DRUG BINDING INTERFACES MAPPED TO 'SPERMINE'

List of Binding Interfaces

(Click on the entry ID to view details of interfaces and pattern clusters)
(Note that ASSAM search use only 3-12 residue containing patterns)
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DrReposER ID PDB Ligand Organism Macromolecule Pfam Res. Interface HETATM
1RFF_A_SPMA700 1rff SPM

DB00127
(Spermine) 		;
Homo sapiens 		TOPOISOMERASE
I-DERIVED PEPTIDE;
TYROSYL-DNA
PHOSPHODIESTERASE 1 		PF06087
(Tyr-DNA_phospho)
no annotation 		4 ASN A 591
TRP A 605
VAL A 606
TYR C 724
 SPM A 700
1RFF_B_SPMB700 1rff SPM

DB00127
(Spermine) 		Homo sapiens TYROSYL-DNA
PHOSPHODIESTERASE 1 		no annotation 4 ASN B 591
ASN B 603
TRP B 605
PRO B 607
 SPM B 700
1RFI_A_SPMA999 1rfi SPM

DB00127
(Spermine) 		;
Homo sapiens 		TOPOISOMERASE
I-DERIVED PEPTIDE;
TYROSYL-DNA
PHOSPHODIESTERASE 1 		PF06087
(Tyr-DNA_phospho)
no annotation 		5 TRP A 590
TRP A 605
VAL A 606
PRO A 607
LYS C 724
 SPM A 999
1RG1_A_SPMA999 1rg1 SPM

DB00127
(Spermine) 		Homo sapiens TYROSYL-DNA
PHOSPHODIESTERASE 1 		PF06087
(Tyr-DNA_phospho) 		3 TRP A 605
VAL A 606
PRO A 607
 SPM A 999
1RG2_A_SPMA999 1rg2 SPM

DB00127
(Spermine) 		Homo sapiens TYROSYL-DNA
PHOSPHODIESTERASE 1 		PF06087
(Tyr-DNA_phospho) 		5 TRP A 590
ASN A 591
TRP A 605
VAL A 606
PRO A 607
 SPM A 999
1RGU_A_SPMA999 1rgu SPM

DB00127
(Spermine) 		Homo sapiens TYROSYL-DNA
PHOSPHODIESTERASE 1 		PF06087
(Tyr-DNA_phospho) 		5 TRP A 590
ASN A 591
TRP A 605
VAL A 606
PRO A 607
 SPM A 999
1RH0_A_SPMA999 1rh0 SPM

DB00127
(Spermine) 		Homo sapiens TYROSYL-DNA
PHOSPHODIESTERASE 1 		PF06087
(Tyr-DNA_phospho) 		3 TRP A 605
VAL A 606
PRO A 607
 SPM A 999
1XL6_B_SPMB3001 1xl6 SPM

DB00127
(Spermine) 		Magnetospirillum
magnetotacticum 		INWARD RECTIFIER
POTASSIUM CHANNEL 		PF01007
(IRK)
no annotation 		5 ALA A 128
ALA B 128
TYR B 132
TYR A 132
GLN B 252
 SPM B3001
1XPQ_A_SPMA924 1xpq SPM

DB00127
(Spermine) 		Saccharomyces
cerevisiae 		FMS1 PROTEIN PF01593
(Amino_oxidase) 		11 TRP A  65
HIS A  67
ASP A  94
PHE A  97
TRP A 174
ASN A 195
LEU A 294
PHE A 359
LEU A 375
TYR A 450
CYS A 488
 SPM A 924
1XPQ_B_SPMB923 1xpq SPM

DB00127
(Spermine) 		Saccharomyces
cerevisiae 		FMS1 PROTEIN no annotation 10 TRP B  65
HIS B  67
ASP B  94
TRP B 174
PHE B 189
ASN B 195
LYS B 312
LEU B 375
TYR B 450
CYS B 488
 SPM B 923
1XPQ_C_SPMC921 1xpq SPM

DB00127
(Spermine) 		Saccharomyces
cerevisiae 		FMS1 PROTEIN no annotation 11 TRP C  65
HIS C  67
ASP C  94
TRP C 174
ASN C 195
LEU C 294
LYS C 312
PHE C 359
LEU C 375
TYR C 450
CYS C 488
 SPM C 921
1XPQ_D_SPMD922 1xpq SPM

DB00127
(Spermine) 		Saccharomyces
cerevisiae 		FMS1 PROTEIN no annotation 10 TRP D  65
HIS D  67
ASP D  94
PHE D  97
TRP D 174
ASN D 195
LEU D 294
LYS D 312
PHE D 359
TYR D 450
 SPM D 922
2B8J_A_SPMA653 2b8j SPM

DB00127
(Spermine) 		Escherichia coli CLASS B ACID
PHOSPHATASE 		PF03767
(Acid_phosphat_B) 		9 ASP A  46
PHE A  56
TRP A  57
LYS A  60
TYR A  70
GLY A 113
ASP A 145
THR A 192
TYR A 193
 SPM A 653
2C12_B_SPMB1433 2c12 SPM

DB00127
(Spermine) 		Fusarium
oxysporum 		NITROALKANE OXIDASE no annotation 11 GLN B  61
MET B  70
GLU B  76
VAL B  95
ALA B  98
MET B 102
SER B 276
LEU B 279
VAL B 280
MET B 283
ASP B 402
 SPM B1433
2C12_C_SPMC1434 2c12 SPM

DB00127
(Spermine) 		Fusarium
oxysporum 		NITROALKANE OXIDASE no annotation 12 GLN C  61
MET C  70
LEU C  73
GLU C  76
VAL C  95
ALA C  98
LEU C  99
MET C 102
SER C 276
LEU C 279
VAL C 280
ASP C 402
 SPM C1434
2C12_D_SPMD1434 2c12 SPM

DB00127
(Spermine) 		Fusarium
oxysporum 		NITROALKANE OXIDASE no annotation 10 GLN D  61
MET D  70
GLU D  76
VAL D  95
ALA D  98
MET D 102
SER D 276
LEU D 279
VAL D 280
ASP D 402
 SPM D1434
2C12_F_SPMF1433 2c12 SPM

DB00127
(Spermine) 		Fusarium
oxysporum 		NITROALKANE OXIDASE no annotation 11 GLN F  61
MET F  70
LEU F  73
GLU F  76
VAL F  95
ALA F  98
LEU F  99
MET F 102
SER F 276
LEU F 279
ASP F 402
 SPM F1433
2WLJ_A_SPMA1303 2wlj SPM

DB00127
(Spermine) 		Magnetospirillum
magnetotacticum 		POTASSIUM CHANNEL PF01007
(IRK) 		3 ARG A 202
ARG A 204
PRO A 206
 SPM A1303
2WLK_B_SPMB1302 2wlk SPM

DB00127
(Spermine) 		Magnetospirillum
magnetotacticum 		ATP-SENSITIVE INWARD
RECTIFIER POTASSIUM
CHANNEL 10 		PF01007
(IRK)
no annotation 		4 ALA A 128
ALA B 128
TYR B 132
TYR A 132
 SPM B1302
3B7P_A_SPMA501 3b7p SPM

DB00127
(Spermine) 		Plasmodium
falciparum 		SPERMIDINE SYNTHASE PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		13 TRP A  51
VAL A  91
GLN A  93
TYR A 102
HIS A 103
ASP A 127
ASP A 196
ASP A 199
GLN A 229
GLU A 231
TYR A 264
PRO A 265
ILE A 269
 SPM A 501
3B7P_B_SPMB502 3b7p SPM

DB00127
(Spermine) 		Plasmodium
falciparum 		SPERMIDINE SYNTHASE no annotation 13 TRP B  51
VAL B  91
GLN B  93
TYR B 102
HIS B 103
ASP B 127
ASP B 196
ASP B 199
GLN B 229
GLU B 231
TYR B 264
PRO B 265
ILE B 269
 SPM B 502
3B7P_C_SPMC503 3b7p SPM

DB00127
(Spermine) 		Plasmodium
falciparum 		SPERMIDINE SYNTHASE no annotation 14 TRP C  51
VAL C  91
GLN C  93
TYR C 102
HIS C 103
ASP C 127
ASP C 196
ASP C 199
GLU C 231
SER C 232
HIS C 236
TYR C 264
PRO C 265
ILE C 269
 SPM C 503
3BJ8_C_SPMC500 3bj8 SPM

DB00127
(Spermine) 		Mus musculus DIAMINE
ACETYLTRANSFERASE 1 		no annotation 6 ASP D  82
LEU D  88
ASP C  93
HIS D 126
LEU C 128
TRP D 154
 SPM C 500
3C6M_A_SPMA501 3c6m SPM

DB00127
(Spermine) 		Homo sapiens SPERMINE SYNTHASE PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		11 TYR A 134
ASP A 167
VAL A 168
ASN A 169
TYR A 177
ASP A 201
ASP A 276
GLN A 315
TYR A 351
GLU A 353
TRP A 355
 SPM A 501
3C6M_B_SPMB501 3c6m SPM

DB00127
(Spermine) 		Homo sapiens SPERMINE SYNTHASE no annotation 9 ASP B 167
ASN B 169
TYR B 177
ASP B 201
ASP B 276
GLN B 315
TYR B 351
GLU B 353
TRP B 355
 SPM B 501
3C6M_C_SPMC501 3c6m SPM

DB00127
(Spermine) 		Homo sapiens SPERMINE SYNTHASE no annotation 10 ASP C 167
VAL C 168
ASN C 169
TYR C 177
ASP C 201
ASP C 276
GLN C 315
TYR C 351
GLU C 353
TRP C 355
 SPM C 501
3C6M_D_SPMD501 3c6m SPM

DB00127
(Spermine) 		Homo sapiens SPERMINE SYNTHASE no annotation 10 TYR D 134
ASP D 167
ASN D 169
TYR D 177
ASP D 201
ASP D 276
GLN D 315
TYR D 351
GLU D 353
TRP D 355
 SPM D 501
3KU9_A_SPMA700 3ku9 SPM

DB00127
(Spermine) 		Zea mays POLYAMINE OXIDASE PF01593
(Amino_oxidase) 		9 TRP A  60
GLU A  62
PHE A  89
TYR A 169
GLU A 170
PHE A 189
TYR A 298
PHE A 403
TYR A 439
 SPM A 700
3KU9_B_SPMB700 3ku9 SPM

DB00127
(Spermine) 		Zea mays POLYAMINE OXIDASE no annotation 7 GLU B  62
TYR B 165
TYR B 169
GLU B 170
TYR B 298
PHE B 403
TYR B 439
 SPM B 700
3KWA_A_SPMA300 3kwa SPM

DB00127
(Spermine) 		Homo sapiens CARBONIC ANHYDRASE 2 PF00194
(Carb_anhydrase) 		11 GLN A  92
HIS A  94
HIS A 119
VAL A 121
PHE A 131
VAL A 143
LEU A 198
THR A 199
THR A 200
PRO A 202
TRP A 209
 SPM A 300
3LP9_D_SPMD230 3lp9 SPM

DB00127
(Spermine) 		Lathyrus sativus LS-24 no annotation 3 GLU D  80
GLU B  80
ASN D  81
 SPM D 230
3QJ7_A_SPMA264 3qj7 SPM

DB00127
(Spermine) 		Mycobacterium
tuberculosis 		THYMIDYLATE SYNTHASE PF00303
(Thymidylat_synt)
no annotation 		8 ARG A 120
ALA A 190
GLN A 191
SER D 195
LEU A 232
ASP A 234
ASP A 236
TYR A 241
 SPM A 264
3TZO_B_SPMB432 3tzo SPM

DB00127
(Spermine) 		Streptomyces
coelicolor 		PUTATIVE CYTOCHROME
P450 		no annotation 4 LYS B 378
ALA B 382
THR B 403
HIS B 405
 SPM B 432
3VKG_A_SPMA9016 3vkg SPM

DB00127
(Spermine) 		Dictyostelium
discoideum 		DYNEIN HEAVY CHAIN,
CYTOPLASMIC 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		4 SER A4091
SER A4416
SER A4420
ARG A4424
 SPM A9016
3VKG_B_SPMB9018 3vkg SPM

DB00127
(Spermine) 		Dictyostelium
discoideum 		DYNEIN HEAVY CHAIN,
CYTOPLASMIC 		no annotation 5 TYR B2430
GLU B2437
ASN B2542
GLU B2666
ARG B2668
 SPM B9018
3VKG_B_SPMB9022 3vkg SPM

DB00127
(Spermine) 		Dictyostelium
discoideum 		DYNEIN HEAVY CHAIN,
CYTOPLASMIC 		no annotation 4 SER B4091
SER B4416
SER B4420
LEU B4660
 SPM B9022
4MI4_A_SPMA201 4mi4 SPM

DB00127
(Spermine) 		Vibrio cholerae SPERMIDINE
N1-ACETYLTRANSFERASE 		PF13302
(Acetyltransf_3) 		6 ASN A  22
GLU A  33
GLU A  34
TYR A  36
GLU A  37
GLU A  41
 SPM A 201
4MI4_B_SPMB201 4mi4 SPM

DB00127
(Spermine) 		Vibrio cholerae SPERMIDINE
N1-ACETYLTRANSFERASE 		no annotation 7 ASN B  22
GLU B  33
GLU B  34
TYR B  36
GLU B  37
GLU B  41
ARG C  56
 SPM B 201
4MI4_C_SPMC201 4mi4 SPM

DB00127
(Spermine) 		Vibrio cholerae SPERMIDINE
N1-ACETYLTRANSFERASE 		PF13302
(Acetyltransf_3)
no annotation 		7 ASN C  22
GLU C  33
GLU C  34
TYR C  36
GLU C  37
GLU C  41
TYR A  78
 SPM C 201
4MJ8_A_SPMA201 4mj8 SPM

DB00127
(Spermine) 		Vibrio cholerae SPERMIDINE
N1-ACETYLTRANSFERASE 		PF13302
(Acetyltransf_3)
no annotation 		8 ASN A  22
MET A  28
GLU A  33
GLU A  34
TYR A  36
GLU A  37
GLU A  41
TYR C  78
 SPM A 201
4MJ8_A_SPMA202 4mj8 SPM

DB00127
(Spermine) 		Vibrio cholerae SPERMIDINE
N1-ACETYLTRANSFERASE 		PF13302
(Acetyltransf_3) 		8 TRP A  31
GLU A  33
ILE A  74
GLU A  75
GLU A  84
GLN A  86
ILE A  87
LEU A 121
 SPM A 202
4MJ8_B_SPMB201 4mj8 SPM

DB00127
(Spermine) 		Vibrio cholerae SPERMIDINE
N1-ACETYLTRANSFERASE 		no annotation 8 ASN B  22
MET B  28
GLU B  33
GLU B  34
TYR B  36
GLU B  37
GLU B  41
ARG C  56
 SPM B 201
4MJ8_C_SPMC201 4mj8 SPM

DB00127
(Spermine) 		Vibrio cholerae SPERMIDINE
N1-ACETYLTRANSFERASE 		no annotation 7 ASN C  22
MET C  28
GLU C  33
GLU C  34
TYR C  36
GLU C  37
GLU C  41
 SPM C 201
4R87_E_SPME202 4r87 SPM

DB00127
(Spermine) 		Vibrio cholerae SPERMIDINE
N1-ACETYLTRANSFERASE 		no annotation 5 GLU E  33
GLU E  34
TYR E  36
GLU E  37
GLU E  41
 SPM E 202
4R87_G_SPMG202 4r87 SPM

DB00127
(Spermine) 		Vibrio cholerae SPERMIDINE
N1-ACETYLTRANSFERASE 		no annotation 9 ASN G  22
MET G  28
GLU G  33
GLU G  34
TYR G  36
GLU G  37
GLU G  41
ASN E  53
ARG E  56
 SPM G 202
4R87_H_SPMH202 4r87 SPM

DB00127
(Spermine) 		Vibrio cholerae SPERMIDINE
N1-ACETYLTRANSFERASE 		no annotation 6 ASN H  22
MET H  28
GLU H  33
TYR H  36
GLU H  37
GLU H  41
 SPM H 202
4R87_I_SPMI202 4r87 SPM

DB00127
(Spermine) 		Vibrio cholerae SPERMIDINE
N1-ACETYLTRANSFERASE 		no annotation 7 ASN I  22
MET I  28
GLU I  33
GLU I  34
TYR I  36
GLU I  37
GLU I  41
 SPM I 202
4R87_J_SPMJ202 4r87 SPM

DB00127
(Spermine) 		Vibrio cholerae SPERMIDINE
N1-ACETYLTRANSFERASE 		no annotation 7 MET J  28
TRP J  31
GLU J  33
TYR J  36
GLU J  37
GLU J  41
ARG L  56
 SPM J 202
4R87_K_SPMK202 4r87 SPM

DB00127
(Spermine) 		Vibrio cholerae SPERMIDINE
N1-ACETYLTRANSFERASE 		no annotation 9 ASN K  22
MET K  28
TRP K  31
GLU K  33
GLU K  34
TYR K  36
GLU K  37
GLU K  41
ARG I  56
 SPM K 202