DRUG BINDING INTERFACES MAPPED TO 'ERYTHROMYCIN'

List of Binding Interfaces
(Click on the entry ID to view details of interfaces and pattern clusters)
(Note that ASSAM search use only 3-12 residue containing patterns)

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DrReposER ID	PDB	Ligand	Organism	Macromolecule	Pfam	Res.	Interface	HETATM
2IYF_A_ERYA1400	2iyf	ERY DB00199 (Erythromycin)	Streptomyces antibioticus	OLEANDOMYCIN GLYCOSYLTRANSFERASE	PF00201 (UDPGT)	11	HIS A 19 TRP A 73 ASN A 80 VAL A 81 PHE A 84 ILE A 111 TYR A 114 ASN A 133 ALA A 182 SER A 183 ASP A 329	ERY A1400
2IYF_B_ERYB1399	2iyf	ERY DB00199 (Erythromycin)	Streptomyces antibioticus	OLEANDOMYCIN GLYCOSYLTRANSFERASE	None	13	HIS B 19 TRP B 73 ASN B 80 VAL B 81 PHE B 84 ILE B 111 TYR B 114 ASN B 133 LEU B 134 TYR B 140 ALA B 182 SER B 183 ASP B 329	ERY B1399
2J0D_A_ERYA1498	2j0d	ERY DB00199 (Erythromycin)	Homo sapiens	CYTOCHROME P450 3A4	PF00067 (p450)	12	PHE A 57 ARG A 106 PHE A 108 SER A 119 ILE A 120 ILE A 301 PHE A 304 ALA A 305 THR A 309 ALA A 370 ARG A 372 GLU A 374	ERY A1498
3AOC_C_ERYC3402	3aoc	ERY DB00199 (Erythromycin)	Escherichia coli	ACRIFLAVINE RESISTANCE PROTEIN B	None	15	SER C 79 THR C 91 SER C 134 SER C 135 LYS C 292 MET C 573 MET C 575 PHE C 615 PHE C 617 ILE C 626 PHE C 666 LEU C 674 ASP C 681 GLU C 683 GLU C 826	ERY C3402
3FRQ_A_ERYA195	3frq	ERY DB00199 (Erythromycin)	Escherichia coli	REPRESSOR PROTEIN MPHR(A)	None PF00440 (TetR_N)	18	THR A 17 LYS A 21 VAL A 66 TYR A 69 LEU A 89 SER A 92 MET A 93 ASN A 102 TYR A 103 SER A 106 ARG A 122 ASN A 123 VAL A 126 HIS A 147 ILE A 150 ALA A 151 THR A 154 MET B 155	ERY A 195
3FRQ_B_ERYB195	3frq	ERY DB00199 (Erythromycin)	Escherichia coli	REPRESSOR PROTEIN MPHR(A)	None PF00440 (TetR_N)	20	THR B 17 LEU B 20 LYS B 21 GLY B 62 VAL B 66 TYR B 69 LEU B 89 SER B 92 MET B 93 ASN B 102 TYR B 103 ILE B 105 SER B 106 ARG B 122 ASN B 123 VAL B 126 HIS B 147 ILE B 150 ALA B 151 MET A 155	ERY B 195
3J7Z_A_ERYA9000	3j7z	ERY DB00199 (Erythromycin)	Escherichia coli; Staphylococcus aureus	23S RRNA; 50S RIBOSOMAL PROTEIN L22; ERMCL NASCENT CHAIN	PF00237 (Ribosomal_L22) PF08253 (Leader_Erm)	3	ILE a 81 PHE a 82 LYS S 90	ERY A9000
4M83_A_ERYA1400	4m83	ERY DB00199 (Erythromycin)	Streptomyces antibioticus	OLEANDOMYCIN GLYCOSYLTRANSFERASE	PF00201 (UDPGT)	11	HIS A 19 TRP A 73 ASN A 80 VAL A 81 PHE A 84 ILE A 111 TYR A 114 ASN A 133 LEU A 134 ALA A 182 SER A 183	ERY A1400
4M83_B_ERYB501	4m83	ERY DB00199 (Erythromycin)	Streptomyces antibioticus	OLEANDOMYCIN GLYCOSYLTRANSFERASE	None	11	HIS B 19 TRP B 73 ASN B 80 VAL B 81 PHE B 84 ILE B 111 TYR B 114 ASN B 133 TYR B 140 ALA B 182 SER B 183	ERY B 501
4ZJL_A_ERYA1101	4zjl	ERY DB00199 (Erythromycin)	Escherichia coli	MULTIDRUG EFFLUX PUMP SUBUNIT ACRB	PF00873 (ACR_tran)	17	SER A 79 ASN A 81 SER A 134 SER A 135 LYS A 292 MET A 573 MET A 575 PHE A 615 PHE A 617 GLU A 673 ASP A 681 GLU A 683 GLU A 826 LEU A 828 THR A 860 GLY A 861 MET A 862	ERY A1101
4ZJL_D_ERYD1101	4zjl	ERY DB00199 (Erythromycin)	Escherichia coli	MULTIDRUG EFFLUX PUMP SUBUNIT ACRB	None	14	SER D 79 ASN D 81 SER D 134 SER D 135 LYS D 292 PHE D 615 PHE D 617 LEU D 674 ASP D 681 ASN D 719 ARG D 815 GLU D 817 GLU D 826 MET D 862	ERY D1101
4ZJO_A_ERYA1101	4zjo	ERY DB00199 (Erythromycin)	Escherichia coli	MULTIDRUG EFFLUX PUMP SUBUNIT ACRB	PF00873 (ACR_tran)	14	SER A 79 ASN A 81 SER A 134 SER A 135 LYS A 292 MET A 573 ALA A 617 ASP A 681 GLU A 683 GLU A 817 GLU A 826 LEU A 828 THR A 860 MET A 862	ERY A1101
4ZJO_D_ERYD1101	4zjo	ERY DB00199 (Erythromycin)	Escherichia coli	MULTIDRUG EFFLUX PUMP SUBUNIT ACRB	None	11	TYR D 77 SER D 79 THR D 91 SER D 134 LYS D 292 ALA D 617 GLU D 673 ASP D 681 GLU D 826 THR D 860 GLY D 861	ERY D1101
4ZJQ_A_ERYA1101	4zjq	ERY DB00199 (Erythromycin)	Escherichia coli	MULTIDRUG EFFLUX PUMP SUBUNIT ACRB	PF00873 (ACR_tran)	11	SER A 79 SER A 134 LYS A 292 MET A 573 LEU A 663 GLU A 668 ASP A 676 ASN A 714 GLU A 821 GLY A 856 MET A 857	ERY A1101
4ZJQ_D_ERYD1101	4zjq	ERY DB00199 (Erythromycin)	Escherichia coli	MULTIDRUG EFFLUX PUMP SUBUNIT ACRB	None	12	SER D 79 ASN D 81 THR D 91 SER D 134 LYS D 292 MET D 573 ILE D 621 PHE D 661 ASP D 676 ARG D 810 GLU D 812 GLU D 821	ERY D1101
5IGP_A_ERYA402	5igp	ERY DB00199 (Erythromycin)	Escherichia coli	MACROLIDE 2'-PHOSPHOTRANSFERAS E	PF01636 (APH)	16	MET A 103 ILE A 105 PRO A 112 ASP A 200 TYR A 202 VAL A 203 GLU A 222 ALA A 233 ALA A 234 MET A 237 VAL A 238 LEU A 270 GLY A 273 THR A 276 TYR A 277 PHE A 280	ERY A 402
5IGT_A_ERYA402	5igt	ERY DB00199 (Erythromycin)	Escherichia coli	MACROLIDE 2'-PHOSPHOTRANSFERAS E	PF01636 (APH)	17	MET A 103 ILE A 105 PRO A 112 ASP A 200 TYR A 202 VAL A 203 HIS A 205 GLU A 222 ALA A 233 ALA A 234 MET A 237 VAL A 238 LEU A 270 GLY A 273 THR A 276 TYR A 277 PHE A 280	ERY A 402
5IGY_A_ERYA403	5igy	ERY DB00199 (Erythromycin)	Escherichia coli	MACROLIDE 2'-PHOSPHOTRANSFERAS E II	PF01636 (APH)	18	ILE A 103 HIS A 105 GLY A 108 ASN A 109 TYR A 110 ASP A 200 HIS A 202 GLU A 222 ILE A 233 PHE A 234 ARG A 237 ALA A 238 TYR A 273 SER A 276 ILE A 277 PHE A 280 TYR A 289 MET A 292	ERY A 403
5IH0_A_ERYA404	5ih0	ERY DB00199 (Erythromycin)	Escherichia coli	MACROLIDE 2'-PHOSPHOTRANSFERAS E II	PF01636 (APH)	18	ILE A 103 HIS A 105 GLY A 108 ASN A 109 TYR A 110 ASP A 200 HIS A 202 GLU A 222 ILE A 233 PHE A 234 ARG A 237 ALA A 238 TYR A 273 SER A 276 ILE A 277 PHE A 280 TYR A 289 MET A 292	ERY A 404
5IWU_A_ERYA404	5iwu	ERY DB00199 (Erythromycin)	Escherichia coli	MACROLIDE 2'-PHOSPHOTRANSFERAS E II	PF01636 (APH)	18	ILE A 103 HIS A 105 GLY A 108 TYR A 110 ASP A 200 HIS A 202 THR A 221 GLU A 222 ILE A 233 PHE A 234 ARG A 237 ALA A 238 TYR A 273 SER A 276 ILE A 277 PHE A 280 TYR A 289 MET A 292	ERY A 404
5YK2_A_ERYA501	5yk2	ERY DB00199 (Erythromycin)	Mycobacterium tuberculosis	PROBABLE CONSERVED ATP-BINDING PROTEIN ABC TRANSPORTER	PF01636 (APH) PF03109 (ABC1)	11	GLU A 196 GLU A 199 ARG A 200 GLY A 285 ASP A 286 ALA A 307 ALA A 309 PRO A 310 ILE A 407 ARG A 410 VAL A 411	ERY A 501

[["2IYF_A_ERYA1400","2iyf","ERY","DB00199(Erythromycin)","Streptomyces antibioticus","OLEANDOMYCIN GLYCOSYLTRANSFERASE","PF00201(UDPGT)",11,"HIS A  19;TRP A  73;ASN A  80;VAL A  81;PHE A  84;ILE A 111;TYR A 114;ASN A 133;ALA A 182;SER A 183;ASP A 329","ERY A1400\r"],["2IYF_B_ERYB1399","2iyf","ERY","DB00199(Erythromycin)","Streptomyces antibioticus","OLEANDOMYCIN GLYCOSYLTRANSFERASE","None",13,"HIS B  19;TRP B  73;ASN B  80;VAL B  81;PHE B  84;ILE B 111;TYR B 114;ASN B 133;LEU B 134;TYR B 140;ALA B 182;SER B 183;ASP B 329","ERY B1399\r"],["2J0D_A_ERYA1498","2j0d","ERY","DB00199(Erythromycin)","Homo sapiens","CYTOCHROME P450 3A4","PF00067(p450)",12,"PHE A  57;ARG A 106;PHE A 108;SER A 119;ILE A 120;ILE A 301;PHE A 304;ALA A 305;THR A 309;ALA A 370;ARG A 372;GLU A 374","ERY A1498\r"],["3AOC_C_ERYC3402","3aoc","ERY","DB00199(Erythromycin)","Escherichia coli","ACRIFLAVINE RESISTANCE PROTEIN B","None",15,"SER C  79;THR C  91;SER C 134;SER C 135;LYS C 292;MET C 573;MET C 575;PHE C 615;PHE C 617;ILE C 626;PHE C 666;LEU C 674;ASP C 681;GLU C 683;GLU C 826","ERY C3402\r"],["3FRQ_A_ERYA195","3frq","ERY","DB00199(Erythromycin)","Escherichia coli","REPRESSOR PROTEIN MPHR(A)","None;PF00440(TetR_N)",18,"THR A  17;LYS A  21;VAL A  66;TYR A  69;LEU A  89;SER A  92;MET A  93;ASN A 102;TYR A 103;SER A 106;ARG A 122;ASN A 123;VAL A 126;HIS A 147;ILE A 150;ALA A 151;THR A 154;MET B 155","ERY A 195\r"],["3FRQ_B_ERYB195","3frq","ERY","DB00199(Erythromycin)","Escherichia coli","REPRESSOR PROTEIN MPHR(A)","None;PF00440(TetR_N)",20,"THR B  17;LEU B  20;LYS B  21;GLY B  62;VAL B  66;TYR B  69;LEU B  89;SER B  92;MET B  93;ASN B 102;TYR B 103;ILE B 105;SER B 106;ARG B 122;ASN B 123;VAL B 126;HIS B 147;ILE B 150;ALA B 151;MET A 155","ERY B 195\r"],["3J7Z_A_ERYA9000","3j7z","ERY","DB00199(Erythromycin)","Escherichia coli;Staphylococcus aureus","23S RRNA;50S RIBOSOMAL PROTEIN L22;ERMCL NASCENT CHAIN","PF00237(Ribosomal_L22);PF08253(Leader_Erm)",3,"ILE a  81;PHE a  82;LYS S  90","ERY A9000\r"],["4M83_A_ERYA1400","4m83","ERY","DB00199(Erythromycin)","Streptomyces antibioticus","OLEANDOMYCIN GLYCOSYLTRANSFERASE","PF00201(UDPGT)",11,"HIS A  19;TRP A  73;ASN A  80;VAL A  81;PHE A  84;ILE A 111;TYR A 114;ASN A 133;LEU A 134;ALA A 182;SER A 183","ERY A1400\r"],["4M83_B_ERYB501","4m83","ERY","DB00199(Erythromycin)","Streptomyces antibioticus","OLEANDOMYCIN GLYCOSYLTRANSFERASE","None",11,"HIS B  19;TRP B  73;ASN B  80;VAL B  81;PHE B  84;ILE B 111;TYR B 114;ASN B 133;TYR B 140;ALA B 182;SER B 183","ERY B 501\r"],["4ZJL_A_ERYA1101","4zjl","ERY","DB00199(Erythromycin)","Escherichia coli","MULTIDRUG EFFLUX PUMP SUBUNIT ACRB","PF00873(ACR_tran)",17,"SER A  79;ASN A  81;SER A 134;SER A 135;LYS A 292;MET A 573;MET A 575;PHE A 615;PHE A 617;GLU A 673;ASP A 681;GLU A 683;GLU A 826;LEU A 828;THR A 860;GLY A 861;MET A 862","ERY A1101\r"],["4ZJL_D_ERYD1101","4zjl","ERY","DB00199(Erythromycin)","Escherichia coli","MULTIDRUG EFFLUX PUMP SUBUNIT ACRB","None",14,"SER D  79;ASN D  81;SER D 134;SER D 135;LYS D 292;PHE D 615;PHE D 617;LEU D 674;ASP D 681;ASN D 719;ARG D 815;GLU D 817;GLU D 826;MET D 862","ERY D1101\r"],["4ZJO_A_ERYA1101","4zjo","ERY","DB00199(Erythromycin)","Escherichia coli","MULTIDRUG EFFLUX PUMP SUBUNIT ACRB","PF00873(ACR_tran)",14,"SER A  79;ASN A  81;SER A 134;SER A 135;LYS A 292;MET A 573;ALA A 617;ASP A 681;GLU A 683;GLU A 817;GLU A 826;LEU A 828;THR A 860;MET A 862","ERY A1101\r"],["4ZJO_D_ERYD1101","4zjo","ERY","DB00199(Erythromycin)","Escherichia coli","MULTIDRUG EFFLUX PUMP SUBUNIT ACRB","None",11,"TYR D  77;SER D  79;THR D  91;SER D 134;LYS D 292;ALA D 617;GLU D 673;ASP D 681;GLU D 826;THR D 860;GLY D 861","ERY D1101\r"],["4ZJQ_A_ERYA1101","4zjq","ERY","DB00199(Erythromycin)","Escherichia coli","MULTIDRUG EFFLUX PUMP SUBUNIT ACRB","PF00873(ACR_tran)",11,"SER A  79;SER A 134;LYS A 292;MET A 573;LEU A 663;GLU A 668;ASP A 676;ASN A 714;GLU A 821;GLY A 856;MET A 857","ERY A1101\r"],["4ZJQ_D_ERYD1101","4zjq","ERY","DB00199(Erythromycin)","Escherichia coli","MULTIDRUG EFFLUX PUMP SUBUNIT ACRB","None",12,"SER D  79;ASN D  81;THR D  91;SER D 134;LYS D 292;MET D 573;ILE D 621;PHE D 661;ASP D 676;ARG D 810;GLU D 812;GLU D 821","ERY D1101\r"],["5IGP_A_ERYA402","5igp","ERY","DB00199(Erythromycin)","Escherichia coli","MACROLIDE 2'-PHOSPHOTRANSFERASE","PF01636(APH)",16,"MET A 103;ILE A 105;PRO A 112;ASP A 200;TYR A 202;VAL A 203;GLU A 222;ALA A 233;ALA A 234;MET A 237;VAL A 238;LEU A 270;GLY A 273;THR A 276;TYR A 277;PHE A 280","ERY A 402\r"],["5IGT_A_ERYA402","5igt","ERY","DB00199(Erythromycin)","Escherichia coli","MACROLIDE 2'-PHOSPHOTRANSFERASE","PF01636(APH)",17,"MET A 103;ILE A 105;PRO A 112;ASP A 200;TYR A 202;VAL A 203;HIS A 205;GLU A 222;ALA A 233;ALA A 234;MET A 237;VAL A 238;LEU A 270;GLY A 273;THR A 276;TYR A 277;PHE A 280","ERY A 402\r"],["5IGY_A_ERYA403","5igy","ERY","DB00199(Erythromycin)","Escherichia coli","MACROLIDE 2'-PHOSPHOTRANSFERASE II","PF01636(APH)",18,"ILE A 103;HIS A 105;GLY A 108;ASN A 109;TYR A 110;ASP A 200;HIS A 202;GLU A 222;ILE A 233;PHE A 234;ARG A 237;ALA A 238;TYR A 273;SER A 276;ILE A 277;PHE A 280;TYR A 289;MET A 292","ERY A 403\r"],["5IH0_A_ERYA404","5ih0","ERY","DB00199(Erythromycin)","Escherichia coli","MACROLIDE 2'-PHOSPHOTRANSFERASE II","PF01636(APH)",18,"ILE A 103;HIS A 105;GLY A 108;ASN A 109;TYR A 110;ASP A 200;HIS A 202;GLU A 222;ILE A 233;PHE A 234;ARG A 237;ALA A 238;TYR A 273;SER A 276;ILE A 277;PHE A 280;TYR A 289;MET A 292","ERY A 404\r"],["5IWU_A_ERYA404","5iwu","ERY","DB00199(Erythromycin)","Escherichia coli","MACROLIDE 2'-PHOSPHOTRANSFERASE II","PF01636(APH)",18,"ILE A 103;HIS A 105;GLY A 108;TYR A 110;ASP A 200;HIS A 202;THR A 221;GLU A 222;ILE A 233;PHE A 234;ARG A 237;ALA A 238;TYR A 273;SER A 276;ILE A 277;PHE A 280;TYR A 289;MET A 292","ERY A 404\r"],["5YK2_A_ERYA501","5yk2","ERY","DB00199(Erythromycin)","Mycobacterium tuberculosis","PROBABLE CONSERVED ATP-BINDING PROTEIN ABC TRANSPORTER","PF01636(APH);PF03109(ABC1)",11,"GLU A 196;GLU A 199;ARG A 200;GLY A 285;ASP A 286;ALA A 307;ALA A 309;PRO A 310;ILE A 407;ARG A 410;VAL A 411","ERY A 501\r"]]