SIMILAR PATTERNS OF AMINO ACIDS FOR 1A27_A_ESTA350

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b25 PROTEIN
(FORMALDEHYDE
FERREDOXIN
OXIDOREDUCTASE)

(Pyrococcus
furiosus) 		PF01314
(AFOR_C)
PF02730
(AFOR_N) 		5 SER A 345
VAL A 392
GLY A 391
LEU A  84
TYR A 171
 None
 1.18A 1a27A-1b25A:
undetectable		 1a27A-1b25A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1edg ENDOGLUCANASE A

([Clostridium]
cellulolyticum) 		PF00150
(Cellulase) 		5 GLY A 269
LEU A 264
ASN A 260
VAL A 311
GLU A 350
 None
 1.40A 1a27A-1edgA:
undetectable		 1a27A-1edgA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1evj GLUCOSE-FRUCTOSE
OXIDOREDUCTASE

(Zymomonas
mobilis) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		5 VAL A  37
GLY A  38
LEU A 106
PHE A  90
GLU A 113
 None
NAD  A 500 (-3.5A)
NAD  A 500 (-3.9A)
None
None
 1.40A 1a27A-1evjA:
undetectable		 1a27A-1evjA:
22.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1fdw 17-BETA-HYDROXYSTERO
ID DEHYDROGENASE

(Homo sapiens) 		PF00106
(adh_short) 		10 SER A 142
VAL A 143
GLY A 144
MET A 147
LEU A 149
ASN A 152
TYR A 155
VAL A 225
PHE A 259
MET A 279
 EST  A 350 (-4.3A)
EST  A 350 (-4.8A)
EST  A 350 ( 4.5A)
None
EST  A 350 (-4.6A)
None
None
None
EST  A 350 (-4.4A)
EST  A 350 (-3.6A)
 0.53A 1a27A-1fdwA:
42.2		 1a27A-1fdwA:
99.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1fdw 17-BETA-HYDROXYSTERO
ID DEHYDROGENASE

(Homo sapiens) 		PF00106
(adh_short) 		8 SER A 142
VAL A 143
GLY A 144
MET A 147
LEU A 149
PHE A 259
MET A 279
GLU A 282
 EST  A 350 (-4.3A)
EST  A 350 (-4.8A)
EST  A 350 ( 4.5A)
None
EST  A 350 (-4.6A)
EST  A 350 (-4.4A)
EST  A 350 (-3.6A)
None
 0.77A 1a27A-1fdwA:
42.2		 1a27A-1fdwA:
99.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1fdw 17-BETA-HYDROXYSTERO
ID DEHYDROGENASE

(Homo sapiens) 		PF00106
(adh_short) 		5 SER A 142
VAL A 143
GLY A 145
MET A 147
TYR A 155
 EST  A 350 (-4.3A)
EST  A 350 (-4.8A)
None
None
None
 1.26A 1a27A-1fdwA:
42.2		 1a27A-1fdwA:
99.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gnx BETA-GLUCOSIDASE

(Streptomyces
sp.) 		PF00232
(Glyco_hydro_1) 		5 VAL A 380
GLY A 426
LEU A  23
VAL A 128
PHE A 303
 None
 1.19A 1a27A-1gnxA:
2.3		 1a27A-1gnxA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gqj ALPHA-D-GLUCURONIDAS
E

(Cellvibrio
japonicus) 		PF03648
(Glyco_hydro_67N)
PF07477
(Glyco_hydro_67C)
PF07488
(Glyco_hydro_67M) 		5 VAL A 321
GLY A 320
TYR A 276
VAL A 206
PHE A 323
 None
 1.28A 1a27A-1gqjA:
undetectable		 1a27A-1gqjA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h54 MALTOSE
PHOSPHORYLASE

(Lactobacillus
brevis) 		PF03632
(Glyco_hydro_65m)
PF03633
(Glyco_hydro_65C)
PF03636
(Glyco_hydro_65N) 		5 GLY A  37
MET A  38
LEU A 141
ASN A  33
VAL A 260
 None
 1.18A 1a27A-1h54A:
undetectable		 1a27A-1h54A:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jkm BREFELDIN A ESTERASE

(Bacillus
subtilis) 		PF07859
(Abhydrolase_3) 		5 SER A 235
GLY A 237
ASN A 262
TYR A 238
GLU A 243
 None
 1.18A 1a27A-1jkmA:
2.9		 1a27A-1jkmA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lnz SPO0B-ASSOCIATED
GTP-BINDING PROTEIN

(Bacillus
subtilis) 		PF01018
(GTP1_OBG)
PF01926
(MMR_HSR1) 		5 VAL A 161
GLY A 162
LEU A 163
VAL A 178
PHE A 208
 None
 1.47A 1a27A-1lnzA:
undetectable		 1a27A-1lnzA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mfq SIGNAL RECOGNITION
PARTICLE 54KDA
PROTEIN

(Homo sapiens) 		PF02978
(SRP_SPB) 		5 VAL C 395
GLY C 392
LEU C 421
TYR C 424
VAL C 406
 None
 1.41A 1a27A-1mfqC:
undetectable		 1a27A-1mfqC:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mkm ICLR TRANSCRIPTIONAL
REGULATOR

(Thermotoga
maritima) 		PF01614
(IclR)
PF09339
(HTH_IclR) 		5 VAL A 197
GLY A 198
LEU A 233
PHE A 221
GLU A 228
 None
 1.50A 1a27A-1mkmA:
undetectable		 1a27A-1mkmA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ne7 GLUCOSAMINE-6-PHOSPH
ATE ISOMERASE

(Homo sapiens) 		PF01182
(Glucosamine_iso) 		5 SER A 155
VAL A 190
GLY A 191
MET A 194
VAL A 220
 16G  A4299 ( 4.8A)
None
None
None
None
 1.48A 1a27A-1ne7A:
3.6		 1a27A-1ne7A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r0d HUNTINGTIN
INTERACTING PROTEIN
12

(Homo sapiens) 		PF01608
(I_LWEQ) 		5 SER A 826
VAL A 949
LEU A 886
MET A 804
GLU A 902
 None
 1.49A 1a27A-1r0dA:
undetectable		 1a27A-1r0dA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r4v HYPOTHETICAL PROTEIN
AQ_328

(Aquifex
aeolicus) 		PF09123
(DUF1931) 		5 VAL A 106
GLY A 105
MET A 104
LEU A  32
VAL A  56
 None
 0.98A 1a27A-1r4vA:
undetectable		 1a27A-1r4vA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sgj CITRATE LYASE, BETA
SUBUNIT

(Deinococcus
radiodurans) 		PF03328
(HpcH_HpaI) 		5 VAL A 134
GLY A 131
LEU A 160
PHE A 151
GLU A 170
 None
 1.43A 1a27A-1sgjA:
undetectable		 1a27A-1sgjA:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1siv SIV PROTEASE

(Simian
immunodeficiency
virus) 		PF00077
(RVP) 		5 VAL A  62
GLY A  73
LEU A  89
ASN A  88
VAL A  33
 None
 0.99A 1a27A-1sivA:
undetectable		 1a27A-1sivA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uwi BETA-GALACTOSIDASE

(Sulfolobus
solfataricus) 		PF00232
(Glyco_hydro_1) 		5 GLY A  56
MET A  21
TYR A 448
VAL A  37
PHE A  17
 None
 1.35A 1a27A-1uwiA:
undetectable		 1a27A-1uwiA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vpx PROTEIN
(TRANSALDOLASE (EC
2.2.1.2))

(Thermotoga
maritima) 		PF00923
(TAL_FSA) 		5 VAL A 179
GLY A 178
MET A 177
ASN A 152
GLU A 146
 None
None
None
GOL  A 219 (-3.2A)
None
 1.40A 1a27A-1vpxA:
undetectable		 1a27A-1vpxA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zgz TORCAD OPERON
TRANSCRIPTIONAL
REGULATORY PROTEIN
TORR

(Escherichia
coli) 		PF00072
(Response_reg) 		5 VAL A  90
GLY A  91
MET A  94
TYR A  99
GLU A  59
 None
 1.22A 1a27A-1zgzA:
7.3		 1a27A-1zgzA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2akc CLASS A NONSPECIFIC
ACID PHOSPHATASE
PHON

(Salmonella
enterica) 		PF01569
(PAP2) 		5 VAL A 113
GLY A 114
LEU A 164
TYR A 161
PHE A  26
 None
 1.31A 1a27A-2akcA:
undetectable		 1a27A-2akcA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ash QUEUINE
TRNA-RIBOSYLTRANSFER
ASE

(Thermotoga
maritima) 		PF01702
(TGT) 		5 SER A 262
GLY A 243
LEU A 248
MET A 339
VAL A 257
 None
 1.22A 1a27A-2ashA:
2.1		 1a27A-2ashA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bbv PROTEIN (BLACK
BEETLE VIRUS CAPSID
PROTEIN)

(Black beetle
virus) 		PF01829
(Peptidase_A6) 		5 VAL A 173
GLY A 174
LEU A 313
TYR A 176
VAL A 301
 None
 1.42A 1a27A-2bbvA:
undetectable		 1a27A-2bbvA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e7j SEP-TRNA:CYS-TRNA
SYNTHASE

(Archaeoglobus
fulgidus) 		PF05889
(SepSecS) 		5 VAL A 264
MET A 211
TYR A 349
VAL A 193
PHE A  66
 None
 1.36A 1a27A-2e7jA:
4.0		 1a27A-2e7jA:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fa0 HMG-COA SYNTHASE

(Brassica juncea) 		PF01154
(HMG_CoA_synt_N)
PF08540
(HMG_CoA_synt_C) 		5 VAL A 324
GLY A 325
MET A 327
VAL A 388
PHE A  14
 None
 1.23A 1a27A-2fa0A:
undetectable		 1a27A-2fa0A:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gpz TRANSTHYRETIN-LIKE
PROTEIN

(Salmonella
enterica) 		PF00576
(Transthyretin) 		5 VAL A  25
GLY A  41
LEU A  52
VAL A 100
PHE A  67
 None
 1.33A 1a27A-2gpzA:
undetectable		 1a27A-2gpzA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q2r GLUCOKINASE 1,
PUTATIVE

(Trypanosoma
cruzi) 		PF02685
(Glucokinase) 		5 VAL A 305
GLY A 306
ASN A 353
VAL A 142
PHE A 152
 None
 1.42A 1a27A-2q2rA:
undetectable		 1a27A-2q2rA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qzc TRANSCRIPTIONAL
ACTIVATOR TENA-1

(Sulfolobus
solfataricus) 		PF03070
(TENA_THI-4) 		5 VAL A  14
GLY A  15
ASN A  19
PHE A 191
GLU A 198
 None
None
None
None
IMD  A 214 (-2.7A)
 1.17A 1a27A-2qzcA:
undetectable		 1a27A-2qzcA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xij METHYLMALONYL-COA
MUTASE,
MITOCHONDRIAL

(Homo sapiens) 		PF01642
(MM_CoA_mutase)
PF02310
(B12-binding) 		5 SER A 183
VAL A 184
MET A 186
ASN A 257
PHE A 199
 None
 1.43A 1a27A-2xijA:
2.5		 1a27A-2xijA:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z4g HISTIDINOL
PHOSPHATASE

(Thermus
thermophilus) 		PF02811
(PHP)
PF13263
(PHP_C) 		5 VAL A  33
GLY A  32
LEU A  73
PHE A  35
GLU A  19
 None
 1.47A 1a27A-2z4gA:
undetectable		 1a27A-2z4gA:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3adk ADENYLATE KINASE

(Sus scrofa) 		PF00406
(ADK) 		5 SER A  51
GLY A  54
MET A  56
LEU A  57
GLU A  70
 None
 1.32A 1a27A-3adkA:
3.3		 1a27A-3adkA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aeq LIGHT-INDEPENDENT
PROTOCHLOROPHYLLIDE
REDUCTASE SUBUNIT B

(Rhodobacter
capsulatus) 		PF00148
(Oxidored_nitro) 		5 VAL B 307
GLY B 309
MET B 310
LEU B 330
GLU B 327
 None
 1.45A 1a27A-3aeqB:
2.7		 1a27A-3aeqB:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bja TRANSCRIPTIONAL
REGULATOR, MARR
FAMILY, PUTATIVE

(Bacillus cereus) 		PF01047
(MarR) 		5 VAL A  40
MET A  56
LEU A  52
VAL A  76
MET A  63
 None
 1.25A 1a27A-3bjaA:
undetectable		 1a27A-3bjaA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bxw CHITINASE
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		no annotation 5 SER B 356
VAL B 355
GLY B 276
ASN B 278
TYR B 239
 None
 1.49A 1a27A-3bxwB:
undetectable		 1a27A-3bxwB:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ci6 PHOSPHOENOLPYRUVATE-
PROTEIN
PHOSPHOTRANSFERASE

(Acinetobacter
sp. ADP1) 		PF01590
(GAF) 		5 VAL A 117
GLY A 116
LEU A 115
ASN A  90
MET A  37
 None
None
None
None
P4G  A 169 ( 4.3A)
 1.25A 1a27A-3ci6A:
undetectable		 1a27A-3ci6A:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dpt RAB FAMILY PROTEIN

(Chlorobaculum
tepidum) 		PF16095
(COR) 		5 VAL A 845
MET A 831
LEU A 833
MET A 817
GLU A 875
 None
 1.37A 1a27A-3dptA:
undetectable		 1a27A-3dptA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gff IROE-LIKE SERINE
HYDROLASE

(Shewanella
oneidensis) 		PF00756
(Esterase) 		5 MET A 198
LEU A 196
TYR A 164
VAL A 186
PHE A 222
 None
 1.27A 1a27A-3gffA:
4.4		 1a27A-3gffA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gjy SPERMIDINE SYNTHASE

(Corynebacterium
glutamicum) 		no annotation 5 SER A 208
GLY A 205
VAL A 222
PHE A 279
MET A 228
 None
 1.48A 1a27A-3gjyA:
5.8		 1a27A-3gjyA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gwj ARYLPHORIN

(Antheraea
pernyi) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		5 VAL A  15
GLY A 579
LEU A 576
VAL A 143
PHE A  19
 None
 1.25A 1a27A-3gwjA:
undetectable		 1a27A-3gwjA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hmj FATTY ACID SYNTHASE
SUBUNIT ALPHA

(Saccharomyces
cerevisiae) 		PF00109
(ketoacyl-synt)
PF01648
(ACPS)
PF02801
(Ketoacyl-synt_C) 		5 SER A1308
VAL A1309
GLY A1589
ASN A1594
VAL A1655
 None
 1.43A 1a27A-3hmjA:
17.9		 1a27A-3hmjA:
10.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hps 2-ISOPROPYLMALATE
SYNTHASE

(Mycobacterium
tuberculosis) 		PF00682
(HMGL-like)
PF08502
(LeuA_dimer) 		5 VAL A 408
GLY A 386
MET A 390
LEU A 387
ASN A 384
 None
 1.40A 1a27A-3hpsA:
2.2		 1a27A-3hpsA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hpx 2-ISOPROPYLMALATE
SYNTHASE

(Mycobacterium
tuberculosis) 		PF00682
(HMGL-like) 		5 VAL A 408
GLY A 386
MET A 390
LEU A 387
ASN A 384
 None
 1.40A 1a27A-3hpxA:
undetectable		 1a27A-3hpxA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3la6 TYROSINE-PROTEIN
KINASE WZC

(Escherichia
coli) 		PF13614
(AAA_31) 		5 VAL A 690
GLY A 692
MET A 664
TYR A 467
GLU A 677
 None
 1.49A 1a27A-3la6A:
2.5		 1a27A-3la6A:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m8y PHOSPHOPENTOMUTASE

(Bacillus cereus) 		PF01676
(Metalloenzyme) 		5 SER A 157
VAL A 191
GLY A 192
LEU A 217
GLU A 182
 None
 1.40A 1a27A-3m8yA:
undetectable		 1a27A-3m8yA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3otn SUSD SUPERFAMILY
PROTEIN

(Parabacteroides
distasonis) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		5 SER A 210
VAL A 209
ASN A 269
VAL A 381
PHE A 144
 None
 1.42A 1a27A-3otnA:
undetectable		 1a27A-3otnA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pr2 TRYPTOPHAN SYNTHASE
ALPHA CHAIN

(Salmonella
enterica) 		PF00290
(Trp_syntA) 		5 VAL A  52
GLY A  51
MET A 101
LEU A  99
VAL A 121
 None
 1.29A 1a27A-3pr2A:
undetectable		 1a27A-3pr2A:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pxx CARVEOL
DEHYDROGENASE

(Mycobacterium
avium) 		PF13561
(adh_short_C2) 		5 SER A 150
VAL A 151
GLY A 153
TYR A 174
MET A 217
 NAD  A 284 (-3.7A)
None
None
NAD  A 284 (-4.5A)
None
 1.20A 1a27A-3pxxA:
25.5		 1a27A-3pxxA:
28.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqp ENOLASE

(Coxiella
burnetii) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		5 SER A 247
GLY A 287
LEU A 272
PHE A 258
GLU A 274
 None
 1.48A 1a27A-3tqpA:
undetectable		 1a27A-3tqpA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ue2 POLY(U)-BINDING-SPLI
CING FACTOR PUF60

(Homo sapiens) 		no annotation 5 VAL A 542
MET A 469
LEU A 466
PHE A 537
GLU A 486
 None
 1.25A 1a27A-3ue2A:
undetectable		 1a27A-3ue2A:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uyq CARBONIC ANHYDRASE 3

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		5 SER A  29
GLY A 195
TYR A 193
VAL A 121
PHE A 197
 None
 1.19A 1a27A-3uyqA:
undetectable		 1a27A-3uyqA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wbb DIAMINOPIMELATE
DEHYDROGENASE

(Symbiobacterium
thermophilum) 		PF01408
(GFO_IDH_MocA)
PF16654
(DAPDH_C) 		5 VAL A 229
GLY A 228
MET A 249
ASN A 253
MET A 152
 None
None
None
NAP  A 305 (-3.6A)
None
 1.32A 1a27A-3wbbA:
8.7		 1a27A-3wbbA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3win HA3

(Clostridium
botulinum) 		PF03505
(Clenterotox) 		5 SER E 538
VAL E 512
LEU E 504
VAL E 571
GLU E 573
 None
 1.16A 1a27A-3winE:
undetectable		 1a27A-3winE:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bjp PENICILLIN BINDING
PROTEIN
TRANSPEPTIDASE
DOMAIN PROTEIN

(Escherichia
coli) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer) 		5 SER A 195
VAL A 192
GLY A 191
ASN A 296
VAL A 272
 None
 1.15A 1a27A-4bjpA:
undetectable		 1a27A-4bjpA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c1o BETA-XYLOSIDASE

(Parageobacillus
thermoglucosidasius) 		PF03512
(Glyco_hydro_52) 		5 SER A 719
VAL A 717
GLY A 716
VAL A 142
PHE A 375
 None
 1.33A 1a27A-4c1oA:
undetectable		 1a27A-4c1oA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ckb MRNA-CAPPING ENZYME
CATALYTIC SUBUNIT

(Vaccinia virus) 		PF03291
(Pox_MCEL)
PF10640
(Pox_ATPase-GT) 		5 GLY A 283
LEU A 282
TYR A 278
VAL A 468
MET A 221
 None
 1.49A 1a27A-4ckbA:
7.6		 1a27A-4ckbA:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d65 PORIN 2

(Providencia
stuartii) 		PF00267
(Porin_1) 		5 VAL A  97
GLY A  96
MET A 123
LEU A 130
ASN A  94
 None
 1.26A 1a27A-4d65A:
undetectable		 1a27A-4d65A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eq5 DNA LIGASE

(Thermococcus
sibiricus) 		PF01068
(DNA_ligase_A_M)
PF04675
(DNA_ligase_A_N)
PF04679
(DNA_ligase_A_C) 		5 VAL A 267
GLY A 310
LEU A 348
ASN A 349
VAL A 327
 None
 1.37A 1a27A-4eq5A:
undetectable		 1a27A-4eq5A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fe9 OUTER MEMBRANE
PROTEIN SUSF

(Bacteroides
thetaiotaomicron) 		PF16411
(SusF_SusE)
PF17142
(DUF5115) 		5 VAL A 367
GLY A 312
LEU A 300
VAL A 322
PHE A 380
 None
EDO  A 511 (-3.4A)
None
None
None
 1.41A 1a27A-4fe9A:
undetectable		 1a27A-4fe9A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4feq TYROSINE-PROTEIN
KINASE RECEPTOR
TYRO3

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		5 VAL A 576
GLY A 575
LEU A 573
PHE A 555
GLU A 558
 None
 1.19A 1a27A-4feqA:
undetectable		 1a27A-4feqA:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g56 HSL7 PROTEIN

(Xenopus laevis) 		PF05185
(PRMT5)
PF17285
(PRMT5_TIM)
PF17286
(PRMT5_C) 		5 VAL A  78
GLY A  79
LEU A 118
VAL A 261
PHE A  35
 None
 1.47A 1a27A-4g56A:
2.3		 1a27A-4g56A:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ha4 BETA-GALACTOSIDASE

(Acidilobus
saccharovorans) 		PF00232
(Glyco_hydro_1) 		5 GLY A  57
MET A  22
TYR A 446
VAL A  38
PHE A  18
 None
 1.36A 1a27A-4ha4A:
undetectable		 1a27A-4ha4A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hds ARSA
ARSB

(Sporomusa ovata) 		PF02277
(DBI_PRT) 		5 SER B 312
VAL B 313
LEU B 295
PHE B  37
GLU A 312
 EDO  B 902 (-2.8A)
None
None
None
None
 1.33A 1a27A-4hdsB:
undetectable		 1a27A-4hdsB:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i7z APOCYTOCHROME F

(Mastigocladus
laminosus) 		PF01333
(Apocytochr_F_C)
PF16639
(Apocytochr_F_N) 		5 VAL C 116
GLY C 117
LEU C 119
VAL C  98
PHE C 103
 None
 1.44A 1a27A-4i7zC:
undetectable		 1a27A-4i7zC:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jga 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2

(Rickettsia
rickettsii) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 SER A 161
GLY A 158
LEU A 155
ASN A 154
MET A  83
 None
 1.26A 1a27A-4jgaA:
undetectable		 1a27A-4jgaA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k68 GH10 XYLANASE

(soil metagenome) 		PF00331
(Glyco_hydro_10) 		5 GLY A 184
MET A 183
MET A 223
VAL A 164
MET A 143
 None
 1.40A 1a27A-4k68A:
undetectable		 1a27A-4k68A:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l37 ARYLPHORIN

(Bombyx mori) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		5 VAL B  14
GLY B 578
LEU B 575
VAL B 142
PHE B  18
 None
 1.23A 1a27A-4l37B:
undetectable		 1a27A-4l37B:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n0i GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A,
MITOCHONDRIAL

(Saccharomyces
cerevisiae) 		PF01425
(Amidase) 		5 SER A 433
GLY A 443
VAL A 419
MET A 248
GLU A 246
 None
 1.18A 1a27A-4n0iA:
undetectable		 1a27A-4n0iA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oah MITOCHONDRIAL
DYNAMIC PROTEIN
MID51

(Mus musculus) 		PF03281
(Mab-21) 		5 GLY A 447
LEU A 450
TYR A 451
VAL A 388
PHE A 435
 None
 1.25A 1a27A-4oahA:
undetectable		 1a27A-4oahA:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4py9 PUTATIVE
EXOPOLYPHOSPHATASE-R
ELATED PROTEIN

(Bacteroides
fragilis) 		PF01368
(DHH) 		5 GLY A  71
MET A  69
LEU A  41
VAL A  58
PHE A  62
 None
 1.37A 1a27A-4py9A:
4.2		 1a27A-4py9A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rhh BETA-XYLOSIDASE

(Geobacillus
stearothermophilus) 		PF03512
(Glyco_hydro_52) 		5 SER A 697
VAL A 695
GLY A 694
VAL A 120
PHE A 353
 None
 1.24A 1a27A-4rhhA:
undetectable		 1a27A-4rhhA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tuf MAJOR EXTRACELLULAR
ENDOGLUCANASE

(Xanthomonas
campestris) 		PF00150
(Cellulase) 		5 LEU A  62
ASN A 105
TYR A 102
VAL A 120
PHE A  52
 None
 1.30A 1a27A-4tufA:
2.0		 1a27A-4tufA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4twl DIOSCORIN 5

(Dioscorea
japonica) 		PF00194
(Carb_anhydrase) 		6 SER A  35
GLY A 180
TYR A 178
VAL A 116
PHE A 182
GLU A 118
 None
None
None
ASC  A 303 (-4.2A)
None
None
 1.34A 1a27A-4twlA:
undetectable		 1a27A-4twlA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4usr MONOOXYGENASE

(Pseudomonas
stutzeri) 		PF13738
(Pyr_redox_3) 		5 VAL A 265
GLY A 264
LEU A 275
VAL A 170
PHE A 257
 None
 1.31A 1a27A-4usrA:
4.9		 1a27A-4usrA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5czc MALONYL-COA-[ACYL-CA
RRIER-PROTEIN]
TRANSACYLASE

(Streptomyces
halstedii) 		no annotation 5 SER A 279
VAL A 276
GLY A 250
VAL A 112
MET A 262
 None
 1.46A 1a27A-5czcA:
undetectable		 1a27A-5czcA:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dbo TRANSLATION
INITIATION FACTOR
EIF-2B-LIKE PROTEIN

(Chaetomium
thermophilum) 		PF01008
(IF-2B) 		5 VAL A 162
GLY A 163
MET A 166
LEU A 216
MET A 222
 None
 1.39A 1a27A-5dboA:
5.0		 1a27A-5dboA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i6h ACETYL-COA
CARBOXYLASE-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF01039
(Carboxyl_trans)
PF08326
(ACC_central) 		5 VAL A1840
GLY A1839
LEU A1767
VAL A1629
PHE A1553
 None
 1.47A 1a27A-5i6hA:
undetectable		 1a27A-5i6hA:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i6i ACETYL-COA
CARBOXYLASE-LIKE
PROTEIN,ACETYL-COA
CARBOXYLASE-LIKE
PROTEIN,ACETYL-COA
CARBOXYLASE-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF01039
(Carboxyl_trans)
PF08326
(ACC_central) 		5 VAL A1840
GLY A1839
LEU A1767
VAL A1629
PHE A1553
 None
 1.41A 1a27A-5i6iA:
2.9		 1a27A-5i6iA:
9.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jn9 CARBONIC ANHYDRASE 4

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		5 SER A  29
GLY A 196
TYR A 194
VAL A 121
GLU A 123
 None
None
None
EZL  A 302 (-4.7A)
None
 1.13A 1a27A-5jn9A:
undetectable		 1a27A-5jn9A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k8g ANTIFREEZE PROTEIN

(Marinomonas
primoryensis) 		no annotation 5 SER A 282
VAL A 283
GLY A 284
VAL A 346
MET A 304
 None
 1.25A 1a27A-5k8gA:
undetectable		 1a27A-5k8gA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m04 GTPASE OBGE/CGTA

(Escherichia
coli) 		PF01018
(GTP1_OBG)
PF01926
(MMR_HSR1) 		5 VAL A 162
GLY A 163
LEU A 242
VAL A 179
PHE A 209
 None
 1.43A 1a27A-5m04A:
2.0		 1a27A-5m04A:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mh5 D-2-HYDROXYACID
DEHYDROGENASE

(Haloferax
mediterranei) 		no annotation 5 SER A 220
GLY A 246
LEU A 239
VAL A 230
GLU A 232
 None
 1.26A 1a27A-5mh5A:
3.6		 1a27A-5mh5A:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nci LEUCINE HYDROXYLASE

(Streptomyces
muensis) 		PF05721
(PhyH) 		5 SER A 212
VAL A 144
LEU A 223
ASN A  97
PHE A 146
 AKG  A 302 (-2.6A)
AKG  A 302 (-4.3A)
AKG  A 302 ( 4.8A)
AKG  A 302 (-3.3A)
None
 1.39A 1a27A-5nciA:
undetectable		 1a27A-5nciA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nfr MALATE DEHYDROGENASE

(Plasmodium
falciparum) 		no annotation 5 VAL A 190
GLY A 189
ASN A 167
VAL A 161
PHE A 195
 None
 1.49A 1a27A-5nfrA:
10.4		 1a27A-5nfrA:
12.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o1r GNA2132

(Neisseria
meningitidis) 		no annotation 5 VAL A 401
GLY A 422
ASN A 320
VAL A 344
PHE A 393
 None
 1.45A 1a27A-5o1rA:
undetectable		 1a27A-5o1rA:
12.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t67 SUGAR 3-C-METHYL
TRANSFERASE

(Actinomadura
kijaniata) 		PF08421
(Methyltransf_13)
PF08484
(Methyltransf_14)
PF13489
(Methyltransf_23) 		5 VAL A 213
GLY A 210
LEU A 209
VAL A  51
PHE A 295
 None
 1.50A 1a27A-5t67A:
5.6		 1a27A-5t67A:
25.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tw1 DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Mycolicibacterium
smegmatis) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF10385
(RNA_pol_Rpb2_45) 		5 VAL C 414
GLY C 383
MET C 387
LEU C 384
VAL C 126
 None
 1.40A 1a27A-5tw1C:
undetectable		 1a27A-5tw1C:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uf2 RIBOSE-5-PHOSPHATE
ISOMERASE A

(Neisseria
gonorrhoeae) 		PF06026
(Rib_5-P_isom_A) 		5 GLY A 153
MET A 151
LEU A 175
VAL A 134
MET A 183
 None
None
EDO  A 309 (-4.4A)
None
None
 1.49A 1a27A-5uf2A:
undetectable		 1a27A-5uf2A:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v0t ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
(UDP-FORMING)

(Paraburkholderia
xenovorans) 		PF00982
(Glyco_transf_20) 		5 SER A 387
VAL A 386
MET A 445
LEU A 409
VAL A 371
 None
 1.44A 1a27A-5v0tA:
7.8		 1a27A-5v0tA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v41 POLYKETIDE SYNTHASE
PKS13 (TERMINATION
POLYKETIDE SYNTHASE)

(Mycobacterium
tuberculosis) 		PF00975
(Thioesterase) 		5 VAL A1556
GLY A1557
LEU A1558
TYR A1658
VAL A1687
 None
 1.09A 1a27A-5v41A:
4.6		 1a27A-5v41A:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vhi 26S PROTEASOME
NON-ATPASE
REGULATORY SUBUNIT 2

(Homo sapiens) 		PF00004
(AAA) 		5 VAL f 229
LEU f 248
ASN f 245
MET f 209
GLU f 210
 None
 1.27A 1a27A-5vhif:
undetectable		 1a27A-5vhif:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vn4 ADENINE
PHOSPHORIBOSYLTRANSF
ERASE, PUTATIVE

(Trypanosoma
brucei) 		PF00156
(Pribosyltran) 		5 VAL A 159
GLY A 158
MET A 155
LEU A 144
GLU A 171
 None
 1.45A 1a27A-5vn4A:
undetectable		 1a27A-5vn4A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w2h INOSITOL
POLYPHOSPHATE
MULTIKINASE,INOSITOL
POLYPHOSPHATE
MULTIKINASE

(Homo sapiens) 		PF03770
(IPK) 		5 VAL A 178
GLY A 199
LEU A 202
TYR A 168
VAL A 299
 None
 1.45A 1a27A-5w2hA:
undetectable		 1a27A-5w2hA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w3f TUBULIN ALPHA-1
CHAIN

(Saccharomyces
cerevisiae) 		PF00091
(Tubulin)
PF03953
(Tubulin_C) 		5 VAL A 333
ASN A 294
VAL A 342
PHE A 352
MET A 378
 None
 1.20A 1a27A-5w3fA:
3.3		 1a27A-5w3fA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w4u DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB3

(Saccharomyces
cerevisiae) 		no annotation 5 VAL C 244
GLY C 247
MET C  37
LEU C  33
VAL C   8
 None
 1.27A 1a27A-5w4uC:
undetectable		 1a27A-5w4uC:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w94 MAU2 CHROMATID
COHESION FACTOR
HOMOLOG
SISTER CHROMATID
COHESION PROTEIN 2

(Saccharomyces
cerevisiae) 		PF10345
(Cohesin_load)
no annotation 		5 SER A 393
GLY B  31
LEU B  32
VAL B  27
PHE A 369
 None
 1.50A 1a27A-5w94A:
undetectable		 1a27A-5w94A:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xjq SMALL NUCLEAR
RIBONUCLEOPROTEIN SM
D1

(Homo sapiens) 		no annotation 5 VAL A  15
GLY A  27
LEU A  40
VAL A  32
PHE A  68
 None
 1.38A 1a27A-5xjqA:
undetectable		 1a27A-5xjqA:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c8a INOSITOL
POLYPHOSPHATE
MULTIKINASE

(Homo sapiens) 		no annotation 5 VAL A 178
GLY A 199
LEU A 202
TYR A 168
VAL A 409
 None
 1.41A 1a27A-6c8aA:
undetectable		 1a27A-6c8aA:
13.57