DRUG BINDING INTERFACES MAPPED TO 'PEMETREXED'

List of Binding Interfaces
(Click on the entry ID to view details of interfaces and pattern clusters)
(Note that ASSAM search use only 3-12 residue containing patterns)

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DrReposER ID	PDB	Ligand	Organism	Macromolecule	Pfam	Res.	Interface	HETATM
1JU6_A_LYAA317	1ju6	LYA DB00642 (Pemetrexed)	Homo sapiens	THYMIDYLATE SYNTHASE	PF00303 (Thymidylat_synt)	11	PHE A 80 ILE A 108 TRP A 109 ASN A 112 ASP A 218 LEU A 221 GLY A 222 PHE A 225 TYR A 258 MET A 311 ALA A 312	LYA A 317
1JU6_B_LYAB315	1ju6	LYA DB00642 (Pemetrexed)	Homo sapiens	THYMIDYLATE SYNTHASE	no annotation	9	LYS B 77 ILE B 108 TRP B 109 ASN B 112 ASP B 218 LEU B 221 GLY B 222 TYR B 258 MET B 311	LYA B 315
1JU6_C_LYAC315	1ju6	LYA DB00642 (Pemetrexed)	Homo sapiens	THYMIDYLATE SYNTHASE	no annotation	10	ILE C 108 TRP C 109 ASN C 112 ASP C 218 LEU C 221 GLY C 222 PHE C 225 TYR C 258 MET C 311 ALA C 312	LYA C 315
1JU6_D_LYAD315	1ju6	LYA DB00642 (Pemetrexed)	Homo sapiens	THYMIDYLATE SYNTHASE	no annotation	11	LYS D 77 PHE D 80 ILE D 108 TRP D 109 ASN D 112 ASP D 218 LEU D 221 GLY D 222 TYR D 258 MET D 311 ALA D 312	LYA D 315
1JUJ_A_LYAA315	1juj	LYA DB00642 (Pemetrexed)	Homo sapiens	THYMIDYLATE SYNTHASE	PF00303 (Thymidylat_synt)	10	LYS A 77 ILE A 108 TRP A 109 ASN A 112 ASP A 218 LEU A 221 GLY A 222 PHE A 225 TYR A 258 MET A 311	LYA A 315
1JUJ_B_LYAB315	1juj	LYA DB00642 (Pemetrexed)	Homo sapiens	THYMIDYLATE SYNTHASE	no annotation	10	LYS B 77 ILE B 108 TRP B 109 ASN B 112 ASP B 218 LEU B 221 GLY B 222 PHE B 225 TYR B 258 MET B 311	LYA B 315
1JUJ_C_LYAC315	1juj	LYA DB00642 (Pemetrexed)	Homo sapiens	THYMIDYLATE SYNTHASE	no annotation	10	LYS C 77 ILE C 108 TRP C 109 ASN C 112 ASP C 218 LEU C 221 GLY C 222 PHE C 225 TYR C 258 MET C 311	LYA C 315
1JUJ_D_LYAD315	1juj	LYA DB00642 (Pemetrexed)	Homo sapiens	THYMIDYLATE SYNTHASE	no annotation	10	LYS D 77 ILE D 108 TRP D 109 ASN D 112 ASP D 218 LEU D 221 GLY D 222 PHE D 225 TYR D 258 MET D 311	LYA D 315
2X9G_A_LYAA1270	2x9g	LYA DB00642 (Pemetrexed)	Trypanosoma brucei	PTERIDINE REDUCTASE	PF13561 (adh_short_C2) no annotation	16	ARG A 14 SER A 95 PHE A 97 PRO A 99 ASP A 161 CYS A 168 MET A 169 PHE A 171 TYR A 174 VAL A 206 LEU A 209 PRO A 210 MET A 213 GLU A 217 TRP A 221 HIS D 267	LYA A1270
2X9G_B_LYAB1270	2x9g	LYA DB00642 (Pemetrexed)	Trypanosoma brucei	PTERIDINE REDUCTASE	no annotation	15	ARG B 14 SER B 95 PHE B 97 PRO B 99 ASP B 161 CYS B 168 MET B 169 PHE B 171 TYR B 174 VAL B 206 LEU B 209 PRO B 210 MET B 213 TRP B 221 HIS C 267	LYA B1270
2X9G_C_LYAC1270	2x9g	LYA DB00642 (Pemetrexed)	Trypanosoma brucei	PTERIDINE REDUCTASE	no annotation	15	ARG C 14 SER C 95 PHE C 97 PRO C 99 ASP C 161 CYS C 168 MET C 169 PHE C 171 TYR C 174 VAL C 206 LEU C 209 PRO C 210 MET C 213 TRP C 221 HIS B 267	LYA C1270
2X9G_D_LYAD1270	2x9g	LYA DB00642 (Pemetrexed)	Trypanosoma brucei	PTERIDINE REDUCTASE	PF13561 (adh_short_C2) no annotation	15	ARG D 14 SER D 95 PHE D 97 PRO D 99 ASP D 161 CYS D 168 MET D 169 PHE D 171 TYR D 174 VAL D 206 LEU D 209 PRO D 210 MET D 213 TRP D 221 HIS A 267	LYA D1270
3K2H_A_LYAA513	3k2h	LYA DB00642 (Pemetrexed)	Babesia bovis	DIHYDROFOLATE REDUCTASE/THYMIDYLAT E SYNTHASE	PF00186 (DHFR_1) PF00303 (Thymidylat_synt)	13	ALA A 278 SER A 281 GLU A 285 ILE A 306 TRP A 307 ASN A 310 LEU A 390 ASP A 416 LEU A 419 GLY A 420 PHE A 423 TYR A 456 MET A 509	LYA A 513
3K2H_A_LYAA514	3k2h	LYA DB00642 (Pemetrexed)	Babesia bovis	DIHYDROFOLATE REDUCTASE/THYMIDYLAT E SYNTHASE	PF00186 (DHFR_1) PF00303 (Thymidylat_synt)	13	ALA A 16 ASP A 37 PHE A 38 LEU A 41 ARG A 42 THR A 69 ILE A 73 SER A 77 LEU A 80 ARG A 83 LEU A 123 TYR A 129 THR A 144	LYA A 514
3K2H_B_LYAB513	3k2h	LYA DB00642 (Pemetrexed)	Babesia bovis	DIHYDROFOLATE REDUCTASE/THYMIDYLAT E SYNTHASE	no annotation	13	ALA B 278 SER B 281 GLU B 285 ILE B 306 TRP B 307 ASN B 310 LEU B 390 ASP B 416 LEU B 419 GLY B 420 PHE B 423 TYR B 456 MET B 509	LYA B 513
3K2H_B_LYAB514	3k2h	LYA DB00642 (Pemetrexed)	Babesia bovis	DIHYDROFOLATE REDUCTASE/THYMIDYLAT E SYNTHASE	no annotation	15	ALA B 16 ILE B 29 ASP B 37 PHE B 38 ARG B 39 LEU B 41 ARG B 42 THR B 69 SER B 72 ILE B 73 SER B 77 LEU B 80 ARG B 83 TYR B 129 THR B 144	LYA B 514
4FQS_A_LYAA302	4fqs	LYA DB00642 (Pemetrexed)	Mycobacterium tuberculosis	THYMIDYLATE SYNTHASE	PF00303 (Thymidylat_synt)	13	HIS A 51 GLU A 58 ILE A 79 TRP A 80 TRP A 83 LEU A 143 ASP A 169 LEU A 172 GLY A 173 PHE A 176 TYR A 209 VAL A 261 ALA A 262	LYA A 302
4FQS_B_LYAB302	4fqs	LYA DB00642 (Pemetrexed)	Mycobacterium tuberculosis	THYMIDYLATE SYNTHASE	no annotation	13	HIS B 51 GLU B 58 ILE B 79 TRP B 80 TRP B 83 LEU B 143 ASP B 169 LEU B 172 GLY B 173 PHE B 176 TYR B 209 VAL B 261 ALA B 262	LYA B 302
4KN2_A_LYAA304	4kn2	LYA DB00642 (Pemetrexed)	Homo sapiens	FOLATE RECEPTOR BETA	PF03024 (Folate_rec)	16	TYR A 76 ASP A 97 THR A 98 TYR A 101 GLN A 116 SER A 117 TRP A 118 ARG A 119 HIS A 151 ARG A 152 GLY A 153 TRP A 154 TRP A 156 TRP A 187 SER A 190 TYR A 191	LYA A 304
4KN2_B_LYAB304	4kn2	LYA DB00642 (Pemetrexed)	Homo sapiens	FOLATE RECEPTOR BETA	no annotation	14	TYR B 76 ASP B 97 THR B 98 TYR B 101 TRP B 118 ARG B 119 HIS B 151 ARG B 152 GLY B 153 TRP B 154 TRP B 156 TRP B 187 SER B 190 TYR B 191	LYA B 304
4KN2_C_LYAC304	4kn2	LYA DB00642 (Pemetrexed)	Homo sapiens	FOLATE RECEPTOR BETA	no annotation	15	TYR C 76 ASP C 97 THR C 98 TYR C 101 GLN C 116 SER C 117 TRP C 118 ARG C 119 HIS C 151 GLY C 153 TRP C 154 TRP C 156 TRP C 187 SER C 190 TYR C 191	LYA C 304

[["1JU6_A_LYAA317","1ju6","LYA","DB00642(Pemetrexed)","Homo sapiens","THYMIDYLATE SYNTHASE","PF00303(Thymidylat_synt)",11,"PHE A  80;ILE A 108;TRP A 109;ASN A 112;ASP A 218;LEU A 221;GLY A 222;PHE A 225;TYR A 258;MET A 311;ALA A 312","LYA A 317\r"],["1JU6_B_LYAB315","1ju6","LYA","DB00642(Pemetrexed)","Homo sapiens","THYMIDYLATE SYNTHASE","no annotation",9,"LYS B  77;ILE B 108;TRP B 109;ASN B 112;ASP B 218;LEU B 221;GLY B 222;TYR B 258;MET B 311","LYA B 315\r"],["1JU6_C_LYAC315","1ju6","LYA","DB00642(Pemetrexed)","Homo sapiens","THYMIDYLATE SYNTHASE","no annotation",10,"ILE C 108;TRP C 109;ASN C 112;ASP C 218;LEU C 221;GLY C 222;PHE C 225;TYR C 258;MET C 311;ALA C 312","LYA C 315\r"],["1JU6_D_LYAD315","1ju6","LYA","DB00642(Pemetrexed)","Homo sapiens","THYMIDYLATE SYNTHASE","no annotation",11,"LYS D  77;PHE D  80;ILE D 108;TRP D 109;ASN D 112;ASP D 218;LEU D 221;GLY D 222;TYR D 258;MET D 311;ALA D 312","LYA D 315\r"],["1JUJ_A_LYAA315","1juj","LYA","DB00642(Pemetrexed)","Homo sapiens","THYMIDYLATE SYNTHASE","PF00303(Thymidylat_synt)",10,"LYS A  77;ILE A 108;TRP A 109;ASN A 112;ASP A 218;LEU A 221;GLY A 222;PHE A 225;TYR A 258;MET A 311","LYA A 315\r"],["1JUJ_B_LYAB315","1juj","LYA","DB00642(Pemetrexed)","Homo sapiens","THYMIDYLATE SYNTHASE","no annotation",10,"LYS B  77;ILE B 108;TRP B 109;ASN B 112;ASP B 218;LEU B 221;GLY B 222;PHE B 225;TYR B 258;MET B 311","LYA B 315\r"],["1JUJ_C_LYAC315","1juj","LYA","DB00642(Pemetrexed)","Homo sapiens","THYMIDYLATE SYNTHASE","no annotation",10,"LYS C  77;ILE C 108;TRP C 109;ASN C 112;ASP C 218;LEU C 221;GLY C 222;PHE C 225;TYR C 258;MET C 311","LYA C 315\r"],["1JUJ_D_LYAD315","1juj","LYA","DB00642(Pemetrexed)","Homo sapiens","THYMIDYLATE SYNTHASE","no annotation",10,"LYS D  77;ILE D 108;TRP D 109;ASN D 112;ASP D 218;LEU D 221;GLY D 222;PHE D 225;TYR D 258;MET D 311","LYA D 315\r"],["2X9G_A_LYAA1270","2x9g","LYA","DB00642(Pemetrexed)","Trypanosoma brucei","PTERIDINE REDUCTASE","PF13561(adh_short_C2);no annotation",16,"ARG A  14;SER A  95;PHE A  97;PRO A  99;ASP A 161;CYS A 168;MET A 169;PHE A 171;TYR A 174;VAL A 206;LEU A 209;PRO A 210;MET A 213;GLU A 217;TRP A 221;HIS D 267","LYA A1270\r"],["2X9G_B_LYAB1270","2x9g","LYA","DB00642(Pemetrexed)","Trypanosoma brucei","PTERIDINE REDUCTASE","no annotation",15,"ARG B  14;SER B  95;PHE B  97;PRO B  99;ASP B 161;CYS B 168;MET B 169;PHE B 171;TYR B 174;VAL B 206;LEU B 209;PRO B 210;MET B 213;TRP B 221;HIS C 267","LYA B1270\r"],["2X9G_C_LYAC1270","2x9g","LYA","DB00642(Pemetrexed)","Trypanosoma brucei","PTERIDINE REDUCTASE","no annotation",15,"ARG C  14;SER C  95;PHE C  97;PRO C  99;ASP C 161;CYS C 168;MET C 169;PHE C 171;TYR C 174;VAL C 206;LEU C 209;PRO C 210;MET C 213;TRP C 221;HIS B 267","LYA C1270\r"],["2X9G_D_LYAD1270","2x9g","LYA","DB00642(Pemetrexed)","Trypanosoma brucei","PTERIDINE REDUCTASE","PF13561(adh_short_C2);no annotation",15,"ARG D  14;SER D  95;PHE D  97;PRO D  99;ASP D 161;CYS D 168;MET D 169;PHE D 171;TYR D 174;VAL D 206;LEU D 209;PRO D 210;MET D 213;TRP D 221;HIS A 267","LYA D1270\r"],["3K2H_A_LYAA513","3k2h","LYA","DB00642(Pemetrexed)","Babesia bovis","DIHYDROFOLATE REDUCTASE\/THYMIDYLATE SYNTHASE","PF00186(DHFR_1);PF00303(Thymidylat_synt)",13,"ALA A 278;SER A 281;GLU A 285;ILE A 306;TRP A 307;ASN A 310;LEU A 390;ASP A 416;LEU A 419;GLY A 420;PHE A 423;TYR A 456;MET A 509","LYA A 513\r"],["3K2H_A_LYAA514","3k2h","LYA","DB00642(Pemetrexed)","Babesia bovis","DIHYDROFOLATE REDUCTASE\/THYMIDYLATE SYNTHASE","PF00186(DHFR_1);PF00303(Thymidylat_synt)",13,"ALA A  16;ASP A  37;PHE A  38;LEU A  41;ARG A  42;THR A  69;ILE A  73;SER A  77;LEU A  80;ARG A  83;LEU A 123;TYR A 129;THR A 144","LYA A 514\r"],["3K2H_B_LYAB513","3k2h","LYA","DB00642(Pemetrexed)","Babesia bovis","DIHYDROFOLATE REDUCTASE\/THYMIDYLATE SYNTHASE","no annotation",13,"ALA B 278;SER B 281;GLU B 285;ILE B 306;TRP B 307;ASN B 310;LEU B 390;ASP B 416;LEU B 419;GLY B 420;PHE B 423;TYR B 456;MET B 509","LYA B 513\r"],["3K2H_B_LYAB514","3k2h","LYA","DB00642(Pemetrexed)","Babesia bovis","DIHYDROFOLATE REDUCTASE\/THYMIDYLATE SYNTHASE","no annotation",15,"ALA B  16;ILE B  29;ASP B  37;PHE B  38;ARG B  39;LEU B  41;ARG B  42;THR B  69;SER B  72;ILE B  73;SER B  77;LEU B  80;ARG B  83;TYR B 129;THR B 144","LYA B 514\r"],["4FQS_A_LYAA302","4fqs","LYA","DB00642(Pemetrexed)","Mycobacterium tuberculosis","THYMIDYLATE SYNTHASE","PF00303(Thymidylat_synt)",13,"HIS A  51;GLU A  58;ILE A  79;TRP A  80;TRP A  83;LEU A 143;ASP A 169;LEU A 172;GLY A 173;PHE A 176;TYR A 209;VAL A 261;ALA A 262","LYA A 302\r"],["4FQS_B_LYAB302","4fqs","LYA","DB00642(Pemetrexed)","Mycobacterium tuberculosis","THYMIDYLATE SYNTHASE","no annotation",13,"HIS B  51;GLU B  58;ILE B  79;TRP B  80;TRP B  83;LEU B 143;ASP B 169;LEU B 172;GLY B 173;PHE B 176;TYR B 209;VAL B 261;ALA B 262","LYA B 302\r"],["4KN2_A_LYAA304","4kn2","LYA","DB00642(Pemetrexed)","Homo sapiens","FOLATE RECEPTOR BETA","PF03024(Folate_rec)",16,"TYR A  76;ASP A  97;THR A  98;TYR A 101;GLN A 116;SER A 117;TRP A 118;ARG A 119;HIS A 151;ARG A 152;GLY A 153;TRP A 154;TRP A 156;TRP A 187;SER A 190;TYR A 191","LYA A 304\r"],["4KN2_B_LYAB304","4kn2","LYA","DB00642(Pemetrexed)","Homo sapiens","FOLATE RECEPTOR BETA","no annotation",14,"TYR B  76;ASP B  97;THR B  98;TYR B 101;TRP B 118;ARG B 119;HIS B 151;ARG B 152;GLY B 153;TRP B 154;TRP B 156;TRP B 187;SER B 190;TYR B 191","LYA B 304\r"],["4KN2_C_LYAC304","4kn2","LYA","DB00642(Pemetrexed)","Homo sapiens","FOLATE RECEPTOR BETA","no annotation",15,"TYR C  76;ASP C  97;THR C  98;TYR C 101;GLN C 116;SER C 117;TRP C 118;ARG C 119;HIS C 151;GLY C 153;TRP C 154;TRP C 156;TRP C 187;SER C 190;TYR C 191","LYA C 304\r"]]