DRUG BINDING INTERFACES MAPPED TO 'LEVOLEUCOVORIN'
DrReposER ID | PDB | Ligand | Organism | Macromolecule | Pfam | Res. | Interface | HETATM |
---|---|---|---|---|---|---|---|---|
1DFO_A_FFOA1002 | 1dfo | FFO DB11596(Levoleucovorin) | Escherichia coli | SERINEHYDROXYMETHYLTRANSFERASE | NonePF00464(SHMT) | 20 | GLU B 57TYR B 64TYR B 65LEU A 121GLY A 124HIS A 126LEU A 127VAL A 133SER A 175ALA A 176SER D 245GLU D 246GLU D 247PHE B 257PRO B 258ASN A 347SER A 355PRO A 356PHE A 357ARG A 363 | FFO A1002 |
1DFO_B_FFOB2002 | 1dfo | FFO DB11596(Levoleucovorin) | Escherichia coli | SERINEHYDROXYMETHYLTRANSFERASE | NonePF00464(SHMT) | 17 | GLU A 57TYR A 64TYR A 65LEU B 121GLY B 124HIS B 126LEU B 127VAL B 133SER B 175ALA B 176PHE A 257PRO A 258ASN B 347SER B 355PRO B 356PHE B 357ARG B 363 | FFO B2002 |
1DFO_C_FFOC3002 | 1dfo | FFO DB11596(Levoleucovorin) | Escherichia coli | SERINEHYDROXYMETHYLTRANSFERASE | None | 20 | GLU D 57TYR D 64TYR D 65LEU C 121GLY C 124HIS C 126LEU C 127VAL C 133SER C 175ALA C 176SER B 245GLU B 246GLU B 247PHE D 257PRO D 258ASN C 347SER C 355PRO C 356PHE C 357ARG C 363 | FFO C3002 |
1DFO_D_FFOD4002 | 1dfo | FFO DB11596(Levoleucovorin) | Escherichia coli | SERINEHYDROXYMETHYLTRANSFERASE | None | 17 | GLU C 57TYR C 64TYR C 65LEU D 121GLY D 124HIS D 126LEU D 127VAL D 133SER D 175ALA D 176PHE C 257PRO C 258ASN D 347SER D 355PRO D 356PHE D 357ARG D 363 | FFO D4002 |
1EQB_A_FFOA1293 | 1eqb | FFO DB11596(Levoleucovorin) | Escherichia coli | SERINEHYDROXYMETHYLTRANSFERASE | NonePF00464(SHMT) | 18 | GLU B 57TYR B 64LEU A 121GLY A 124HIS A 126LEU A 127VAL A 133SER A 175ALA A 176SER D 245GLU D 246GLU D 247PHE B 257ASN A 347SER A 355PRO A 356PHE A 357ARG A 363 | FFO A1293 |
1EQB_B_FFOB2293 | 1eqb | FFO DB11596(Levoleucovorin) | Escherichia coli | SERINEHYDROXYMETHYLTRANSFERASE | NonePF00464(SHMT) | 15 | GLU A 57TYR A 64LEU B 121GLY B 124HIS B 126LEU B 127VAL B 133SER B 175ALA B 176PHE A 257ASN B 347SER B 355PRO B 356PHE B 357ARG B 363 | FFO B2293 |
1EQB_C_FFOC3293 | 1eqb | FFO DB11596(Levoleucovorin) | Escherichia coli | SERINEHYDROXYMETHYLTRANSFERASE | None | 18 | GLU D 57TYR D 64LEU C 121GLY C 124HIS C 126LEU C 127VAL C 133SER C 175ALA C 176SER B 245GLU B 246GLU B 247PHE D 257ASN C 347SER C 355PRO C 356PHE C 357ARG C 363 | FFO C3293 |
1EQB_D_FFOD4293 | 1eqb | FFO DB11596(Levoleucovorin) | Escherichia coli | SERINEHYDROXYMETHYLTRANSFERASE | None | 15 | GLU C 57TYR C 64LEU D 121GLY D 124HIS D 126LEU D 127VAL D 133SER D 175ALA D 176PHE C 257ASN D 347SER D 355PRO D 356PHE D 357ARG D 363 | FFO D4293 |
1JOL_A_FFOA161 | 1jol | FFO DB11596(Levoleucovorin) | Escherichia coli | DIHYDROFOLATEREDUCTASE | PF00186(DHFR_1) | 13 | ILE A 5ALA A 7ASP A 27LEU A 28TRP A 30PHE A 31LYS A 32ILE A 50ARG A 52LEU A 54ARG A 57TYR A 100THR A 113 | FFO A 161 |
1JOL_B_FFOB361 | 1jol | FFO DB11596(Levoleucovorin) | Escherichia coli | DIHYDROFOLATEREDUCTASE | None | 13 | ILE B 5ALA B 7ASP B 27LEU B 28PHE B 31LYS B 32ILE B 50ARG B 52LEU B 54PRO B 55ARG B 57TYR B 100THR B 113 | FFO B 361 |
1JOM_A_FFOA161 | 1jom | FFO DB11596(Levoleucovorin) | Escherichia coli | DIHYDROFOLATEREDUCTASE | PF00186(DHFR_1) | 11 | ALA A 7GLU A 17ASP A 27LEU A 28PHE A 31LYS A 32ILE A 50LEU A 54ARG A 57TYR A 100THR A 113 | FFO A 161 |
1PJ7_A_FFOA2887 | 1pj7 | FFO DB11596(Levoleucovorin) | Arthrobacterglobiformis | N,N-DIMETHYLGLYCINEOXIDASE | PF01266(GCV_T_C)PF01571(GCV_T)PF08669(FAO_M)PF16350(DAO) | 15 | MET A 505LEU A 508TYR A 539ASP A 552THR A 554GLY A 566ASN A 568TYR A 631PHE A 632LEU A 649TYR A 651GLU A 658TYR A 660TYR A 699PHE A 719 | FFO A2887 |
1WOP_A_FFOA2887 | 1wop | FFO DB11596(Levoleucovorin) | Thermotogamaritima | AMINOMETHYLTRANSFERASE | PF01571(GCV_T)PF08669(GCV_T_C) | 15 | MET A 51TYR A 83ASP A 96VAL A 98TYR A 100VAL A 110ASN A 112TYR A 168TYR A 169TYR A 188GLU A 195ARG A 227TYR A 236TRP A 256ARG A 362 | FFO A2887 |
1WOP_A_FFOA2888 | 1wop | FFO DB11596(Levoleucovorin) | Thermotogamaritima | AMINOMETHYLTRANSFERASE | PF01571(GCV_T)PF08669(GCV_T_C) | 10 | LEU A 55GLU A 106LEU A 108ILE A 137GLU A 160LYS A 173ILE A 175GLU A 180LEU A 182MET A 197 | FFO A2888 |
2VMY_A_FFOA505 | 2vmy | FFO DB11596(Levoleucovorin) | Geobacillusstearothermophilus | SERINEHYDROXYMETHYLTRANSFERASE | NonePF00464(SHMT) | 18 | GLU A 53TYR A 60TYR A 61LEU B 117GLY B 120HIS B 122LEU B 123VAL B 129SER B 172ALA B 173LYS A 248PHE A 251PRO A 252ASN B 341SER B 349PRO B 350GLY B 351ARG B 357 | FFO A 505 |
2VMY_B_FFOB505 | 2vmy | FFO DB11596(Levoleucovorin) | Geobacillusstearothermophilus | SERINEHYDROXYMETHYLTRANSFERASE | NonePF00464(SHMT) | 17 | GLU B 53TYR B 60TYR B 61LEU A 117GLY A 120HIS A 122LEU A 123VAL A 129SER A 172ALA A 173PHE B 251ASN A 339ASN A 341SER A 349PRO A 350GLY A 351ARG A 357 | FFO B 505 |
3UWL_B_FOZB316 | 3uwl | FOZ DB11596(Levoleucovorin) | Enterococcusfaecalis | THYMIDYLATE SYNTHASE | PF00303(Thymidylat_synt) | 14 | LEU B 55ILE B 80TRP B 81TRP B 84LEU B 194HIS B 198ASP B 220LEU B 223GLY B 224PHE B 227ASN B 228TYR B 260ILE B 313ALA B 314 | FOZ B 316 |
3UWL_D_FOZD316 | 3uwl | FOZ DB11596(Levoleucovorin) | Enterococcusfaecalis | THYMIDYLATE SYNTHASE | None | 13 | LEU D 55TRP D 81TRP D 84LEU D 194HIS D 198ASP D 220LEU D 223GLY D 224PHE D 227ASN D 228TYR D 260ILE D 313ALA D 314 | FOZ D 316 |
6QXS_B_FOZB403 | 6qxs | FOZ DB11596(Levoleucovorin) | Enterococcusfaecalis | THYMIDYLATE SYNTHASE | PF00303(Thymidylat_synt) | 13 | PRO B 52LEU B 55ILE B 80TRP B 81TRP B 84LEU B 194ASP B 220LEU B 223GLY B 224PHE B 227ASN B 228TYR B 260ILE B 313 | FOZ B 403 |
6QXS_D_FOZD403 | 6qxs | FOZ DB11596(Levoleucovorin) | Enterococcusfaecalis | THYMIDYLATE SYNTHASE | None | 12 | PRO D 52LEU D 55ILE D 80TRP D 81TRP D 84LEU D 194ASP D 220LEU D 223GLY D 224ASN D 228ILE D 313ALA D 314 | FOZ D 403 |
6QYA_B_FOZB401 | 6qya | FOZ DB11596(Levoleucovorin) | Enterococcusfaecalis | THYMIDYLATE SYNTHASE | PF00303(Thymidylat_synt) | 14 | LEU B 55ILE B 80TRP B 81TRP B 84LEU B 194HIS B 198ASP B 220LEU B 223GLY B 224PHE B 227ASN B 228TYR B 260ILE B 313ALA B 314 | FOZ B 401 |
6QYA_D_FOZD401 | 6qya | FOZ DB11596(Levoleucovorin) | Enterococcusfaecalis | THYMIDYLATE SYNTHASE | None | 14 | LEU D 55ILE D 80TRP D 81TRP D 84LEU D 194HIS D 198ASP D 220LEU D 223GLY D 224PHE D 227ASN D 228TYR D 260ILE D 313ALA D 314 | FOZ D 401 |
6R2E_A_FFOA403 | 6r2e | FFO DB11596(Levoleucovorin) | Homo sapiens | THYMIDYLATE SYNTHASE | PF00303(Thymidylat_synt) | 12 | PHE A 80ILE A 108TRP A 109ASN A 112LEU A 192ASP A 218LEU A 221GLY A 222PHE A 225ASN A 226TYR A 258MET A 311 | FFO A 403 |
6R2E_B_FFOB403 | 6r2e | FFO DB11596(Levoleucovorin) | Homo sapiens | THYMIDYLATE SYNTHASE | None | 10 | PHE B 80ILE B 108TRP B 109ASN B 112LEU B 192ASP B 218LEU B 221GLY B 222ASN B 226MET B 311 | FFO B 403 |
6R2E_C_FFOC404 | 6r2e | FFO DB11596(Levoleucovorin) | Homo sapiens | THYMIDYLATE SYNTHASE | None | 10 | PHE C 80ILE C 108TRP C 109ASN C 112LEU C 192ASP C 218LEU C 221GLY C 222ASN C 226MET C 311 | FFO C 404 |
6R2E_D_FFOD403 | 6r2e | FFO DB11596(Levoleucovorin) | Homo sapiens | THYMIDYLATE SYNTHASE | None | 10 | PHE D 80ILE D 108TRP D 109ASN D 112LEU D 192ASP D 218LEU D 221GLY D 222ASN D 226MET D 311 | FFO D 403 |
6R2E_E_FFOE403 | 6r2e | FFO DB11596(Levoleucovorin) | Homo sapiens | THYMIDYLATE SYNTHASE | PF00303(Thymidylat_synt) | 13 | PHE E 80ILE E 108TRP E 109ASN E 112TYR E 135LEU E 192ASP E 218LEU E 221GLY E 222PHE E 225ASN E 226MET E 311ALA E 312 | FFO E 403 |
6R2E_F_FFOF403 | 6r2e | FFO DB11596(Levoleucovorin) | Homo sapiens | THYMIDYLATE SYNTHASE | None | 11 | PHE F 80ILE F 108TRP F 109ASN F 112LEU F 192ASP F 218LEU F 221GLY F 222ASN F 226MET F 311ALA F 312 | FFO F 403 |
6R2E_G_FFOG403 | 6r2e | FFO DB11596(Levoleucovorin) | Homo sapiens | THYMIDYLATE SYNTHASE | None | 11 | PHE G 80ILE G 108TRP G 109ASN G 112LEU G 192ASP G 218LEU G 221GLY G 222PHE G 225ASN G 226MET G 311 | FFO G 403 |
6R2E_H_FFOH403 | 6r2e | FFO DB11596(Levoleucovorin) | Homo sapiens | THYMIDYLATE SYNTHASE | None | 12 | PHE H 80ILE H 108TRP H 109ASN H 112TYR H 135LEU H 192ASP H 218LEU H 221GLY H 222ASN H 226MET H 311ALA H 312 | FFO H 403 |