DRUG BINDING INTERFACES MAPPED TO 'METHOTREXATE'

List of Binding Interfaces
(Click on the entry ID to view details of interfaces and pattern clusters)
(Note that ASSAM search use only 3-12 residue containing patterns)

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DrReposER ID	PDB	Ligand	Organism	Macromolecule	Pfam	Res.	Interface	HETATM
1AO8_A_MTXA170	1ao8	MTX DB00563 (Methotrexate)	Lactobacillus casei	DIHYDROFOLATE REDUCTASE	PF00186 (DHFR_1)	16	LEU A 4 TRP A 5 ALA A 6 LEU A 19 ASP A 26 LEU A 27 PHE A 30 ARG A 31 THR A 34 THR A 45 SER A 48 PHE A 49 LEU A 54 ARG A 57 ALA A 97 THR A 116	MTX A 170
1AXW_A_MTXA732	1axw	MTX DB00563 (Methotrexate)	Escherichia coli	THYMIDYLATE SYNTHASE	PF00303 (Thymidylat_synt)	12	LYS A 48 HIS A 51 ILE A 79 TRP A 83 LEU A 143 ASP A 169 LEU A 172 GLY A 173 PHE A 176 TYR A 209 VAL A 262 ALA A 263	MTX A 732
1AXW_B_MTXB733	1axw	MTX DB00563 (Methotrexate)	Escherichia coli	THYMIDYLATE SYNTHASE	no annotation	11	LYS B 48 HIS B 51 ILE B 79 TRP B 80 TRP B 83 ASP B 169 LEU B 172 GLY B 173 PHE B 176 TYR B 209 VAL B 262	MTX B 733
1D1G_A_MTXA171	1d1g	MTX DB00563 (Methotrexate)	Thermotoga maritima	DIHYDROFOLATE REDUCTASE	PF00186 (DHFR_1)	13	VAL A 6 ALA A 8 ASP A 27 ARG A 28 LYS A 29 ARG A 32 GLU A 50 ILE A 51 ARG A 53 LEU A 55 ARG A 58 ILE A 100 THR A 121	MTX A 171
1D1G_B_MTXB171	1d1g	MTX DB00563 (Methotrexate)	Thermotoga maritima	DIHYDROFOLATE REDUCTASE	no annotation	12	VAL B 6 ALA B 8 ASP B 27 ARG B 28 ARG B 32 GLU B 50 ILE B 51 ARG B 53 LEU B 55 ARG B 58 ILE B 100 THR B 121	MTX B 171
1DDR_A_MTXA200	1ddr	MTX DB00563 (Methotrexate)	Escherichia coli	DIHYDROFOLATE REDUCTASE	PF00186 (DHFR_1)	14	ILE A 5 ALA A 7 ASP A 27 LEU A 28 LYS A 32 THR A 46 SER A 49 ILE A 50 ARG A 52 LEU A 54 ARG A 57 ILE A 94 TYR A 100 THR A 113	MTX A 200
1DDR_B_MTXB200	1ddr	MTX DB00563 (Methotrexate)	Escherichia coli	DIHYDROFOLATE REDUCTASE	no annotation	14	ILE B 5 ALA B 7 ASP B 27 LEU B 28 TRP B 30 PHE B 31 LYS B 32 ILE B 50 ARG B 52 LEU B 54 ARG B 57 ILE B 94 TYR B 100 THR B 113	MTX B 200
1DDS_A_MTXA201	1dds	MTX DB00563 (Methotrexate)	Escherichia coli	DIHYDROFOLATE REDUCTASE	PF00186 (DHFR_1)	13	ILE A 5 ALA A 7 ASP A 27 LEU A 28 LYS A 32 THR A 46 ILE A 50 ARG A 52 LEU A 54 ARG A 57 ILE A 94 TYR A 100 THR A 113	MTX A 201
1DDS_B_MTXB201	1dds	MTX DB00563 (Methotrexate)	Escherichia coli	DIHYDROFOLATE REDUCTASE	no annotation	13	ILE B 5 ALA B 7 ASP B 27 LEU B 28 LYS B 32 SER B 49 ILE B 50 ARG B 52 LEU B 54 ARG B 57 ILE B 94 TYR B 100 THR B 113	MTX B 201
1DF7_A_MTXA501	1df7	MTX DB00563 (Methotrexate)	Mycobacterium tuberculosis	DIHYDROFOLATE REDUCTASE	PF00186 (DHFR_1)	15	ILE A 5 TRP A 6 ALA A 7 ILE A 20 ASP A 27 GLN A 28 ARG A 32 LEU A 50 PRO A 51 VAL A 54 LEU A 57 ARG A 60 ILE A 94 TYR A 100 THR A 113	MTX A 501
1DHI_A_MTXA161	1dhi	MTX DB00563 (Methotrexate)	Escherichia coli	DIHYDROFOLATE REDUCTASE	PF00186 (DHFR_1)	12	ILE A 5 ALA A 7 LEU A 28 LYS A 32 SER A 49 ILE A 50 ARG A 52 LEU A 54 ARG A 57 ILE A 94 TYR A 100 THR A 113	MTX A 161
1DHI_B_MTXB361	1dhi	MTX DB00563 (Methotrexate)	Escherichia coli	DIHYDROFOLATE REDUCTASE	no annotation	11	ILE B 5 ALA B 7 LEU B 28 LYS B 32 ILE B 50 ARG B 52 LEU B 54 ARG B 57 ILE B 94 TYR B 100 THR B 113	MTX B 361
1DHJ_A_MTXA161	1dhj	MTX DB00563 (Methotrexate)	Escherichia coli	DIHYDROFOLATE REDUCTASE	PF00186 (DHFR_1)	12	ILE A 5 ALA A 7 LEU A 28 LYS A 32 SER A 49 ILE A 50 ARG A 52 LEU A 54 ARG A 57 ILE A 94 TYR A 100 THR A 113	MTX A 161
1DHJ_B_MTXB361	1dhj	MTX DB00563 (Methotrexate)	Escherichia coli	DIHYDROFOLATE REDUCTASE	no annotation	12	ILE B 5 ALA B 7 LEU B 28 LYS B 32 ILE B 50 ARG B 52 LEU B 54 PRO B 55 ARG B 57 ILE B 94 TYR B 100 THR B 113	MTX B 361
1DLS_A_MTXA188	1dls	MTX DB00563 (Methotrexate)	Homo sapiens	DIHYDROFOLATE REDUCTASE	PF00186 (DHFR_1)	16	ILE A 7 ALA A 9 TYR A 22 ARG A 28 GLU A 30 PHE A 31 GLN A 35 SER A 59 ILE A 60 PRO A 61 ASN A 64 LEU A 67 ARG A 70 VAL A 115 TYR A 121 THR A 136	MTX A 188
1DRA_A_MTXA161	1dra	MTX DB00563 (Methotrexate)	Escherichia coli	DIHYDROFOLATE REDUCTASE	PF00186 (DHFR_1)	13	ILE A 5 ALA A 7 GLU A 27 LEU A 28 LYS A 32 SER A 49 ILE A 50 ARG A 52 LEU A 54 ARG A 57 ILE A 94 TYR A 100 THR A 113	MTX A 161
1DRA_B_MTXB361	1dra	MTX DB00563 (Methotrexate)	Escherichia coli	DIHYDROFOLATE REDUCTASE	no annotation	12	ILE B 5 ALA B 7 GLU B 27 LEU B 28 LYS B 32 ILE B 50 ARG B 52 LEU B 54 ARG B 57 ILE B 94 TYR B 100 THR B 113	MTX B 361
1DRB_A_MTXA161	1drb	MTX DB00563 (Methotrexate)	Escherichia coli	DIHYDROFOLATE REDUCTASE	PF00186 (DHFR_1)	12	ILE A 5 ALA A 7 LEU A 28 LYS A 32 SER A 49 ILE A 50 ARG A 52 LEU A 54 ARG A 57 ILE A 94 TYR A 100 THR A 113	MTX A 161
1DRB_B_MTXB361	1drb	MTX DB00563 (Methotrexate)	Escherichia coli	DIHYDROFOLATE REDUCTASE	no annotation	12	ILE B 5 ALA B 7 LEU B 28 PHE B 31 LYS B 32 ILE B 50 ARG B 52 LEU B 54 ARG B 57 ILE B 94 TYR B 100 THR B 113	MTX B 361
1DRE_A_MTXA161	1dre	MTX DB00563 (Methotrexate)	Escherichia coli	DIHYDROFOLATE REDUCTASE	PF00186 (DHFR_1)	14	ILE A 5 ALA A 7 MET A 20 ASP A 27 LEU A 28 PHE A 31 LYS A 32 SER A 49 ILE A 50 ARG A 52 LEU A 54 ARG A 57 ILE A 94 TYR A 100	MTX A 161
1E7W_A_MTXA301	1e7w	MTX DB00563 (Methotrexate)	Leishmania major	PTERIDINE REDUCTASE	PF00106 (adh_short) PF13561 (adh_short_C2)	12	ARG A 17 SER A 111 PHE A 113 PRO A 115 ASP A 181 LEU A 188 TYR A 191 TYR A 194 LEU A 226 LEU A 229 ASP A 232 MET A 233	MTX A 301
1E7W_B_MTXB301	1e7w	MTX DB00563 (Methotrexate)	Leishmania major	PTERIDINE REDUCTASE	no annotation	11	ARG B 17 SER B 111 PHE B 113 PRO B 115 ASP B 181 LEU B 188 TYR B 191 TYR B 194 LEU B 226 TRP B 238 HIS B 241	MTX B 301
1MXF_A_MTXA1278	1mxf	MTX DB00563 (Methotrexate)	Trypanosoma cruzi	PTERIDINE REDUCTASE 2	PF13561 (adh_short_C2)	10	ARG A 22 SER A 103 TYR A 105 ASP A 169 LEU A 176 TYR A 182 LEU A 214 PRO A 218 THR A 225 TYR A 229	MTX A1278
1MXF_B_MTXB2278	1mxf	MTX DB00563 (Methotrexate)	Trypanosoma cruzi	PTERIDINE REDUCTASE 2	no annotation	11	ARG B 22 SER B 103 TYR B 105 ASP B 169 LEU B 176 PHE B 179 TYR B 182 LEU B 214 PRO B 218 THR B 225 TYR B 229	MTX B2278
1MXF_C_MTXC3278	1mxf	MTX DB00563 (Methotrexate)	Trypanosoma cruzi	PTERIDINE REDUCTASE 2	no annotation	11	ARG C 22 SER C 103 TYR C 105 ASP C 169 LEU C 176 PHE C 179 TYR C 182 LEU C 214 PRO C 218 THR C 225 TYR C 229	MTX C3278
1MXF_D_MTXD4278	1mxf	MTX DB00563 (Methotrexate)	Trypanosoma cruzi	PTERIDINE REDUCTASE 2	no annotation	11	ARG D 22 SER D 103 TYR D 105 ASP D 169 LEU D 176 PHE D 179 TYR D 182 LEU D 214 PRO D 218 THR D 225 TYR D 229	MTX D4278
1P33_A_MTXA351	1p33	MTX DB00563 (Methotrexate)	Leishmania tarentolae	PTERIDINE REDUCTASE 1	PF13561 (adh_short_C2)	13	ARG A 17 SER A 111 PHE A 113 PRO A 115 ASP A 181 LEU A 188 TYR A 191 TYR A 194 LEU A 226 LEU A 229 PRO A 230 MET A 233 TYR A 241	MTX A 351
1P33_B_MTXB352	1p33	MTX DB00563 (Methotrexate)	Leishmania tarentolae	PTERIDINE REDUCTASE 1	no annotation	13	ARG B 17 SER B 111 PHE B 113 PRO B 115 ASP B 181 LEU B 188 TYR B 191 TYR B 194 LEU B 226 LEU B 229 PRO B 230 MET B 233 TYR B 241	MTX B 352
1P33_C_MTXC353	1p33	MTX DB00563 (Methotrexate)	Leishmania tarentolae	PTERIDINE REDUCTASE 1	no annotation	13	ARG C 17 SER C 111 PHE C 113 PRO C 115 ASP C 181 LEU C 188 TYR C 191 TYR C 194 LEU C 226 LEU C 229 PRO C 230 MET C 233 TYR C 241	MTX C 353
1P33_D_MTXD354	1p33	MTX DB00563 (Methotrexate)	Leishmania tarentolae	PTERIDINE REDUCTASE 1	no annotation	12	ARG D 17 SER D 111 PHE D 113 PRO D 115 ASP D 181 LEU D 188 TYR D 191 TYR D 194 LEU D 229 PRO D 230 MET D 233 TYR D 241	MTX D 354
1RA3_A_MTXA161	1ra3	MTX DB00563 (Methotrexate)	Escherichia coli	DIHYDROFOLATE REDUCTASE	PF00186 (DHFR_1)	12	ILE A 5 ALA A 7 ASP A 27 LEU A 28 LYS A 32 ILE A 50 ARG A 52 LEU A 54 ARG A 57 ILE A 94 TYR A 100 THR A 113	MTX A 161
1RB3_A_MTXA161	1rb3	MTX DB00563 (Methotrexate)	Escherichia coli	DIHYDROFOLATE REDUCTASE	PF00186 (DHFR_1)	10	ILE A 5 ALA A 7 ASP A 27 LEU A 28 LYS A 32 ILE A 50 ARG A 57 ILE A 94 TYR A 100 THR A 113	MTX A 161
1RB3_B_MTXB161	1rb3	MTX DB00563 (Methotrexate)	Escherichia coli	DIHYDROFOLATE REDUCTASE	no annotation	13	ILE B 5 ALA B 7 ASP B 27 LEU B 28 TRP B 30 LYS B 32 SER B 49 ILE B 50 LEU B 54 ARG B 57 ILE B 94 TYR B 100 THR B 113	MTX B 161
1RG7_A_MTXA161	1rg7	MTX DB00563 (Methotrexate)	Escherichia coli	DIHYDROFOLATE REDUCTASE	PF00186 (DHFR_1)	15	ILE A 5 ALA A 7 ALA A 19 ASN A 23 ASP A 27 LEU A 28 LYS A 32 THR A 46 SER A 49 ILE A 50 LEU A 54 ARG A 57 ILE A 94 TYR A 100 THR A 113	MTX A 161
1RH3_A_MTXA161	1rh3	MTX DB00563 (Methotrexate)	Escherichia coli	DIHYDROFOLATE REDUCTASE	PF00186 (DHFR_1)	13	ILE A 5 MET A 20 ASP A 27 LEU A 28 PHE A 31 LYS A 32 SER A 49 ILE A 50 ARG A 52 LEU A 54 ARG A 57 ILE A 94 TYR A 100	MTX A 161
1RX3_A_MTXA161	1rx3	MTX DB00563 (Methotrexate)	Escherichia coli	DIHYDROFOLATE REDUCTASE	PF00186 (DHFR_1)	15	ILE A 5 ALA A 7 MET A 20 ASP A 27 LEU A 28 PHE A 31 LYS A 32 SER A 49 ILE A 50 ARG A 52 LEU A 54 ARG A 57 ILE A 94 TYR A 100 THR A 113	MTX A 161
1TDR_A_MTXA170	1tdr	MTX DB00563 (Methotrexate)	Escherichia coli	TELLUROMETHIONYL DIHYDROFOLATE REDUCTASE	PF00186 (DHFR_1)	15	ILE A 5 ALA A 7 ASP A 27 LEU A 28 PHE A 31 LYS A 32 THR A 46 SER A 49 ILE A 50 ARG A 52 LEU A 54 ARG A 57 ILE A 94 TYR A 100 THR A 113	MTX A 170
1TDR_B_MTXB170	1tdr	MTX DB00563 (Methotrexate)	Escherichia coli	TELLUROMETHIONYL DIHYDROFOLATE REDUCTASE	no annotation	10	ALA B 7 ASP B 27 LEU B 28 LYS B 32 ILE B 50 ARG B 52 LEU B 54 ARG B 57 TYR B 100 THR B 113	MTX B 170
1U70_A_MTXA187	1u70	MTX DB00563 (Methotrexate)	Mus musculus	DIHYDROFOLATE REDUCTASE	PF00186 (DHFR_1)	16	ILE A 7 ALA A 9 ARG A 22 GLU A 30 PHE A 31 GLN A 35 SER A 59 ILE A 60 PRO A 61 ASN A 64 LEU A 67 LYS A 68 ARG A 70 VAL A 115 TYR A 121 THR A 136	MTX A 187
1U72_A_MTXA188	1u72	MTX DB00563 (Methotrexate)	Homo sapiens	DIHYDROFOLATE REDUCTASE	PF00186 (DHFR_1)	14	ALA A 9 LEU A 22 GLU A 30 PHE A 31 GLN A 35 SER A 59 ILE A 60 PRO A 61 ASN A 64 LEU A 67 ARG A 70 VAL A 115 TYR A 121 THR A 136	MTX A 188
2C7V_A_MTXA1272	2c7v	MTX DB00563 (Methotrexate)	Trypanosoma brucei	PTERIDINE REDUCTASE	PF13561 (adh_short_C2)	9	ARG A 14 SER A 95 PHE A 97 PRO A 99 PHE A 171 TYR A 174 PRO A 210 MET A 213 TRP A 221	MTX A1272
2C7V_B_MTXB1272	2c7v	MTX DB00563 (Methotrexate)	Trypanosoma brucei	PTERIDINE REDUCTASE	no annotation	12	ARG B 14 SER B 95 PHE B 97 PRO B 99 ASP B 161 PHE B 171 TYR B 174 LEU B 209 PRO B 210 MET B 213 GLU B 217 TRP B 221	MTX B1272
2C7V_C_MTXC1272	2c7v	MTX DB00563 (Methotrexate)	Trypanosoma brucei	PTERIDINE REDUCTASE	no annotation	12	ARG C 14 SER C 95 PHE C 97 PRO C 99 ASP C 161 PHE C 171 TYR C 174 LEU C 209 PRO C 210 MET C 213 GLU C 217 TRP C 221	MTX C1272
2C7V_D_MTXD1272	2c7v	MTX DB00563 (Methotrexate)	Trypanosoma brucei	PTERIDINE REDUCTASE	no annotation	10	ARG D 14 SER D 95 PHE D 97 PRO D 99 ASP D 161 PHE D 171 TYR D 174 PRO D 210 MET D 213 TRP D 221	MTX D1272
2DRC_A_MTXA161	2drc	MTX DB00563 (Methotrexate)	Escherichia coli	DIHYDROFOLATE REDUCTASE	PF00186 (DHFR_1)	13	ILE A 5 ALA A 7 ASP A 27 LEU A 28 LYS A 32 SER A 49 ILE A 50 ARG A 52 LEU A 54 ARG A 57 ILE A 94 TYR A 100 THR A 113	MTX A 161
2DRC_B_MTXB161	2drc	MTX DB00563 (Methotrexate)	Escherichia coli	DIHYDROFOLATE REDUCTASE	no annotation	12	ILE B 5 ALA B 7 ASP B 27 LEU B 28 LYS B 32 ILE B 50 ARG B 52 LEU B 54 ARG B 57 ILE B 94 TYR B 100 THR B 113	MTX B 161
2OIP_A_MTXA605	2oip	MTX DB00563 (Methotrexate)	Cryptosporidium hominis	CHAIN A, CRYSTAL STRUCTURE OF DHFR	PF00186 (DHFR_1) PF00303 (Thymidylat_synt)	14	VAL A 9 ALA A 11 LEU A 25 ASP A 32 LEU A 33 LYS A 34 PHE A 36 SER A 37 THR A 58 ILE A 62 LEU A 67 ARG A 70 TYR A 119 THR A 134	MTX A 605
2OIP_B_MTXB609	2oip	MTX DB00563 (Methotrexate)	Cryptosporidium hominis	CHAIN A, CRYSTAL STRUCTURE OF DHFR	no annotation	14	VAL B 9 ALA B 11 LEU B 25 ASP B 32 LEU B 33 LYS B 34 PHE B 36 SER B 37 THR B 58 ILE B 62 LEU B 67 ARG B 70 TYR B 119 THR B 134	MTX B 609
2OIP_C_MTXC613	2oip	MTX DB00563 (Methotrexate)	Cryptosporidium hominis	CHAIN A, CRYSTAL STRUCTURE OF DHFR	no annotation	12	VAL C 9 ALA C 11 LEU C 25 ASP C 32 LEU C 33 PHE C 36 SER C 37 THR C 58 LEU C 67 ARG C 70 TYR C 119 THR C 134	MTX C 613
2OIP_D_MTXD617	2oip	MTX DB00563 (Methotrexate)	Cryptosporidium hominis	CHAIN A, CRYSTAL STRUCTURE OF DHFR	no annotation	14	VAL D 9 ALA D 11 LEU D 25 ASP D 32 LEU D 33 PHE D 36 SER D 37 THR D 58 ILE D 62 LEU D 67 ARG D 70 CYS D 113 TYR D 119 THR D 134	MTX D 617
2OIP_E_MTXE621	2oip	MTX DB00563 (Methotrexate)	Cryptosporidium hominis	CHAIN A, CRYSTAL STRUCTURE OF DHFR	no annotation	14	VAL E 9 ALA E 11 LEU E 25 ASP E 32 LEU E 33 LYS E 34 PHE E 36 SER E 37 THR E 58 ILE E 62 LEU E 67 ARG E 70 TYR E 119 THR E 134	MTX E 621
2QK8_A_MTXA200	2qk8	MTX DB00563 (Methotrexate)	Bacillus anthracis	DIHYDROFOLATE REDUCTASE	PF00186 (DHFR_1)	16	MET A 6 ALA A 8 LEU A 21 GLU A 28 LEU A 29 VAL A 32 LYS A 33 ASN A 47 ILE A 51 ARG A 53 LEU A 55 PRO A 56 ARG A 58 PHE A 96 TYR A 102 THR A 115	MTX A 200
3CD2_A_MTXA307	3cd2	MTX DB00563 (Methotrexate)	Pneumocystis carinii	DIHYDROFOLATE REDUCTASE	PF00186 (DHFR_1)	13	ILE A 10 LEU A 25 GLU A 32 ILE A 33 SER A 34 LYS A 37 PRO A 66 PHE A 69 LEU A 72 ARG A 75 ILE A 123 TYR A 129 THR A 144	MTX A 307
3CL9_A_MTXA602	3cl9	MTX DB00563 (Methotrexate)	Trypanosoma cruzi	BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLAT E SYNTHASE (DHFR-TS)	PF00186 (DHFR_1) PF00303 (Thymidylat_synt)	16	VAL A 26 ALA A 28 ILE A 41 ASP A 48 MET A 49 ARG A 53 THR A 80 SER A 83 ILE A 84 PRO A 85 PHE A 88 LEU A 91 PRO A 92 ARG A 94 TYR A 160 THR A 178	MTX A 602
3DAT_A_MTXA201	3dat	MTX DB00563 (Methotrexate)	Bacillus anthracis	DIHYDROFOLATE REDUCTASE	PF00186 (DHFR_1)	16	MET A 6 ALA A 8 LEU A 21 GLU A 28 LEU A 29 GLN A 30 VAL A 32 LYS A 33 ASN A 47 ILE A 51 ARG A 53 LEU A 55 ARG A 58 PHE A 96 TYR A 102 THR A 115	MTX A 201
3DAU_A_MTXA201	3dau	MTX DB00563 (Methotrexate)	Escherichia coli	DIHYDROFOLATE REDUCTASE	PF00186 (DHFR_1)	15	ILE A 5 ALA A 7 MET A 20 ASP A 27 LEU A 28 ALA A 29 LYS A 32 SER A 49 ILE A 50 ARG A 52 LEU A 54 ARG A 57 ILE A 94 TYR A 100 THR A 113	MTX A 201
3DFR_A_MTXA164	3dfr	MTX DB00563 (Methotrexate)	Lactobacillus casei	DIHYDROFOLATE REDUCTASE	PF00186 (DHFR_1)	14	LEU A 4 TRP A 5 ALA A 6 LEU A 19 ASP A 26 LEU A 27 HIS A 28 ARG A 31 SER A 48 PRO A 50 LEU A 54 ARG A 57 ALA A 97 THR A 116	MTX A 164
3DRC_A_MTXA161	3drc	MTX DB00563 (Methotrexate)	Escherichia coli	DIHYDROFOLATE REDUCTASE	PF00186 (DHFR_1)	13	ILE A 5 ALA A 7 ASP A 27 LEU A 28 LYS A 32 SER A 49 ILE A 50 ARG A 52 LEU A 54 ARG A 57 ILE A 94 TYR A 100 THR A 113	MTX A 161
3DRC_B_MTXB361	3drc	MTX DB00563 (Methotrexate)	Escherichia coli	DIHYDROFOLATE REDUCTASE	no annotation	12	ILE B 5 ALA B 7 ASP B 27 LEU B 28 LYS B 32 ILE B 50 ARG B 52 LEU B 54 ARG B 57 ILE B 94 TYR B 100 THR B 113	MTX B 361
3EIG_A_MTXA200	3eig	MTX DB00563 (Methotrexate)	Homo sapiens	DIHYDROFOLATE REDUCTASE	PF00186 (DHFR_1)	17	ILE A 7 ALA A 9 ASP A 21 LEU A 22 GLU A 30 ARG A 31 ARG A 32 GLU A 35 SER A 59 ILE A 60 PRO A 61 ASN A 64 LEU A 67 ARG A 70 VAL A 115 TYR A 121 THR A 136	MTX A 200
3HJ3_A_MTXA605	3hj3	MTX DB00563 (Methotrexate)	Cryptosporidium hominis	CHAIN A, CRYSTAL STRUCTURE OF DHFR	PF00186 (DHFR_1) PF00303 (Thymidylat_synt)	13	VAL A 9 ALA A 11 LEU A 25 ASP A 32 LEU A 33 PHE A 36 SER A 37 THR A 58 ILE A 62 LEU A 67 ARG A 70 TYR A 119 THR A 134	MTX A 605
3HJ3_B_MTXB609	3hj3	MTX DB00563 (Methotrexate)	Cryptosporidium hominis	CHAIN A, CRYSTAL STRUCTURE OF DHFR	no annotation	14	VAL B 9 ALA B 11 LEU B 25 ASP B 32 LEU B 33 LYS B 34 PHE B 36 SER B 37 THR B 58 ILE B 62 LEU B 67 ARG B 70 TYR B 119 THR B 134	MTX B 609
3HJ3_C_MTXC613	3hj3	MTX DB00563 (Methotrexate)	Cryptosporidium hominis	CHAIN A, CRYSTAL STRUCTURE OF DHFR	no annotation	12	VAL C 9 ALA C 11 LEU C 25 ASP C 32 LEU C 33 PHE C 36 SER C 37 THR C 58 LEU C 67 ARG C 70 TYR C 119 THR C 134	MTX C 613
3HJ3_D_MTXD615	3hj3	MTX DB00563 (Methotrexate)	Cryptosporidium hominis	CHAIN A, CRYSTAL STRUCTURE OF DHFR	no annotation	14	VAL D 9 ALA D 11 LEU D 25 ASP D 32 LEU D 33 PHE D 36 SER D 37 THR D 58 ILE D 62 LEU D 67 ARG D 70 CYS D 113 TYR D 119 THR D 134	MTX D 615
3IA4_A_MTXA164	3ia4	MTX DB00563 (Methotrexate)	Moritella profunda	DIHYDROFOLATE REDUCTASE	PF00186 (DHFR_1)	16	ILE A 6 ALA A 8 MET A 21 GLU A 28 LEU A 29 GLN A 30 PHE A 32 LYS A 33 SER A 50 ILE A 51 ARG A 53 LEU A 55 ARG A 58 ILE A 96 TYR A 102 THR A 115	MTX A 164
3IA4_B_MTXB164	3ia4	MTX DB00563 (Methotrexate)	Moritella profunda	DIHYDROFOLATE REDUCTASE	no annotation	16	ILE B 6 ALA B 8 MET B 21 GLU B 28 LEU B 29 GLN B 30 PHE B 32 LYS B 33 SER B 50 ILE B 51 ARG B 53 LEU B 55 ARG B 58 ILE B 96 TYR B 102 THR B 115	MTX B 164
3IA4_C_MTXC164	3ia4	MTX DB00563 (Methotrexate)	Moritella profunda	DIHYDROFOLATE REDUCTASE	no annotation	16	ILE C 6 ALA C 8 MET C 21 GLU C 28 LEU C 29 GLN C 30 PHE C 32 LYS C 33 SER C 50 ILE C 51 ARG C 53 LEU C 55 ARG C 58 ILE C 96 TYR C 102 THR C 115	MTX C 164
3IA4_D_MTXD164	3ia4	MTX DB00563 (Methotrexate)	Moritella profunda	DIHYDROFOLATE REDUCTASE	no annotation	15	ILE D 6 ALA D 8 MET D 21 GLU D 28 LEU D 29 PHE D 32 LYS D 33 SER D 50 ILE D 51 ARG D 53 LEU D 55 ARG D 58 ILE D 96 TYR D 102 THR D 115	MTX D 164
3IX9_A_MTXA200	3ix9	MTX DB00563 (Methotrexate)	Streptococcus pneumoniae	DIHYDROFOLATE REDUCTASE	PF00186 (DHFR_1) no annotation	13	ILE A 8 TRP A 9 ALA A 10 ASP B 20 LEU A 23 GLU A 30 LEU A 31 GLN A 32 LYS A 35 LEU A 58 ARG A 61 VAL A 100 THR A 119	MTX A 200
3IX9_B_MTXB200	3ix9	MTX DB00563 (Methotrexate)	Streptococcus pneumoniae	DIHYDROFOLATE REDUCTASE	PF00186 (DHFR_1) no annotation	14	ILE B 8 TRP B 9 ALA B 10 ARG A 22 LEU B 23 GLU B 30 LEU B 31 GLN B 32 LYS B 35 ARG B 56 LEU B 58 ARG B 61 VAL B 100 THR B 119	MTX B 200
3QXT_A_MTXA2000	3qxt	MTX DB00563 (Methotrexate)	Lama glama	ANTI-METHOTREXATE CDR1-3 GRAFT VHH	PF07686 (V-set)	12	VAL A 4 ALA A 26 ARG A 28 SER A 30 SER A 31 ARG A 32 TRP A 34 MET A 36 ARG A 74 ASN A 79 VAL A 81 ALA A 100	MTX A2000
3QXT_B_MTXB2000	3qxt	MTX DB00563 (Methotrexate)	Lama glama	ANTI-METHOTREXATE CDR1-3 GRAFT VHH	no annotation	14	VAL B 4 LEU B 6 ALA B 26 ARG B 28 SER B 30 SER B 31 ARG B 32 TRP B 34 MET B 36 ARG B 74 ASN B 79 VAL B 81 ALA B 100 TYR B 120	MTX B2000
3QXV_A_MTXA2000	3qxv	MTX DB00563 (Methotrexate)	Lama glama	ANTI-METHOTREXATE CDR1-4 GRAFT VHH	PF07686 (V-set)	13	VAL A 4 LEU A 6 ALA A 26 SER A 30 SER A 31 TRP A 34 MET A 36 ARG A 74 ASN A 76 TYR A 79 VAL A 81 ALA A 100 TYR A 120	MTX A2000
3QXV_B_MTXB2000	3qxv	MTX DB00563 (Methotrexate)	Lama glama	ANTI-METHOTREXATE CDR1-4 GRAFT VHH	no annotation	14	VAL B 4 LEU B 6 ALA B 26 ARG B 28 SER B 30 SER B 31 TRP B 34 MET B 36 ARG B 74 ASN B 76 TYR B 79 VAL B 81 ALA B 100 TYR B 120	MTX B2000
3QXV_C_MTXC2000	3qxv	MTX DB00563 (Methotrexate)	Lama glama	ANTI-METHOTREXATE CDR1-4 GRAFT VHH	no annotation	11	VAL C 4 ALA C 26 ARG C 28 SER C 30 TRP C 34 MET C 36 ARG C 74 ASN C 76 TYR C 79 VAL C 81 ALA C 100	MTX C2000
3QXV_D_MTXD2000	3qxv	MTX DB00563 (Methotrexate)	Lama glama	ANTI-METHOTREXATE CDR1-4 GRAFT VHH	no annotation	15	VAL D 4 LEU D 6 ALA D 26 ARG D 28 SER D 30 SER D 31 ARG D 32 TRP D 34 MET D 36 ARG D 74 ASN D 76 TYR D 79 VAL D 81 ALA D 100 TYR D 120	MTX D2000
3QXV_E_MTXE2000	3qxv	MTX DB00563 (Methotrexate)	Lama glama	ANTI-METHOTREXATE CDR1-4 GRAFT VHH	no annotation	13	CYS E 24 ALA E 26 ARG E 28 SER E 30 SER E 31 TRP E 34 MET E 36 ARG E 74 ASN E 76 TYR E 79 VAL E 81 ALA E 100 TYR E 120	MTX E2000
3TQ9_A_MTXA2001	3tq9	MTX DB00563 (Methotrexate)	Coxiella burnetii	DIHYDROFOLATE REDUCTASE	PF00186 (DHFR_1)	12	ILE A 6 ALA A 8 LEU A 21 ASP A 28 LEU A 29 LYS A 33 SER A 50 ILE A 51 LEU A 55 ARG A 58 ILE A 96 THR A 115	MTX A2001
4DFR_A_MTXA161	4dfr	MTX DB00563 (Methotrexate)	Escherichia coli	DIHYDROFOLATE REDUCTASE	PF00186 (DHFR_1)	14	ILE A 5 ALA A 7 ASP A 27 LEU A 28 LYS A 32 THR A 46 SER A 49 ILE A 50 ARG A 52 LEU A 54 ARG A 57 ILE A 94 TYR A 100 THR A 113	MTX A 161
4DFR_B_MTXB162	4dfr	MTX DB00563 (Methotrexate)	Escherichia coli	DIHYDROFOLATE REDUCTASE	no annotation	12	ILE B 5 ALA B 7 ASP B 27 LEU B 28 LYS B 32 ILE B 50 ARG B 52 LEU B 54 ARG B 57 ILE B 94 TYR B 100 THR B 113	MTX B 162
4GH8_A_MTXA201	4gh8	MTX DB00563 (Methotrexate)	Escherichia coli	DIHYDROFOLATE REDUCTASE	PF00186 (DHFR_1)	15	ILE A 5 ALA A 7 MET A 20 ASP A 28 LEU A 29 LYS A 33 SER A 50 ILE A 51 PRO A 52 ASN A 55 LEU A 58 ARG A 61 ILE A 98 TYR A 104 THR A 117	MTX A 201
4GH8_B_MTXB201	4gh8	MTX DB00563 (Methotrexate)	Escherichia coli	DIHYDROFOLATE REDUCTASE	no annotation	14	ILE B 5 ALA B 7 MET B 20 ASP B 28 LEU B 29 LYS B 33 SER B 50 ILE B 51 PRO B 52 ASN B 55 ARG B 61 ILE B 98 TYR B 104 THR B 117	MTX B 201
4KN0_A_MTXA301	4kn0	MTX DB00563 (Methotrexate)	Homo sapiens	FOLATE RECEPTOR BETA	PF03024 (Folate_rec)	13	TYR A 76 PHE A 78 ASP A 97 TYR A 101 GLN A 116 TRP A 118 ARG A 119 ARG A 152 GLY A 153 TRP A 154 TRP A 156 TRP A 187 SER A 190	MTX A 301
4KY8_A_MTXA603	4ky8	MTX DB00563 (Methotrexate)	Cryptosporidium hominis	BIFUNCTIONAL THYMIDYLATE SYNTHASE-DIHYDROFOLA TE REDUCTASE	PF00186 (DHFR_1) PF00303 (Thymidylat_synt)	12	VAL A 9 ALA A 11 LEU A 25 ASP A 32 LEU A 33 LYS A 34 SER A 37 SER A 61 ILE A 62 LEU A 67 ARG A 70 THR A 134	MTX A 603
4KY8_B_MTXB603	4ky8	MTX DB00563 (Methotrexate)	Cryptosporidium hominis	BIFUNCTIONAL THYMIDYLATE SYNTHASE-DIHYDROFOLA TE REDUCTASE	no annotation	12	VAL B 9 ALA B 11 LEU B 25 ASP B 32 LEU B 33 LYS B 34 SER B 37 SER B 61 ILE B 62 LEU B 67 ARG B 70 THR B 134	MTX B 603
4KY8_C_MTXC603	4ky8	MTX DB00563 (Methotrexate)	Cryptosporidium hominis	BIFUNCTIONAL THYMIDYLATE SYNTHASE-DIHYDROFOLA TE REDUCTASE	no annotation	12	VAL C 9 ALA C 11 LEU C 25 ASP C 32 LEU C 33 LYS C 34 SER C 37 SER C 61 ILE C 62 LEU C 67 ARG C 70 THR C 134	MTX C 603
4KY8_D_MTXD603	4ky8	MTX DB00563 (Methotrexate)	Cryptosporidium hominis	BIFUNCTIONAL THYMIDYLATE SYNTHASE-DIHYDROFOLA TE REDUCTASE	no annotation	12	VAL D 9 ALA D 11 LEU D 25 ASP D 32 LEU D 33 LYS D 34 SER D 37 SER D 61 ILE D 62 LEU D 67 ARG D 70 THR D 134	MTX D 603
4KY8_E_MTXE603	4ky8	MTX DB00563 (Methotrexate)	Cryptosporidium hominis	BIFUNCTIONAL THYMIDYLATE SYNTHASE-DIHYDROFOLA TE REDUCTASE	no annotation	12	VAL E 9 ALA E 11 LEU E 25 ASP E 32 LEU E 33 LYS E 34 SER E 37 SER E 61 ILE E 62 LEU E 67 ARG E 70 THR E 134	MTX E 603
4L6H_A_MTXA803	4l6h	MTX DB00563 (Methotrexate)	Candida albicans	5-METHYLTETRAHYDROPT EROYLTRIGLUTAMATE--H OMOCYSTEINE METHYLTRANSFERASE	PF01717 (Meth_synt_2) PF08267 (Meth_synt_1)	10	LYS A 19 ASP A 504 TRP A 523 SER A 526 TYR A 527 ARG A 530 TYR A 531 VAL A 532 PRO A 535 TRP A 576	MTX A 803
4L8F_B_MTXB301	4l8f	MTX DB00563 (Methotrexate)	Danio rerio	GAMMA-GLUTAMYL HYDROLASE	no annotation	11	PHE B 20 GLY B 71 GLY B 72 GLY B 73 ALA B 108 LEU B 109 GLU B 112 HIS B 169 GLN B 170 TRP B 171 HIS B 218	MTX B 301
4L8F_D_MTXD301	4l8f	MTX DB00563 (Methotrexate)	Danio rerio	GAMMA-GLUTAMYL HYDROLASE	no annotation	11	PHE D 20 GLY D 71 GLY D 72 GLY D 73 ALA D 108 LEU D 109 GLU D 112 HIS D 169 GLN D 170 TRP D 171 HIS D 218	MTX D 301
4L8W_G_MTXG301	4l8w	MTX DB00563 (Methotrexate)	Danio rerio	GAMMA-GLUTAMYL HYDROLASE	no annotation	9	PHE G 20 GLY G 71 GLY G 73 CYS G 108 LEU G 109 GLU G 112 HIS G 169 GLN G 170 TRP G 171	MTX G 301
4L8W_I_MTXI301	4l8w	MTX DB00563 (Methotrexate)	Danio rerio	GAMMA-GLUTAMYL HYDROLASE	no annotation	9	PHE I 20 GLY I 71 GLY I 73 CYS I 108 LEU I 109 GLU I 112 HIS I 169 GLN I 170 TRP I 171	MTX I 301
4P66_A_MTXA201	4p66	MTX DB00563 (Methotrexate)	Escherichia coli	DIHYDROFOLATE REDUCTASE	PF00186 (DHFR_1)	11	ILE A 5 ALA A 7 MET A 20 ASP A 27 LEU A 28 LYS A 32 LEU A 54 ARG A 57 ILE A 94 TYR A 100 THR A 113	MTX A 201
4P68_A_MTXA201	4p68	MTX DB00563 (Methotrexate)	Escherichia coli	DIHYDROFOLATE REDUCTASE	PF00186 (DHFR_1)	11	ILE A 5 MET A 20 ASP A 27 PHE A 31 LYS A 32 SER A 49 ILE A 50 ARG A 57 ILE A 94 TYR A 100 THR A 113	MTX A 201
4Q0D_A_MTXA604	4q0d	MTX DB00563 (Methotrexate)	Cryptosporidium hominis	BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLAT E SYNTHASE	PF00186 (DHFR_1) PF00303 (Thymidylat_synt)	12	VAL A 9 ALA A 11 LEU A 25 ASP A 32 LEU A 33 LYS A 34 SER A 37 ILE A 62 LEU A 67 ARG A 70 TYR A 119 THR A 134	MTX A 604
4Q0D_B_MTXB604	4q0d	MTX DB00563 (Methotrexate)	Cryptosporidium hominis	BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLAT E SYNTHASE	no annotation	12	VAL B 9 ALA B 11 LEU B 25 ASP B 32 LEU B 33 LYS B 34 SER B 37 ILE B 62 LEU B 67 ARG B 70 TYR B 119 THR B 134	MTX B 604
4Q0D_C_MTXC604	4q0d	MTX DB00563 (Methotrexate)	Cryptosporidium hominis	BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLAT E SYNTHASE	no annotation	14	VAL C 9 ALA C 11 LEU C 25 ASP C 32 LEU C 33 LYS C 34 SER C 37 SER C 61 ILE C 62 LEU C 67 ARG C 70 CYS C 113 TYR C 119 THR C 134	MTX C 604
4Q0D_D_MTXD604	4q0d	MTX DB00563 (Methotrexate)	Cryptosporidium hominis	BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLAT E SYNTHASE	no annotation	14	VAL D 9 ALA D 11 LEU D 25 ASP D 32 LEU D 33 LYS D 34 SER D 37 SER D 61 ILE D 62 LEU D 67 ARG D 70 CYS D 113 TYR D 119 THR D 134	MTX D 604
4Q0D_E_MTXE604	4q0d	MTX DB00563 (Methotrexate)	Cryptosporidium hominis	BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLAT E SYNTHASE	no annotation	12	VAL E 9 ALA E 11 LEU E 25 ASP E 32 LEU E 33 LYS E 34 SER E 37 ILE E 62 LEU E 67 ARG E 70 TYR E 119 THR E 134	MTX E 604
4QI9_A_MTXA201	4qi9	MTX DB00563 (Methotrexate)	Yersinia pestis	DIHYDROFOLATE REDUCTASE	PF00186 (DHFR_1)	12	ILE A 6 ALA A 8 ASP A 28 LEU A 29 LYS A 33 SER A 50 ILE A 51 ARG A 53 LEU A 55 ARG A 58 TYR A 101 THR A 114	MTX A 201
4QI9_B_MTXB201	4qi9	MTX DB00563 (Methotrexate)	Yersinia pestis	DIHYDROFOLATE REDUCTASE	no annotation	12	ILE B 6 ALA B 8 ASP B 28 LEU B 29 LYS B 33 SER B 50 ILE B 51 ARG B 53 LEU B 55 ARG B 58 TYR B 101 THR B 114	MTX B 201
4QI9_C_MTXC201	4qi9	MTX DB00563 (Methotrexate)	Yersinia pestis	DIHYDROFOLATE REDUCTASE	no annotation	11	ILE C 6 ALA C 8 ASP C 28 LYS C 33 SER C 50 ILE C 51 ARG C 53 LEU C 55 ARG C 58 TYR C 101 THR C 114	MTX C 201
5HI6_A_MTXA201	5hi6	MTX DB00563 (Methotrexate)	Yersinia pestis	DIHYDROFOLATE REDUCTASE	PF00186 (DHFR_1)	12	ILE A 6 ALA A 8 ASP A 28 LEU A 29 LYS A 33 SER A 50 ILE A 51 ARG A 53 LEU A 55 ARG A 58 TYR A 101 THR A 114	MTX A 201
5HI6_B_MTXB201	5hi6	MTX DB00563 (Methotrexate)	Yersinia pestis	DIHYDROFOLATE REDUCTASE	no annotation	12	ILE B 6 ALA B 8 ASP B 28 LEU B 29 LYS B 33 SER B 50 ILE B 51 ARG B 53 LEU B 55 ARG B 58 TYR B 101 THR B 114	MTX B 201
5J7W_C_MTXC402	5j7w	MTX DB00563 (Methotrexate)	Enterococcus faecalis	THYMIDYLATE SYNTHASE	no annotation	13	LEU C 55 GLU C 59 ILE C 80 TRP C 81 TRP C 84 LEU C 194 ASP C 220 LEU C 223 GLY C 224 PHE C 227 TYR C 260 ILE C 313 ALA C 314	MTX C 402
5J7W_D_MTXD402	5j7w	MTX DB00563 (Methotrexate)	Enterococcus faecalis	THYMIDYLATE SYNTHASE	no annotation	13	LEU D 55 GLU D 59 ILE D 80 TRP D 81 TRP D 84 LEU D 194 ASP D 220 LEU D 223 GLY D 224 PHE D 227 TYR D 260 ILE D 313 ALA D 314	MTX D 402
5X66_A_MTXA402	5x66	MTX DB00563 (Methotrexate)	Homo sapiens	THYMIDYLATE SYNTHASE	PF00303 (Thymidylat_synt) no annotation	12	ARG A 78 PHE A 80 ILE A 108 ASP B 119 ASP A 218 LEU A 221 GLY A 222 PHE A 225 ASN A 226 TYR A 258 MET A 311 ALA A 312	MTX A 402
5X66_B_MTXB402	5x66	MTX DB00563 (Methotrexate)	Homo sapiens	THYMIDYLATE SYNTHASE	no annotation	11	PHE B 80 ILE B 108 ASP B 218 LEU B 221 GLY B 222 PHE B 225 ASN B 226 TYR B 258 THR B 306 MET B 311 ALA B 312	MTX B 402
5X66_C_MTXC402	5x66	MTX DB00563 (Methotrexate)	Homo sapiens	THYMIDYLATE SYNTHASE	no annotation	9	ILE C 108 ASP C 218 LEU C 221 GLY C 222 PHE C 225 ASN C 226 TYR C 258 MET C 311 ALA C 312	MTX C 402
5X66_D_MTXD402	5x66	MTX DB00563 (Methotrexate)	Homo sapiens	THYMIDYLATE SYNTHASE	no annotation	10	ARG D 78 PHE D 80 ILE D 108 ASP D 218 GLY D 222 PHE D 225 ASN D 226 TYR D 258 MET D 311 ALA D 312	MTX D 402
5X66_E_MTXE402	5x66	MTX DB00563 (Methotrexate)	Homo sapiens	THYMIDYLATE SYNTHASE	no annotation	11	PHE E 80 LYS E 107 ILE E 108 ASP E 218 LEU E 221 GLY E 222 PHE E 225 ASN E 226 TYR E 258 MET E 311 ALA E 312	MTX E 402
5X66_F_MTXF402	5x66	MTX DB00563 (Methotrexate)	Homo sapiens	THYMIDYLATE SYNTHASE	no annotation	12	LYS F 77 PHE F 80 ILE F 108 ASP F 218 LEU F 221 GLY F 222 PHE F 225 TYR F 258 THR F 306 MET F 311 ALA F 312 VAL F 313	MTX F 402
6DEB_B_MTXB302	6deb	MTX DB00563 (Methotrexate)	Campylobacter jejuni	BIFUNCTIONAL PROTEIN FOLD	no annotation	13	LEU B 93 GLN B 95 LEU B 96 PRO B 97 LYS B 104 ASP B 118 PHE B 120 THR B 140 SER B 166 ILE B 168 VAL B 169 VAL B 228 THR B 265	MTX B 302
6DEB_B_MTXB303	6deb	MTX DB00563 (Methotrexate)	Campylobacter jejuni	BIFUNCTIONAL PROTEIN FOLD	no annotation	5	TYR B 47 LYS B 51 GLN B 95 GLY B 209 ILE B 230	MTX B 303

[["1AO8_A_MTXA170","1ao8","MTX","DB00563(Methotrexate)","Lactobacillus casei","DIHYDROFOLATE REDUCTASE","PF00186(DHFR_1)",16,"LEU A   4;TRP A   5;ALA A   6;LEU A  19;ASP A  26;LEU A  27;PHE A  30;ARG A  31;THR A  34;THR A  45;SER A  48;PHE A  49;LEU A  54;ARG A  57;ALA A  97;THR A 116","MTX A 170\r"],["1AXW_A_MTXA732","1axw","MTX","DB00563(Methotrexate)","Escherichia coli","THYMIDYLATE SYNTHASE","PF00303(Thymidylat_synt)",12,"LYS A  48;HIS A  51;ILE A  79;TRP A  83;LEU A 143;ASP A 169;LEU A 172;GLY A 173;PHE A 176;TYR A 209;VAL A 262;ALA A 263","MTX A 732\r"],["1AXW_B_MTXB733","1axw","MTX","DB00563(Methotrexate)","Escherichia coli","THYMIDYLATE SYNTHASE","no annotation",11,"LYS B  48;HIS B  51;ILE B  79;TRP B  80;TRP B  83;ASP B 169;LEU B 172;GLY B 173;PHE B 176;TYR B 209;VAL B 262","MTX B 733\r"],["1D1G_A_MTXA171","1d1g","MTX","DB00563(Methotrexate)","Thermotoga maritima","DIHYDROFOLATE REDUCTASE","PF00186(DHFR_1)",13,"VAL A   6;ALA A   8;ASP A  27;ARG A  28;LYS A  29;ARG A  32;GLU A  50;ILE A  51;ARG A  53;LEU A  55;ARG A  58;ILE A 100;THR A 121","MTX A 171\r"],["1D1G_B_MTXB171","1d1g","MTX","DB00563(Methotrexate)","Thermotoga maritima","DIHYDROFOLATE REDUCTASE","no annotation",12,"VAL B   6;ALA B   8;ASP B  27;ARG B  28;ARG B  32;GLU B  50;ILE B  51;ARG B  53;LEU B  55;ARG B  58;ILE B 100;THR B 121","MTX B 171\r"],["1DDR_A_MTXA200","1ddr","MTX","DB00563(Methotrexate)","Escherichia coli","DIHYDROFOLATE REDUCTASE","PF00186(DHFR_1)",14,"ILE A   5;ALA A   7;ASP A  27;LEU A  28;LYS A  32;THR A  46;SER A  49;ILE A  50;ARG A  52;LEU A  54;ARG A  57;ILE A  94;TYR A 100;THR A 113","MTX A 200\r"],["1DDR_B_MTXB200","1ddr","MTX","DB00563(Methotrexate)","Escherichia coli","DIHYDROFOLATE REDUCTASE","no annotation",14,"ILE B   5;ALA B   7;ASP B  27;LEU B  28;TRP B  30;PHE B  31;LYS B  32;ILE B  50;ARG B  52;LEU B  54;ARG B  57;ILE B  94;TYR B 100;THR B 113","MTX B 200\r"],["1DDS_A_MTXA201","1dds","MTX","DB00563(Methotrexate)","Escherichia coli","DIHYDROFOLATE REDUCTASE","PF00186(DHFR_1)",13,"ILE A   5;ALA A   7;ASP A  27;LEU A  28;LYS A  32;THR A  46;ILE A  50;ARG A  52;LEU A  54;ARG A  57;ILE A  94;TYR A 100;THR A 113","MTX A 201\r"],["1DDS_B_MTXB201","1dds","MTX","DB00563(Methotrexate)","Escherichia coli","DIHYDROFOLATE REDUCTASE","no annotation",13,"ILE B   5;ALA B   7;ASP B  27;LEU B  28;LYS B  32;SER B  49;ILE B  50;ARG B  52;LEU B  54;ARG B  57;ILE B  94;TYR B 100;THR B 113","MTX B 201\r"],["1DF7_A_MTXA501","1df7","MTX","DB00563(Methotrexate)","Mycobacterium tuberculosis","DIHYDROFOLATE REDUCTASE","PF00186(DHFR_1)",15,"ILE A   5;TRP A   6;ALA A   7;ILE A  20;ASP A  27;GLN A  28;ARG A  32;LEU A  50;PRO A  51;VAL A  54;LEU A  57;ARG A  60;ILE A  94;TYR A 100;THR A 113","MTX A 501\r"],["1DHI_A_MTXA161","1dhi","MTX","DB00563(Methotrexate)","Escherichia coli","DIHYDROFOLATE REDUCTASE","PF00186(DHFR_1)",12,"ILE A   5;ALA A   7;LEU A  28;LYS A  32;SER A  49;ILE A  50;ARG A  52;LEU A  54;ARG A  57;ILE A  94;TYR A 100;THR A 113","MTX A 161\r"],["1DHI_B_MTXB361","1dhi","MTX","DB00563(Methotrexate)","Escherichia coli","DIHYDROFOLATE REDUCTASE","no annotation",11,"ILE B   5;ALA B   7;LEU B  28;LYS B  32;ILE B  50;ARG B  52;LEU B  54;ARG B  57;ILE B  94;TYR B 100;THR B 113","MTX B 361\r"],["1DHJ_A_MTXA161","1dhj","MTX","DB00563(Methotrexate)","Escherichia coli","DIHYDROFOLATE REDUCTASE","PF00186(DHFR_1)",12,"ILE A   5;ALA A   7;LEU A  28;LYS A  32;SER A  49;ILE A  50;ARG A  52;LEU A  54;ARG A  57;ILE A  94;TYR A 100;THR A 113","MTX A 161\r"],["1DHJ_B_MTXB361","1dhj","MTX","DB00563(Methotrexate)","Escherichia coli","DIHYDROFOLATE REDUCTASE","no annotation",12,"ILE B   5;ALA B   7;LEU B  28;LYS B  32;ILE B  50;ARG B  52;LEU B  54;PRO B  55;ARG B  57;ILE B  94;TYR B 100;THR B 113","MTX B 361\r"],["1DLS_A_MTXA188","1dls","MTX","DB00563(Methotrexate)","Homo sapiens","DIHYDROFOLATE REDUCTASE","PF00186(DHFR_1)",16,"ILE A   7;ALA A   9;TYR A  22;ARG A  28;GLU A  30;PHE A  31;GLN A  35;SER A  59;ILE A  60;PRO A  61;ASN A  64;LEU A  67;ARG A  70;VAL A 115;TYR A 121;THR A 136","MTX A 188\r"],["1DRA_A_MTXA161","1dra","MTX","DB00563(Methotrexate)","Escherichia coli","DIHYDROFOLATE REDUCTASE","PF00186(DHFR_1)",13,"ILE A   5;ALA A   7;GLU A  27;LEU A  28;LYS A  32;SER A  49;ILE A  50;ARG A  52;LEU A  54;ARG A  57;ILE A  94;TYR A 100;THR A 113","MTX A 161\r"],["1DRA_B_MTXB361","1dra","MTX","DB00563(Methotrexate)","Escherichia coli","DIHYDROFOLATE REDUCTASE","no annotation",12,"ILE B   5;ALA B   7;GLU B  27;LEU B  28;LYS B  32;ILE B  50;ARG B  52;LEU B  54;ARG B  57;ILE B  94;TYR B 100;THR B 113","MTX B 361\r"],["1DRB_A_MTXA161","1drb","MTX","DB00563(Methotrexate)","Escherichia coli","DIHYDROFOLATE REDUCTASE","PF00186(DHFR_1)",12,"ILE A   5;ALA A   7;LEU A  28;LYS A  32;SER A  49;ILE A  50;ARG A  52;LEU A  54;ARG A  57;ILE A  94;TYR A 100;THR A 113","MTX A 161\r"],["1DRB_B_MTXB361","1drb","MTX","DB00563(Methotrexate)","Escherichia coli","DIHYDROFOLATE REDUCTASE","no annotation",12,"ILE B   5;ALA B   7;LEU B  28;PHE B  31;LYS B  32;ILE B  50;ARG B  52;LEU B  54;ARG B  57;ILE B  94;TYR B 100;THR B 113","MTX B 361\r"],["1DRE_A_MTXA161","1dre","MTX","DB00563(Methotrexate)","Escherichia coli","DIHYDROFOLATE REDUCTASE","PF00186(DHFR_1)",14,"ILE A   5;ALA A   7;MET A  20;ASP A  27;LEU A  28;PHE A  31;LYS A  32;SER A  49;ILE A  50;ARG A  52;LEU A  54;ARG A  57;ILE A  94;TYR A 100","MTX A 161\r"],["1E7W_A_MTXA301","1e7w","MTX","DB00563(Methotrexate)","Leishmania major","PTERIDINE REDUCTASE","PF00106(adh_short);PF13561(adh_short_C2)",12,"ARG A  17;SER A 111;PHE A 113;PRO A 115;ASP A 181;LEU A 188;TYR A 191;TYR A 194;LEU A 226;LEU A 229;ASP A 232;MET A 233","MTX A 301\r"],["1E7W_B_MTXB301","1e7w","MTX","DB00563(Methotrexate)","Leishmania major","PTERIDINE REDUCTASE","no annotation",11,"ARG B  17;SER B 111;PHE B 113;PRO B 115;ASP B 181;LEU B 188;TYR B 191;TYR B 194;LEU B 226;TRP B 238;HIS B 241","MTX B 301\r"],["1MXF_A_MTXA1278","1mxf","MTX","DB00563(Methotrexate)","Trypanosoma cruzi","PTERIDINE REDUCTASE 2","PF13561(adh_short_C2)",10,"ARG A  22;SER A 103;TYR A 105;ASP A 169;LEU A 176;TYR A 182;LEU A 214;PRO A 218;THR A 225;TYR A 229","MTX A1278\r"],["1MXF_B_MTXB2278","1mxf","MTX","DB00563(Methotrexate)","Trypanosoma cruzi","PTERIDINE REDUCTASE 2","no annotation",11,"ARG B  22;SER B 103;TYR B 105;ASP B 169;LEU B 176;PHE B 179;TYR B 182;LEU B 214;PRO B 218;THR B 225;TYR B 229","MTX B2278\r"],["1MXF_C_MTXC3278","1mxf","MTX","DB00563(Methotrexate)","Trypanosoma cruzi","PTERIDINE REDUCTASE 2","no annotation",11,"ARG C  22;SER C 103;TYR C 105;ASP C 169;LEU C 176;PHE C 179;TYR C 182;LEU C 214;PRO C 218;THR C 225;TYR C 229","MTX C3278\r"],["1MXF_D_MTXD4278","1mxf","MTX","DB00563(Methotrexate)","Trypanosoma cruzi","PTERIDINE REDUCTASE 2","no annotation",11,"ARG D  22;SER D 103;TYR D 105;ASP D 169;LEU D 176;PHE D 179;TYR D 182;LEU D 214;PRO D 218;THR D 225;TYR D 229","MTX D4278\r"],["1P33_A_MTXA351","1p33","MTX","DB00563(Methotrexate)","Leishmania tarentolae","PTERIDINE REDUCTASE 1","PF13561(adh_short_C2)",13,"ARG A  17;SER A 111;PHE A 113;PRO A 115;ASP A 181;LEU A 188;TYR A 191;TYR A 194;LEU A 226;LEU A 229;PRO A 230;MET A 233;TYR A 241","MTX A 351\r"],["1P33_B_MTXB352","1p33","MTX","DB00563(Methotrexate)","Leishmania tarentolae","PTERIDINE REDUCTASE 1","no annotation",13,"ARG B  17;SER B 111;PHE B 113;PRO B 115;ASP B 181;LEU B 188;TYR B 191;TYR B 194;LEU B 226;LEU B 229;PRO B 230;MET B 233;TYR B 241","MTX B 352\r"],["1P33_C_MTXC353","1p33","MTX","DB00563(Methotrexate)","Leishmania tarentolae","PTERIDINE REDUCTASE 1","no annotation",13,"ARG C  17;SER C 111;PHE C 113;PRO C 115;ASP C 181;LEU C 188;TYR C 191;TYR C 194;LEU C 226;LEU C 229;PRO C 230;MET C 233;TYR C 241","MTX C 353\r"],["1P33_D_MTXD354","1p33","MTX","DB00563(Methotrexate)","Leishmania tarentolae","PTERIDINE REDUCTASE 1","no annotation",12,"ARG D  17;SER D 111;PHE D 113;PRO D 115;ASP D 181;LEU D 188;TYR D 191;TYR D 194;LEU D 229;PRO D 230;MET D 233;TYR D 241","MTX D 354\r"],["1RA3_A_MTXA161","1ra3","MTX","DB00563(Methotrexate)","Escherichia coli","DIHYDROFOLATE REDUCTASE","PF00186(DHFR_1)",12,"ILE A   5;ALA A   7;ASP A  27;LEU A  28;LYS A  32;ILE A  50;ARG A  52;LEU A  54;ARG A  57;ILE A  94;TYR A 100;THR A 113","MTX A 161\r"],["1RB3_A_MTXA161","1rb3","MTX","DB00563(Methotrexate)","Escherichia coli","DIHYDROFOLATE REDUCTASE","PF00186(DHFR_1)",10,"ILE A   5;ALA A   7;ASP A  27;LEU A  28;LYS A  32;ILE A  50;ARG A  57;ILE A  94;TYR A 100;THR A 113","MTX A 161\r"],["1RB3_B_MTXB161","1rb3","MTX","DB00563(Methotrexate)","Escherichia coli","DIHYDROFOLATE REDUCTASE","no annotation",13,"ILE B   5;ALA B   7;ASP B  27;LEU B  28;TRP B  30;LYS B  32;SER B  49;ILE B  50;LEU B  54;ARG B  57;ILE B  94;TYR B 100;THR B 113","MTX B 161\r"],["1RG7_A_MTXA161","1rg7","MTX","DB00563(Methotrexate)","Escherichia coli","DIHYDROFOLATE REDUCTASE","PF00186(DHFR_1)",15,"ILE A   5;ALA A   7;ALA A  19;ASN A  23;ASP A  27;LEU A  28;LYS A  32;THR A  46;SER A  49;ILE A  50;LEU A  54;ARG A  57;ILE A  94;TYR A 100;THR A 113","MTX A 161\r"],["1RH3_A_MTXA161","1rh3","MTX","DB00563(Methotrexate)","Escherichia coli","DIHYDROFOLATE REDUCTASE","PF00186(DHFR_1)",13,"ILE A   5;MET A  20;ASP A  27;LEU A  28;PHE A  31;LYS A  32;SER A  49;ILE A  50;ARG A  52;LEU A  54;ARG A  57;ILE A  94;TYR A 100","MTX A 161\r"],["1RX3_A_MTXA161","1rx3","MTX","DB00563(Methotrexate)","Escherichia coli","DIHYDROFOLATE REDUCTASE","PF00186(DHFR_1)",15,"ILE A   5;ALA A   7;MET A  20;ASP A  27;LEU A  28;PHE A  31;LYS A  32;SER A  49;ILE A  50;ARG A  52;LEU A  54;ARG A  57;ILE A  94;TYR A 100;THR A 113","MTX A 161\r"],["1TDR_A_MTXA170","1tdr","MTX","DB00563(Methotrexate)","Escherichia coli","TELLUROMETHIONYL DIHYDROFOLATE REDUCTASE","PF00186(DHFR_1)",15,"ILE A   5;ALA A   7;ASP A  27;LEU A  28;PHE A  31;LYS A  32;THR A  46;SER A  49;ILE A  50;ARG A  52;LEU A  54;ARG A  57;ILE A  94;TYR A 100;THR A 113","MTX A 170\r"],["1TDR_B_MTXB170","1tdr","MTX","DB00563(Methotrexate)","Escherichia coli","TELLUROMETHIONYL DIHYDROFOLATE REDUCTASE","no annotation",10,"ALA B   7;ASP B  27;LEU B  28;LYS B  32;ILE B  50;ARG B  52;LEU B  54;ARG B  57;TYR B 100;THR B 113","MTX B 170\r"],["1U70_A_MTXA187","1u70","MTX","DB00563(Methotrexate)","Mus musculus","DIHYDROFOLATE REDUCTASE","PF00186(DHFR_1)",16,"ILE A   7;ALA A   9;ARG A  22;GLU A  30;PHE A  31;GLN A  35;SER A  59;ILE A  60;PRO A  61;ASN A  64;LEU A  67;LYS A  68;ARG A  70;VAL A 115;TYR A 121;THR A 136","MTX A 187\r"],["1U72_A_MTXA188","1u72","MTX","DB00563(Methotrexate)","Homo sapiens","DIHYDROFOLATE REDUCTASE","PF00186(DHFR_1)",14,"ALA A   9;LEU A  22;GLU A  30;PHE A  31;GLN A  35;SER A  59;ILE A  60;PRO A  61;ASN A  64;LEU A  67;ARG A  70;VAL A 115;TYR A 121;THR A 136","MTX A 188\r"],["2C7V_A_MTXA1272","2c7v","MTX","DB00563(Methotrexate)","Trypanosoma brucei","PTERIDINE REDUCTASE","PF13561(adh_short_C2)",9,"ARG A  14;SER A  95;PHE A  97;PRO A  99;PHE A 171;TYR A 174;PRO A 210;MET A 213;TRP A 221","MTX A1272\r"],["2C7V_B_MTXB1272","2c7v","MTX","DB00563(Methotrexate)","Trypanosoma brucei","PTERIDINE REDUCTASE","no annotation",12,"ARG B  14;SER B  95;PHE B  97;PRO B  99;ASP B 161;PHE B 171;TYR B 174;LEU B 209;PRO B 210;MET B 213;GLU B 217;TRP B 221","MTX B1272\r"],["2C7V_C_MTXC1272","2c7v","MTX","DB00563(Methotrexate)","Trypanosoma brucei","PTERIDINE REDUCTASE","no annotation",12,"ARG C  14;SER C  95;PHE C  97;PRO C  99;ASP C 161;PHE C 171;TYR C 174;LEU C 209;PRO C 210;MET C 213;GLU C 217;TRP C 221","MTX C1272\r"],["2C7V_D_MTXD1272","2c7v","MTX","DB00563(Methotrexate)","Trypanosoma brucei","PTERIDINE REDUCTASE","no annotation",10,"ARG D  14;SER D  95;PHE D  97;PRO D  99;ASP D 161;PHE D 171;TYR D 174;PRO D 210;MET D 213;TRP D 221","MTX D1272\r"],["2DRC_A_MTXA161","2drc","MTX","DB00563(Methotrexate)","Escherichia coli","DIHYDROFOLATE REDUCTASE","PF00186(DHFR_1)",13,"ILE A   5;ALA A   7;ASP A  27;LEU A  28;LYS A  32;SER A  49;ILE A  50;ARG A  52;LEU A  54;ARG A  57;ILE A  94;TYR A 100;THR A 113","MTX A 161\r"],["2DRC_B_MTXB161","2drc","MTX","DB00563(Methotrexate)","Escherichia coli","DIHYDROFOLATE REDUCTASE","no annotation",12,"ILE B   5;ALA B   7;ASP B  27;LEU B  28;LYS B  32;ILE B  50;ARG B  52;LEU B  54;ARG B  57;ILE B  94;TYR B 100;THR B 113","MTX B 161\r"],["2OIP_A_MTXA605","2oip","MTX","DB00563(Methotrexate)","Cryptosporidium hominis","CHAIN A, CRYSTAL STRUCTURE OF DHFR","PF00186(DHFR_1);PF00303(Thymidylat_synt)",14,"VAL A   9;ALA A  11;LEU A  25;ASP A  32;LEU A  33;LYS A  34;PHE A  36;SER A  37;THR A  58;ILE A  62;LEU A  67;ARG A  70;TYR A 119;THR A 134","MTX A 605\r"],["2OIP_B_MTXB609","2oip","MTX","DB00563(Methotrexate)","Cryptosporidium hominis","CHAIN A, CRYSTAL STRUCTURE OF DHFR","no annotation",14,"VAL B   9;ALA B  11;LEU B  25;ASP B  32;LEU B  33;LYS B  34;PHE B  36;SER B  37;THR B  58;ILE B  62;LEU B  67;ARG B  70;TYR B 119;THR B 134","MTX B 609\r"],["2OIP_C_MTXC613","2oip","MTX","DB00563(Methotrexate)","Cryptosporidium hominis","CHAIN A, CRYSTAL STRUCTURE OF DHFR","no annotation",12,"VAL C   9;ALA C  11;LEU C  25;ASP C  32;LEU C  33;PHE C  36;SER C  37;THR C  58;LEU C  67;ARG C  70;TYR C 119;THR C 134","MTX C 613\r"],["2OIP_D_MTXD617","2oip","MTX","DB00563(Methotrexate)","Cryptosporidium hominis","CHAIN A, CRYSTAL STRUCTURE OF DHFR","no annotation",14,"VAL D   9;ALA D  11;LEU D  25;ASP D  32;LEU D  33;PHE D  36;SER D  37;THR D  58;ILE D  62;LEU D  67;ARG D  70;CYS D 113;TYR D 119;THR D 134","MTX D 617\r"],["2OIP_E_MTXE621","2oip","MTX","DB00563(Methotrexate)","Cryptosporidium hominis","CHAIN A, CRYSTAL STRUCTURE OF DHFR","no annotation",14,"VAL E   9;ALA E  11;LEU E  25;ASP E  32;LEU E  33;LYS E  34;PHE E  36;SER E  37;THR E  58;ILE E  62;LEU E  67;ARG E  70;TYR E 119;THR E 134","MTX E 621\r"],["2QK8_A_MTXA200","2qk8","MTX","DB00563(Methotrexate)","Bacillus anthracis","DIHYDROFOLATE REDUCTASE","PF00186(DHFR_1)",16,"MET A   6;ALA A   8;LEU A  21;GLU A  28;LEU A  29;VAL A  32;LYS A  33;ASN A  47;ILE A  51;ARG A  53;LEU A  55;PRO A  56;ARG A  58;PHE A  96;TYR A 102;THR A 115","MTX A 200\r"],["3CD2_A_MTXA307","3cd2","MTX","DB00563(Methotrexate)","Pneumocystis carinii","DIHYDROFOLATE REDUCTASE","PF00186(DHFR_1)",13,"ILE A  10;LEU A  25;GLU A  32;ILE A  33;SER A  34;LYS A  37;PRO A  66;PHE A  69;LEU A  72;ARG A  75;ILE A 123;TYR A 129;THR A 144","MTX A 307\r"],["3CL9_A_MTXA602","3cl9","MTX","DB00563(Methotrexate)","Trypanosoma cruzi","BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE (DHFR-TS)","PF00186(DHFR_1);PF00303(Thymidylat_synt)",16,"VAL A  26;ALA A  28;ILE A  41;ASP A  48;MET A  49;ARG A  53;THR A  80;SER A  83;ILE A  84;PRO A  85;PHE A  88;LEU A  91;PRO A  92;ARG A  94;TYR A 160;THR A 178","MTX A 602\r"],["3DAT_A_MTXA201","3dat","MTX","DB00563(Methotrexate)","Bacillus anthracis","DIHYDROFOLATE REDUCTASE","PF00186(DHFR_1)",16,"MET A   6;ALA A   8;LEU A  21;GLU A  28;LEU A  29;GLN A  30;VAL A  32;LYS A  33;ASN A  47;ILE A  51;ARG A  53;LEU A  55;ARG A  58;PHE A  96;TYR A 102;THR A 115","MTX A 201\r"],["3DAU_A_MTXA201","3dau","MTX","DB00563(Methotrexate)","Escherichia coli","DIHYDROFOLATE REDUCTASE","PF00186(DHFR_1)",15,"ILE A   5;ALA A   7;MET A  20;ASP A  27;LEU A  28;ALA A  29;LYS A  32;SER A  49;ILE A  50;ARG A  52;LEU A  54;ARG A  57;ILE A  94;TYR A 100;THR A 113","MTX A 201\r"],["3DFR_A_MTXA164","3dfr","MTX","DB00563(Methotrexate)","Lactobacillus casei","DIHYDROFOLATE REDUCTASE","PF00186(DHFR_1)",14,"LEU A   4;TRP A   5;ALA A   6;LEU A  19;ASP A  26;LEU A  27;HIS A  28;ARG A  31;SER A  48;PRO A  50;LEU A  54;ARG A  57;ALA A  97;THR A 116","MTX A 164\r"],["3DRC_A_MTXA161","3drc","MTX","DB00563(Methotrexate)","Escherichia coli","DIHYDROFOLATE REDUCTASE","PF00186(DHFR_1)",13,"ILE A   5;ALA A   7;ASP A  27;LEU A  28;LYS A  32;SER A  49;ILE A  50;ARG A  52;LEU A  54;ARG A  57;ILE A  94;TYR A 100;THR A 113","MTX A 161\r"],["3DRC_B_MTXB361","3drc","MTX","DB00563(Methotrexate)","Escherichia coli","DIHYDROFOLATE REDUCTASE","no annotation",12,"ILE B   5;ALA B   7;ASP B  27;LEU B  28;LYS B  32;ILE B  50;ARG B  52;LEU B  54;ARG B  57;ILE B  94;TYR B 100;THR B 113","MTX B 361\r"],["3EIG_A_MTXA200","3eig","MTX","DB00563(Methotrexate)","Homo sapiens","DIHYDROFOLATE REDUCTASE","PF00186(DHFR_1)",17,"ILE A   7;ALA A   9;ASP A  21;LEU A  22;GLU A  30;ARG A  31;ARG A  32;GLU A  35;SER A  59;ILE A  60;PRO A  61;ASN A  64;LEU A  67;ARG A  70;VAL A 115;TYR A 121;THR A 136","MTX A 200\r"],["3HJ3_A_MTXA605","3hj3","MTX","DB00563(Methotrexate)","Cryptosporidium hominis","CHAIN A, CRYSTAL STRUCTURE OF DHFR","PF00186(DHFR_1);PF00303(Thymidylat_synt)",13,"VAL A   9;ALA A  11;LEU A  25;ASP A  32;LEU A  33;PHE A  36;SER A  37;THR A  58;ILE A  62;LEU A  67;ARG A  70;TYR A 119;THR A 134","MTX A 605\r"],["3HJ3_B_MTXB609","3hj3","MTX","DB00563(Methotrexate)","Cryptosporidium hominis","CHAIN A, CRYSTAL STRUCTURE OF DHFR","no annotation",14,"VAL B   9;ALA B  11;LEU B  25;ASP B  32;LEU B  33;LYS B  34;PHE B  36;SER B  37;THR B  58;ILE B  62;LEU B  67;ARG B  70;TYR B 119;THR B 134","MTX B 609\r"],["3HJ3_C_MTXC613","3hj3","MTX","DB00563(Methotrexate)","Cryptosporidium hominis","CHAIN A, CRYSTAL STRUCTURE OF DHFR","no annotation",12,"VAL C   9;ALA C  11;LEU C  25;ASP C  32;LEU C  33;PHE C  36;SER C  37;THR C  58;LEU C  67;ARG C  70;TYR C 119;THR C 134","MTX C 613\r"],["3HJ3_D_MTXD615","3hj3","MTX","DB00563(Methotrexate)","Cryptosporidium hominis","CHAIN A, CRYSTAL STRUCTURE OF DHFR","no annotation",14,"VAL D   9;ALA D  11;LEU D  25;ASP D  32;LEU D  33;PHE D  36;SER D  37;THR D  58;ILE D  62;LEU D  67;ARG D  70;CYS D 113;TYR D 119;THR D 134","MTX D 615\r"],["3IA4_A_MTXA164","3ia4","MTX","DB00563(Methotrexate)","Moritella profunda","DIHYDROFOLATE REDUCTASE","PF00186(DHFR_1)",16,"ILE A   6;ALA A   8;MET A  21;GLU A  28;LEU A  29;GLN A  30;PHE A  32;LYS A  33;SER A  50;ILE A  51;ARG A  53;LEU A  55;ARG A  58;ILE A  96;TYR A 102;THR A 115","MTX A 164\r"],["3IA4_B_MTXB164","3ia4","MTX","DB00563(Methotrexate)","Moritella profunda","DIHYDROFOLATE REDUCTASE","no annotation",16,"ILE B   6;ALA B   8;MET B  21;GLU B  28;LEU B  29;GLN B  30;PHE B  32;LYS B  33;SER B  50;ILE B  51;ARG B  53;LEU B  55;ARG B  58;ILE B  96;TYR B 102;THR B 115","MTX B 164\r"],["3IA4_C_MTXC164","3ia4","MTX","DB00563(Methotrexate)","Moritella profunda","DIHYDROFOLATE REDUCTASE","no annotation",16,"ILE C   6;ALA C   8;MET C  21;GLU C  28;LEU C  29;GLN C  30;PHE C  32;LYS C  33;SER C  50;ILE C  51;ARG C  53;LEU C  55;ARG C  58;ILE C  96;TYR C 102;THR C 115","MTX C 164\r"],["3IA4_D_MTXD164","3ia4","MTX","DB00563(Methotrexate)","Moritella profunda","DIHYDROFOLATE REDUCTASE","no annotation",15,"ILE D   6;ALA D   8;MET D  21;GLU D  28;LEU D  29;PHE D  32;LYS D  33;SER D  50;ILE D  51;ARG D  53;LEU D  55;ARG D  58;ILE D  96;TYR D 102;THR D 115","MTX D 164\r"],["3IX9_A_MTXA200","3ix9","MTX","DB00563(Methotrexate)","Streptococcus pneumoniae","DIHYDROFOLATE REDUCTASE","PF00186(DHFR_1);no annotation",13,"ILE A   8;TRP A   9;ALA A  10;ASP B  20;LEU A  23;GLU A  30;LEU A  31;GLN A  32;LYS A  35;LEU A  58;ARG A  61;VAL A 100;THR A 119","MTX A 200\r"],["3IX9_B_MTXB200","3ix9","MTX","DB00563(Methotrexate)","Streptococcus pneumoniae","DIHYDROFOLATE REDUCTASE","PF00186(DHFR_1);no annotation",14,"ILE B   8;TRP B   9;ALA B  10;ARG A  22;LEU B  23;GLU B  30;LEU B  31;GLN B  32;LYS B  35;ARG B  56;LEU B  58;ARG B  61;VAL B 100;THR B 119","MTX B 200\r"],["3QXT_A_MTXA2000","3qxt","MTX","DB00563(Methotrexate)","Lama glama","ANTI-METHOTREXATE CDR1-3 GRAFT VHH","PF07686(V-set)",12,"VAL A   4;ALA A  26;ARG A  28;SER A  30;SER A  31;ARG A  32;TRP A  34;MET A  36;ARG A  74;ASN A  79;VAL A  81;ALA A 100","MTX A2000\r"],["3QXT_B_MTXB2000","3qxt","MTX","DB00563(Methotrexate)","Lama glama","ANTI-METHOTREXATE CDR1-3 GRAFT VHH","no annotation",14,"VAL B   4;LEU B   6;ALA B  26;ARG B  28;SER B  30;SER B  31;ARG B  32;TRP B  34;MET B  36;ARG B  74;ASN B  79;VAL B  81;ALA B 100;TYR B 120","MTX B2000\r"],["3QXV_A_MTXA2000","3qxv","MTX","DB00563(Methotrexate)","Lama glama","ANTI-METHOTREXATE CDR1-4 GRAFT VHH","PF07686(V-set)",13,"VAL A   4;LEU A   6;ALA A  26;SER A  30;SER A  31;TRP A  34;MET A  36;ARG A  74;ASN A  76;TYR A  79;VAL A  81;ALA A 100;TYR A 120","MTX A2000\r"],["3QXV_B_MTXB2000","3qxv","MTX","DB00563(Methotrexate)","Lama glama","ANTI-METHOTREXATE CDR1-4 GRAFT VHH","no annotation",14,"VAL B   4;LEU B   6;ALA B  26;ARG B  28;SER B  30;SER B  31;TRP B  34;MET B  36;ARG B  74;ASN B  76;TYR B  79;VAL B  81;ALA B 100;TYR B 120","MTX B2000\r"],["3QXV_C_MTXC2000","3qxv","MTX","DB00563(Methotrexate)","Lama glama","ANTI-METHOTREXATE CDR1-4 GRAFT VHH","no annotation",11,"VAL C   4;ALA C  26;ARG C  28;SER C  30;TRP C  34;MET C  36;ARG C  74;ASN C  76;TYR C  79;VAL C  81;ALA C 100","MTX C2000\r"],["3QXV_D_MTXD2000","3qxv","MTX","DB00563(Methotrexate)","Lama glama","ANTI-METHOTREXATE CDR1-4 GRAFT VHH","no annotation",15,"VAL D   4;LEU D   6;ALA D  26;ARG D  28;SER D  30;SER D  31;ARG D  32;TRP D  34;MET D  36;ARG D  74;ASN D  76;TYR D  79;VAL D  81;ALA D 100;TYR D 120","MTX D2000\r"],["3QXV_E_MTXE2000","3qxv","MTX","DB00563(Methotrexate)","Lama glama","ANTI-METHOTREXATE CDR1-4 GRAFT VHH","no annotation",13,"CYS E  24;ALA E  26;ARG E  28;SER E  30;SER E  31;TRP E  34;MET E  36;ARG E  74;ASN E  76;TYR E  79;VAL E  81;ALA E 100;TYR E 120","MTX E2000\r"],["3TQ9_A_MTXA2001","3tq9","MTX","DB00563(Methotrexate)","Coxiella burnetii","DIHYDROFOLATE REDUCTASE","PF00186(DHFR_1)",12,"ILE A   6;ALA A   8;LEU A  21;ASP A  28;LEU A  29;LYS A  33;SER A  50;ILE A  51;LEU A  55;ARG A  58;ILE A  96;THR A 115","MTX A2001\r"],["4DFR_A_MTXA161","4dfr","MTX","DB00563(Methotrexate)","Escherichia coli","DIHYDROFOLATE REDUCTASE","PF00186(DHFR_1)",14,"ILE A   5;ALA A   7;ASP A  27;LEU A  28;LYS A  32;THR A  46;SER A  49;ILE A  50;ARG A  52;LEU A  54;ARG A  57;ILE A  94;TYR A 100;THR A 113","MTX A 161\r"],["4DFR_B_MTXB162","4dfr","MTX","DB00563(Methotrexate)","Escherichia coli","DIHYDROFOLATE REDUCTASE","no annotation",12,"ILE B   5;ALA B   7;ASP B  27;LEU B  28;LYS B  32;ILE B  50;ARG B  52;LEU B  54;ARG B  57;ILE B  94;TYR B 100;THR B 113","MTX B 162\r"],["4GH8_A_MTXA201","4gh8","MTX","DB00563(Methotrexate)","Escherichia coli","DIHYDROFOLATE REDUCTASE","PF00186(DHFR_1)",15,"ILE A   5;ALA A   7;MET A  20;ASP A  28;LEU A  29;LYS A  33;SER A  50;ILE A  51;PRO A  52;ASN A  55;LEU A  58;ARG A  61;ILE A  98;TYR A 104;THR A 117","MTX A 201\r"],["4GH8_B_MTXB201","4gh8","MTX","DB00563(Methotrexate)","Escherichia coli","DIHYDROFOLATE REDUCTASE","no annotation",14,"ILE B   5;ALA B   7;MET B  20;ASP B  28;LEU B  29;LYS B  33;SER B  50;ILE B  51;PRO B  52;ASN B  55;ARG B  61;ILE B  98;TYR B 104;THR B 117","MTX B 201\r"],["4KN0_A_MTXA301","4kn0","MTX","DB00563(Methotrexate)","Homo sapiens","FOLATE RECEPTOR BETA","PF03024(Folate_rec)",13,"TYR A  76;PHE A  78;ASP A  97;TYR A 101;GLN A 116;TRP A 118;ARG A 119;ARG A 152;GLY A 153;TRP A 154;TRP A 156;TRP A 187;SER A 190","MTX A 301\r"],["4KY8_A_MTXA603","4ky8","MTX","DB00563(Methotrexate)","Cryptosporidium hominis","BIFUNCTIONAL THYMIDYLATE SYNTHASE-DIHYDROFOLATE REDUCTASE","PF00186(DHFR_1);PF00303(Thymidylat_synt)",12,"VAL A   9;ALA A  11;LEU A  25;ASP A  32;LEU A  33;LYS A  34;SER A  37;SER A  61;ILE A  62;LEU A  67;ARG A  70;THR A 134","MTX A 603\r"],["4KY8_B_MTXB603","4ky8","MTX","DB00563(Methotrexate)","Cryptosporidium hominis","BIFUNCTIONAL THYMIDYLATE SYNTHASE-DIHYDROFOLATE REDUCTASE","no annotation",12,"VAL B   9;ALA B  11;LEU B  25;ASP B  32;LEU B  33;LYS B  34;SER B  37;SER B  61;ILE B  62;LEU B  67;ARG B  70;THR B 134","MTX B 603\r"],["4KY8_C_MTXC603","4ky8","MTX","DB00563(Methotrexate)","Cryptosporidium hominis","BIFUNCTIONAL THYMIDYLATE SYNTHASE-DIHYDROFOLATE REDUCTASE","no annotation",12,"VAL C   9;ALA C  11;LEU C  25;ASP C  32;LEU C  33;LYS C  34;SER C  37;SER C  61;ILE C  62;LEU C  67;ARG C  70;THR C 134","MTX C 603\r"],["4KY8_D_MTXD603","4ky8","MTX","DB00563(Methotrexate)","Cryptosporidium hominis","BIFUNCTIONAL THYMIDYLATE SYNTHASE-DIHYDROFOLATE REDUCTASE","no annotation",12,"VAL D   9;ALA D  11;LEU D  25;ASP D  32;LEU D  33;LYS D  34;SER D  37;SER D  61;ILE D  62;LEU D  67;ARG D  70;THR D 134","MTX D 603\r"],["4KY8_E_MTXE603","4ky8","MTX","DB00563(Methotrexate)","Cryptosporidium hominis","BIFUNCTIONAL THYMIDYLATE SYNTHASE-DIHYDROFOLATE REDUCTASE","no annotation",12,"VAL E   9;ALA E  11;LEU E  25;ASP E  32;LEU E  33;LYS E  34;SER E  37;SER E  61;ILE E  62;LEU E  67;ARG E  70;THR E 134","MTX E 603\r"],["4L6H_A_MTXA803","4l6h","MTX","DB00563(Methotrexate)","Candida albicans","5-METHYLTETRAHYDROPTEROYLTRIGLUTAMATE--HOMOCYSTEINE METHYLTRANSFERASE","PF01717(Meth_synt_2);PF08267(Meth_synt_1)",10,"LYS A  19;ASP A 504;TRP A 523;SER A 526;TYR A 527;ARG A 530;TYR A 531;VAL A 532;PRO A 535;TRP A 576","MTX A 803\r"],["4L8F_B_MTXB301","4l8f","MTX","DB00563(Methotrexate)","Danio rerio","GAMMA-GLUTAMYL HYDROLASE","no annotation",11,"PHE B  20;GLY B  71;GLY B  72;GLY B  73;ALA B 108;LEU B 109;GLU B 112;HIS B 169;GLN B 170;TRP B 171;HIS B 218","MTX B 301\r"],["4L8F_D_MTXD301","4l8f","MTX","DB00563(Methotrexate)","Danio rerio","GAMMA-GLUTAMYL HYDROLASE","no annotation",11,"PHE D  20;GLY D  71;GLY D  72;GLY D  73;ALA D 108;LEU D 109;GLU D 112;HIS D 169;GLN D 170;TRP D 171;HIS D 218","MTX D 301\r"],["4L8W_G_MTXG301","4l8w","MTX","DB00563(Methotrexate)","Danio rerio","GAMMA-GLUTAMYL HYDROLASE","no annotation",9,"PHE G  20;GLY G  71;GLY G  73;CYS G 108;LEU G 109;GLU G 112;HIS G 169;GLN G 170;TRP G 171","MTX G 301\r"],["4L8W_I_MTXI301","4l8w","MTX","DB00563(Methotrexate)","Danio rerio","GAMMA-GLUTAMYL HYDROLASE","no annotation",9,"PHE I  20;GLY I  71;GLY I  73;CYS I 108;LEU I 109;GLU I 112;HIS I 169;GLN I 170;TRP I 171","MTX I 301\r"],["4P66_A_MTXA201","4p66","MTX","DB00563(Methotrexate)","Escherichia coli","DIHYDROFOLATE REDUCTASE","PF00186(DHFR_1)",11,"ILE A   5;ALA A   7;MET A  20;ASP A  27;LEU A  28;LYS A  32;LEU A  54;ARG A  57;ILE A  94;TYR A 100;THR A 113","MTX A 201\r"],["4P68_A_MTXA201","4p68","MTX","DB00563(Methotrexate)","Escherichia coli","DIHYDROFOLATE REDUCTASE","PF00186(DHFR_1)",11,"ILE A   5;MET A  20;ASP A  27;PHE A  31;LYS A  32;SER A  49;ILE A  50;ARG A  57;ILE A  94;TYR A 100;THR A 113","MTX A 201\r"],["4Q0D_A_MTXA604","4q0d","MTX","DB00563(Methotrexate)","Cryptosporidium hominis","BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE","PF00186(DHFR_1);PF00303(Thymidylat_synt)",12,"VAL A   9;ALA A  11;LEU A  25;ASP A  32;LEU A  33;LYS A  34;SER A  37;ILE A  62;LEU A  67;ARG A  70;TYR A 119;THR A 134","MTX A 604\r"],["4Q0D_B_MTXB604","4q0d","MTX","DB00563(Methotrexate)","Cryptosporidium hominis","BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE","no annotation",12,"VAL B   9;ALA B  11;LEU B  25;ASP B  32;LEU B  33;LYS B  34;SER B  37;ILE B  62;LEU B  67;ARG B  70;TYR B 119;THR B 134","MTX B 604\r"],["4Q0D_C_MTXC604","4q0d","MTX","DB00563(Methotrexate)","Cryptosporidium hominis","BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE","no annotation",14,"VAL C   9;ALA C  11;LEU C  25;ASP C  32;LEU C  33;LYS C  34;SER C  37;SER C  61;ILE C  62;LEU C  67;ARG C  70;CYS C 113;TYR C 119;THR C 134","MTX C 604\r"],["4Q0D_D_MTXD604","4q0d","MTX","DB00563(Methotrexate)","Cryptosporidium hominis","BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE","no annotation",14,"VAL D   9;ALA D  11;LEU D  25;ASP D  32;LEU D  33;LYS D  34;SER D  37;SER D  61;ILE D  62;LEU D  67;ARG D  70;CYS D 113;TYR D 119;THR D 134","MTX D 604\r"],["4Q0D_E_MTXE604","4q0d","MTX","DB00563(Methotrexate)","Cryptosporidium hominis","BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE","no annotation",12,"VAL E   9;ALA E  11;LEU E  25;ASP E  32;LEU E  33;LYS E  34;SER E  37;ILE E  62;LEU E  67;ARG E  70;TYR E 119;THR E 134","MTX E 604\r"],["4QI9_A_MTXA201","4qi9","MTX","DB00563(Methotrexate)","Yersinia pestis","DIHYDROFOLATE REDUCTASE","PF00186(DHFR_1)",12,"ILE A   6;ALA A   8;ASP A  28;LEU A  29;LYS A  33;SER A  50;ILE A  51;ARG A  53;LEU A  55;ARG A  58;TYR A 101;THR A 114","MTX A 201\r"],["4QI9_B_MTXB201","4qi9","MTX","DB00563(Methotrexate)","Yersinia pestis","DIHYDROFOLATE REDUCTASE","no annotation",12,"ILE B   6;ALA B   8;ASP B  28;LEU B  29;LYS B  33;SER B  50;ILE B  51;ARG B  53;LEU B  55;ARG B  58;TYR B 101;THR B 114","MTX B 201\r"],["4QI9_C_MTXC201","4qi9","MTX","DB00563(Methotrexate)","Yersinia pestis","DIHYDROFOLATE REDUCTASE","no annotation",11,"ILE C   6;ALA C   8;ASP C  28;LYS C  33;SER C  50;ILE C  51;ARG C  53;LEU C  55;ARG C  58;TYR C 101;THR C 114","MTX C 201\r"],["5HI6_A_MTXA201","5hi6","MTX","DB00563(Methotrexate)","Yersinia pestis","DIHYDROFOLATE REDUCTASE","PF00186(DHFR_1)",12,"ILE A   6;ALA A   8;ASP A  28;LEU A  29;LYS A  33;SER A  50;ILE A  51;ARG A  53;LEU A  55;ARG A  58;TYR A 101;THR A 114","MTX A 201\r"],["5HI6_B_MTXB201","5hi6","MTX","DB00563(Methotrexate)","Yersinia pestis","DIHYDROFOLATE REDUCTASE","no annotation",12,"ILE B   6;ALA B   8;ASP B  28;LEU B  29;LYS B  33;SER B  50;ILE B  51;ARG B  53;LEU B  55;ARG B  58;TYR B 101;THR B 114","MTX B 201\r"],["5J7W_C_MTXC402","5j7w","MTX","DB00563(Methotrexate)","Enterococcus faecalis","THYMIDYLATE SYNTHASE","no annotation",13,"LEU C  55;GLU C  59;ILE C  80;TRP C  81;TRP C  84;LEU C 194;ASP C 220;LEU C 223;GLY C 224;PHE C 227;TYR C 260;ILE C 313;ALA C 314","MTX C 402\r"],["5J7W_D_MTXD402","5j7w","MTX","DB00563(Methotrexate)","Enterococcus faecalis","THYMIDYLATE SYNTHASE","no annotation",13,"LEU D  55;GLU D  59;ILE D  80;TRP D  81;TRP D  84;LEU D 194;ASP D 220;LEU D 223;GLY D 224;PHE D 227;TYR D 260;ILE D 313;ALA D 314","MTX D 402\r"],["5X66_A_MTXA402","5x66","MTX","DB00563(Methotrexate)","Homo sapiens","THYMIDYLATE SYNTHASE","PF00303(Thymidylat_synt);no annotation",12,"ARG A  78;PHE A  80;ILE A 108;ASP B 119;ASP A 218;LEU A 221;GLY A 222;PHE A 225;ASN A 226;TYR A 258;MET A 311;ALA A 312","MTX A 402\r"],["5X66_B_MTXB402","5x66","MTX","DB00563(Methotrexate)","Homo sapiens","THYMIDYLATE SYNTHASE","no annotation",11,"PHE B  80;ILE B 108;ASP B 218;LEU B 221;GLY B 222;PHE B 225;ASN B 226;TYR B 258;THR B 306;MET B 311;ALA B 312","MTX B 402\r"],["5X66_C_MTXC402","5x66","MTX","DB00563(Methotrexate)","Homo sapiens","THYMIDYLATE SYNTHASE","no annotation",9,"ILE C 108;ASP C 218;LEU C 221;GLY C 222;PHE C 225;ASN C 226;TYR C 258;MET C 311;ALA C 312","MTX C 402\r"],["5X66_D_MTXD402","5x66","MTX","DB00563(Methotrexate)","Homo sapiens","THYMIDYLATE SYNTHASE","no annotation",10,"ARG D  78;PHE D  80;ILE D 108;ASP D 218;GLY D 222;PHE D 225;ASN D 226;TYR D 258;MET D 311;ALA D 312","MTX D 402\r"],["5X66_E_MTXE402","5x66","MTX","DB00563(Methotrexate)","Homo sapiens","THYMIDYLATE SYNTHASE","no annotation",11,"PHE E  80;LYS E 107;ILE E 108;ASP E 218;LEU E 221;GLY E 222;PHE E 225;ASN E 226;TYR E 258;MET E 311;ALA E 312","MTX E 402\r"],["5X66_F_MTXF402","5x66","MTX","DB00563(Methotrexate)","Homo sapiens","THYMIDYLATE SYNTHASE","no annotation",12,"LYS F  77;PHE F  80;ILE F 108;ASP F 218;LEU F 221;GLY F 222;PHE F 225;TYR F 258;THR F 306;MET F 311;ALA F 312;VAL F 313","MTX F 402\r"],["6DEB_B_MTXB302","6deb","MTX","DB00563(Methotrexate)","Campylobacter jejuni","BIFUNCTIONAL PROTEIN FOLD","no annotation",13,"LEU B  93;GLN B  95;LEU B  96;PRO B  97;LYS B 104;ASP B 118;PHE B 120;THR B 140;SER B 166;ILE B 168;VAL B 169;VAL B 228;THR B 265","MTX B 302\r"],["6DEB_B_MTXB303","6deb","MTX","DB00563(Methotrexate)","Campylobacter jejuni","BIFUNCTIONAL PROTEIN FOLD","no annotation",5,"TYR B  47;LYS B  51;GLN B  95;GLY B 209;ILE B 230","MTX B 303\r"]]