DRUG BINDING INTERFACES MAPPED TO 'PYRIMETHAMINE'

List of Binding Interfaces
(Click on the entry ID to view details of interfaces and pattern clusters)
(Note that ASSAM search use only 3-12 residue containing patterns)

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DrReposER ID	PDB	Ligand	Organism	Macromolecule	Pfam	Res.	Interface	HETATM
1J3J_A_CP6A609	1j3j	CP6 DB00205 (Pyrimethamine)	Plasmodium falciparum	BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLAT E SYNTHASE	PF00186 (DHFR_1)	10	ILE A 14 ALA A 16 ASP A 54 PHE A 58 ASN A 108 SER A 111 ILE A 112 ILE A 164 TYR A 170 THR A 185	CP6 A 609
1J3J_B_CP6B709	1j3j	CP6 DB00205 (Pyrimethamine)	Plasmodium falciparum	BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLAT E SYNTHASE	no annotation	9	ALA B 16 ASP B 54 PHE B 58 ASN B 108 SER B 111 ILE B 112 ILE B 164 TYR B 170 THR B 185	CP6 B 709
2BL9_A_CP6A1240	2bl9	CP6 DB00205 (Pyrimethamine)	Plasmodium vivax	DIHYDROFOLATE REDUCTASE-THYMIDYLAT E SYNTHASE	PF00186 (DHFR_1)	12	ILE A 13 ALA A 15 LEU A 45 ASP A 53 MET A 54 PHE A 57 SER A 117 SER A 120 ILE A 121 ILE A 173 TYR A 179 THR A 194	CP6 A1240
2BLA_A_CP6A302	2bla	CP6 DB00205 (Pyrimethamine)	Plasmodium vivax	DIHYDROFOLATE REDUCTASE-THYMIDYLAT E SYNTHASE	PF00186 (DHFR_1)	11	ILE A 13 ALA A 15 ASP A 53 MET A 54 PHE A 57 ASN A 117 SER A 120 ILE A 121 ILE A 173 TYR A 179 THR A 194	CP6 A 302
3LMY_A_CP6A562	3lmy	CP6 DB00205 (Pyrimethamine)	Homo sapiens	BETA-HEXOSAMINIDASE SUBUNIT BETA	PF00728 (Glyco_hydro_20) PF14845 (Glycohydro_20b2)	13	ARG A 211 HIS A 237 ASP A 240 ASP A 290 HIS A 294 ASP A 354 GLU A 355 TRP A 424 TYR A 450 ASP A 452 LEU A 453 TRP A 489 GLU A 491	CP6 A 562
3LMY_B_CP6B563	3lmy	CP6 DB00205 (Pyrimethamine)	Homo sapiens	BETA-HEXOSAMINIDASE SUBUNIT BETA	no annotation	13	ARG B 211 HIS B 237 ASP B 240 ASP B 290 HIS B 294 ASP B 354 GLU B 355 TRP B 405 TRP B 424 TYR B 450 LEU B 453 TRP B 489 GLU B 491	CP6 B 563
3QFX_A_CP6A602	3qfx	CP6 DB00205 (Pyrimethamine)	Trypanosoma brucei	BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLAT E SYNTHASE	PF00186 (DHFR_1)	12	VAL A 32 ALA A 34 ILE A 47 ASP A 54 MET A 55 PHE A 58 THR A 86 SER A 89 LEU A 90 ILE A 160 TYR A 166 THR A 184	CP6 A 602
3QFX_B_CP6B702	3qfx	CP6 DB00205 (Pyrimethamine)	Trypanosoma brucei	BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLAT E SYNTHASE	no annotation	12	VAL B 32 ALA B 34 ILE B 47 ASP B 54 MET B 55 PHE B 58 THR B 86 SER B 89 LEU B 90 ILE B 160 TYR B 166 THR B 184	CP6 B 702
3QG2_A_CP6A609	3qg2	CP6 DB00205 (Pyrimethamine)	Plasmodium falciparum	BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLAT E SYNTHASE	PF00186 (DHFR_1) PF00303 (Thymidylat_synt)	10	ILE A 14 ALA A 16 ASP A 54 MET A 55 PHE A 58 ASN A 108 SER A 111 ILE A 112 TYR A 170 THR A 185	CP6 A 609
3QG2_B_CP6B709	3qg2	CP6 DB00205 (Pyrimethamine)	Plasmodium falciparum	BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLAT E SYNTHASE	no annotation	11	ILE B 14 ALA B 16 ASP B 54 MET B 55 PHE B 58 ASN B 108 SER B 111 ILE B 112 LEU B 164 TYR B 170 THR B 185	CP6 B 709
3QGT_A_CP6A609	3qgt	CP6 DB00205 (Pyrimethamine)	Plasmodium falciparum	BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLAT E SYNTHASE	PF00186 (DHFR_1) PF00303 (Thymidylat_synt)	10	ILE A 14 ALA A 16 ASP A 54 PHE A 58 SER A 108 SER A 111 ILE A 112 ILE A 164 TYR A 170 THR A 185	CP6 A 609
3QGT_B_CP6B609	3qgt	CP6 DB00205 (Pyrimethamine)	Plasmodium falciparum	BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLAT E SYNTHASE	no annotation	10	ILE B 14 ALA B 16 ASP B 54 PHE B 58 SER B 108 SER B 111 ILE B 112 ILE B 164 TYR B 170 THR B 185	CP6 B 609
3UM5_A_CP6A609	3um5	CP6 DB00205 (Pyrimethamine)	Plasmodium falciparum	BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLAT E SYNTHASE	PF00186 (DHFR_1) PF00303 (Thymidylat_synt)	10	ILE A 14 VAL A 16 ASP A 54 PHE A 58 THR A 108 SER A 111 ILE A 112 ILE A 164 TYR A 170 THR A 185	CP6 A 609
3UM5_B_CP6B709	3um5	CP6 DB00205 (Pyrimethamine)	Plasmodium falciparum	BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLAT E SYNTHASE	no annotation	10	ILE B 14 VAL B 16 ASP B 54 PHE B 58 THR B 108 SER B 111 ILE B 112 ILE B 164 TYR B 170 THR B 185	CP6 B 709
4KM0_A_CP6A201	4km0	CP6 DB00205 (Pyrimethamine)	Mycobacterium tuberculosis	DIHYDROFOLATE REDUCTASE	PF00186 (DHFR_1)	10	ILE A 5 TRP A 6 ALA A 7 ASP A 27 PHE A 31 THR A 46 LEU A 50 ILE A 94 TYR A 100 THR A 113	CP6 A 201
4KM0_B_CP6B201	4km0	CP6 DB00205 (Pyrimethamine)	Mycobacterium tuberculosis	DIHYDROFOLATE REDUCTASE	no annotation	12	ILE B 5 TRP B 6 ALA B 7 ILE B 20 ASP B 27 GLN B 28 PHE B 31 THR B 46 LEU B 50 ILE B 94 TYR B 100 THR B 113	CP6 B 201
6AOG_A_CP6A704	6aog	CP6 DB00205 (Pyrimethamine)	Toxoplasma gondii	BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLAT E SYNTHASE	PF00186 (DHFR_1) PF00303 (Thymidylat_synt)	10	VAL A 8 ALA A 10 ASP A 31 HIS A 34 PHE A 35 THR A 83 MET A 87 VAL A 151 TYR A 157 THR A 172	CP6 A 704
6AOG_B_CP6B704	6aog	CP6 DB00205 (Pyrimethamine)	Toxoplasma gondii	BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLAT E SYNTHASE	None	10	VAL B 8 ALA B 10 ASP B 31 HIS B 34 PHE B 35 THR B 83 MET B 87 VAL B 151 TYR B 157 THR B 172	CP6 B 704

[["1J3J_A_CP6A609","1j3j","CP6","DB00205(Pyrimethamine)","Plasmodium falciparum","BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE","PF00186(DHFR_1)",10,"ILE A  14;ALA A  16;ASP A  54;PHE A  58;ASN A 108;SER A 111;ILE A 112;ILE A 164;TYR A 170;THR A 185","CP6 A 609\r"],["1J3J_B_CP6B709","1j3j","CP6","DB00205(Pyrimethamine)","Plasmodium falciparum","BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE","no annotation",9,"ALA B  16;ASP B  54;PHE B  58;ASN B 108;SER B 111;ILE B 112;ILE B 164;TYR B 170;THR B 185","CP6 B 709\r"],["2BL9_A_CP6A1240","2bl9","CP6","DB00205(Pyrimethamine)","Plasmodium vivax","DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE","PF00186(DHFR_1)",12,"ILE A  13;ALA A  15;LEU A  45;ASP A  53;MET A  54;PHE A  57;SER A 117;SER A 120;ILE A 121;ILE A 173;TYR A 179;THR A 194","CP6 A1240\r"],["2BLA_A_CP6A302","2bla","CP6","DB00205(Pyrimethamine)","Plasmodium vivax","DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE","PF00186(DHFR_1)",11,"ILE A  13;ALA A  15;ASP A  53;MET A  54;PHE A  57;ASN A 117;SER A 120;ILE A 121;ILE A 173;TYR A 179;THR A 194","CP6 A 302\r"],["3LMY_A_CP6A562","3lmy","CP6","DB00205(Pyrimethamine)","Homo sapiens","BETA-HEXOSAMINIDASE SUBUNIT BETA","PF00728(Glyco_hydro_20);PF14845(Glycohydro_20b2)",13,"ARG A 211;HIS A 237;ASP A 240;ASP A 290;HIS A 294;ASP A 354;GLU A 355;TRP A 424;TYR A 450;ASP A 452;LEU A 453;TRP A 489;GLU A 491","CP6 A 562\r"],["3LMY_B_CP6B563","3lmy","CP6","DB00205(Pyrimethamine)","Homo sapiens","BETA-HEXOSAMINIDASE SUBUNIT BETA","no annotation",13,"ARG B 211;HIS B 237;ASP B 240;ASP B 290;HIS B 294;ASP B 354;GLU B 355;TRP B 405;TRP B 424;TYR B 450;LEU B 453;TRP B 489;GLU B 491","CP6 B 563\r"],["3QFX_A_CP6A602","3qfx","CP6","DB00205(Pyrimethamine)","Trypanosoma brucei","BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE","PF00186(DHFR_1)",12,"VAL A  32;ALA A  34;ILE A  47;ASP A  54;MET A  55;PHE A  58;THR A  86;SER A  89;LEU A  90;ILE A 160;TYR A 166;THR A 184","CP6 A 602\r"],["3QFX_B_CP6B702","3qfx","CP6","DB00205(Pyrimethamine)","Trypanosoma brucei","BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE","no annotation",12,"VAL B  32;ALA B  34;ILE B  47;ASP B  54;MET B  55;PHE B  58;THR B  86;SER B  89;LEU B  90;ILE B 160;TYR B 166;THR B 184","CP6 B 702\r"],["3QG2_A_CP6A609","3qg2","CP6","DB00205(Pyrimethamine)","Plasmodium falciparum","BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE","PF00186(DHFR_1);PF00303(Thymidylat_synt)",10,"ILE A  14;ALA A  16;ASP A  54;MET A  55;PHE A  58;ASN A 108;SER A 111;ILE A 112;TYR A 170;THR A 185","CP6 A 609\r"],["3QG2_B_CP6B709","3qg2","CP6","DB00205(Pyrimethamine)","Plasmodium falciparum","BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE","no annotation",11,"ILE B  14;ALA B  16;ASP B  54;MET B  55;PHE B  58;ASN B 108;SER B 111;ILE B 112;LEU B 164;TYR B 170;THR B 185","CP6 B 709\r"],["3QGT_A_CP6A609","3qgt","CP6","DB00205(Pyrimethamine)","Plasmodium falciparum","BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE","PF00186(DHFR_1);PF00303(Thymidylat_synt)",10,"ILE A  14;ALA A  16;ASP A  54;PHE A  58;SER A 108;SER A 111;ILE A 112;ILE A 164;TYR A 170;THR A 185","CP6 A 609\r"],["3QGT_B_CP6B609","3qgt","CP6","DB00205(Pyrimethamine)","Plasmodium falciparum","BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE","no annotation",10,"ILE B  14;ALA B  16;ASP B  54;PHE B  58;SER B 108;SER B 111;ILE B 112;ILE B 164;TYR B 170;THR B 185","CP6 B 609\r"],["3UM5_A_CP6A609","3um5","CP6","DB00205(Pyrimethamine)","Plasmodium falciparum","BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE","PF00186(DHFR_1);PF00303(Thymidylat_synt)",10,"ILE A  14;VAL A  16;ASP A  54;PHE A  58;THR A 108;SER A 111;ILE A 112;ILE A 164;TYR A 170;THR A 185","CP6 A 609\r"],["3UM5_B_CP6B709","3um5","CP6","DB00205(Pyrimethamine)","Plasmodium falciparum","BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE","no annotation",10,"ILE B  14;VAL B  16;ASP B  54;PHE B  58;THR B 108;SER B 111;ILE B 112;ILE B 164;TYR B 170;THR B 185","CP6 B 709\r"],["4KM0_A_CP6A201","4km0","CP6","DB00205(Pyrimethamine)","Mycobacterium tuberculosis","DIHYDROFOLATE REDUCTASE","PF00186(DHFR_1)",10,"ILE A   5;TRP A   6;ALA A   7;ASP A  27;PHE A  31;THR A  46;LEU A  50;ILE A  94;TYR A 100;THR A 113","CP6 A 201\r"],["4KM0_B_CP6B201","4km0","CP6","DB00205(Pyrimethamine)","Mycobacterium tuberculosis","DIHYDROFOLATE REDUCTASE","no annotation",12,"ILE B   5;TRP B   6;ALA B   7;ILE B  20;ASP B  27;GLN B  28;PHE B  31;THR B  46;LEU B  50;ILE B  94;TYR B 100;THR B 113","CP6 B 201\r"],["6AOG_A_CP6A704","6aog","CP6","DB00205(Pyrimethamine)","Toxoplasma gondii","BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE","PF00186(DHFR_1);PF00303(Thymidylat_synt)",10,"VAL A   8;ALA A  10;ASP A  31;HIS A  34;PHE A  35;THR A  83;MET A  87;VAL A 151;TYR A 157;THR A 172","CP6 A 704\r"],["6AOG_B_CP6B704","6aog","CP6","DB00205(Pyrimethamine)","Toxoplasma gondii","BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE","None",10,"VAL B   8;ALA B  10;ASP B  31;HIS B  34;PHE B  35;THR B  83;MET B  87;VAL B 151;TYR B 157;THR B 172","CP6 B 704\r"]]