SIMILAR PATTERNS OF AMINO ACIDS FOR 13GS_A_SASA211_1
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1aec | ACTINIDIN (Actinidiachinensis) |
PF00112(Peptidase_C1) | 5 | PRO A 132VAL A 128VAL A 13ILE A 196GLY A 168 | None | 1.49A | 13gsA-1aecA:undetectable | 13gsA-1aecA:20.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1b2h | PERIPLASMICOLIGOPEPTIDE-BINDINGPROTEIN (Salmonellaenterica) |
PF00496(SBP_bac_5) | 5 | TYR A 269PRO A 268ILE A 507TYR A 498GLY A 500 | None | 1.45A | 13gsA-1b2hA:undetectable | 13gsA-1b2hA:17.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1i9g | HYPOTHETICAL PROTEINRV2118C (Mycobacteriumtuberculosis) |
PF08704(GCD14)PF14801(GCD14_N) | 5 | PHE A 98PRO A 99VAL A 121ILE A 128GLY A 125 | None | 1.25A | 13gsA-1i9gA:0.0 | 13gsA-1i9gA:21.23 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1lbk | GLUTATHIONES-TRANSFERASE CLASSPI CHIMAERA (CODA) (Homo sapiens) |
PF02798(GST_N)PF14497(GST_C_3) | 9 | TYR A 7PHE A 8PRO A 9VAL A 10ARG A 13VAL A 35ILE A 104TYR A 108PRO A 202 | NoneGSH A 504 (-4.7A)NoneNoneGSH A 504 (-3.7A)NoneNoneNoneNone | 0.59A | 13gsA-1lbkA:35.8 | 13gsA-1lbkA:97.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1sdo | BSTYI (Geobacillusstearothermophilus) |
PF09195(Endonuc-BglII) | 5 | VAL A 156VAL A 18ILE A 199PRO A 195GLY A 12 | None | 1.00A | 13gsA-1sdoA:undetectable | 13gsA-1sdoA:23.14 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1tu7 | GLUTATHIONES-TRANSFERASE 2 (Onchocercavolvulus) |
PF02798(GST_N)PF14497(GST_C_3) | 5 | TYR A 7PHE A 8TYR A 106PRO A 201GLY A 204 | NoneGSH A1001 (-4.8A)NoneNoneNone | 0.45A | 13gsA-1tu7A:30.7 | 13gsA-1tu7A:42.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2cev | PROTEIN (ARGINASE) ([Bacillus]caldovelox) |
PF00491(Arginase) | 5 | VAL A 272VAL A 287ILE A 101PRO A 274GLY A 23 | None | 1.32A | 13gsA-2cevA:0.3 | 13gsA-2cevA:21.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2cxi | PHENYLALANYL-TRNASYNTHETASE BETACHAIN (Pyrococcushorikoshii) |
PF03483(B3_4)PF03484(B5) | 5 | PRO A 214VAL A 140ILE A 154TYR A 106PRO A 200 | None | 1.32A | 13gsA-2cxiA:undetectable | 13gsA-2cxiA:21.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ekc | TRYPTOPHAN SYNTHASEALPHA CHAIN (Aquifexaeolicus) |
PF00290(Trp_syntA) | 5 | PHE A 176PRO A 156VAL A 177VAL A 198ILE A 127 | None | 1.43A | 13gsA-2ekcA:undetectable | 13gsA-2ekcA:22.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2esv | KK50.4 T CELLRECEPTOR BETA CHAIN (Homo sapiens) |
PF07654(C1-set)PF07686(V-set) | 5 | VAL E 123VAL E 158ILE E 13PRO E 233GLY E 219 | None | 1.43A | 13gsA-2esvE:undetectable | 13gsA-2esvE:20.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2eyr | NKT12 (Homo sapiens) |
PF07654(C1-set)PF07686(V-set) | 5 | VAL B 123VAL B 158ILE B 13PRO B 233GLY B 219 | None | 1.46A | 13gsA-2eyrB:undetectable | 13gsA-2eyrB:20.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2g39 | ACETYL-COA HYDROLASE (Pseudomonasaeruginosa) |
PF02550(AcetylCoA_hydro)PF13336(AcetylCoA_hyd_C) | 5 | PRO A 259ARG A 436VAL A 346ILE A 425GLY A 353 | None | 1.44A | 13gsA-2g39A:undetectable | 13gsA-2g39A:19.72 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2gsr | CLASS PI GSTGLUTATHIONES-TRANSFERASE (Sus scrofa) |
PF02798(GST_N)PF14497(GST_C_3) | 8 | TYR A 7PHE A 8PRO A 9VAL A 10ARG A 13TYR A 106PRO A 200GLY A 203 | GTS A 208 (-4.5A)GTS A 208 (-4.7A)NoneNoneGTS A 208 (-4.0A)NoneNoneNone | 0.24A | 13gsA-2gsrA:35.5 | 13gsA-2gsrA:82.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2j8x | URACIL-DNAGLYCOSYLASE (Humangammaherpesvirus4) |
PF03167(UDG) | 5 | TYR A 93VAL A 105ILE A 118TYR A 119GLY A 135 | None | 1.09A | 13gsA-2j8xA:undetectable | 13gsA-2j8xA:22.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2jhq | URACILDNA-GLYCOSYLASE (Vibrio cholerae) |
PF03167(UDG) | 5 | TYR A 66VAL A 79ILE A 92TYR A 93GLY A 109 | None | 1.06A | 13gsA-2jhqA:undetectable | 13gsA-2jhqA:22.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2rha | TRANSCRIPTIONALREGULATOR, TETRFAMILY (Novosphingobiumaromaticivorans) |
PF14514(TetR_C_9) | 5 | VAL A 153ARG A 155ILE A 157PRO A 89GLY A 148 | None | 1.16A | 13gsA-2rhaA:undetectable | 13gsA-2rhaA:23.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yqu | 2-OXOGLUTARATEDEHYDROGENASE E3COMPONENT (Thermusthermophilus) |
PF02852(Pyr_redox_dim)PF07992(Pyr_redox_2) | 5 | PRO A 167VAL A 166VAL A 193ILE A 58GLY A 190 | None | 1.42A | 13gsA-2yquA:undetectable | 13gsA-2yquA:19.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2zoo | PROBABLE NITRITEREDUCTASE (Pseudoalteromonashaloplanktis) |
PF00034(Cytochrom_C)PF00394(Cu-oxidase)PF07732(Cu-oxidase_3) | 5 | PRO A 13VAL A 17ILE A 86TYR A 123GLY A 59 | None | 1.34A | 13gsA-2zooA:undetectable | 13gsA-2zooA:18.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3agf | GLUTAMINASE 1 (Bacillussubtilis) |
PF04960(Glutaminase) | 5 | PHE A 70PRO A 300VAL A 68ILE A 295GLY A 50 | None | 1.45A | 13gsA-3agfA:undetectable | 13gsA-3agfA:23.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bol | 5-METHYLTETRAHYDROFOLATE S-HOMOCYSTEINEMETHYLTRANSFERASE (Thermotogamaritima) |
PF00809(Pterin_bind)PF02574(S-methyl_trans) | 5 | PRO A 277VAL A 280VAL A 49ILE A 268GLY A 20 | NoneNoneNoneNone K A 703 (-3.9A) | 1.26A | 13gsA-3bolA:undetectable | 13gsA-3bolA:18.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cea | MYO-INOSITOL2-DEHYDROGENASE (Lactobacillusplantarum) |
PF01408(GFO_IDH_MocA)PF02894(GFO_IDH_MocA_C) | 5 | PHE A 107VAL A 110ILE A 187PRO A 84GLY A 104 | None | 1.40A | 13gsA-3ceaA:undetectable | 13gsA-3ceaA:19.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cxm | URACIL-DNAGLYCOSYLASE (Leishmanianaiffi) |
PF03167(UDG) | 5 | TYR A 208VAL A 221ILE A 234TYR A 235GLY A 251 | URB A 401 ( 3.3A)NoneNoneNoneNone | 1.05A | 13gsA-3cxmA:undetectable | 13gsA-3cxmA:23.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fy4 | 6-4 PHOTOLYASE (Arabidopsisthaliana) |
PF00875(DNA_photolyase)PF03441(FAD_binding_7) | 5 | ARG A 439ILE A 453TYR A 454PRO A 249GLY A 428 | None | 1.48A | 13gsA-3fy4A:undetectable | 13gsA-3fy4A:16.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nzq | BIOSYNTHETICARGININEDECARBOXYLASE (Escherichiacoli) |
PF02784(Orn_Arg_deC_N) | 5 | PRO A 506VAL A 507VAL A 565ILE A 376GLY A 561 | None | 1.30A | 13gsA-3nzqA:undetectable | 13gsA-3nzqA:15.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3o0d | TRIACYLGLYCEROLLIPASE (Yarrowialipolytica) |
PF01764(Lipase_3)PF03893(Lipase3_N) | 5 | VAL A 184VAL A 201ILE A 85PRO A 182GLY A 172 | None | 1.29A | 13gsA-3o0dA:undetectable | 13gsA-3o0dA:19.54 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3o76 | GLUTATHIONES-TRANSFERASE P 1 (Mus musculus) |
PF02798(GST_N)PF14497(GST_C_3) | 8 | TYR A 7PHE A 8PRO A 9VAL A 10ARG A 13TYR A 108PRO A 202GLY A 205 | NoneGTB A 210 (-4.5A)NoneNoneGTB A 210 (-3.9A)GTB A 210 (-4.1A)NoneGTB A 210 (-3.7A) | 0.31A | 13gsA-3o76A:36.0 | 13gsA-3o76A:84.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3p5u | ACTINIDIN (Actinidiaarguta) |
PF00112(Peptidase_C1) | 5 | PRO A 132VAL A 128VAL A 13ILE A 196GLY A 168 | None | 1.49A | 13gsA-3p5uA:undetectable | 13gsA-3p5uA:22.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3p9h | TUMOR SUSCEPTIBILITYGENE 101 PROTEIN (Homo sapiens) |
PF05743(UEV) | 5 | PHE A 135VAL A 61VAL A 130PRO A 62GLY A 136 | None | 1.31A | 13gsA-3p9hA:undetectable | 13gsA-3p9hA:19.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pfr | MANDELATERACEMASE/MUCONATELACTONIZING PROTEIN (Actinobacillussuccinogenes) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 5 | TYR A 154PHE A 212VAL A 446PRO A 237GLY A 214 | None | 1.34A | 13gsA-3pfrA:undetectable | 13gsA-3pfrA:19.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rmt | 3-PHOSPHOSHIKIMATE1-CARBOXYVINYLTRANSFERASE 1 (Bacillushalodurans) |
PF00275(EPSP_synthase) | 5 | PHE A 47VAL A 233ARG A 73PRO A 234GLY A 23 | None | 1.46A | 13gsA-3rmtA:undetectable | 13gsA-3rmtA:21.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tqp | ENOLASE (Coxiellaburnetii) |
PF00113(Enolase_C)PF03952(Enolase_N) | 5 | TYR A 417PHE A 177PRO A 145VAL A 146ILE A 239 | None | 1.41A | 13gsA-3tqpA:undetectable | 13gsA-3tqpA:21.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3txa | CELL WALL SURFACEANCHOR FAMILYPROTEIN (Streptococcusagalactiae) |
PF00092(VWA) | 5 | PHE A 711PRO A 712ILE A 658TYR A 675PRO A 714 | None | 1.42A | 13gsA-3txaA:undetectable | 13gsA-3txaA:14.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bqn | CAPSULARPOLYSACCHARIDEBIOSYNTHESIS PROTEIN (Burkholderiapseudomallei) |
no annotation | 5 | PRO A 67VAL A 68VAL A 95ILE A 49GLY A 12 | NoneCOA A 320 (-3.9A)NoneNoneNone | 1.35A | 13gsA-4bqnA:undetectable | 13gsA-4bqnA:23.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bxs | VENOM PROTHROMBINACTIVATORPSEUTARIN-CNON-CATALYTICSUBUNIT (Pseudonajatextilis) |
PF00754(F5_F8_type_C)PF07732(Cu-oxidase_3) | 5 | TYR V 798PRO V 857ARG V 796ILE V 967PRO V 958 | None | 1.38A | 13gsA-4bxsV:undetectable | 13gsA-4bxsV:9.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4elk | HY19.3 TCR BETACHAIN (MOUSEVARIABLE DOMAIN,HUMAN CONSTANTDOMAIN) (Mus musculus) |
PF07654(C1-set)PF07686(V-set) | 5 | VAL B 121VAL B 156ILE B 14PRO B 231GLY B 217 | None | 1.46A | 13gsA-4elkB:undetectable | 13gsA-4elkB:21.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4id0 | GLUTATHIONES-TRANSFERASE-LIKEPROTEIN YIBF (Pseudomonasfluorescens) |
PF13410(GST_C_2)PF13417(GST_N_3) | 5 | PRO A 10ILE A 191TYR A 188PRO A 202GLY A 166 | None | 0.91A | 13gsA-4id0A:15.8 | 13gsA-4id0A:22.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4iug | BETA-GALACTOSIDASE A (Aspergillusoryzae) |
PF01301(Glyco_hydro_35)PF10435(BetaGal_dom2)PF13363(BetaGal_dom3)PF13364(BetaGal_dom4_5) | 5 | PRO A 73VAL A 74VAL A 945PRO A 993GLY A 948 | None | 1.10A | 13gsA-4iugA:undetectable | 13gsA-4iugA:12.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lyl | URACIL-DNAGLYCOSYLASE (Gadus morhua) |
PF03167(UDG) | 5 | TYR A 147VAL A 160ILE A 173TYR A 174GLY A 190 | None | 1.07A | 13gsA-4lylA:undetectable | 13gsA-4lylA:22.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4m8u | OLIGO-1,6-GLUCOSIDASE 1 (Bacillussubtilis) |
PF00128(Alpha-amylase)PF16657(Malt_amylase_C) | 5 | PHE A 53VAL A 52VAL A 99ILE A 84PRO A 15 | None | 1.47A | 13gsA-4m8uA:undetectable | 13gsA-4m8uA:15.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4r9g | MBP1 (Caldanaerobiuspolysaccharolyticus) |
PF13416(SBP_bac_8) | 5 | PHE A 116PRO A 346VAL A 136ILE A 374TYR A 376 | None | 1.48A | 13gsA-4r9gA:undetectable | 13gsA-4r9gA:20.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4s3m | 2-DEHYDROPANTOATE2-REDUCTASE (Staphylococcusaureus) |
PF02558(ApbA)PF08546(ApbA_C) | 5 | TYR A 40VAL A 126VAL A 53ILE A 117GLY A 11 | NoneNoneNoneNoneNAP A 500 (-3.1A) | 0.92A | 13gsA-4s3mA:undetectable | 13gsA-4s3mA:21.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4tr6 | DNA POLYMERASE IIISUBUNIT BETA (Bacillussubtilis) |
PF00712(DNA_pol3_beta)PF02767(DNA_pol3_beta_2)PF02768(DNA_pol3_beta_3) | 5 | VAL A 23VAL A 16ILE A 31TYR A 125GLY A 48 | None | 1.29A | 13gsA-4tr6A:undetectable | 13gsA-4tr6A:21.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4tuf | MAJOR EXTRACELLULARENDOGLUCANASE (Xanthomonascampestris) |
PF00150(Cellulase) | 5 | TYR A 263PHE A 236ILE A 143PRO A 260GLY A 238 | None | 1.26A | 13gsA-4tufA:undetectable | 13gsA-4tufA:21.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4uqm | URACIL-DNAGLYCOSYLASE (Deinococcusradiodurans) |
PF03167(UDG) | 5 | TYR A 85VAL A 98ILE A 111TYR A 112GLY A 128 | CL A1245 (-4.3A)NoneNoneNoneNone | 1.13A | 13gsA-4uqmA:undetectable | 13gsA-4uqmA:23.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wva | UNCHARACTERIZEDPROTEIN (Thermusthermophilus) |
PF01204(Trehalase) | 5 | PHE A 230PRO A 229VAL A 177VAL A 157PRO A 178 | None | 1.49A | 13gsA-4wvaA:2.0 | 13gsA-4wvaA:20.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ydq | PROLINE--TRNA LIGASE (Plasmodiumfalciparum) |
PF00587(tRNA-synt_2b)PF03129(HGTP_anticodon)PF09180(ProRS-C_1) | 5 | TYR A 435VAL A 441ARG A 514VAL A 535ILE A 400 | NoneNoneANP A 801 (-3.2A)NoneNone | 1.35A | 13gsA-4ydqA:undetectable | 13gsA-4ydqA:19.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4yte | H(2)-FORMINGMETHYLENETETRAHYDROMETHANOPTERINDEHYDROGENASE-RELATED PROTEIN MJ0715 (Methanocaldococcusjannaschii) |
no annotation | 5 | TYR A 157PRO A 189VAL A 182VAL A 191ILE A 3 | None | 1.41A | 13gsA-4yteA:undetectable | 13gsA-4yteA:20.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4yzw | AGAP004976-PA (Anophelesgambiae) |
PF00372(Hemocyanin_M)PF03722(Hemocyanin_N)PF03723(Hemocyanin_C) | 5 | ARG A 646VAL A 568TYR A 230PRO A 651GLY A 644 | None | 1.36A | 13gsA-4yzwA:undetectable | 13gsA-4yzwA:14.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4z17 | ENOLASE (Chloroflexusaurantiacus) |
PF00113(Enolase_C)PF03952(Enolase_N) | 5 | TYR A 418PHE A 176PRO A 144VAL A 145ILE A 238 | None | 1.49A | 13gsA-4z17A:undetectable | 13gsA-4z17A:18.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zrm | UDP-GLUCOSE4-EPIMERASE (Thermotogamaritima) |
PF01370(Epimerase) | 5 | PHE A 71VAL A 16VAL A 70ILE A 236TYR A 170 | NoneNoneNoneNoneNAD A 401 (-4.7A) | 1.47A | 13gsA-4zrmA:undetectable | 13gsA-4zrmA:22.01 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5d73 | GLUTATHIONES-TRANSFERASE (Wuchereriabancrofti) |
PF02798(GST_N)PF14497(GST_C_3) | 6 | TYR A 7PHE A 8PRO A 9TYR A 106PRO A 201GLY A 204 | NoneGSH A 301 (-4.9A)NoneNoneNoneNone | 0.41A | 13gsA-5d73A:31.0 | 13gsA-5d73A:42.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dot | CARBAMOYL-PHOSPHATESYNTHASE [AMMONIA],MITOCHONDRIAL (Homo sapiens) |
PF00117(GATase)PF00988(CPSase_sm_chain)PF02142(MGS)PF02786(CPSase_L_D2)PF02787(CPSase_L_D3) | 5 | PHE A 192VAL A 190ILE A 173PRO A 195GLY A 69 | None | 1.23A | 13gsA-5dotA:undetectable | 13gsA-5dotA:9.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5h6j | PIERISIN-1 (Pieris rapae) |
no annotation | 5 | VAL A 113VAL A 148ILE A 177PRO A 86GLY A 171 | None | 1.41A | 13gsA-5h6jA:undetectable | 13gsA-5h6jA:22.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5h6n | PIERISIN-1 (Pieris rapae) |
no annotation | 5 | VAL A 113VAL A 148ILE A 177PRO A 86GLY A 171 | None | 1.43A | 13gsA-5h6nA:undetectable | 13gsA-5h6nA:20.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5i2h | O-METHYLTRANSFERASEFAMILY 2 (Planctopiruslimnophila) |
PF00891(Methyltransf_2)PF16864(Dimerisation2) | 5 | PHE A 257PRO A 256VAL A 254ILE A 222GLY A 250 | None | 1.49A | 13gsA-5i2hA:undetectable | 13gsA-5i2hA:20.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5k1c | WD REPEAT-CONTAININGPROTEIN 20 (Homo sapiens) |
PF00400(WD40) | 5 | TYR C 74PHE C 67VAL C 69VAL C 50GLY C 553 | None | 1.37A | 13gsA-5k1cC:undetectable | 13gsA-5k1cC:16.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5koh | NITROGENASE FEMOBETA SUBUNIT PROTEINNIFK (Gluconacetobacterdiazotrophicus) |
PF00148(Oxidored_nitro)PF11844(DUF3364) | 5 | TYR B 196PHE B 76VAL B 77ILE B 249GLY B 80 | None | 1.29A | 13gsA-5kohB:undetectable | 13gsA-5kohB:18.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5lmx | DNA-DIRECTED RNAPOLYMERASE I SUBUNITRPA49 (Saccharomycescerevisiae) |
PF06870(RNA_pol_I_A49) | 5 | TYR M 76PRO M 94VAL M 95VAL M 21GLY M 24 | TYR M 76 ( 1.3A)PRO M 94 ( 1.1A)VAL M 95 ( 0.6A)VAL M 21 ( 0.5A)GLY M 24 ( 0.0A) | 1.37A | 13gsA-5lmxM:undetectable | 13gsA-5lmxM:20.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5m2o | GROUP I DOCKERIN (Ruminococcusflavefaciens) |
no annotation | 5 | PRO B 93VAL B 67ARG B 62VAL B 95GLY B 29 | None | 1.45A | 13gsA-5m2oB:undetectable | 13gsA-5m2oB:17.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mkc | CELL WALL SURFACEANCHOR FAMILYPROTEIN (JO),CELLWALL SURFACE ANCHORFAMILY PROTEIN (IN) (Streptococcuspneumoniae) |
no annotation | 5 | PHE A 713PRO A 714ILE A 661TYR A 678PRO A 716 | None | 1.43A | 13gsA-5mkcA:undetectable | 13gsA-5mkcA:22.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5tkf | LYTIC POLYSACCHARIDEMONOOXYGENASE (Neurosporacrassa) |
PF03443(Glyco_hydro_61) | 5 | VAL A 188VAL A 220ILE A 37TYR A 194GLY A 217 | None | 1.47A | 13gsA-5tkfA:undetectable | 13gsA-5tkfA:18.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5x55 | PROBABLE URACIL-DNAGLYCOSYLASE (Acanthamoebapolyphagamimivirus) |
PF03167(UDG) | 5 | TYR A 193VAL A 211ILE A 224TYR A 225GLY A 241 | None | 0.98A | 13gsA-5x55A:undetectable | 13gsA-5x55A:18.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5yac | TRNA(GUANINE(37)-N1)-METHYLTRANSFERASE TRM5B (Pyrococcusabyssi) |
PF02475(Met_10) | 5 | PHE A 326VAL A 306VAL A 273ILE A 322GLY A 308 | None | 1.26A | 13gsA-5yacA:undetectable | 13gsA-5yacA:20.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5zbi | PEPTIDE ASPARAGINYLLIGASE (Violacanadensis) |
no annotation | 5 | PRO A 249ILE A 93TYR A 59PRO A 242GLY A 253 | None | 1.43A | 13gsA-5zbiA:undetectable | 13gsA-5zbiA:18.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6ao1 | BETA-LACTAMASEDOMAIN PROTEIN (Paraburkholderiaphymatum) |
PF00753(Lactamase_B) | 5 | TYR A 10PRO A 11ARG A 229VAL A 25GLY A 15 | None | 1.46A | 13gsA-6ao1A:undetectable | 13gsA-6ao1A:20.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6eoj | PROTEIN CFT1 (Saccharomycescerevisiae) |
no annotation | 5 | TYR A 871PRO A 870VAL A 869ILE A1344GLY A 843 | None | 1.44A | 13gsA-6eojA:undetectable | 13gsA-6eojA:10.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6fn0 | - (-) |
no annotation | 5 | ARG A 432ILE A 446TYR A 447PRO A 242GLY A 421 | None | 1.40A | 13gsA-6fn0A:undetectable | 13gsA-6fn0A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6gsw | MU CLASS GLUTATHIONES-TRANSFERASE OFISOENZYME 3-3 (Rattus rattus) |
PF00043(GST_C)PF02798(GST_N) | 5 | TYR A 6VAL A 9ILE A 111TYR A 115PRO A 206 | NoneNoneGPS A 221 (-4.5A)NoneNone | 0.79A | 13gsA-6gswA:25.7 | 13gsA-6gswA:30.00 |