372
 None
 1.40A 1a52B-6fhsA:
undetectable		 1a52B-6fhsA:
15.28