SIMILAR PATTERNS OF AMINO ACIDS FOR 1A4L_D_DCFD1853_1
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1dbn | PROTEIN(LEUKOAGGLUTININ) (Maackiaamurensis) |
PF00139(Lectin_legB) | 5 | GLY A 88GLU A 127HIS A 145ASP A 140ASP A 137 | None MN A 302 (-2.8A) MN A 302 (-3.2A) MN A 302 ( 2.5A)GAL A 823 ( 3.1A) | 1.11A | 1a4lD-1dbnA:undetectable | 1a4lD-1dbnA:22.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1eqw | CU,ZN SUPEROXIDEDISMUTASE (Salmonellaenterica) |
PF00080(Sod_Cu) | 5 | HIS A 69ASP A 130GLY A 138HIS A 44HIS A 46 | ZN A 501 (-2.9A)NoneNone CU A 502 (-3.3A) CU A 502 (-3.2A) | 1.44A | 1a4lD-1eqwA:undetectable | 1a4lD-1eqwA:19.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1eso | CU, ZN SUPEROXIDEDISMUTASE (Escherichiacoli) |
PF00080(Sod_Cu) | 5 | HIS A 69ASP A 130GLY A 138HIS A 44HIS A 46 | ZN A 149 ( 3.0A)NoneNone CU A 150 ( 3.2A) CU A 150 ( 3.3A) | 1.49A | 1a4lD-1esoA:undetectable | 1a4lD-1esoA:18.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1h0n | RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE (Mus musculus) |
PF00268(Ribonuc_red_sm) | 5 | HIS A 173PHE A 241GLY A 268HIS A 270ASP A 139 | CO A1353 (-3.2A)NoneNone CO A1354 (-3.3A) CO A1353 (-1.8A) | 1.23A | 1a4lD-1h0nA:undetectable | 1a4lD-1h0nA:22.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1h0n | RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE (Mus musculus) |
PF00268(Ribonuc_red_sm) | 5 | PHE A 237PHE A 241GLY A 268HIS A 270ASP A 139 | NoneNoneNone CO A1354 (-3.3A) CO A1353 (-1.8A) | 1.34A | 1a4lD-1h0nA:undetectable | 1a4lD-1h0nA:22.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1k0f | PERIPLASMICZINC-BINDING PROTEINTROA (Treponemapallidum) |
PF01297(ZnuA) | 5 | HIS A 68GLY A 218GLU A 248ASP A 279ASP A 66 | None | 1.15A | 1a4lD-1k0fA:undetectable | 1a4lD-1k0fA:21.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1kq0 | METHIONINEAMINOPEPTIDASE 2 (Homo sapiens) |
PF00557(Peptidase_M24) | 5 | PHE A 219ALA A 362HIS A 331HIS A 339ASP A 251 | MED A 601 ( 3.9A) ZN A 480 ( 3.7A) ZN A 480 ( 3.4A)MED A 601 (-3.3A) ZN A 479 ( 1.9A) | 1.28A | 1a4lD-1kq0A:undetectable | 1a4lD-1kq0A:19.64 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1krm | ADENOSINE DEAMINASE (Bos taurus) |
PF00962(A_deaminase) | 11 | HIS A 14ASP A 16PHE A 58PHE A 62MET A 152ALA A 180GLY A 181HIS A 211HIS A 235ASP A 292ASP A 293 | PRH A 401 ( 3.0A)PRH A 401 (-3.4A)NonePRH A 401 ( 4.4A)PRH A 401 (-4.1A)PRH A 401 ( 3.8A)PRH A 401 (-4.0A) ZN A 501 ( 3.4A)PRH A 401 (-4.0A)PRH A 401 ( 2.5A)PRH A 401 (-3.5A) | 0.60A | 1a4lD-1krmA:58.3 | 1a4lD-1krmA:84.81 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1krm | ADENOSINE DEAMINASE (Bos taurus) |
PF00962(A_deaminase) | 5 | HIS A 14ASP A 293PHE A 58ALA A 180GLY A 181 | PRH A 401 ( 3.0A)PRH A 401 (-3.5A)NonePRH A 401 ( 3.8A)PRH A 401 (-4.0A) | 1.46A | 1a4lD-1krmA:58.3 | 1a4lD-1krmA:84.81 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1krm | ADENOSINE DEAMINASE (Bos taurus) |
PF00962(A_deaminase) | 5 | HIS A 14PHE A 58ALA A 180GLY A 181ASP A 292 | PRH A 401 ( 3.0A)NonePRH A 401 ( 3.8A)PRH A 401 (-4.0A)PRH A 401 ( 2.5A) | 0.96A | 1a4lD-1krmA:58.3 | 1a4lD-1krmA:84.81 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1krm | ADENOSINE DEAMINASE (Bos taurus) |
PF00962(A_deaminase) | 11 | HIS A 14PHE A 58PHE A 62MET A 152ALA A 180GLY A 181HIS A 211GLU A 214HIS A 235ASP A 292ASP A 293 | PRH A 401 ( 3.0A)NonePRH A 401 ( 4.4A)PRH A 401 (-4.1A)PRH A 401 ( 3.8A)PRH A 401 (-4.0A) ZN A 501 ( 3.4A)PRH A 401 (-2.5A)PRH A 401 (-4.0A)PRH A 401 ( 2.5A)PRH A 401 (-3.5A) | 0.44A | 1a4lD-1krmA:58.3 | 1a4lD-1krmA:84.81 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1krm | ADENOSINE DEAMINASE (Bos taurus) |
PF00962(A_deaminase) | 6 | HIS A 14PHE A 62MET A 152ALA A 180GLY A 181ASP A 293 | PRH A 401 ( 3.0A)PRH A 401 ( 4.4A)PRH A 401 (-4.1A)PRH A 401 ( 3.8A)PRH A 401 (-4.0A)PRH A 401 (-3.5A) | 1.29A | 1a4lD-1krmA:58.3 | 1a4lD-1krmA:84.81 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1krm | ADENOSINE DEAMINASE (Bos taurus) |
PF00962(A_deaminase) | 6 | HIS A 14PHE A 62MET A 152ALA A 180GLY A 181ASP A 293 | PRH A 401 ( 3.0A)PRH A 401 ( 4.4A)PRH A 401 (-4.1A)PRH A 401 ( 3.8A)PRH A 401 (-4.0A)PRH A 401 (-3.5A) | 1.43A | 1a4lD-1krmA:58.3 | 1a4lD-1krmA:84.81 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1krm | ADENOSINE DEAMINASE (Bos taurus) |
PF00962(A_deaminase) | 7 | PHE A 58PHE A 62MET A 152ALA A 180GLY A 181HIS A 12ASP A 293 | NonePRH A 401 ( 4.4A)PRH A 401 (-4.1A)PRH A 401 ( 3.8A)PRH A 401 (-4.0A) ZN A 501 ( 3.3A)PRH A 401 (-3.5A) | 1.33A | 1a4lD-1krmA:58.3 | 1a4lD-1krmA:84.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1kwc | 2,3-DIHYDROXYBIPHENYL DIOXYGENASE (Pseudomonas sp.KKS102) |
PF00903(Glyoxalase) | 5 | HIS B 194ALA B 145GLY B 144HIS B 209ASP B 243 | BPY B 401 (-4.3A)NoneNoneBPY B 401 (-3.7A)BPY B 401 (-3.9A) | 1.37A | 1a4lD-1kwcB:undetectable | 1a4lD-1kwcB:20.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1li7 | CYSTEINYL-TRNASYNTHETASE (Escherichiacoli) |
PF01406(tRNA-synt_1e)PF09190(DALR_2) | 5 | PHE A 44GLY A 225HIS A 235GLU A 238HIS A 234 | NoneNoneNone ZN A 963 (-3.8A) ZN A 963 ( 3.1A) | 1.49A | 1a4lD-1li7A:undetectable | 1a4lD-1li7A:22.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1o0x | METHIONINEAMINOPEPTIDASE (Thermotogamaritima) |
PF00557(Peptidase_M24) | 5 | PHE A 62ALA A 205HIS A 174HIS A 181ASP A 100 | None | 1.43A | 1a4lD-1o0xA:undetectable | 1a4lD-1o0xA:24.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1r2f | PROTEIN(RIBONUCLEOTIDEREDUCTASE R2) (Salmonellaenterica) |
PF00268(Ribonuc_red_sm) | 5 | HIS A 101PHE A 162HIS A 195GLU A 158ASP A 67 | FE A 400 (-3.4A) FE A 400 ( 4.7A) FE A 401 (-3.3A) FE A 401 (-1.7A) FE A 400 (-3.0A) | 1.21A | 1a4lD-1r2fA:undetectable | 1a4lD-1r2fA:21.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1toa | PROTEIN (PERIPLASMICBINDING PROTEINTROA) (Treponemapallidum) |
PF01297(ZnuA) | 5 | HIS A 68GLY A 218GLU A 248ASP A 279ASP A 66 | ZN A 501 ( 3.4A)NoneNone ZN A 501 ( 2.0A)None | 1.10A | 1a4lD-1toaA:undetectable | 1a4lD-1toaA:21.76 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1uio | ADENOSINE DEAMINASE (Mus musculus) |
PF00962(A_deaminase) | 6 | HIS A 17ASP A 19PHE A 61PHE A 65HIS A 15ASP A 296 | HPR A 353 ( 3.1A)HPR A 353 (-2.7A)HPR A 353 (-4.6A)HPR A 353 (-3.9A) ZN A 400 (-3.4A)HPR A 353 (-2.6A) | 1.47A | 1a4lD-1uioA:63.3 | 1a4lD-1uioA:99.71 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1uio | ADENOSINE DEAMINASE (Mus musculus) |
PF00962(A_deaminase) | 11 | HIS A 17ASP A 19PHE A 61PHE A 65MET A 155ALA A 183GLY A 184HIS A 214GLU A 217ASP A 295ASP A 296 | HPR A 353 ( 3.1A)HPR A 353 (-2.7A)HPR A 353 (-4.6A)HPR A 353 (-3.9A)HPR A 353 (-4.1A)HPR A 353 (-3.2A)HPR A 353 (-3.8A) ZN A 400 ( 3.3A)HPR A 353 (-2.7A)HPR A 353 ( 2.5A)HPR A 353 (-2.6A) | 0.33A | 1a4lD-1uioA:63.3 | 1a4lD-1uioA:99.71 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1uio | ADENOSINE DEAMINASE (Mus musculus) |
PF00962(A_deaminase) | 5 | HIS A 17ASP A 296PHE A 61ALA A 183GLY A 184 | HPR A 353 ( 3.1A)HPR A 353 (-2.6A)HPR A 353 (-4.6A)HPR A 353 (-3.2A)HPR A 353 (-3.8A) | 1.45A | 1a4lD-1uioA:63.3 | 1a4lD-1uioA:99.71 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1uio | ADENOSINE DEAMINASE (Mus musculus) |
PF00962(A_deaminase) | 7 | HIS A 17MET A 155ALA A 183GLY A 184HIS A 214GLU A 217ASP A 296 | HPR A 353 ( 3.1A)HPR A 353 (-4.1A)HPR A 353 (-3.2A)HPR A 353 (-3.8A) ZN A 400 ( 3.3A)HPR A 353 (-2.7A)HPR A 353 (-2.6A) | 1.24A | 1a4lD-1uioA:63.3 | 1a4lD-1uioA:99.71 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1uio | ADENOSINE DEAMINASE (Mus musculus) |
PF00962(A_deaminase) | 5 | HIS A 17PHE A 61ALA A 183GLY A 184ASP A 295 | HPR A 353 ( 3.1A)HPR A 353 (-4.6A)HPR A 353 (-3.2A)HPR A 353 (-3.8A)HPR A 353 ( 2.5A) | 0.99A | 1a4lD-1uioA:63.3 | 1a4lD-1uioA:99.71 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1uio | ADENOSINE DEAMINASE (Mus musculus) |
PF00962(A_deaminase) | 7 | HIS A 17PHE A 65MET A 155ALA A 183GLY A 184HIS A 214ASP A 296 | HPR A 353 ( 3.1A)HPR A 353 (-3.9A)HPR A 353 (-4.1A)HPR A 353 (-3.2A)HPR A 353 (-3.8A) ZN A 400 ( 3.3A)HPR A 353 (-2.6A) | 1.40A | 1a4lD-1uioA:63.3 | 1a4lD-1uioA:99.71 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1uio | ADENOSINE DEAMINASE (Mus musculus) |
PF00962(A_deaminase) | 5 | HIS A 17PHE A 300PHE A 61HIS A 15ASP A 296 | HPR A 353 ( 3.1A)NoneHPR A 353 (-4.6A) ZN A 400 (-3.4A)HPR A 353 (-2.6A) | 1.28A | 1a4lD-1uioA:63.3 | 1a4lD-1uioA:99.71 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1uio | ADENOSINE DEAMINASE (Mus musculus) |
PF00962(A_deaminase) | 8 | PHE A 61PHE A 65MET A 155ALA A 183GLY A 184HIS A 15ASP A 295ASP A 296 | HPR A 353 (-4.6A)HPR A 353 (-3.9A)HPR A 353 (-4.1A)HPR A 353 (-3.2A)HPR A 353 (-3.8A) ZN A 400 (-3.4A)HPR A 353 ( 2.5A)HPR A 353 (-2.6A) | 1.42A | 1a4lD-1uioA:63.3 | 1a4lD-1uioA:99.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vme | FLAVOPROTEIN (Thermotogamaritima) |
PF00258(Flavodoxin_1) | 5 | HIS A 228HIS A 90GLU A 87HIS A 85ASP A 168 | FEO A 401 (-3.3A)FEO A 401 (-3.3A)FEO A 401 (-2.9A)FEO A 401 (-3.4A)FEO A 401 (-2.5A) | 1.34A | 1a4lD-1vmeA:undetectable | 1a4lD-1vmeA:22.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wkm | METHIONINEAMINOPEPTIDASE (Pyrococcusfuriosus) |
PF00557(Peptidase_M24) | 5 | PHE A 50ALA A 185HIS A 153HIS A 161ASP A 82 | MET A1298 (-3.8A) MN A 296 ( 3.9A) MN A 296 ( 3.3A)MET A1298 (-4.0A) MN A 297 ( 1.7A) | 1.30A | 1a4lD-1wkmA:undetectable | 1a4lD-1wkmA:22.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2a3l | AMP DEAMINASE (Arabidopsisthaliana) |
PF00962(A_deaminase) | 6 | HIS A 393HIS A 659GLU A 662HIS A 681ASP A 736ASP A 737 | ZN A 840 ( 3.2A) ZN A 840 ( 3.1A)CF5 A 841 (-2.6A)CF5 A 841 (-4.2A)CF5 A 841 ( 2.5A)CF5 A 841 (-2.5A) | 0.65A | 1a4lD-2a3lA:20.5 | 1a4lD-2a3lA:18.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2amx | ADENOSINE DEAMINASE (Plasmodiumyoelii) |
PF00962(A_deaminase) | 7 | HIS A 57ASP A 59GLY A 213GLU A 242HIS A 266ASP A 323ASP A 324 | CO A1000 (-3.2A)NoneNoneUNX A2004 ( 4.8A)None CO A1000 (-2.7A)None | 0.75A | 1a4lD-2amxA:39.9 | 1a4lD-2amxA:25.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2amx | ADENOSINE DEAMINASE (Plasmodiumyoelii) |
PF00962(A_deaminase) | 9 | HIS A 57ASP A 59PHE A 101GLY A 214HIS A 239GLU A 242HIS A 266ASP A 323ASP A 324 | CO A1000 (-3.2A)NoneUNX A2004 ( 4.8A)None CO A1000 (-3.4A)UNX A2004 ( 4.8A)None CO A1000 (-2.7A)None | 0.65A | 1a4lD-2amxA:39.9 | 1a4lD-2amxA:25.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2amx | ADENOSINE DEAMINASE (Plasmodiumyoelii) |
PF00962(A_deaminase) | 5 | HIS A 57PHE A 328PHE A 101HIS A 55ASP A 324 | CO A1000 (-3.2A)NoneUNX A2004 ( 4.8A) CO A1000 (-3.3A)None | 1.36A | 1a4lD-2amxA:39.9 | 1a4lD-2amxA:25.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bty | ACETYLGLUTAMATEKINASE (Thermotogamaritima) |
PF00696(AA_kinase) | 5 | HIS A 253PHE A 24PHE A 19ALA A 251GLY A 250 | ARG A1283 ( 4.9A)NoneARG A1283 (-4.7A)NoneNone | 1.37A | 1a4lD-2btyA:undetectable | 1a4lD-2btyA:22.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2i9u | CYTOSINE/GUANINEDEAMINASE RELATEDPROTEIN (Clostridiumacetobutylicum) |
PF01979(Amidohydro_1) | 5 | HIS A 75HIS A 229GLU A 232HIS A 269ASP A 320 | FE A 501 ( 3.6A)GUN A 503 ( 3.5A)GUN A 503 (-3.1A)GUN A 503 ( 4.4A) FE A 501 ( 2.7A) | 0.48A | 1a4lD-2i9uA:21.4 | 1a4lD-2i9uA:24.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2imr | HYPOTHETICAL PROTEINDR_0824 (Deinococcusradiodurans) |
PF01979(Amidohydro_1) | 6 | HIS A 99PHE A 107HIS A 238GLU A 241HIS A 301ASP A 352 | ZN A 500 (-3.2A)None ZN A 500 (-3.2A)NoneNone ZN A 500 (-3.9A) | 0.84A | 1a4lD-2imrA:17.6 | 1a4lD-2imrA:22.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2imr | HYPOTHETICAL PROTEINDR_0824 (Deinococcusradiodurans) |
PF01979(Amidohydro_1) | 5 | HIS A 99PHE A 113HIS A 238HIS A 301ASP A 352 | ZN A 500 (-3.2A)None ZN A 500 (-3.2A)None ZN A 500 (-3.9A) | 0.90A | 1a4lD-2imrA:17.6 | 1a4lD-2imrA:22.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ood | BLR3880 PROTEIN (Bradyrhizobiumdiazoefficiens) |
PF01979(Amidohydro_1) | 5 | HIS A 81HIS A 234GLU A 237HIS A 273ASP A 326 | ZN A 500 ( 3.3A)GUN A 600 ( 2.8A)GUN A 600 (-2.8A)GUN A 600 (-3.9A)GUN A 600 ( 2.5A) | 0.43A | 1a4lD-2oodA:21.1 | 1a4lD-2oodA:21.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pok | PEPTIDASE,M20/M25/M40 FAMILY (Streptococcuspneumoniae) |
PF01546(Peptidase_M20)PF07687(M20_dimer) | 5 | HIS A 431GLU A 157HIS A 90ASP A 123ASP A 430 | None MN A 460 ( 3.8A) MN A 460 (-3.7A) MN A 460 (-2.6A)None | 1.34A | 1a4lD-2pokA:undetectable | 1a4lD-2pokA:21.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pok | PEPTIDASE,M20/M25/M40 FAMILY (Streptococcuspneumoniae) |
PF01546(Peptidase_M20)PF07687(M20_dimer) | 5 | HIS A 431GLU A 184HIS A 90ASP A 123ASP A 430 | None MN A 460 (-2.3A) MN A 460 (-3.7A) MN A 460 (-2.6A)None | 1.10A | 1a4lD-2pokA:undetectable | 1a4lD-2pokA:21.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2q9u | A-TYPE FLAVOPROTEIN (Giardiaintestinalis) |
no annotation | 5 | HIS A 85ASP A 155GLY A 88HIS A 230ASP A 171 | FEO A 701 (-3.5A)NoneNoneFEO A 701 ( 3.3A)FEO A 701 ( 2.5A) | 1.32A | 1a4lD-2q9uA:undetectable | 1a4lD-2q9uA:21.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2q9u | A-TYPE FLAVOPROTEIN (Giardiaintestinalis) |
no annotation | 5 | HIS A 230HIS A 90GLU A 87HIS A 85ASP A 171 | FEO A 701 ( 3.3A)FEO A 701 (-3.3A)FEO A 701 (-2.9A)FEO A 701 (-3.5A)FEO A 701 ( 2.5A) | 1.35A | 1a4lD-2q9uA:undetectable | 1a4lD-2q9uA:21.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qt3 | N-ISOPROPYLAMMELIDEISOPROPYLAMIDOHYDROLASE (Pseudomonas sp.ADP) |
PF01979(Amidohydro_1) | 5 | HIS A 62ASP A 64HIS A 217HIS A 249ASP A 303 | ZN A 501 (-3.3A)None ZN A 501 (-3.5A)None ZN A 501 (-3.2A) | 0.88A | 1a4lD-2qt3A:21.6 | 1a4lD-2qt3A:21.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2r7d | RIBONUCLEASE IIFAMILY PROTEIN (Deinococcusradiodurans) |
PF00773(RNB) | 5 | ALA A 247GLY A 251HIS A 394HIS A 393ASP A 51 | None | 1.25A | 1a4lD-2r7dA:undetectable | 1a4lD-2r7dA:22.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2v4j | SULFITE REDUCTASE,DISSIMILATORY-TYPESUBUNIT ALPHASULFITE REDUCTASE,DISSIMILATORY-TYPESUBUNIT BETA (Desulfovibriovulgaris) |
PF01077(NIR_SIR)PF03460(NIR_SIR_ferr) | 5 | HIS A 206ASP B 20PHE A 153GLY A 75ASP A 163 | None | 1.40A | 1a4lD-2v4jA:undetectable | 1a4lD-2v4jA:20.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xr1 | CLEAVAGE ANDPOLYADENYLATIONSPECIFICITY FACTOR100 KD SUBUNIT (Methanosarcinamazei) |
PF07521(RMMBL)PF07650(KH_2)PF10996(Beta-Casp)PF16661(Lactamase_B_6)PF17214(KH_7) | 5 | HIS A 244GLY A 579HIS A 329GLU A 377ASP A 246 | ZN A1638 (-3.0A)None ZN A1638 (-3.5A)None ZN A1639 (-2.7A) | 1.35A | 1a4lD-2xr1A:undetectable | 1a4lD-2xr1A:20.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3azq | AMINOPEPTIDASE (Streptomycesmorookaense) |
PF00326(Peptidase_S9) | 5 | ALA A 315GLY A 314GLU A 285HIS A 311ASP A 330 | NoneSO4 A1006 ( 3.8A)NoneNoneNone | 1.42A | 1a4lD-3azqA:undetectable | 1a4lD-3azqA:19.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3e0l | GUANINE DEAMINASE (Homo sapiens) |
PF01979(Amidohydro_1) | 5 | HIS A 84HIS A 238GLU A 241HIS A 277ASP A 328 | ZN A1452 (-3.1A) ZN A1452 (-3.2A)NoneNone ZN A1452 (-2.8A) | 0.48A | 1a4lD-3e0lA:21.2 | 1a4lD-3e0lA:23.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ewd | ADENOSINE DEAMINASE (Plasmodiumvivax) |
PF00962(A_deaminase) | 8 | HIS A 44ASP A 46PHE A 88GLY A 199GLU A 228HIS A 252ASP A 309ASP A 310 | MCF A 372 ( 3.3A)MCF A 372 (-3.5A)MCF A 372 (-4.5A)MCF A 372 ( 3.9A)MCF A 372 (-2.8A)MCF A 372 (-4.1A)MCF A 372 ( 2.4A)MCF A 372 (-2.9A) | 0.79A | 1a4lD-3ewdA:42.4 | 1a4lD-3ewdA:26.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ewd | ADENOSINE DEAMINASE (Plasmodiumvivax) |
PF00962(A_deaminase) | 9 | HIS A 44ASP A 46PHE A 88GLY A 200HIS A 225GLU A 228HIS A 252ASP A 309ASP A 310 | MCF A 372 ( 3.3A)MCF A 372 (-3.5A)MCF A 372 (-4.5A)MCF A 372 (-3.4A) ZN A 371 ( 3.4A)MCF A 372 (-2.8A)MCF A 372 (-4.1A)MCF A 372 ( 2.4A)MCF A 372 (-2.9A) | 0.57A | 1a4lD-3ewdA:42.4 | 1a4lD-3ewdA:26.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3g77 | CYTOSINE DEAMINASE (Escherichiacoli) |
PF07969(Amidohydro_3) | 6 | HIS A 63ASP A 65HIS A 214GLU A 217HIS A 246ASP A 313 | FE A 502 (-3.1A)None FE A 502 (-3.6A)None FE A 502 ( 4.8A) FE A 502 (-3.2A) | 0.73A | 1a4lD-3g77A:23.0 | 1a4lD-3g77A:21.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3giu | PYRROLIDONE-CARBOXYLATE PEPTIDASE (Staphylococcusaureus) |
PF01470(Peptidase_C15) | 5 | HIS A 103ASP A 105GLY A 149HIS A 147HIS A 143 | None | 1.34A | 1a4lD-3giuA:undetectable | 1a4lD-3giuA:18.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ie1 | RIBONUCLEASETTHA0252 (Thermusthermophilus) |
PF00753(Lactamase_B)PF07521(RMMBL)PF10996(Beta-Casp) | 5 | HIS A 61PHE A 223GLY A 379HIS A 141ASP A 63 | ZN A 453 (-3.4A) U E 1 ( 3.9A)SO4 A 447 (-3.8A) ZN A 453 (-3.3A) ZN A 452 (-2.5A) | 1.37A | 1a4lD-3ie1A:undetectable | 1a4lD-3ie1A:23.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ie1 | RIBONUCLEASETTHA0252 (Thermusthermophilus) |
PF00753(Lactamase_B)PF07521(RMMBL)PF10996(Beta-Casp) | 5 | HIS A 61PHE A 223GLY A 379HIS A 400ASP A 63 | ZN A 453 (-3.4A) U E 1 ( 3.9A)SO4 A 447 (-3.8A) ZN A 452 (-3.3A) ZN A 452 (-2.5A) | 1.31A | 1a4lD-3ie1A:undetectable | 1a4lD-3ie1A:23.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3k0z | PUTATIVE POLYKETIDECYCLASE (Bacillus cereus) |
PF07366(SnoaL) | 5 | HIS A 161PHE A 62PHE A 82ASP A 147ASP A 159 | None | 1.18A | 1a4lD-3k0zA:undetectable | 1a4lD-3k0zA:19.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lgg | ADENOSINE DEAMINASECECR1 (Homo sapiens) |
PF00962(A_deaminase)PF08451(A_deaminase_N) | 8 | HIS A 88ASP A 89GLY A 300HIS A 330GLU A 333HIS A 358ASP A 415ASP A 416 | CFE A 513 ( 3.3A)CFE A 513 (-3.0A)CFE A 513 (-3.3A) ZN A 512 ( 3.5A)CFE A 513 (-3.0A)CFE A 513 ( 4.3A)CFE A 513 ( 2.8A)CFE A 513 (-2.8A) | 0.98A | 1a4lD-3lggA:33.5 | 1a4lD-3lggA:21.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lgg | ADENOSINE DEAMINASECECR1 (Homo sapiens) |
PF00962(A_deaminase)PF08451(A_deaminase_N) | 5 | HIS A 88PHE A 181GLY A 300HIS A 330ASP A 416 | CFE A 513 ( 3.3A)CFE A 513 (-4.8A)CFE A 513 (-3.3A) ZN A 512 ( 3.5A)CFE A 513 (-2.8A) | 1.35A | 1a4lD-3lggA:33.5 | 1a4lD-3lggA:21.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lgg | ADENOSINE DEAMINASECECR1 (Homo sapiens) |
PF00962(A_deaminase)PF08451(A_deaminase_N) | 8 | HIS A 88PHE A 181PHE A 185GLY A 300HIS A 330HIS A 358ASP A 415ASP A 416 | CFE A 513 ( 3.3A)CFE A 513 (-4.8A)CFE A 513 ( 3.7A)CFE A 513 (-3.3A) ZN A 512 ( 3.5A)CFE A 513 ( 4.3A)CFE A 513 ( 2.8A)CFE A 513 (-2.8A) | 0.59A | 1a4lD-3lggA:33.5 | 1a4lD-3lggA:21.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lgg | ADENOSINE DEAMINASECECR1 (Homo sapiens) |
PF00962(A_deaminase)PF08451(A_deaminase_N) | 8 | HIS A 88PHE A 185GLY A 300HIS A 330GLU A 333HIS A 358ASP A 415ASP A 416 | CFE A 513 ( 3.3A)CFE A 513 ( 3.7A)CFE A 513 (-3.3A) ZN A 512 ( 3.5A)CFE A 513 (-3.0A)CFE A 513 ( 4.3A)CFE A 513 ( 2.8A)CFE A 513 (-2.8A) | 0.41A | 1a4lD-3lggA:33.5 | 1a4lD-3lggA:21.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lmf | UNCHARACTERIZEDPROTEIN (Nitrosospiramultiformis) |
no annotation | 5 | HIS A 32ALA A 36GLY A 37HIS A 40HIS A 45 | None | 1.38A | 1a4lD-3lmfA:undetectable | 1a4lD-3lmfA:15.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mdu | N-FORMIMINO-L-GLUTAMATE IMINOHYDROLASE (Pseudomonasaeruginosa) |
PF01979(Amidohydro_1) | 5 | HIS A 58HIS A 232GLU A 235HIS A 269ASP A 320 | ZN A 454 ( 3.2A) ZN A 454 (-3.3A)NGQ A 455 (-2.9A)None ZN A 454 (-2.9A) | 0.34A | 1a4lD-3mduA:21.3 | 1a4lD-3mduA:21.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mdu | N-FORMIMINO-L-GLUTAMATE IMINOHYDROLASE (Pseudomonasaeruginosa) |
PF01979(Amidohydro_1) | 5 | HIS A 58PHE A 60HIS A 232HIS A 269ASP A 320 | ZN A 454 ( 3.2A)None ZN A 454 (-3.3A)None ZN A 454 (-2.9A) | 1.29A | 1a4lD-3mduA:21.3 | 1a4lD-3mduA:21.93 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3pao | ADENOSINE DEAMINASE (Pseudomonasaeruginosa) |
PF00962(A_deaminase) | 6 | HIS A 18ASP A 100PHE A 59GLU A 199HIS A 220ASP A 277 | ADE A 328 ( 3.0A)NoneNoneADE A 328 (-3.0A)ADE A 328 ( 4.2A) ZN A 327 ( 2.6A) | 1.34A | 1a4lD-3paoA:39.6 | 1a4lD-3paoA:30.03 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3pao | ADENOSINE DEAMINASE (Pseudomonasaeruginosa) |
PF00962(A_deaminase) | 7 | HIS A 18PHE A 59HIS A 196GLU A 199HIS A 220ASP A 277ASP A 278 | ADE A 328 ( 3.0A)None ZN A 327 ( 3.5A)ADE A 328 (-3.0A)ADE A 328 ( 4.2A) ZN A 327 ( 2.6A)ADE A 328 (-2.8A) | 0.52A | 1a4lD-3paoA:39.6 | 1a4lD-3paoA:30.03 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3pao | ADENOSINE DEAMINASE (Pseudomonasaeruginosa) |
PF00962(A_deaminase) | 5 | HIS A 18PHE A 282PHE A 59HIS A 196ASP A 278 | ADE A 328 ( 3.0A)NoneNone ZN A 327 ( 3.5A)ADE A 328 (-2.8A) | 1.41A | 1a4lD-3paoA:39.6 | 1a4lD-3paoA:30.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pjl | 34 KDA MEMBRANEANTIGEN (Treponemapallidum) |
PF10634(Iron_transport) | 5 | HIS A 124ALA A 119GLY A 120GLU A 30ASP A 74 | CO A 186 (-3.3A)NoneNoneEDO A 189 (-4.4A)None | 1.39A | 1a4lD-3pjlA:undetectable | 1a4lD-3pjlA:18.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rys | ADENOSINE DEAMINASE1 (Paenarthrobacteraurescens) |
PF00962(A_deaminase) | 6 | HIS A 21ASP A 103PHE A 62GLU A 202HIS A 223ASP A 280 | ADE A 345 ( 3.2A)NoneNoneADE A 345 (-2.8A)ADE A 345 ( 4.2A) ZN A 344 ( 2.5A) | 1.31A | 1a4lD-3rysA:40.7 | 1a4lD-3rysA:29.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rys | ADENOSINE DEAMINASE1 (Paenarthrobacteraurescens) |
PF00962(A_deaminase) | 7 | HIS A 21PHE A 62HIS A 199GLU A 202HIS A 223ASP A 280ASP A 281 | ADE A 345 ( 3.2A)None ZN A 344 ( 3.4A)ADE A 345 (-2.8A)ADE A 345 ( 4.2A) ZN A 344 ( 2.5A)ADE A 345 (-2.8A) | 0.48A | 1a4lD-3rysA:40.7 | 1a4lD-3rysA:29.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rys | ADENOSINE DEAMINASE1 (Paenarthrobacteraurescens) |
PF00962(A_deaminase) | 5 | HIS A 21PHE A 285PHE A 62HIS A 199ASP A 281 | ADE A 345 ( 3.2A)NoneNone ZN A 344 ( 3.4A)ADE A 345 (-2.8A) | 1.41A | 1a4lD-3rysA:40.7 | 1a4lD-3rysA:29.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3t8l | ADENINE DEAMINASE 2 (Agrobacteriumfabrum) |
PF01979(Amidohydro_1)PF13382(Adenine_deam_C) | 5 | HIS A 94GLU A 240HIS A 239ASP A 289ASP A 290 | UNX A 608 ( 3.4A)UNX A 606 ( 3.0A)UNX A 606 ( 3.6A)UNX A 608 ( 2.4A)None | 1.07A | 1a4lD-3t8lA:16.6 | 1a4lD-3t8lA:21.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3v7p | AMIDOHYDROLASEFAMILY PROTEIN (Nitratiruptorsp. SB155-2) |
PF01979(Amidohydro_1) | 5 | HIS A 63HIS A 206GLU A 209HIS A 257ASP A 306 | FE A 429 (-3.2A) FE A 429 (-3.3A)UNL A 436 ( 2.8A)None FE A 429 (-3.1A) | 0.33A | 1a4lD-3v7pA:19.9 | 1a4lD-3v7pA:22.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vpo | RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASESUBUNIT M2 (Homo sapiens) |
PF00268(Ribonuc_red_sm) | 5 | HIS A 172PHE A 236PHE A 240GLY A 267HIS A 269 | NoneNoneNoneNone FE A 402 (-3.3A) | 1.28A | 1a4lD-3vpoA:undetectable | 1a4lD-3vpoA:18.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4djn | RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASESUBUNIT M2 B (Homo sapiens) |
PF00268(Ribonuc_red_sm) | 5 | HIS A 134PHE A 198GLY A 229HIS A 231ASP A 100 | None | 1.28A | 1a4lD-4djnA:undetectable | 1a4lD-4djnA:21.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4djn | RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASESUBUNIT M2 B (Homo sapiens) |
PF00268(Ribonuc_red_sm) | 5 | HIS A 134PHE A 198PHE A 202GLY A 229HIS A 231 | None | 1.34A | 1a4lD-4djnA:undetectable | 1a4lD-4djnA:21.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4dyk | AMIDOHYDROLASE (Pseudomonasaeruginosa) |
PF01979(Amidohydro_1) | 5 | HIS A 74HIS A 221GLU A 224HIS A 258ASP A 309 | ZN A 501 (-3.2A) ZN A 501 (-3.3A)NoneNone ZN A 501 (-2.6A) | 0.43A | 1a4lD-4dykA:20.9 | 1a4lD-4dykA:21.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4dzh | AMIDOHYDROLASE (Xanthomonascampestris) |
PF01979(Amidohydro_1) | 5 | HIS A 80HIS A 227GLU A 230HIS A 264ASP A 315 | ZN A 504 (-3.1A) ZN A 504 (-3.3A) ZN A 505 ( 4.2A) ZN A 505 ( 4.8A) ZN A 505 ( 2.0A) | 0.45A | 1a4lD-4dzhA:20.6 | 1a4lD-4dzhA:19.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ewt | PEPTIDASE,M20/M25/M40 FAMILY (Staphylococcusaureus) |
PF01546(Peptidase_M20)PF07687(M20_dimer) | 5 | HIS A 108PHE A 346MET A 166GLU A 139ASP A 78 | NoneNoneNone MN A 401 ( 2.2A) MN A 402 ( 4.4A) | 1.35A | 1a4lD-4ewtA:undetectable | 1a4lD-4ewtA:22.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4f0l | AMIDOHYDROLASE (Brucellaabortus) |
PF01979(Amidohydro_1) | 5 | HIS A 63HIS A 237GLU A 240HIS A 274ASP A 325 | FE A 501 (-3.4A) FE A 501 (-3.5A)NoneNone FE A 501 (-2.8A) | 0.35A | 1a4lD-4f0lA:20.2 | 1a4lD-4f0lA:21.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4f0l | AMIDOHYDROLASE (Brucellaabortus) |
PF01979(Amidohydro_1) | 5 | HIS A 63PHE A 65HIS A 237HIS A 274ASP A 325 | FE A 501 (-3.4A)None FE A 501 (-3.5A)None FE A 501 (-2.8A) | 1.34A | 1a4lD-4f0lA:20.2 | 1a4lD-4f0lA:21.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4f0s | 5-METHYLTHIOADENOSINE/S-ADENOSYLHOMOCYSTEINE DEAMINASE (Chromobacteriumviolaceum) |
PF01979(Amidohydro_1) | 5 | HIS A 72HIS A 219GLU A 222HIS A 256ASP A 307 | NOS A 501 (-3.7A)NOS A 501 (-3.5A)NOS A 501 (-3.0A)NOS A 501 (-4.0A)NOS A 501 (-2.8A) | 0.46A | 1a4lD-4f0sA:21.4 | 1a4lD-4f0sA:20.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gxw | ADENOSINE DEAMINASE (Burkholderiaambifaria) |
PF00962(A_deaminase) | 6 | HIS A 36HIS A 215GLU A 218HIS A 240ASP A 300ASP A 301 | ZN A 401 (-3.3A) ZN A 401 (-3.4A)NoneNone ZN A 401 (-2.6A)None | 0.47A | 1a4lD-4gxwA:39.6 | 1a4lD-4gxwA:26.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4oxr | MANGANESE ABCTRANSPORTER,PERIPLASMIC-BINDINGPROTEIN SITA (Staphylococcuspseudintermedius) |
PF01297(ZnuA) | 5 | HIS A 64GLY A 204HIS A 137ASP A 278ASP A 62 | MN A 401 (-3.4A)None MN A 401 (-3.4A) MN A 401 (-2.0A)None | 1.19A | 1a4lD-4oxrA:undetectable | 1a4lD-4oxrA:22.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4q7a | N-ACETYL-ORNITHINE/N-ACETYL-LYSINEDEACETYLASE (Sphaerobacterthermophilus) |
PF01546(Peptidase_M20) | 5 | HIS A 329GLU A 126HIS A 71ASP A 95ASP A 328 | NoneNoneNoneNoneSO4 A 401 ( 4.6A) | 1.30A | 1a4lD-4q7aA:undetectable | 1a4lD-4q7aA:21.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qn9 | N-ACYL-PHOSPHATIDYLETHANOLAMINE-HYDROLYZING PHOSPHOLIPASE D (Homo sapiens) |
PF12706(Lactamase_B_2) | 5 | ALA A 310GLY A 309HIS A 321HIS A 253ASP A 189 | 3PE A 503 ( 4.7A)None3PE A 503 (-3.8A) ZN A 501 ( 3.5A) ZN A 502 ( 2.5A) | 1.10A | 1a4lD-4qn9A:2.3 | 1a4lD-4qn9A:21.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4r85 | CYTOSINE DEAMINASE (Klebsiellapneumoniae) |
PF07969(Amidohydro_3) | 6 | HIS A 58ASP A 60HIS A 209GLU A 212HIS A 241ASP A 308 | FE2 A 502 ( 3.5A)NoneFE2 A 502 ( 3.4A)17E A 501 (-2.9A)FE2 A 502 ( 3.7A)FE2 A 502 ( 2.8A) | 0.91A | 1a4lD-4r85A:22.6 | 1a4lD-4r85A:20.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4v1y | ATRAZINECHLOROHYDROLASE (Pseudomonas sp.ADP) |
PF01979(Amidohydro_1) | 5 | HIS A 68HIS A 243GLU A 246HIS A 276ASP A 327 | FE A 481 (-3.9A) FE A 481 (-4.1A) FE A 481 ( 4.3A) FE A 481 (-3.9A) FE A 481 (-2.8A) | 0.57A | 1a4lD-4v1yA:22.0 | 1a4lD-4v1yA:20.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4x8i | LYSYL AMINOPEPTIDASE (Pyrococcusfuriosus) |
PF05343(Peptidase_M42) | 5 | HIS A 314PHE A 233GLU A 207HIS A 63ASP A 177 | CO A 402 (-3.5A)None CL A 403 ( 2.8A) ZN A 401 (-3.3A) ZN A 401 ( 2.6A) | 1.31A | 1a4lD-4x8iA:undetectable | 1a4lD-4x8iA:21.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5aeb | LRA-12 (unculturedbacterium BLR12) |
PF00753(Lactamase_B) | 5 | HIS A 118ASP A 153PHE A 156HIS A 263ASP A 120 | ZN A1308 (-3.0A)NoneNone ZN A1307 (-3.2A) ZN A1307 (-2.5A) | 1.15A | 1a4lD-5aebA:undetectable | 1a4lD-5aebA:21.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5cbk | SHHTL5 (Strigahermonthica) |
PF12697(Abhydrolase_6) | 5 | HIS A 24MET A 181ALA A 54GLY A 53HIS A 8 | None | 1.13A | 1a4lD-5cbkA:undetectable | 1a4lD-5cbkA:19.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fll | 6-CARBOXYHEXANOATE-COA LIGASE (Bacillussubtilis) |
PF03744(BioW) | 5 | MET A 12GLY A 29HIS A 26ASP A 195ASP A 196 | NonePPV A 701 (-3.7A)PPV A 701 (-3.8A) MG A 704 (-2.7A) MG A 704 (-2.6A) | 1.40A | 1a4lD-5fllA:undetectable | 1a4lD-5fllA:23.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gw7 | GLUCOSIDASE YGJK (Escherichiacoli) |
PF01204(Trehalase) | 5 | ASP A 362PHE A 365ALA A 442GLY A 441HIS A 448 | None | 1.49A | 1a4lD-5gw7A:undetectable | 1a4lD-5gw7A:20.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5i4k | MANGANESE-BINDINGLIPOPROTEIN MNTA (Listeriamonocytogenes) |
PF01297(ZnuA) | 5 | HIS A 67GLY A 207HIS A 140ASP A 281ASP A 65 | MN A 501 (-3.4A)None MN A 501 (-3.3A) MN A 501 (-2.0A)None | 1.26A | 1a4lD-5i4kA:undetectable | 1a4lD-5i4kA:22.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jm6 | AMINOPEPTIDASE-LIKEPROTEIN (Chaetomiumthermophilum) |
PF02127(Peptidase_M18) | 5 | HIS A 485ALA A 162GLU A 339HIS A 133ASP A 306 | ZN A 601 (-3.0A)None ZN A 602 (-3.5A) ZN A 602 (-3.3A) ZN A 601 ( 2.1A) | 1.43A | 1a4lD-5jm6A:undetectable | 1a4lD-5jm6A:20.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5lmc | ANAEROBIC NITRICOXIDE REDUCTASEFLAVORUBREDOXIN (Escherichiacoli) |
PF00258(Flavodoxin_1)PF00301(Rubredoxin)PF00753(Lactamase_B) | 5 | HIS A 227HIS A 84GLU A 81HIS A 79ASP A 166 | FEO A 501 ( 3.3A)FEO A 501 (-3.2A)FEO A 501 (-3.1A)FEO A 501 (-3.3A)FEO A 501 ( 2.5A) | 1.35A | 1a4lD-5lmcA:undetectable | 1a4lD-5lmcA:21.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5o25 | TMPDE (Thermotogamaritima) |
no annotation | 5 | HIS A 104GLY A 285HIS A 19ASP A 80ASP A 103 | MN A 402 (-3.5A)PG4 A 403 (-3.5A) MN A 401 (-3.5A) MN A 401 ( 2.6A)None | 1.48A | 1a4lD-5o25A:undetectable | 1a4lD-5o25A:22.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5tp4 | AMIDASE,HYDANTOINASE/CARBAMOYLASE FAMILY (Burkholderiaambifaria) |
PF01546(Peptidase_M20) | 5 | ALA A 356GLY A 355HIS A 358HIS A 190ASP A 95 | MES A 503 (-3.7A)NoneNone ZN A 501 (-3.6A) ZN A 502 ( 4.1A) | 1.47A | 1a4lD-5tp4A:undetectable | 1a4lD-5tp4A:20.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5w57 | PERIPLASMIC SOLUTEBINDING PROTEIN (Paracoccusdenitrificans) |
PF01297(ZnuA) | 5 | HIS A 61GLY A 223GLU A 253ASP A 279ASP A 59 | ZN A 401 (-3.2A)NoneNone ZN A 401 (-2.3A)None | 1.30A | 1a4lD-5w57A:undetectable | 1a4lD-5w57A:21.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wru | PROBABLE INORGANICPYROPHOSPHATASE (Plasmodiumfalciparum) |
no annotation | 5 | ALA A 170GLY A 169GLU A 138ASP A 198ASP A 235 | None | 1.31A | 1a4lD-5wruA:undetectable | 1a4lD-5wruA:20.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5x7l | TSRD (Streptomyceslaurentii) |
no annotation | 5 | HIS A 117PHE A 13HIS A 35ASP A 119ASP A 105 | IPA A 202 (-3.5A)NoneNoneIPA A 202 ( 4.8A)IPA A 202 (-2.9A) | 1.26A | 1a4lD-5x7lA:undetectable | 1a4lD-5x7lA:13.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xoy | [LYSW]-LYSINEHYDROLASE (Thermusthermophilus) |
PF01546(Peptidase_M20) | 5 | HIS A 326GLU A 124HIS A 67ASP A 91ASP A 325 | NoneLYS A 401 (-3.0A)NoneNoneNone | 1.14A | 1a4lD-5xoyA:undetectable | 1a4lD-5xoyA:24.34 |