SIMILAR PATTERNS OF AMINO ACIDS FOR 1A28_B_STRB2_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1chk CHITOSANASE

(Streptomyces
sp. N174) 		PF01374
(Glyco_hydro_46) 		5 LEU A 221
LEU A 138
ASN A 218
LEU A 214
LEU A  17
 None
 1.32A 1a28B-1chkA:
undetectable		 1a28B-1chkA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ctt CYTIDINE DEAMINASE

(Escherichia
coli) 		PF00383
(dCMP_cyt_deam_1)
PF08211
(dCMP_cyt_deam_2) 		5 LEU A 215
LEU A 247
MET A  90
ARG A   4
LEU A 283
 None
 1.40A 1a28B-1cttA:
undetectable		 1a28B-1cttA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dbw TRANSCRIPTIONAL
REGULATORY PROTEIN
FIXJ

(Sinorhizobium
meliloti) 		PF00072
(Response_reg) 		5 LEU A  72
LEU A  69
ASN A  68
LEU A  66
MET A  60
 None
 1.32A 1a28B-1dbwA:
undetectable		 1a28B-1dbwA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gc7 RADIXIN

(Mus musculus) 		PF00373
(FERM_M)
PF09379
(FERM_N)
PF09380
(FERM_C) 		5 LEU A  29
LEU A  59
ARG A 279
LEU A  76
THR A  24
 LEU  A  29 ( 0.6A)
LEU  A  59 ( 0.6A)
ARG  A 279 ( 0.6A)
LEU  A  76 ( 0.6A)
THR  A  24 ( 0.8A)
 1.41A 1a28B-1gc7A:
undetectable		 1a28B-1gc7A:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lrz FACTOR ESSENTIAL FOR
EXPRESSION OF
METHICILLIN
RESISTANCE

(Staphylococcus
aureus) 		PF02388
(FemAB) 		5 LEU A  57
LEU A  42
LEU A   6
LEU A  34
THR A  59
 None
 1.42A 1a28B-1lrzA:
undetectable		 1a28B-1lrzA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lxy ARGININE DEIMINASE

(Mycoplasma
arginini) 		PF02274
(Amidinotransf) 		5 LEU A  78
LEU A  75
LEU A 156
ARG A 180
LEU A 403
 None
None
None
CIR  A 500 (-4.0A)
None
 1.39A 1a28B-1lxyA:
undetectable		 1a28B-1lxyA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1miv TRNA CCA-ADDING
ENZYME

(Geobacillus
stearothermophilus) 		PF01743
(PolyA_pol)
PF12627
(PolyA_pol_RNAbd)
PF13735
(tRNA_NucTran2_2) 		5 LEU A 234
LEU A 215
ASN A 221
LEU A 220
LEU A 255
 None
 1.18A 1a28B-1mivA:
undetectable		 1a28B-1mivA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mx3 C-TERMINAL BINDING
PROTEIN 1

(Homo sapiens) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		5 LEU A 223
LEU A 226
LEU A 201
LEU A 235
THR A 251
 None
 1.24A 1a28B-1mx3A:
undetectable		 1a28B-1mx3A:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ouo NUCLEASE

(Vibrio
vulnificus) 		PF04231
(Endonuclease_1) 		5 LEU A 119
ASN A 118
LEU A 116
GLN A 217
MET A 177
 None
 1.33A 1a28B-1ouoA:
undetectable		 1a28B-1ouoA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u0n PLATELET
GLYCOPROTEIN IB

(Homo sapiens) 		PF01462
(LRRNT)
PF13855
(LRR_8) 		5 LEU D  36
LEU D  60
LEU D  82
LEU D  25
THR D  33
 None
 1.30A 1a28B-1u0nD:
undetectable		 1a28B-1u0nD:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uhl RETINOIC ACID
RECEPTOR RXR-BETA

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 LEU A 496
LEU A 493
LEU A 490
LEU A 379
MET A 433
 None
 1.36A 1a28B-1uhlA:
23.3		 1a28B-1uhlA:
25.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xb7 STEROID HORMONE
RECEPTOR ERR1

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 LEU A 324
LEU A 327
MET A 362
ARG A 372
LEU A 401
 None
 0.64A 1a28B-1xb7A:
25.6		 1a28B-1xb7A:
26.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ytu HYPOTHETICAL PROTEIN
AF1318

(Archaeoglobus
fulgidus) 		PF02171
(Piwi) 		5 ASN A 155
LEU A 156
GLN A 137
LEU A  33
THR A  26
 G  C   2 ( 3.3A)
G  C   2 ( 4.2A)
A  C   1 ( 3.3A)
None
None
 1.36A 1a28B-1ytuA:
undetectable		 1a28B-1ytuA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z5x ULTRASPIRACLE
PROTEIN (USP) A
HOMOLOGUE OF RXR

(Bemisia tabaci) 		PF00104
(Hormone_recep) 		5 LEU U 460
LEU U 457
LEU U 454
LEU U 343
MET U 397
 None
 1.30A 1a28B-1z5xU:
15.8		 1a28B-1z5xU:
25.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a5l TRP REPRESSOR
BINDING PROTEIN WRBA

(Pseudomonas
aeruginosa) 		PF03358
(FMN_red) 		5 LEU A 133
LEU A 130
MET A  84
LEU A   9
THR A  95
 None
 0.97A 1a28B-2a5lA:
undetectable		 1a28B-2a5lA:
20.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ax9 ANDROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		7 LEU A 701
LEU A 704
ASN A 705
LEU A 707
GLN A 711
MET A 742
ARG A 752
 None
BHM  A   1 (-4.0A)
BHM  A   1 (-3.6A)
BHM  A   1 ( 4.2A)
BHM  A   1 (-2.2A)
BHM  A   1 ( 4.0A)
BHM  A   1 (-3.8A)
 0.61A 1a28B-2ax9A:
34.7		 1a28B-2ax9A:
53.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ax9 ANDROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 LEU A 704
LEU A 707
GLN A 711
MET A 742
ARG A 752
MET A 787
 BHM  A   1 (-4.0A)
BHM  A   1 ( 4.2A)
BHM  A   1 (-2.2A)
BHM  A   1 ( 4.0A)
BHM  A   1 (-3.8A)
BHM  A   1 (-3.6A)
 0.83A 1a28B-2ax9A:
34.7		 1a28B-2ax9A:
53.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ax9 ANDROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 LEU A 707
GLN A 711
MET A 742
ARG A 752
MET A 895
 BHM  A   1 ( 4.2A)
BHM  A   1 (-2.2A)
BHM  A   1 ( 4.0A)
BHM  A   1 (-3.8A)
None
 1.02A 1a28B-2ax9A:
34.7		 1a28B-2ax9A:
53.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g7e ENDONUCLEASE I

(Vibrio cholerae) 		PF04231
(Endonuclease_1) 		5 LEU A 119
ASN A 118
LEU A 116
GLN A 217
MET A 177
 None
 1.28A 1a28B-2g7eA:
undetectable		 1a28B-2g7eA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gpv ESTROGEN-RELATED
RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 LEU A 265
LEU A 268
LEU A 271
MET A 306
ARG A 316
LEU A 345
 None
OHT  A 500 (-4.1A)
OHT  A 500 ( 4.4A)
OHT  A 500 (-3.9A)
OHT  A 500 (-3.8A)
OHT  A 500 (-4.3A)
 0.63A 1a28B-2gpvA:
25.7		 1a28B-2gpvA:
28.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i6l MITOGEN-ACTIVATED
PROTEIN KINASE 6

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A 136
ASN A  76
LEU A 137
LEU A 115
MET A 225
 None
 1.24A 1a28B-2i6lA:
undetectable		 1a28B-2i6lA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pu3 ENDONUCLEASE I

(Aliivibrio
salmonicida) 		PF04231
(Endonuclease_1) 		5 LEU A 119
ASN A 118
LEU A 116
GLN A 217
MET A 177
 None
 1.27A 1a28B-2pu3A:
undetectable		 1a28B-2pu3A:
19.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2q3y ANCESTRAL CORTICIOD
RECEPTOR

(unidentified) 		PF00104
(Hormone_recep) 		9 ASN A  33
LEU A  35
GLN A  39
MET A  70
ARG A  80
LEU A 111
MET A 115
CYH A 205
THR A 208
 1CA  A 247 (-2.9A)
1CA  A 247 ( 4.4A)
1CA  A 247 (-3.1A)
1CA  A 247 ( 3.8A)
1CA  A 247 (-3.8A)
None
1CA  A 247 ( 3.7A)
1CA  A 247 (-4.0A)
1CA  A 247 (-3.4A)
 0.73A 1a28B-2q3yA:
37.4		 1a28B-2q3yA:
63.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2q3y ANCESTRAL CORTICIOD
RECEPTOR

(unidentified) 		PF00104
(Hormone_recep) 		10 LEU A  29
LEU A  32
ASN A  33
LEU A  35
GLN A  39
MET A  70
ARG A  80
MET A 115
CYH A 205
THR A 208
 1CA  A 247 ( 3.6A)
1CA  A 247 (-4.0A)
1CA  A 247 (-2.9A)
1CA  A 247 ( 4.4A)
1CA  A 247 (-3.1A)
1CA  A 247 ( 3.8A)
1CA  A 247 (-3.8A)
1CA  A 247 ( 3.7A)
1CA  A 247 (-4.0A)
1CA  A 247 (-3.4A)
 0.52A 1a28B-2q3yA:
37.4		 1a28B-2q3yA:
63.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2q3y ANCESTRAL CORTICIOD
RECEPTOR

(unidentified) 		PF00104
(Hormone_recep) 		5 LEU A  35
LEU A  32
LEU A  29
LEU A  77
MET A 115
 1CA  A 247 ( 4.4A)
1CA  A 247 (-4.0A)
1CA  A 247 ( 3.6A)
1CA  A 247 ( 3.9A)
1CA  A 247 ( 3.7A)
 1.29A 1a28B-2q3yA:
37.4		 1a28B-2q3yA:
63.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qjx PROTEIN BIM1

(Saccharomyces
cerevisiae) 		no annotation 5 LEU A  13
LEU A  16
ASN A  17
LEU A  20
GLN A  38
 None
 1.40A 1a28B-2qjxA:
undetectable		 1a28B-2qjxA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r09 CYTOHESIN-3

(Mus musculus) 		PF00169
(PH)
PF01369
(Sec7) 		5 LEU A 231
LEU A 235
GLN A 147
CYH A 190
THR A 189
 None
None
SO4  A 400 (-3.8A)
None
None
 1.38A 1a28B-2r09A:
undetectable		 1a28B-2r09A:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2whn PILUS ASSEMBLY
PROTEIN PILC

(Thermus
thermophilus) 		PF00482
(T2SSF) 		5 LEU A 104
LEU A  88
LEU A  85
MET A  77
THR A  95
 None
 1.38A 1a28B-2whnA:
undetectable		 1a28B-2whnA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bga BETA-GALACTOSIDASE

(Bacteroides
thetaiotaomicron) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF02929
(Bgal_small_N)
PF16353
(DUF4981) 		5 LEU A 985
LEU A 876
LEU A 784
GLN A 814
LEU A1018
 None
 1.13A 1a28B-3bgaA:
undetectable		 1a28B-3bgaA:
12.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ciy TOLL-LIKE RECEPTOR 3

(Mus musculus) 		PF00560
(LRR_1)
PF13855
(LRR_8) 		5 LEU A 492
LEU A 513
ASN A 516
GLN A 538
LEU A 485
 None
 1.39A 1a28B-3ciyA:
undetectable		 1a28B-3ciyA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ct9 ACETYLORNITHINE
DEACETYLASE

(Bacteroides
thetaiotaomicron) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		5 LEU A 350
LEU A 347
MET A 165
LEU A 112
MET A 296
 None
 1.37A 1a28B-3ct9A:
undetectable		 1a28B-3ct9A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cuo UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR YGAV

(Escherichia
coli) 		PF01022
(HTH_5) 		5 LEU A  33
LEU A  30
LEU A  27
LEU A  59
THR A  39
 None
 1.27A 1a28B-3cuoA:
undetectable		 1a28B-3cuoA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d7a UPF0201 PROTEIN
PH1010

(Pyrococcus
horikoshii) 		PF01877
(RNA_binding) 		5 LEU A  57
LEU A  60
LEU A  63
GLN A  67
LEU A  77
 None
 1.35A 1a28B-3d7aA:
undetectable		 1a28B-3d7aA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eap RHO
GTPASE-ACTIVATING
PROTEIN 11A

(Homo sapiens) 		PF00620
(RhoGAP) 		5 LEU A  15
LEU A  12
LEU A   9
LEU A 137
CYH A 161
 None
 1.16A 1a28B-3eapA:
undetectable		 1a28B-3eapA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hcz POSSIBLE
THIOL-DISULFIDE
ISOMERASE

(Cytophaga
hutchinsonii) 		PF00578
(AhpC-TSA) 		5 LEU A 352
LEU A 340
ASN A 339
ARG A 400
LEU A 418
 None
None
SO4  A   1 (-4.9A)
SO4  A   5 (-3.9A)
None
 1.40A 1a28B-3hczA:
undetectable		 1a28B-3hczA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hly FLAVODOXIN-LIKE
DOMAIN

(Synechococcus
elongatus) 		no annotation 5 LEU A 361
LEU A 370
GLN A 343
LEU A 332
THR A 319
 None
 1.27A 1a28B-3hlyA:
undetectable		 1a28B-3hlyA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3izq ELONGATION FACTOR 1
ALPHA-LIKE PROTEIN

(Saccharomyces
cerevisiae) 		PF00009
(GTP_EFTU)
PF03143
(GTP_EFTU_D3)
PF08938
(HBS1_N) 		5 LEU 1 508
LEU 1 510
LEU 1 580
CYH 1 505
THR 1 610
 None
 1.16A 1a28B-3izq1:
undetectable		 1a28B-3izq1:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j9t V-TYPE PROTON ATPASE
SUBUNIT H

(Saccharomyces
cerevisiae) 		PF03224
(V-ATPase_H_N)
PF11698
(V-ATPase_H_C) 		5 LEU P 314
LEU P 313
ASN P 317
LEU P 319
GLN P 323
 None
 1.37A 1a28B-3j9tP:
undetectable		 1a28B-3j9tP:
21.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kba PROGESTERONE
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		8 ASN A 719
LEU A 721
GLN A 725
MET A 756
ARG A 766
MET A 801
CYH A 891
THR A 894
 WOW  A   1 (-3.3A)
WOW  A   1 ( 4.3A)
WOW  A   1 ( 4.1A)
WOW  A   1 ( 4.1A)
WOW  A   1 (-3.8A)
WOW  A   1 (-4.2A)
WOW  A   1 (-3.5A)
WOW  A   1 (-3.9A)
 0.60A 1a28B-3kbaA:
40.1		 1a28B-3kbaA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kba PROGESTERONE
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		9 LEU A 715
LEU A 718
ASN A 719
LEU A 721
MET A 756
ARG A 766
MET A 801
CYH A 891
THR A 894
 WOW  A   1 (-3.9A)
WOW  A   1 (-4.2A)
WOW  A   1 (-3.3A)
WOW  A   1 ( 4.3A)
WOW  A   1 ( 4.1A)
WOW  A   1 (-3.8A)
WOW  A   1 (-4.2A)
WOW  A   1 (-3.5A)
WOW  A   1 (-3.9A)
 0.36A 1a28B-3kbaA:
40.1		 1a28B-3kbaA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kba PROGESTERONE
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		8 LEU A 715
LEU A 718
ASN A 719
LEU A 721
MET A 756
CYH A 891
THR A 894
MET A 909
 WOW  A   1 (-3.9A)
WOW  A   1 (-4.2A)
WOW  A   1 (-3.3A)
WOW  A   1 ( 4.3A)
WOW  A   1 ( 4.1A)
WOW  A   1 (-3.5A)
WOW  A   1 (-3.9A)
None
 0.59A 1a28B-3kbaA:
40.1		 1a28B-3kbaA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kba PROGESTERONE
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 LEU A 721
LEU A 718
LEU A 715
LEU A 763
MET A 801
 WOW  A   1 ( 4.3A)
WOW  A   1 (-4.2A)
WOW  A   1 (-3.9A)
WOW  A   1 ( 4.0A)
WOW  A   1 (-4.2A)
 1.21A 1a28B-3kbaA:
40.1		 1a28B-3kbaA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kn5 RIBOSOMAL PROTEIN S6
KINASE ALPHA-5

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A 676
LEU A 667
LEU A 668
LEU A 687
MET A 525
 None
 1.29A 1a28B-3kn5A:
undetectable		 1a28B-3kn5A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kqf ENOYL-COA
HYDRATASE/ISOMERASE
FAMILY PROTEIN

(Bacillus
anthracis) 		PF00378
(ECH_1) 		5 LEU A  38
LEU A  35
LEU A  32
ARG A  73
LEU A 117
 None
 1.34A 1a28B-3kqfA:
undetectable		 1a28B-3kqfA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lq9 DNA-DAMAGE-INDUCIBLE
TRANSCRIPT 4 PROTEIN

(Homo sapiens) 		PF07809
(RTP801_C) 		5 LEU A  92
LEU A  96
ASN A  95
GLN A 101
LEU A 132
 None
 1.42A 1a28B-3lq9A:
undetectable		 1a28B-3lq9A:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lq9 DNA-DAMAGE-INDUCIBLE
TRANSCRIPT 4 PROTEIN

(Homo sapiens) 		PF07809
(RTP801_C) 		5 LEU A 123
LEU A 210
LEU A 181
GLN A 153
LEU A 100
 None
 1.37A 1a28B-3lq9A:
undetectable		 1a28B-3lq9A:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3muq UNCHARACTERIZED
CONSERVED PROTEIN

(Vibrio
parahaemolyticus) 		PF12849
(PBP_like_2) 		5 LEU A  47
LEU A  46
GLN A 251
LEU A  31
MET A  81
 None
 1.28A 1a28B-3muqA:
undetectable		 1a28B-3muqA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nr7 DNA-BINDING PROTEIN
H-NS

(Salmonella
enterica) 		PF00816
(Histone_HNS) 		5 LEU A  14
LEU A   8
LEU A   5
LEU A  26
MET A  29
 None
 1.14A 1a28B-3nr7A:
undetectable		 1a28B-3nr7A:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3poc ALPHA-GLUCOSIDASE

(Blautia obeum) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2) 		5 LEU A 435
LEU A 432
ASN A 431
LEU A 429
THR A 472
 None
 1.33A 1a28B-3pocA:
undetectable		 1a28B-3pocA:
16.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1

(synthetic
construct) 		PF00104
(Hormone_recep) 		10 LEU A  29
LEU A  32
ASN A  33
LEU A  35
GLN A  39
MET A  70
ARG A  80
MET A 115
CYH A 205
THR A 208
 1CA  A 249 ( 3.8A)
1CA  A 249 (-3.9A)
1CA  A 249 (-3.0A)
1CA  A 249 ( 4.4A)
1CA  A 249 (-3.0A)
1CA  A 249 ( 3.8A)
1CA  A 249 (-3.5A)
1CA  A 249 (-3.6A)
1CA  A 249 (-4.0A)
1CA  A 249 (-3.2A)
 0.53A 1a28B-3ry9A:
36.6		 1a28B-3ry9A:
62.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1

(synthetic
construct) 		PF00104
(Hormone_recep) 		10 LEU A  32
ASN A  33
LEU A  35
GLN A  39
MET A  70
ARG A  80
LEU A 111
MET A 115
CYH A 205
THR A 208
 1CA  A 249 (-3.9A)
1CA  A 249 (-3.0A)
1CA  A 249 ( 4.4A)
1CA  A 249 (-3.0A)
1CA  A 249 ( 3.8A)
1CA  A 249 (-3.5A)
None
1CA  A 249 (-3.6A)
1CA  A 249 (-4.0A)
1CA  A 249 (-3.2A)
 0.73A 1a28B-3ry9A:
36.6		 1a28B-3ry9A:
62.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1

(synthetic
construct) 		PF00104
(Hormone_recep) 		5 LEU A  35
LEU A  32
LEU A  29
LEU A  77
MET A 115
 1CA  A 249 ( 4.4A)
1CA  A 249 (-3.9A)
1CA  A 249 ( 3.8A)
1CA  A 249 ( 4.1A)
1CA  A 249 (-3.6A)
 1.35A 1a28B-3ry9A:
36.6		 1a28B-3ry9A:
62.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rys ADENOSINE DEAMINASE
1

(Paenarthrobacter
aurescens) 		PF00962
(A_deaminase) 		5 LEU A 273
ASN A 274
LEU A 237
LEU A 265
CYH A 276
 None
 1.07A 1a28B-3rysA:
undetectable		 1a28B-3rysA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tex PROTECTIVE ANTIGEN

(Bacillus
anthracis) 		PF03495
(Binary_toxB)
PF07691
(PA14)
PF17475
(Binary_toxB_2)
PF17476
(Binary_toxB_3) 		5 LEU A 450
LEU A 385
GLN A 438
LEU A 421
THR A 381
 None
 1.22A 1a28B-3texA:
undetectable		 1a28B-3texA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tex PROTECTIVE ANTIGEN

(Bacillus
anthracis) 		PF03495
(Binary_toxB)
PF07691
(PA14)
PF17475
(Binary_toxB_2)
PF17476
(Binary_toxB_3) 		5 LEU A 450
LEU A 448
LEU A 385
LEU A 421
THR A 381
 None
 1.31A 1a28B-3texA:
undetectable		 1a28B-3texA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wgo MESO-DIAMINOPIMELATE
DEHYDROGENASE

(Clostridium
tetani) 		PF16654
(DAPDH_C) 		5 LEU A 127
LEU A 130
ASN A 131
LEU A 133
LEU A 313
 None
 1.02A 1a28B-3wgoA:
undetectable		 1a28B-3wgoA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wpe TOLL-LIKE RECEPTOR 9

(Bos taurus) 		PF13516
(LRR_6)
PF13855
(LRR_8) 		5 LEU A 531
LEU A 550
ASN A 553
LEU A 580
LEU A 524
 None
 1.42A 1a28B-3wpeA:
undetectable		 1a28B-3wpeA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wrt BETA-LACTAMASE

(Chromohalobacter
sp. 560) 		PF00144
(Beta-lactamase) 		5 LEU A 249
MET A 175
LEU A 235
MET A 185
THR A 256
 None
 1.37A 1a28B-3wrtA:
undetectable		 1a28B-3wrtA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wxf UNCHARACTERIZED
PROTEIN

(Danio rerio) 		PF00443
(UCH) 		5 LEU A 697
LEU A 695
LEU A 694
MET A 789
LEU A 729
 None
 1.27A 1a28B-3wxfA:
undetectable		 1a28B-3wxfA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x0v L-LYSINE OXIDASE

(Trichoderma
viride) 		PF01593
(Amino_oxidase) 		5 LEU A 406
LEU A 403
ASN A 402
LEU A 400
THR A 343
 None
 1.18A 1a28B-3x0vA:
undetectable		 1a28B-3x0vA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4am6 ACTIN-LIKE PROTEIN
ARP8

(Saccharomyces
cerevisiae) 		PF00022
(Actin) 		5 LEU A 536
LEU A 539
GLN A 543
LEU A 609
MET A 330
 None
 1.26A 1a28B-4am6A:
undetectable		 1a28B-4am6A:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4am9 CHAPERONE SYCD

(Yersinia
enterocolitica) 		PF07720
(TPR_3) 		5 LEU A  36
LEU A  39
LEU A  42
GLN A  46
CYH A  63
 None
 0.77A 1a28B-4am9A:
undetectable		 1a28B-4am9A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4byf UNCONVENTIONAL
MYOSIN-IC

(Homo sapiens) 		PF00063
(Myosin_head)
PF00612
(IQ) 		5 LEU A 314
LEU A 303
LEU A 306
LEU A 346
THR A 538
 None
 1.41A 1a28B-4byfA:
undetectable		 1a28B-4byfA:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ez5 CYCLIN-DEPENDENT
KINASE 6

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A 129
ASN A  75
LEU A 130
LEU A 105
MET A 212
 None
 1.32A 1a28B-4ez5A:
undetectable		 1a28B-4ez5A:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fdh CYTOCHROME P450
11B2, MITOCHONDRIAL

(Homo sapiens) 		PF00067
(p450) 		5 LEU A 324
LEU A 327
LEU A 330
GLN A 337
ARG A 341
 None
 1.20A 1a28B-4fdhA:
undetectable		 1a28B-4fdhA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iw7 8-AMINO-7-OXONONANOA
TE SYNTHASE

(Francisella
tularensis) 		PF00155
(Aminotran_1_2) 		5 LEU A  40
LEU A  38
ASN A 273
LEU A 277
GLN A 278
 None
 1.41A 1a28B-4iw7A:
undetectable		 1a28B-4iw7A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j25 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Pseudomonas
putida) 		PF13640
(2OG-FeII_Oxy_3) 		5 LEU A 140
LEU A 142
LEU A 193
LEU A  33
CYH A  83
 None
 1.29A 1a28B-4j25A:
undetectable		 1a28B-4j25A:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lu0 2-DEHYDRO-3-DEOXYPHO
SPHOOCTONATE
ALDOLASE

(Pseudomonas
aeruginosa) 		PF00793
(DAHP_synth_1) 		5 LEU A 268
LEU A 271
LEU A 274
LEU A 242
THR A  51
 None
 1.41A 1a28B-4lu0A:
undetectable		 1a28B-4lu0A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n0r PUTATIVE GLYCOSIDE
HYDROLASE

(Bacteroides
vulgatus) 		PF13204
(DUF4038)
PF16586
(DUF5060) 		5 LEU A 382
ASN A 452
LEU A 528
LEU A 419
CYH A 375
 None
 1.40A 1a28B-4n0rA:
undetectable		 1a28B-4n0rA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n1y ESTROGEN RECEPTOR

(Crassostrea
gigas) 		PF00104
(Hormone_recep) 		5 LEU A 280
LEU A 283
LEU A 286
MET A 321
ARG A 331
 None
 0.41A 1a28B-4n1yA:
27.9		 1a28B-4n1yA:
29.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nhd 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3 PROTEIN 1

(Vibrio cholerae) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		5 LEU A 240
LEU A 299
LEU A 313
MET A 116
LEU A 219
 None
 1.21A 1a28B-4nhdA:
undetectable		 1a28B-4nhdA:
20.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p6w GLUCOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		9 LEU A 563
ASN A 564
LEU A 566
GLN A 570
MET A 601
ARG A 611
MET A 646
CYH A 736
THR A 739
 MOF  A 801 (-3.9A)
MOF  A 801 (-3.0A)
MOF  A 801 ( 4.6A)
MOF  A 801 (-2.9A)
MOF  A 801 (-3.7A)
MOF  A 801 (-4.2A)
MOF  A 801 (-4.4A)
MOF  A 801 (-3.7A)
MOF  A 801 (-3.9A)
 0.55A 1a28B-4p6wA:
36.2		 1a28B-4p6wA:
54.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u1a ENOYL-COA DELTA
ISOMERASE 2

(Homo sapiens) 		PF00378
(ECH_1) 		5 LEU A 188
LEU A 189
ASN A 185
LEU A 336
GLN A 242
 CL  A 401 ( 4.9A)
CL  A 401 ( 4.4A)
CL  A 401 ( 4.2A)
None
None
 1.25A 1a28B-4u1aA:
undetectable		 1a28B-4u1aA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u1a ENOYL-COA DELTA
ISOMERASE 2

(Homo sapiens) 		PF00378
(ECH_1) 		5 LEU A 188
LEU A 189
ASN A 185
LEU A 336
THR A 131
 CL  A 401 ( 4.9A)
CL  A 401 ( 4.4A)
CL  A 401 ( 4.2A)
None
None
 1.37A 1a28B-4u1aA:
undetectable		 1a28B-4u1aA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u48 PUTATIVE INNER
MEMBRANE LIPOPROTEIN

(Salmonella
enterica) 		PF00207
(A2M)
PF01835
(A2M_N)
PF07703
(A2M_N_2)
PF10569
(Thiol-ester_cl)
PF11974
(MG1) 		5 LEU A 754
LEU A 767
LEU A 802
GLN A 791
LEU A 842
 None
 1.37A 1a28B-4u48A:
undetectable		 1a28B-4u48A:
9.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4udb MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		8 LEU A 766
ASN A 770
GLN A 776
MET A 807
ARG A 817
LEU A 848
CYH A 942
THR A 945
 CV7  A1987 (-3.6A)
CV7  A1987 (-3.1A)
CV7  A1987 (-3.0A)
CV7  A1987 ( 3.9A)
CV7  A1987 (-3.7A)
CV7  A1987 ( 4.4A)
CV7  A1987 (-4.0A)
CV7  A1987 (-3.1A)
 0.64A 1a28B-4udbA:
35.4		 1a28B-4udbA:
54.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4udb MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		10 LEU A 766
LEU A 769
ASN A 770
LEU A 772
GLN A 776
MET A 807
ARG A 817
MET A 852
CYH A 942
THR A 945
 CV7  A1987 (-3.6A)
CV7  A1987 (-4.1A)
CV7  A1987 (-3.1A)
CV7  A1987 ( 4.5A)
CV7  A1987 (-3.0A)
CV7  A1987 ( 3.9A)
CV7  A1987 (-3.7A)
CV7  A1987 ( 3.7A)
CV7  A1987 (-4.0A)
CV7  A1987 (-3.1A)
 0.53A 1a28B-4udbA:
35.4		 1a28B-4udbA:
54.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4udb MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 LEU A 772
LEU A 769
LEU A 766
LEU A 814
MET A 852
 CV7  A1987 ( 4.5A)
CV7  A1987 (-4.1A)
CV7  A1987 (-3.6A)
CV7  A1987 ( 4.0A)
CV7  A1987 ( 3.7A)
 1.41A 1a28B-4udbA:
35.4		 1a28B-4udbA:
54.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yjf D-AMINO-ACID OXIDASE

(Sus scrofa) 		PF01266
(DAO) 		5 LEU B 145
LEU B 148
LEU B  17
LEU B 316
THR B  43
 None
None
None
FAD  B 401 (-3.8A)
FAD  B 401 (-3.9A)
 1.41A 1a28B-4yjfB:
undetectable		 1a28B-4yjfB:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yu9 GLUTAMINYL-PEPTIDE
CYCLOTRANSFERASE

(Homo sapiens) 		PF04389
(Peptidase_M28) 		5 LEU A 347
LEU A 351
ASN A 348
LEU A 170
MET A  65
 None
 1.20A 1a28B-4yu9A:
undetectable		 1a28B-4yu9A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zkt BOTULINUM NEUROTOXIN
TYPE E,
NONTOXIC-NONHEMAGGLU
TININ COMPONENT,
NTNH

(Clostridium
botulinum) 		PF01742
(Peptidase_M27)
PF07953
(Toxin_R_bind_N)
PF08470
(NTNH_C) 		5 LEU B 465
ASN B 468
LEU B 470
THR B 461
MET B 381
 None
 1.17A 1a28B-4zktB:
undetectable		 1a28B-4zktB:
12.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bsw 4-COUMARATE--COA
LIGASE 2

(Nicotiana
tabacum) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		5 LEU A 316
LEU A 456
ASN A 457
LEU A 455
THR A 319
 None
 1.11A 1a28B-5bswA:
undetectable		 1a28B-5bswA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c70 GLUCURONIDASE

(Aspergillus
oryzae) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N) 		5 LEU A 490
LEU A 486
GLN A 475
LEU A 466
THR A 494
 None
 1.42A 1a28B-5c70A:
undetectable		 1a28B-5c70A:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gmh TOLL-LIKE RECEPTOR 7

(Macaca mulatta) 		PF00560
(LRR_1)
PF13306
(LRR_5)
PF13855
(LRR_8) 		5 LEU A 179
LEU A 155
ASN A 182
LEU A 139
LEU A 168
 None
 1.38A 1a28B-5gmhA:
undetectable		 1a28B-5gmhA:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gs0 TOLL-LIKE RECEPTOR 3

(Homo sapiens) 		PF13516
(LRR_6)
PF13855
(LRR_8) 		5 LEU A 386
LEU A 414
ASN A 413
LEU A 438
LEU A 404
 None
None
NAG  A 814 (-2.6A)
None
None
 1.32A 1a28B-5gs0A:
undetectable		 1a28B-5gs0A:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gz1 MESO-DIAMINOPIMELATE
D-DEHYDROGENASE

(Ureibacillus
thermosphaericus) 		PF01113
(DapB_N)
PF16654
(DAPDH_C) 		5 LEU A 127
LEU A 130
ASN A 131
LEU A 133
LEU A 313
 None
 1.13A 1a28B-5gz1A:
undetectable		 1a28B-5gz1A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5htv PUTATIVE XYLULOSE
KINASE

(Arabidopsis
thaliana) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		5 LEU A 214
LEU A 164
LEU A 163
LEU A  15
MET A  17
 None
 1.24A 1a28B-5htvA:
undetectable		 1a28B-5htvA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ihr PROBABLE
BETA-GALACTOSIDASE A

(Aspergillus
niger) 		PF01301
(Glyco_hydro_35)
PF10435
(BetaGal_dom2)
PF13363
(BetaGal_dom3)
PF13364
(BetaGal_dom4_5) 		5 LEU A 979
LEU A 910
ASN A 911
GLN A 942
LEU A 952
 None
None
MAN  A1376 (-3.8A)
None
None
 1.39A 1a28B-5ihrA:
undetectable		 1a28B-5ihrA:
12.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5mwp MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		no annotation 7 ASN A 770
GLN A 776
MET A 807
ARG A 817
LEU A 848
CYH A 942
THR A 945
 ECV  A1101 (-3.1A)
ECV  A1101 (-2.9A)
ECV  A1101 (-3.6A)
ECV  A1101 (-4.0A)
None
ECV  A1101 (-4.0A)
ECV  A1101 (-3.2A)
 0.81A 1a28B-5mwpA:
36.5		 1a28B-5mwpA:
46.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5mwp MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		no annotation 9 LEU A 766
LEU A 769
ASN A 770
LEU A 772
GLN A 776
MET A 807
ARG A 817
CYH A 942
THR A 945
 ECV  A1101 ( 3.9A)
ECV  A1101 (-4.7A)
ECV  A1101 (-3.1A)
ECV  A1101 ( 3.9A)
ECV  A1101 (-2.9A)
ECV  A1101 (-3.6A)
ECV  A1101 (-4.0A)
ECV  A1101 (-4.0A)
ECV  A1101 (-3.2A)
 0.39A 1a28B-5mwpA:
36.5		 1a28B-5mwpA:
46.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5mwp MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		no annotation 5 LEU A 772
GLN A 776
MET A 807
ARG A 817
MET A 852
 ECV  A1101 ( 3.9A)
ECV  A1101 (-2.9A)
ECV  A1101 (-3.6A)
ECV  A1101 (-4.0A)
ECV  A1101 (-3.7A)
 1.16A 1a28B-5mwpA:
36.5		 1a28B-5mwpA:
46.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5sy1 STRA6

(Danio rerio) 		PF14752
(RBP_receptor) 		5 LEU A 360
LEU A 357
ASN A 356
LEU A 354
MET A 414
 None
 1.41A 1a28B-5sy1A:
undetectable		 1a28B-5sy1A:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5syt CAAX PRENYL PROTEASE
1 HOMOLOG

(Homo sapiens) 		PF01435
(Peptidase_M48)
PF16491
(Peptidase_M48_N) 		5 LEU A 185
LEU A 179
GLN A 175
LEU A 388
THR A 204
 None
None
None
CXE  A 504 ( 3.3A)
CXE  A 504 ( 3.8A)
 1.39A 1a28B-5sytA:
undetectable		 1a28B-5sytA:
19.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5uc1 GLUCOCORTICOID
RECEPTOR

(Heterocephalus
glaber) 		no annotation 7 LEU A 559
ASN A 560
LEU A 562
GLN A 566
MET A 597
ARG A 607
MET A 642
 486  A 801 (-4.7A)
486  A 801 (-4.2A)
486  A 801 ( 4.8A)
486  A 801 (-2.8A)
CPS  A 803 ( 3.9A)
486  A 801 (-3.5A)
486  A 801 ( 3.8A)
 0.79A 1a28B-5uc1A:
25.0		 1a28B-5uc1A:
56.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ufs ANCESTRAL
GLUCOCORTICOID
RECEPTOR2

(unidentified) 		PF00104
(Hormone_recep) 		9 LEU A  32
ASN A  33
LEU A  35
GLN A  39
MET A  70
ARG A  80
MET A 115
CYH A 205
THR A 208
 1TA  A 301 (-3.5A)
1TA  A 301 (-3.0A)
1TA  A 301 ( 3.6A)
1TA  A 301 (-3.0A)
1TA  A 301 ( 3.1A)
1TA  A 301 (-3.5A)
1TA  A 301 ( 2.8A)
1TA  A 301 (-3.6A)
1TA  A 301 (-3.0A)
 0.51A 1a28B-5ufsA:
37.2		 1a28B-5ufsA:
58.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vzj EXOSOME COMPLEX
EXONUCLEASE RRP6

(Saccharomyces
cerevisiae) 		PF00570
(HRDC)
PF01612
(DNA_pol_A_exo1) 		5 LEU J 468
LEU J 469
LEU J 428
LEU J 501
THR J 491
 None
 1.28A 1a28B-5vzjJ:
undetectable		 1a28B-5vzjJ:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5za2 BETA-LACTAMASE

(Escherichia
coli) 		no annotation 5 LEU A  69
LEU A 178
LEU A 173
GLN A 168
THR A 187
 None
 1.37A 1a28B-5za2A:
undetectable		 1a28B-5za2A:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bbp CYTOHESIN-3,ADP-RIBO
SYLATION FACTOR 6

(Homo sapiens;
Mus musculus) 		no annotation 5 LEU A 231
LEU A 235
GLN A 147
CYH A 190
THR A 189
 None
 1.37A 1a28B-6bbpA:
undetectable		 1a28B-6bbpA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6el8 FORKHEAD BOX PROTEIN
N1

(Homo sapiens) 		no annotation 5 LEU A 322
ASN A 321
LEU A 278
MET A 354
CYH A 327
 None
 1.24A 1a28B-6el8A:
undetectable		 1a28B-6el8A:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fcx METHYLENETETRAHYDROF
OLATE REDUCTASE

(Homo sapiens) 		no annotation 5 LEU A 621
ASN A 620
LEU A 513
LEU A 526
THR A 549
 None
 1.32A 1a28B-6fcxA:
undetectable		 1a28B-6fcxA:
14.72