SIMILAR PATTERNS OF AMINO ACIDS FOR 1A29_A_TFPA154_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f8w NADH PEROXIDASE

(Enterococcus
faecalis) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 GLU A 166
GLU A 163
ALA A 164
LEU A 185
GLU A 200
 None
FAD  A 448 ( 4.3A)
None
None
None
 1.45A 1a29A-1f8wA:
undetectable		 1a29A-1f8wA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1idm 3-ISOPROPYLMALATE
DEHYDROGENASE

(Thermus
thermophilus) 		PF00180
(Iso_dh) 		5 ALA A 292
MET A   1
LEU A  32
GLU A  30
GLU A 304
 None
 1.50A 1a29A-1idmA:
undetectable		 1a29A-1idmA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iug PUTATIVE ASPARTATE
AMINOTRANSFERASE

(Thermus
thermophilus) 		PF00266
(Aminotran_5) 		5 GLU A 244
ALA A  39
LEU A  43
LEU A 165
GLU A 245
 None
 1.25A 1a29A-1iugA:
undetectable		 1a29A-1iugA:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iyx ENOLASE

(Enterococcus
hirae) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		5 GLU A 223
ALA A 224
LEU A 188
LEU A 211
GLU A 215
 None
 1.48A 1a29A-1iyxA:
0.0		 1a29A-1iyxA:
15.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j93 UROPORPHYRINOGEN
DECARBOXYLASE

(Nicotiana
tabacum) 		PF01208
(URO-D) 		5 GLU A 345
ALA A 347
LEU A 325
LEU A 300
GLU A 338
 None
 1.46A 1a29A-1j93A:
undetectable		 1a29A-1j93A:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jhs MOG1 PROTEIN

(Saccharomyces
cerevisiae) 		PF04603
(Mog1) 		5 GLU A 190
LEU A 123
LEU A 178
GLU A 182
GLU A 181
 None
 1.09A 1a29A-1jhsA:
undetectable		 1a29A-1jhsA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jn0 GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
A

(Spinacia
oleracea) 		no annotation 5 GLU O 261
ALA O 263
LEU O 271
LEU O 161
GLU O 254
 None
 1.39A 1a29A-1jn0O:
0.0		 1a29A-1jn0O:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mvl PPC DECARBOXYLASE
ATHAL3A

(Arabidopsis
thaliana) 		PF02441
(Flavoprotein) 		5 ALA A  50
LEU A  23
LEU A  89
GLU A  77
GLU A  75
 None
 1.24A 1a29A-1mvlA:
undetectable		 1a29A-1mvlA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ons CHAPERONE PROTEIN
HCHA

(Escherichia
coli) 		no annotation 5 GLU A  92
ALA A  94
LEU A 132
LEU A 139
GLU A 144
 None
 1.31A 1a29A-1onsA:
undetectable		 1a29A-1onsA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1paq TRANSLATION
INITIATION FACTOR
EIF-2B EPSILON
SUBUNIT

(Saccharomyces
cerevisiae) 		PF02020
(W2) 		5 GLU A 554
ALA A 556
GLU A 569
LEU A 573
GLU A 548
 None
 1.36A 1a29A-1paqA:
1.0		 1a29A-1paqA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r4n AMYLOID BETA
PRECURSOR
PROTEIN-BINDING
PROTEIN 1

(Homo sapiens) 		PF00899
(ThiF) 		5 GLU A 181
ALA A 275
LEU A 185
LEU A 342
MET A 332
 None
 1.36A 1a29A-1r4nA:
0.0		 1a29A-1r4nA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vrn PHOTOSYNTHETIC
REACTION CENTER
CYTOCHROME C SUBUNIT

(Blastochloris
viridis) 		PF02276
(CytoC_RC) 		5 ALA C  76
GLU C 327
LEU C  65
GLU C  69
GLU C  67
 None
 1.37A 1a29A-1vrnC:
undetectable		 1a29A-1vrnC:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vyv CALCIUM CHANNEL
BETA-4SUBUNIT

(Rattus
norvegicus) 		PF00625
(Guanylate_kin)
PF12052
(VGCC_beta4Aa_N) 		5 GLU A 388
LEU A 394
LEU A 378
GLU A 380
GLU A 384
 None
 1.38A 1a29A-1vyvA:
undetectable		 1a29A-1vyvA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xb7 STEROID HORMONE
RECEPTOR ERR1

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 GLU A 301
LEU A 365
GLU A 331
LEU A 305
GLU A 303
 None
 1.42A 1a29A-1xb7A:
0.6		 1a29A-1xb7A:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xb7 STEROID HORMONE
RECEPTOR ERR1

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 GLU A 459
ALA A 474
LEU A 477
GLU A 421
GLU A 420
 None
 1.41A 1a29A-1xb7A:
0.6		 1a29A-1xb7A:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xqw PROLINE
IMINOPEPTIDASE

(Thermoplasma
acidophilum) 		PF00561
(Abhydrolase_1) 		5 GLU A  84
GLU A  85
ALA A  88
LEU A  89
MET A  32
 None
 1.37A 1a29A-1xqwA:
undetectable		 1a29A-1xqwA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yc9 MULTIDRUG RESISTANCE
PROTEIN

(Vibrio cholerae) 		PF02321
(OEP) 		5 GLU A 448
GLU A 447
ALA A 446
LEU A 426
GLU A 247
 None
 1.28A 1a29A-1yc9A:
undetectable		 1a29A-1yc9A:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zbr CONSERVED
HYPOTHETICAL PROTEIN

(Porphyromonas
gingivalis) 		PF04371
(PAD_porph) 		5 GLU A 151
ALA A 278
LEU A 260
MET A 304
LEU A 307
 None
 1.40A 1a29A-1zbrA:
undetectable		 1a29A-1zbrA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dc0 PROBABLE AMIDASE

(Thermus
thermophilus) 		PF01425
(Amidase) 		5 GLU A  43
GLU A  42
LEU A  40
LEU A  21
GLU A  22
 None
 1.36A 1a29A-2dc0A:
undetectable		 1a29A-2dc0A:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fiq PUTATIVE TAGATOSE
6-PHOSPHATE KINASE 1

(Escherichia
coli) 		PF08013
(Tagatose_6_P_K) 		5 GLU A 317
GLU A 316
ALA A 313
LEU A 312
GLU A 322
 None
 1.40A 1a29A-2fiqA:
undetectable		 1a29A-2fiqA:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fkj OUTER SURFACE
PROTEIN A

(Borreliella
burgdorferi) 		PF00820
(Lipoprotein_1) 		5 GLU A 215
GLU A 216
LEU A 201
GLU A 193
GLU A 192
 None
 1.28A 1a29A-2fkjA:
undetectable		 1a29A-2fkjA:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h5r MSTRAWBERRY

(Discosoma sp.) 		PF01353
(GFP) 		5 ALA A  44
LEU A 213
LEU A  61
GLU A  28
MET A  18
 None
CRO  A  66 ( 4.3A)
None
None
None
 1.31A 1a29A-2h5rA:
undetectable		 1a29A-2h5rA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hqy CONSERVED
HYPOTHETICAL PROTEIN

(Bacteroides
thetaiotaomicron) 		PF09924
(DUF2156) 		5 GLU A 236
ALA A 219
LEU A 171
LEU A 194
GLU A 190
 None
None
None
None
COA  A1001 (-3.2A)
 1.37A 1a29A-2hqyA:
undetectable		 1a29A-2hqyA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kqv NON-STRUCTURAL
PROTEIN 3

(Severe acute
respiratory
syndrome-related
coronavirus) 		PF11633
(SUD-M) 		5 GLU A  20
GLU A  19
ALA A  16
LEU A  15
MET A  25
 None
 1.49A 1a29A-2kqvA:
undetectable		 1a29A-2kqvA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2luh VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN VTA1

(Saccharomyces
cerevisiae) 		PF04652
(Vta1) 		5 GLU A  66
GLU A  68
ALA A  69
LEU A  76
GLU A  57
 None
 1.00A 1a29A-2luhA:
undetectable		 1a29A-2luhA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p9b POSSIBLE PROLIDASE

(Bifidobacterium
longum) 		PF01979
(Amidohydro_1) 		5 GLU A 361
ALA A 416
LEU A 406
LEU A  73
GLU A 359
 None
 1.28A 1a29A-2p9bA:
undetectable		 1a29A-2p9bA:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pcq PUTATIVE
DIHYDRODIPICOLINATE
SYNTHASE

(Thermus
thermophilus) 		PF00701
(DHDPS) 		5 GLU A  83
ALA A  86
MET A 119
LEU A  92
GLU A  71
 None
 1.20A 1a29A-2pcqA:
undetectable		 1a29A-2pcqA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vx2 ENOYL-COA HYDRATASE
DOMAIN-CONTAINING
PROTEIN 3

(Homo sapiens) 		PF00378
(ECH_1) 		5 GLU A 213
ALA A 211
LEU A 220
GLU A 201
MET A 202
 None
 1.49A 1a29A-2vx2A:
undetectable		 1a29A-2vx2A:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wn4 ADP-RIBOSYLTRANSFERA
SE ENZYMATIC
COMPONENT

(Clostridioides
difficile) 		PF03496
(ADPrib_exo_Tox) 		5 GLU A  79
GLU A  82
GLU A  42
LEU A  38
GLU A  47
 None
 1.46A 1a29A-2wn4A:
undetectable		 1a29A-2wn4A:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xz3 MALTOSE ABC
TRANSPORTER
PERIPLASMIC PROTEIN,
ENVELOPE
GLYCOPROTEIN

(Bovine leukemia
virus;
Escherichia
coli) 		PF00429
(TLV_coat)
PF13416
(SBP_bac_8) 		5 GLU A 156
GLU A 157
LEU A 161
MET A 250
LEU A 141
 None
 1.50A 1a29A-2xz3A:
undetectable		 1a29A-2xz3A:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z00 DIHYDROOROTASE

(Thermus
thermophilus) 		PF01979
(Amidohydro_1) 		5 GLU A 105
ALA A 107
LEU A  69
GLU A  60
GLU A  98
 None
 1.43A 1a29A-2z00A:
undetectable		 1a29A-2z00A:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a3c MALTOSE-BINDING
PERIPLASMIC PROTEIN,
LINKER,
MITOCHONDRIAL
INTERMEMBRANE SPACE
IMPORT AND ASSEMBLY
PROTEIN 40

(Escherichia
coli;
Saccharomyces
cerevisiae;
synthetic
construct) 		PF06747
(CHCH)
PF13416
(SBP_bac_8) 		5 GLU A 130
GLU A 131
LEU A 135
MET A 224
LEU A 115
 None
 1.43A 1a29A-3a3cA:
undetectable		 1a29A-3a3cA:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aqo PROBABLE SECDF
PROTEIN-EXPORT
MEMBRANE PROTEIN

(Thermus
thermophilus) 		no annotation 5 ALA A 168
LEU A 182
LEU A 232
GLU A 237
GLU A 236
 None
 1.40A 1a29A-3aqoA:
undetectable		 1a29A-3aqoA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3can PYRUVATE-FORMATE
LYASE-ACTIVATING
ENZYME

(Bacteroides
vulgatus) 		PF04055
(Radical_SAM) 		5 GLU A 120
ALA A 123
LEU A 125
LEU A  85
MET A  68
 None
 1.31A 1a29A-3canA:
undetectable		 1a29A-3canA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmg PUTATIVE
BETA-GALACTOSIDASE

(Bacteroides
fragilis) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF16355
(DUF4982) 		5 GLU A 341
GLU A 342
ALA A 345
LEU A 346
MET A 366
 None
 1.42A 1a29A-3cmgA:
undetectable		 1a29A-3cmgA:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmt PROTEIN RECA

(Escherichia
coli) 		PF00154
(RecA) 		5 GLU A1096
ALA A2179
LEU A2178
LEU A2215
GLU A1068
 ALF  A1501 ( 3.1A)
None
None
None
None
 1.46A 1a29A-3cmtA:
undetectable		 1a29A-3cmtA:
6.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmt PROTEIN RECA

(Escherichia
coli) 		PF00154
(RecA) 		5 GLU A2096
ALA A3179
LEU A3178
LEU A3215
GLU A2068
 ALF  A2501 ( 3.3A)
None
None
None
None
 1.46A 1a29A-3cmtA:
undetectable		 1a29A-3cmtA:
6.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmt PROTEIN RECA

(Escherichia
coli) 		PF00154
(RecA) 		5 GLU A3096
ALA A4179
LEU A4178
LEU A4215
GLU A3068
 ALF  A3501 ( 3.2A)
None
None
None
None
 1.44A 1a29A-3cmtA:
undetectable		 1a29A-3cmtA:
6.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3do5 HOMOSERINE
DEHYDROGENASE

(Archaeoglobus
fulgidus) 		PF00742
(Homoserine_dh)
PF03447
(NAD_binding_3) 		5 GLU A 192
ALA A 193
LEU A 196
GLU A 181
GLU A 180
 None
 1.03A 1a29A-3do5A:
undetectable		 1a29A-3do5A:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3doc GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE

(Brucella
abortus) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		5 GLU A 264
ALA A 266
LEU A 274
LEU A 165
GLU A 257
 None
 1.26A 1a29A-3docA:
undetectable		 1a29A-3docA:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ec4 PUTATIVE
ACETYLTRANSFERASE
FROM THE GNAT FAMILY

(Novosphingobium
aromaticivorans) 		PF08445
(FR47) 		5 ALA A 113
LEU A 114
MET A 145
LEU A 103
GLU A 105
 None
 1.49A 1a29A-3ec4A:
undetectable		 1a29A-3ec4A:
21.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3evr MYOSIN LIGHT CHAIN
KINASE, GREEN
FLUORESCENT PROTEIN,
CALMODULIN-1 CHIMERA

(Aequorea
victoria;
Rattus
norvegicus) 		PF01353
(GFP)
PF13499
(EF-hand_7) 		5 MET A 412
LEU A 419
GLU A 423
GLU A 426
MET A 427
 None
 0.68A 1a29A-3evrA:
18.5		 1a29A-3evrA:
38.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f8t PREDICTED ATPASE
INVOLVED IN
REPLICATION CONTROL,
CDC46/MCM FAMILY

(Methanopyrus
kandleri) 		PF00493
(MCM) 		5 GLU A 219
ALA A 218
MET A 224
LEU A 482
GLU A 481
 None
 1.41A 1a29A-3f8tA:
undetectable		 1a29A-3f8tA:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fkf THIOL-DISULFIDE
OXIDOREDUCTASE

(Bacteroides
fragilis) 		PF13905
(Thioredoxin_8) 		5 ALA A 126
LEU A 117
LEU A  55
GLU A  51
GLU A 132
 None
 1.44A 1a29A-3fkfA:
undetectable		 1a29A-3fkfA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h4c TRANSCRIPTION FACTOR
TFIIB-LIKE

(Trypanosoma
brucei) 		no annotation 5 GLU A 193
ALA A 181
GLU A 177
LEU A 163
MET A 151
 None
 1.50A 1a29A-3h4cA:
undetectable		 1a29A-3h4cA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k7t 6-HYDROXY-L-NICOTINE
OXIDASE

(Paenarthrobacter
nicotinovorans) 		PF01593
(Amino_oxidase) 		5 GLU A 296
ALA A 297
LEU A 348
GLU A 350
GLU A 352
 None
 1.01A 1a29A-3k7tA:
undetectable		 1a29A-3k7tA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n94 FUSION PROTEIN OF
MALTOSE-BINDING
PERIPLASMIC PROTEIN
AND PITUITARY
ADENYLATE CYCLASE 1
RECEPTOR-SHORT

(Escherichia
coli;
Homo sapiens) 		PF02793
(HRM)
PF13416
(SBP_bac_8) 		5 GLU A -67
GLU A -70
ALA A -72
LEU A -73
GLU A -74
 None
 1.46A 1a29A-3n94A:
undetectable		 1a29A-3n94A:
15.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o3u MALTOSE-BINDING
PERIPLASMIC PROTEIN,
ADVANCED
GLYCOSYLATION END
PRODUCT-SPECIFIC
RECEPTOR

(Escherichia
coli;
Homo sapiens) 		PF08205
(C2-set_2)
PF13416
(SBP_bac_8) 		5 GLU N 130
GLU N 131
LEU N 135
MET N 224
LEU N 115
 None
 1.47A 1a29A-3o3uN:
undetectable		 1a29A-3o3uN:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3osr MALTOSE-BINDING
PERIPLASMIC
PROTEIN,GREEN
FLUORESCENT PROTEIN

(Aequorea
victoria;
Escherichia
coli) 		PF01353
(GFP)
PF01547
(SBP_bac_1) 		5 GLU A 130
GLU A 131
LEU A 135
MET A 224
LEU A 115
 None
 1.48A 1a29A-3osrA:
0.4		 1a29A-3osrA:
13.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1

(Toxoplasma
gondii) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		5 GLU A 386
ALA A 362
LEU A 375
GLU A 379
GLU A 382
 None
 1.34A 1a29A-3sxfA:
3.5		 1a29A-3sxfA:
13.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3u0k RCAMP

(Entacmaea
quadricolor) 		PF01353
(GFP)
PF13499
(EF-hand_7) 		6 LEU A 312
MET A 403
GLU A 408
LEU A 410
GLU A 414
MET A 418
 None
 1.03A 1a29A-3u0kA:
17.8		 1a29A-3u0kA:
38.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a25 FERRITIN DPS FAMILY
PROTEIN

(Kineococcus
radiotolerans) 		PF00210
(Ferritin) 		5 GLU A 115
ALA A 119
LEU A 120
LEU A  63
GLU A 163
 None
 1.29A 1a29A-4a25A:
undetectable		 1a29A-4a25A:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aoa BETA-PHENYLALANINE
AMINOTRANSFERASE

(Variovorax
paradoxus) 		PF00202
(Aminotran_3) 		5 GLU A 241
ALA A 248
LEU A 357
GLU A 207
MET A 209
 None
None
None
IK2  A1435 (-4.0A)
None
 1.41A 1a29A-4aoaA:
undetectable		 1a29A-4aoaA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e0t CYCLIC DIPEPTIDE
N-PRENYLTRANSFERASE

(Aspergillus
fumigatus) 		PF11991
(Trp_DMAT) 		5 GLU A 301
GLU A 300
ALA A 297
LEU A 296
LEU A 365
 None
 1.36A 1a29A-4e0tA:
undetectable		 1a29A-4e0tA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e3c INHIBITOR OF NUCLEAR
FACTOR KAPPA-B
KINASE SUBUNIT BETA

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A 170
LEU A 178
GLU A  61
LEU A  94
GLU A  97
 None
 1.44A 1a29A-4e3cA:
undetectable		 1a29A-4e3cA:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4egc MALTOSE-BINDING
PERIPLASMIC PROTEIN,
HOMEOBOX PROTEIN
SIX1 CHIMERA

(Escherichia
coli;
Homo sapiens) 		PF00046
(Homeobox)
PF13416
(SBP_bac_8)
PF16878
(SIX1_SD) 		5 GLU A 130
GLU A 131
LEU A 135
MET A 224
LEU A 115
 None
 1.49A 1a29A-4egcA:
undetectable		 1a29A-4egcA:
12.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4giz MALTOSE-BINDING
PERIPLASMIC PROTEIN,
UBIQUITIN LIGASE
EA6P: CHIMERIC
PROTEIN

(Escherichia
coli;
Homo sapiens) 		PF01547
(SBP_bac_1) 		5 GLU A 131
GLU A 132
LEU A 136
MET A 225
LEU A 116
 None
 1.46A 1a29A-4gizA:
undetectable		 1a29A-4gizA:
17.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4gow CALMODULIN

(Homo sapiens) 		PF13499
(EF-hand_7) 		5 LEU D  18
MET D 109
GLU D 114
LEU D 116
MET D 124
 LEU  D  18 ( 0.6A)
MET  D 109 ( 0.0A)
GLU  D 114 ( 0.6A)
LEU  D 116 ( 0.6A)
MET  D 124 ( 0.0A)
 1.27A 1a29A-4gowD:
14.6		 1a29A-4gowD:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4gow CALMODULIN

(Homo sapiens) 		PF13499
(EF-hand_7) 		5 MET D 109
LEU D 116
GLU D 120
GLU D 123
MET D 124
 MET  D 109 ( 0.0A)
LEU  D 116 ( 0.6A)
GLU  D 120 ( 0.6A)
GLU  D 123 ( 0.6A)
MET  D 124 ( 0.0A)
 1.12A 1a29A-4gowD:
14.6		 1a29A-4gowD:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hbk ALDO-KETO REDUCTASE
FAMILY 1, MEMBER B4
(ALDOSE REDUCTASE)

(Schistosoma
japonicum) 		PF00248
(Aldo_ket_red) 		5 GLU A  94
GLU A  51
ALA A  52
LEU A 104
GLU A  93
 None
 1.29A 1a29A-4hbkA:
undetectable		 1a29A-4hbkA:
15.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4i2y RGECO1

(Discosoma sp.;
Gallus gallus;
Rattus
norvegicus) 		PF01353
(GFP)
PF13499
(EF-hand_7) 		5 LEU A 321
MET A 412
LEU A 419
GLU A 423
MET A 427
 None
 0.72A 1a29A-4i2yA:
18.2		 1a29A-4i2yA:
65.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4i2y RGECO1

(Discosoma sp.;
Gallus gallus;
Rattus
norvegicus) 		PF01353
(GFP)
PF13499
(EF-hand_7) 		5 MET A 412
GLU A 417
LEU A 419
GLU A 423
MET A 427
 None
 0.63A 1a29A-4i2yA:
18.2		 1a29A-4i2yA:
65.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ifp MALTOSE-BINDING
PERIPLASMIC
PROTEIN,NACHT, LRR
AND PYD
DOMAINS-CONTAINING
PROTEIN 1

(Escherichia
coli;
Homo sapiens) 		PF00619
(CARD)
PF13416
(SBP_bac_8) 		5 GLU A 131
GLU A 132
LEU A 136
MET A 225
LEU A 116
 None
 1.47A 1a29A-4ifpA:
undetectable		 1a29A-4ifpA:
14.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4irl MALTOSE-BINDING
PERIPLASMIC PROTEIN,
NOVEL PROTEIN
SIMILAR TO
VERTEBRATE GUANYLATE
BINDING PROTEIN
FAMILY

(Danio rerio;
Escherichia
coli) 		PF00619
(CARD)
PF13416
(SBP_bac_8) 		5 GLU A 131
GLU A 132
LEU A 136
MET A 225
LEU A 116
 None
 1.48A 1a29A-4irlA:
undetectable		 1a29A-4irlA:
13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kop SINGLE-STRANDED
DNA-BINDING PROTEIN
WHY2, MITOCHONDRIAL

(Arabidopsis
thaliana) 		PF08536
(Whirly) 		5 GLU A 133
LEU A 167
MET A  94
LEU A 115
GLU A 119
 None
 1.40A 1a29A-4kopA:
undetectable		 1a29A-4kopA:
24.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o2x MALTOSE-BINDING
PERIPLASMIC PROTEIN,
ATP-DEPENDENT CLP
PROTEASE ADAPTOR
PROTEIN CLPS
CONTAINING PROTEIN
CHIMERIC CONSTRUCT

(Escherichia
coli;
Plasmodium
falciparum) 		PF02617
(ClpS)
PF13416
(SBP_bac_8) 		5 GLU A 131
GLU A 132
LEU A 136
MET A 225
LEU A 116
 None
 1.41A 1a29A-4o2xA:
undetectable		 1a29A-4o2xA:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r0s PROTEIN TYROSINE
PHOSPHATASE TPBA

(Pseudomonas
aeruginosa) 		PF03162
(Y_phosphatase2) 		5 ALA A 144
MET A  52
LEU A  56
GLU A 123
MET A 130
 None
 1.38A 1a29A-4r0sA:
undetectable		 1a29A-4r0sA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x0q DNA POLYMERASE THETA

(Homo sapiens) 		PF00476
(DNA_pol_A) 		5 GLU A2049
ALA A2046
MET A2023
LEU A2020
GLU A2016
 None
 1.33A 1a29A-4x0qA:
undetectable		 1a29A-4x0qA:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT M

(Oryctolagus
cuniculus) 		PF01399
(PCI) 		5 GLU M  47
ALA M  43
LEU M  42
GLU M  35
GLU M  32
 None
 1.39A 1a29A-5a5tM:
undetectable		 1a29A-5a5tM:
19.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5b7x CALMODULIN, PUTATIVE

(Entamoeba
histolytica) 		PF13405
(EF-hand_6)
PF13499
(EF-hand_7) 		5 GLU A  48
ALA A  45
GLU A  75
LEU A  72
GLU A  68
 None
 1.39A 1a29A-5b7xA:
2.0		 1a29A-5b7xA:
33.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cwq DESIGNED HELICAL
REPEAT PROTEIN

(synthetic
construct) 		no annotation 5 GLU A  75
GLU A  76
ALA A  77
LEU A  40
GLU A  68
 None
 1.37A 1a29A-5cwqA:
undetectable		 1a29A-5cwqA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cwq DESIGNED HELICAL
REPEAT PROTEIN

(synthetic
construct) 		no annotation 5 GLU A 132
GLU A 133
ALA A 134
LEU A  97
GLU A 125
 None
 1.39A 1a29A-5cwqA:
undetectable		 1a29A-5cwqA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cwq DESIGNED HELICAL
REPEAT PROTEIN

(synthetic
construct) 		no annotation 5 GLU A 196
ALA A 198
LEU A 154
GLU A 190
GLU A 188
 None
 1.47A 1a29A-5cwqA:
undetectable		 1a29A-5cwqA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d0f UNCHARACTERIZED
PROTEIN

([Candida]
glabrata) 		PF06202
(GDE_C)
PF14699
(hGDE_N)
PF14701
(hDGE_amylase)
PF14702
(hGDE_central) 		5 GLU A1094
GLU A1095
ALA A1096
LEU A1087
LEU A 891
 None
 1.47A 1a29A-5d0fA:
undetectable		 1a29A-5d0fA:
6.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dm7 50S RIBOSOMAL
PROTEIN L5

(Deinococcus
radiodurans) 		PF00281
(Ribosomal_L5)
PF00673
(Ribosomal_L5_C) 		5 GLU D  56
ALA D  54
LEU D  57
GLU D  38
LEU D  40
 None
 1.47A 1a29A-5dm7D:
undetectable		 1a29A-5dm7D:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5elr KH
DOMAIN-CONTAINING,
RNA-BINDING, SIGNAL
TRANSDUCTION-ASSOCIA
TED PROTEIN 3

(Homo sapiens) 		PF00013
(KH_1) 		5 ALA C 107
MET C 103
GLU C 109
LEU C 123
GLU C 117
 None
 1.45A 1a29A-5elrC:
undetectable		 1a29A-5elrC:
26.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5elr KH
DOMAIN-CONTAINING,
RNA-BINDING, SIGNAL
TRANSDUCTION-ASSOCIA
TED PROTEIN 3

(Homo sapiens) 		PF00013
(KH_1) 		5 GLU C 110
ALA C 107
MET C 103
LEU C 123
GLU C 117
 None
 1.19A 1a29A-5elrC:
undetectable		 1a29A-5elrC:
26.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f1u 4-HYDROXY-TETRAHYDRO
DIPICOLINATE
SYNTHASE

(Campylobacter
jejuni) 		PF00701
(DHDPS) 		5 GLU A  64
ALA A  66
LEU A  54
GLU A  58
GLU A  57
 None
 1.31A 1a29A-5f1uA:
undetectable		 1a29A-5f1uA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hdi CYTOCHROME P450 144

(Mycobacterium
tuberculosis) 		PF00067
(p450) 		5 GLU A 186
ALA A 155
LEU A 179
GLU A 395
LEU A 391
 None
None
None
None
HEM  A 501 ( 4.5A)
 1.49A 1a29A-5hdiA:
undetectable		 1a29A-5hdiA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hdi CYTOCHROME P450 144

(Mycobacterium
tuberculosis) 		PF00067
(p450) 		5 GLU A 314
GLU A 313
ALA A 310
LEU A 283
GLU A 319
 None
None
None
HEM  A 501 ( 4.1A)
None
 1.20A 1a29A-5hdiA:
undetectable		 1a29A-5hdiA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iy9 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB4

(Homo sapiens) 		PF03874
(RNA_pol_Rpb4) 		5 ALA D  17
LEU D  20
GLU D  96
LEU D 118
GLU D 110
 None
 1.48A 1a29A-5iy9D:
undetectable		 1a29A-5iy9D:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j1i PLECTIN

(Homo sapiens) 		no annotation 5 GLU A1075
ALA A1072
LEU A1098
GLU A1095
GLU A1093
 None
 1.18A 1a29A-5j1iA:
undetectable		 1a29A-5j1iA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jph ACETYLTRANSFERASE
SACOL1063

(Staphylococcus
aureus) 		PF13673
(Acetyltransf_10) 		5 ALA A  94
MET A  87
GLU A  91
GLU A 135
MET A 104
 None
 1.49A 1a29A-5jphA:
undetectable		 1a29A-5jphA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ktk POLYKETIDE SYNTHASE
PKSJ

(Bacillus
subtilis) 		PF08659
(KR) 		5 GLU A 398
ALA A 397
MET A 135
LEU A 125
GLU A 126
 None
 1.28A 1a29A-5ktkA:
undetectable		 1a29A-5ktkA:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tky PUTATIVE
UNCHARACTERIZED
PROTEIN

(Chaetomium
thermophilum) 		PF00012
(HSP70) 		5 GLU A 121
ALA A 124
LEU A 515
GLU A 519
GLU A 521
 None
 1.38A 1a29A-5tkyA:
undetectable		 1a29A-5tkyA:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vgt GENE 7 PROTEIN

(Shigella virus
Sf6) 		no annotation 5 GLU A  71
ALA A  58
MET A  45
LEU A  41
GLU A   9
 None
 1.11A 1a29A-5vgtA:
undetectable		 1a29A-5vgtA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xhw PUTATIVE
6-DEOXY-D-MANNOHEPTO
SE PATHWAY PROTEIN

(Yersinia
pseudotuberculosis) 		no annotation 5 ALA A   8
LEU A  54
LEU A  65
GLU A  40
MET A  39
 None
None
None
SO4  A 301 ( 4.8A)
None
 1.22A 1a29A-5xhwA:
undetectable		 1a29A-5xhwA:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6avh GH3.15 ACYL ACID
AMIDO SYNTHETASE

(Arabidopsis
thaliana) 		no annotation 5 GLU A 508
ALA A 447
LEU A 454
GLU A 502
GLU A 501
 None
 1.43A 1a29A-6avhA:
undetectable		 1a29A-6avhA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b6l GLYCOSYL HYDROLASE
FAMILY 2, SUGAR
BINDING DOMAIN
PROTEIN

(Bacteroides
cellulosilyticus) 		no annotation 5 GLU A 339
GLU A 340
ALA A 368
LEU A 372
GLU A 344
 None
 1.17A 1a29A-6b6lA:
undetectable		 1a29A-6b6lA:
11.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6brd RIFAMPIN
MONOOXYGENASE

(Streptomyces
venezuelae) 		no annotation 5 ALA A 455
LEU A 387
MET A 392
LEU A 395
GLU A 434
 None
 1.47A 1a29A-6brdA:
undetectable		 1a29A-6brdA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eo5 PPBBE-LIKE 1 D396N

(Physcomitrella
patens) 		no annotation 5 GLU A 298
ALA A 285
LEU A 308
GLU A 327
GLU A 328
 None
 1.27A 1a29A-6eo5A:
0.0		 1a29A-6eo5A:
19.15