DRUG BINDING INTERFACES MAPPED TO 'TRIMETREXATE'

List of Binding Interfaces
(Click on the entry ID to view details of interfaces and pattern clusters)
(Note that ASSAM search use only 3-12 residue containing patterns)

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DrReposER ID	PDB	Ligand	Organism	Macromolecule	Pfam	Res.	Interface	HETATM
1BZF_A_TMQA170	1bzf	TMQ DB01157 (Trimetrexate)	Lactobacillus casei	DIHYDROFOLATE REDUCTASE	PF00186 (DHFR_1)	12	LEU A 4 ALA A 6 HIS A 18 LEU A 19 ASP A 26 LEU A 27 PHE A 30 THR A 45 PHE A 49 LEU A 54 ALA A 97 THR A 116	TMQ A 170
2X9V_A_TMQA1270	2x9v	TMQ DB01157 (Trimetrexate)	Trypanosoma brucei	PTERIDINE REDUCTASE	PF13561 (adh_short_C2)	11	ARG A 14 SER A 95 PHE A 97 ASP A 161 CYS A 168 TYR A 174 LEU A 209 PRO A 210 MET A 213 GLU A 217 TRP A 221	TMQ A1270
2X9V_B_TMQB1270	2x9v	TMQ DB01157 (Trimetrexate)	Trypanosoma brucei	PTERIDINE REDUCTASE	no annotation	9	ARG B 14 SER B 95 PHE B 97 ASP B 161 CYS B 168 TYR B 174 LEU B 209 PRO B 210 MET B 213	TMQ B1270
2X9V_C_TMQC1270	2x9v	TMQ DB01157 (Trimetrexate)	Trypanosoma brucei	PTERIDINE REDUCTASE	no annotation	10	ARG C 14 SER C 95 PHE C 97 ASP C 161 CYS C 168 PHE C 171 TYR C 174 LEU C 209 PRO C 210 MET C 213	TMQ C1270
2X9V_D_TMQD1270	2x9v	TMQ DB01157 (Trimetrexate)	Trypanosoma brucei	PTERIDINE REDUCTASE	no annotation	9	SER D 95 PHE D 97 ASP D 161 CYS D 168 PHE D 171 TYR D 174 LEU D 209 PRO D 210 MET D 213	TMQ D1270
3CLB_A_TMQA611	3clb	TMQ DB01157 (Trimetrexate)	Trypanosoma cruzi	DHFR-TS	PF00186 (DHFR_1) PF00303 (Thymidylat_synt)	11	VAL A 26 ALA A 28 ILE A 41 ASP A 48 MET A 49 ILE A 84 PRO A 85 LEU A 91 ILE A 154 TYR A 160 THR A 178	TMQ A 611
3CLB_B_TMQB612	3clb	TMQ DB01157 (Trimetrexate)	Trypanosoma cruzi	DHFR-TS	no annotation	13	VAL B 26 ALA B 28 ILE B 41 ASP B 48 MET B 49 PHE B 52 THR B 80 SER B 83 ILE B 84 PRO B 85 PHE B 88 ILE B 154 TYR B 160	TMQ B 612
3CLB_C_TMQC613	3clb	TMQ DB01157 (Trimetrexate)	Trypanosoma cruzi	DHFR-TS	no annotation	12	VAL C 26 ALA C 28 ILE C 41 ASP C 48 MET C 49 THR C 80 ILE C 84 PRO C 85 LEU C 91 ILE C 154 TYR C 160 THR C 178	TMQ C 613
3CLB_D_TMQD614	3clb	TMQ DB01157 (Trimetrexate)	Trypanosoma cruzi	DHFR-TS	no annotation	10	VAL D 26 ALA D 28 ILE D 41 ASP D 48 MET D 49 ILE D 84 PRO D 85 ILE D 154 TYR D 160 THR D 178	TMQ D 614
3HBB_A_TMQA611	3hbb	TMQ DB01157 (Trimetrexate)	Trypanosoma cruzi	DIHYDROFOLATE REDUCTASE-THYMIDYLAT E SYNTHASE	PF00186 (DHFR_1) PF00303 (Thymidylat_synt)	10	VAL A 26 ALA A 28 ILE A 41 ASP A 48 MET A 49 ILE A 84 PRO A 85 LEU A 91 ILE A 154 TYR A 160	TMQ A 611
3HBB_B_TMQB612	3hbb	TMQ DB01157 (Trimetrexate)	Trypanosoma cruzi	DIHYDROFOLATE REDUCTASE-THYMIDYLAT E SYNTHASE	no annotation	9	VAL B 26 ALA B 28 ILE B 41 ASP B 48 THR B 80 SER B 83 PHE B 88 ILE B 154 TYR B 160	TMQ B 612
3HBB_C_TMQC613	3hbb	TMQ DB01157 (Trimetrexate)	Trypanosoma cruzi	DIHYDROFOLATE REDUCTASE-THYMIDYLAT E SYNTHASE	no annotation	11	VAL C 26 ALA C 28 ILE C 41 ASP C 48 MET C 49 ILE C 84 PRO C 85 LEU C 91 ILE C 154 TYR C 160 THR C 178	TMQ C 613
3HBB_D_TMQD614	3hbb	TMQ DB01157 (Trimetrexate)	Trypanosoma cruzi	DIHYDROFOLATE REDUCTASE-THYMIDYLAT E SYNTHASE	no annotation	10	VAL D 26 ALA D 28 ILE D 41 ASP D 48 MET D 49 ILE D 84 PRO D 85 ILE D 154 TYR D 160 THR D 178	TMQ D 614
4M2X_A_TMQA202	4m2x	TMQ DB01157 (Trimetrexate)	Mycobacterium tuberculosis	DIHYDROFOLATE REDUCTASE	PF00186 (DHFR_1)	15	ILE A 5 TRP A 6 ALA A 7 ASP A 19 ILE A 20 ARG A 23 ASP A 27 GLN A 28 PHE A 31 LEU A 50 PRO A 51 LEU A 57 ILE A 94 TYR A 100 THR A 113	TMQ A 202
4M2X_C_TMQC202	4m2x	TMQ DB01157 (Trimetrexate)	Mycobacterium tuberculosis	DIHYDROFOLATE REDUCTASE	no annotation	13	ILE C 5 TRP C 6 ALA C 7 ILE C 20 ARG C 23 ASP C 27 GLN C 28 LEU C 50 PRO C 51 LEU C 57 ILE C 94 TYR C 100 THR C 113	TMQ C 202
4M2X_E_TMQE202	4m2x	TMQ DB01157 (Trimetrexate)	Mycobacterium tuberculosis	DIHYDROFOLATE REDUCTASE	no annotation	14	ILE E 5 TRP E 6 ALA E 7 ASP E 19 ILE E 20 ARG E 23 ASP E 27 GLN E 28 LEU E 50 PRO E 51 LEU E 57 ILE E 94 TYR E 100 THR E 113	TMQ E 202
4M2X_G_TMQG202	4m2x	TMQ DB01157 (Trimetrexate)	Mycobacterium tuberculosis	DIHYDROFOLATE REDUCTASE	no annotation	13	ILE G 5 TRP G 6 ALA G 7 ILE G 20 ARG G 23 ASP G 27 GLN G 28 LEU G 50 PRO G 51 VAL G 54 ILE G 94 TYR G 100 THR G 113	TMQ G 202
4XT8_A_TMQA302	4xt8	TMQ DB01157 (Trimetrexate)	Mycobacterium tuberculosis	RV2671	PF01872 (RibD_C)	12	ASN A 44 ILE A 46 SER A 59 GLY A 60 ALA A 63 ASP A 67 PHE A 71 ARG A 75 GLU A 91 TYR A 93 GLU A 193 THR A 214	TMQ A 302

[["1BZF_A_TMQA170","1bzf","TMQ","DB01157(Trimetrexate)","Lactobacillus casei","DIHYDROFOLATE REDUCTASE","PF00186(DHFR_1)",12,"LEU A   4;ALA A   6;HIS A  18;LEU A  19;ASP A  26;LEU A  27;PHE A  30;THR A  45;PHE A  49;LEU A  54;ALA A  97;THR A 116","TMQ A 170\r"],["2X9V_A_TMQA1270","2x9v","TMQ","DB01157(Trimetrexate)","Trypanosoma brucei","PTERIDINE REDUCTASE","PF13561(adh_short_C2)",11,"ARG A  14;SER A  95;PHE A  97;ASP A 161;CYS A 168;TYR A 174;LEU A 209;PRO A 210;MET A 213;GLU A 217;TRP A 221","TMQ A1270\r"],["2X9V_B_TMQB1270","2x9v","TMQ","DB01157(Trimetrexate)","Trypanosoma brucei","PTERIDINE REDUCTASE","no annotation",9,"ARG B  14;SER B  95;PHE B  97;ASP B 161;CYS B 168;TYR B 174;LEU B 209;PRO B 210;MET B 213","TMQ B1270\r"],["2X9V_C_TMQC1270","2x9v","TMQ","DB01157(Trimetrexate)","Trypanosoma brucei","PTERIDINE REDUCTASE","no annotation",10,"ARG C  14;SER C  95;PHE C  97;ASP C 161;CYS C 168;PHE C 171;TYR C 174;LEU C 209;PRO C 210;MET C 213","TMQ C1270\r"],["2X9V_D_TMQD1270","2x9v","TMQ","DB01157(Trimetrexate)","Trypanosoma brucei","PTERIDINE REDUCTASE","no annotation",9,"SER D  95;PHE D  97;ASP D 161;CYS D 168;PHE D 171;TYR D 174;LEU D 209;PRO D 210;MET D 213","TMQ D1270\r"],["3CLB_A_TMQA611","3clb","TMQ","DB01157(Trimetrexate)","Trypanosoma cruzi","DHFR-TS","PF00186(DHFR_1);PF00303(Thymidylat_synt)",11,"VAL A  26;ALA A  28;ILE A  41;ASP A  48;MET A  49;ILE A  84;PRO A  85;LEU A  91;ILE A 154;TYR A 160;THR A 178","TMQ A 611\r"],["3CLB_B_TMQB612","3clb","TMQ","DB01157(Trimetrexate)","Trypanosoma cruzi","DHFR-TS","no annotation",13,"VAL B  26;ALA B  28;ILE B  41;ASP B  48;MET B  49;PHE B  52;THR B  80;SER B  83;ILE B  84;PRO B  85;PHE B  88;ILE B 154;TYR B 160","TMQ B 612\r"],["3CLB_C_TMQC613","3clb","TMQ","DB01157(Trimetrexate)","Trypanosoma cruzi","DHFR-TS","no annotation",12,"VAL C  26;ALA C  28;ILE C  41;ASP C  48;MET C  49;THR C  80;ILE C  84;PRO C  85;LEU C  91;ILE C 154;TYR C 160;THR C 178","TMQ C 613\r"],["3CLB_D_TMQD614","3clb","TMQ","DB01157(Trimetrexate)","Trypanosoma cruzi","DHFR-TS","no annotation",10,"VAL D  26;ALA D  28;ILE D  41;ASP D  48;MET D  49;ILE D  84;PRO D  85;ILE D 154;TYR D 160;THR D 178","TMQ D 614\r"],["3HBB_A_TMQA611","3hbb","TMQ","DB01157(Trimetrexate)","Trypanosoma cruzi","DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE","PF00186(DHFR_1);PF00303(Thymidylat_synt)",10,"VAL A  26;ALA A  28;ILE A  41;ASP A  48;MET A  49;ILE A  84;PRO A  85;LEU A  91;ILE A 154;TYR A 160","TMQ A 611\r"],["3HBB_B_TMQB612","3hbb","TMQ","DB01157(Trimetrexate)","Trypanosoma cruzi","DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE","no annotation",9,"VAL B  26;ALA B  28;ILE B  41;ASP B  48;THR B  80;SER B  83;PHE B  88;ILE B 154;TYR B 160","TMQ B 612\r"],["3HBB_C_TMQC613","3hbb","TMQ","DB01157(Trimetrexate)","Trypanosoma cruzi","DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE","no annotation",11,"VAL C  26;ALA C  28;ILE C  41;ASP C  48;MET C  49;ILE C  84;PRO C  85;LEU C  91;ILE C 154;TYR C 160;THR C 178","TMQ C 613\r"],["3HBB_D_TMQD614","3hbb","TMQ","DB01157(Trimetrexate)","Trypanosoma cruzi","DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE","no annotation",10,"VAL D  26;ALA D  28;ILE D  41;ASP D  48;MET D  49;ILE D  84;PRO D  85;ILE D 154;TYR D 160;THR D 178","TMQ D 614\r"],["4M2X_A_TMQA202","4m2x","TMQ","DB01157(Trimetrexate)","Mycobacterium tuberculosis","DIHYDROFOLATE REDUCTASE","PF00186(DHFR_1)",15,"ILE A   5;TRP A   6;ALA A   7;ASP A  19;ILE A  20;ARG A  23;ASP A  27;GLN A  28;PHE A  31;LEU A  50;PRO A  51;LEU A  57;ILE A  94;TYR A 100;THR A 113","TMQ A 202\r"],["4M2X_C_TMQC202","4m2x","TMQ","DB01157(Trimetrexate)","Mycobacterium tuberculosis","DIHYDROFOLATE REDUCTASE","no annotation",13,"ILE C   5;TRP C   6;ALA C   7;ILE C  20;ARG C  23;ASP C  27;GLN C  28;LEU C  50;PRO C  51;LEU C  57;ILE C  94;TYR C 100;THR C 113","TMQ C 202\r"],["4M2X_E_TMQE202","4m2x","TMQ","DB01157(Trimetrexate)","Mycobacterium tuberculosis","DIHYDROFOLATE REDUCTASE","no annotation",14,"ILE E   5;TRP E   6;ALA E   7;ASP E  19;ILE E  20;ARG E  23;ASP E  27;GLN E  28;LEU E  50;PRO E  51;LEU E  57;ILE E  94;TYR E 100;THR E 113","TMQ E 202\r"],["4M2X_G_TMQG202","4m2x","TMQ","DB01157(Trimetrexate)","Mycobacterium tuberculosis","DIHYDROFOLATE REDUCTASE","no annotation",13,"ILE G   5;TRP G   6;ALA G   7;ILE G  20;ARG G  23;ASP G  27;GLN G  28;LEU G  50;PRO G  51;VAL G  54;ILE G  94;TYR G 100;THR G 113","TMQ G 202\r"],["4XT8_A_TMQA302","4xt8","TMQ","DB01157(Trimetrexate)","Mycobacterium tuberculosis","RV2671","PF01872(RibD_C)",12,"ASN A  44;ILE A  46;SER A  59;GLY A  60;ALA A  63;ASP A  67;PHE A  71;ARG A  75;GLU A  91;TYR A  93;GLU A 193;THR A 214","TMQ A 302\r"]]