DRUG BINDING INTERFACES MAPPED TO 'OFLOXACIN'

List of Binding Interfaces

(Click on the entry ID to view details of interfaces and pattern clusters)
(Note that ASSAM search use only 3-12 residue containing patterns)
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DrReposER ID PDB Ligand Organism Macromolecule Pfam Res. Interface HETATM
1T9U_A_CPFA5002 1t9u CPF

DB00537
(Ciprofloxacin) 		Escherichia coli ACRIFLAVINE
RESISTANCE PROTEIN B 		PF00873
(ACR_tran) 		6 PHE A 664
PHE A 666
ASN A 667
ARG A 717
ASN A 719
GLN A 830
 CPF A5002
2XCT_G_CPFG1020 2xct CPF

DB00537
(Ciprofloxacin) 		Staphylococcus
aureus;
synthetic
construct 		DNA GYRASE SUBUNIT
B, DNA GYRASE
SUBUNIT A 		PF00521
(DNA_topoisoIV)
PF00986
(DNA_gyraseB_C)
PF01751
(Toprim)
no annotation 		3 ARG B 458
GLY B 459
SER B1084
 CPF G1020
2XCT_H_CPFH1020 2xct CPF

DB00537
(Ciprofloxacin) 		Staphylococcus
aureus;
synthetic
construct 		DNA GYRASE SUBUNIT
B, DNA GYRASE
SUBUNIT A 		no annotation 3 ARG D 458
GLU D 477
SER D1084
 CPF H1020
2XCT_X_CPFX1020 2xct CPF

DB00537
(Ciprofloxacin) 		Staphylococcus
aureus;
synthetic
construct 		DNA GYRASE SUBUNIT
B, DNA GYRASE
SUBUNIT A 		no annotation 4 ARG S 458
GLY S 459
GLU S 477
SER U1084
 CPF X1020
3K9F_F_LFXF0 3k9f LFX

DB01137
(Levofloxacin)
DB01165
(Ofloxacin) 		;
Streptococcus
pneumoniae 		DNA TOPOISOMERASE 4
SUBUNIT A;
DNA TOPOISOMERASE 4
SUBUNIT B 		PF00521
(DNA_topoisoIV)
PF00986
(DNA_gyraseB_C)
PF01751
(Toprim)
no annotation 		5 SER A  79
ARG B 117
ARG C 456
GLY C 457
GLU C 475
 LFX F   0
3K9F_H_LFXH0 3k9f LFX

DB01137
(Levofloxacin)
DB01165
(Ofloxacin) 		;
Streptococcus
pneumoniae 		DNA TOPOISOMERASE 4
SUBUNIT A;
DNA TOPOISOMERASE 4
SUBUNIT B 		PF00521
(DNA_topoisoIV)
no annotation 		6 SER B  79
ARG A 117
ARG D 456
GLY D 457
GLU D 474
GLU D 475
 LFX H   0
3RAE_F_LFXF101 3rae LFX

DB01137
(Levofloxacin)
DB01165
(Ofloxacin) 		;
Streptococcus
pneumoniae 		DNA TOPOISOMERASE 4
SUBUNIT A;
DNA TOPOISOMERASE 4
SUBUNIT B 		PF00521
(DNA_topoisoIV)
PF00986
(DNA_gyraseB_C)
PF01751
(Toprim)
no annotation 		4 SER A  79
ARG C 456
GLY C 457
GLU C 474
 LFX F 101
3RAE_H_LFXH101 3rae LFX

DB01137
(Levofloxacin)
DB01165
(Ofloxacin) 		;
Streptococcus
pneumoniae 		DNA TOPOISOMERASE 4
SUBUNIT A;
DNA TOPOISOMERASE 4
SUBUNIT B 		no annotation 5 SER B  79
ARG D 456
GLY D 457
GLU D 474
GLU D 475
 LFX H 101
4BVV_A_CPFA1081 4bvv CPF

DB00537
(Ciprofloxacin) 		Homo sapiens APOLIPOPROTEIN(A) PF00051
(Kringle) 		9 HIS A  33
SER A  34
THR A  35
ASP A  55
ASP A  57
TRP A  62
TYR A  64
LEU A  71
PHE A  72
 CPF A1081
4JUO_F_LFXF101 4juo LFX

DB01137
(Levofloxacin)
DB01165
(Ofloxacin) 		;
Streptococcus
pneumoniae 		DNA TOPOISOMERASE 4
SUBUNIT A;
DNA TOPOISOMERASE 4
SUBUNIT B;
E-SITE DNA 		PF00204
(DNA_gyraseB)
PF00521
(DNA_topoisoIV)
PF00986
(DNA_gyraseB_C)
PF01751
(Toprim)
PF02518
(HATPase_c)
no annotation 		4 SER A  79
ARG C 456
GLY C 457
GLU C 474
 LFX F 101
4KRA_C_CPFC401 4kra CPF

DB00537
(Ciprofloxacin) 		Salmonella
enterica 		OUTER MEMBRANE
PROTEIN F 		no annotation 9 ARG C  20
TYR C  36
ARG C  60
ARG C  77
TYR C 112
GLU C 116
GLY C 120
THR C 123
ARG C 130
 CPF C 401
4Z2D_F_LFXF102 4z2d LFX

DB01137
(Levofloxacin)
DB01165
(Ofloxacin) 		Escherichia coli;
Streptococcus
pneumoniae 		DNA GYRASE SUBUNIT
A;
DNA GYRASE SUBUNIT
B;
SYMMETRIZED E-SITE
DNA 		PF00986
(DNA_gyraseB_C)
PF01751
(Toprim)
no annotation 		4 SER B  81
ARG C 456
GLY C 457
GLU C 475
 LFX F 102
4Z2D_H_LFXH101 4z2d LFX

DB01137
(Levofloxacin)
DB01165
(Ofloxacin) 		Escherichia coli;
Streptococcus
pneumoniae 		DNA GYRASE SUBUNIT
A;
DNA GYRASE SUBUNIT
B;
SYMMETRIZED E-SITE
DNA 		PF00521
(DNA_topoisoIV)
no annotation 		4 SER A  81
ARG D 456
GLY D 457
GLU D 475
 LFX H 101
5BTC_G_CPFG101 5btc CPF

DB00537
(Ciprofloxacin) 		Mycobacterium
tuberculosis;
synthetic
construct 		DNA GYRASE SUBUNIT
A;
DNA GYRASE SUBUNIT
B;
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC 		PF00521
(DNA_topoisoIV)
no annotation 		6 SER C  90
ARG A 128
ARG D 482
GLY D 483
THR D 500
GLU D 501
 CPF G 101
5BTC_G_CPFG102 5btc CPF

DB00537
(Ciprofloxacin) 		Mycobacterium
tuberculosis;
synthetic
construct 		DNA GYRASE SUBUNIT
A;
DNA GYRASE SUBUNIT
B;
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC 		PF00521
(DNA_topoisoIV)
PF00986
(DNA_gyraseB_C)
PF01751
(Toprim)
no annotation 		6 SER A  90
ARG C 128
ARG B 482
GLY B 483
THR B 500
GLU B 501
 CPF G 102
5BTG_E_LFXE101 5btg LFX

DB01137
(Levofloxacin)
DB01165
(Ofloxacin) 		Mycobacterium
tuberculosis;
synthetic
construct 		DNA GYRASE SUBUNIT
A;
DNA GYRASE SUBUNIT
B;
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA 		PF00521
(DNA_topoisoIV)
PF00986
(DNA_gyraseB_C)
PF01751
(Toprim)
no annotation 		6 ALA A  90
ARG C 128
ARG B 482
GLY B 483
THR B 500
GLU B 501
 LFX E 101
5BTG_F_LFXF101 5btg LFX

DB01137
(Levofloxacin)
DB01165
(Ofloxacin) 		Mycobacterium
tuberculosis;
synthetic
construct 		DNA GYRASE SUBUNIT
A;
DNA GYRASE SUBUNIT
B;
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC 		PF00521
(DNA_topoisoIV)
no annotation 		7 ALA C  90
ARG A 128
ASP D 461
ARG D 482
GLY D 483
THR D 500
GLU D 501
 LFX F 101
5BTI_E_LFXE101 5bti LFX

DB01137
(Levofloxacin)
DB01165
(Ofloxacin) 		Mycobacterium
tuberculosis;
synthetic
construct 		DNA GYRASE SUBUNIT
A;
DNA GYRASE SUBUNIT
B;
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA 		PF00521
(DNA_topoisoIV)
PF00986
(DNA_gyraseB_C)
PF01751
(Toprim)
no annotation 		5 SER A  90
ARG B 482
GLY B 483
THR B 500
GLU B 501
 LFX E 101
5BTI_F_LFXF101 5bti LFX

DB01137
(Levofloxacin)
DB01165
(Ofloxacin) 		Mycobacterium
tuberculosis;
synthetic
construct 		DNA GYRASE SUBUNIT
A;
DNA GYRASE SUBUNIT
B;
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC 		no annotation 5 SER C  90
ARG D 482
GLY D 483
THR D 500
GLU D 501
 LFX F 101