DRUG BINDING INTERFACES MAPPED TO 'DB00877'

List of Binding Interfaces
(Click on the entry ID to view details of interfaces and pattern clusters)
(Note that ASSAM search use only 3-12 residue containing patterns)

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DrReposER ID	PDB	Ligand	Organism	Macromolecule	Pfam	Res.	Interface	HETATM
1C9H_A_RAPA108	1c9h	RAP DB00877 (Sirolimus)	Homo sapiens	FKBP12.6	PF00254 (FKBP_C)	13	TYR A 26 ASP A 37 PHE A 46 GLN A 53 GLU A 54 VAL A 55 ILE A 56 PHE A 59 TYR A 82 HIS A 87 VAL A 90 ILE A 91 PHE A 99	RAP A 108
1FAP_A_RAPA108	1fap	RAP DB00877 (Sirolimus)	Homo sapiens	FK506-BINDING PROTEIN; FRAP	PF00254 (FKBP_C) PF08771 (FRB_dom)	20	TYR A 26 ASP A 37 PHE A 46 GLN A 53 GLU A 54 VAL A 55 ILE A 56 TRP A 59 TYR A 82 ILE A 90 ILE A 91 PHE A 99 LEU B2031 SER B2035 ARG B2036 PHE B2039 GLY B2040 TRP B2101 TYR B2105 PHE B2108	RAP A 108
1FKB_A_RAPA108	1fkb	RAP DB00877 (Sirolimus)	Homo sapiens	FK506 BINDING PROTEIN	PF00254 (FKBP_C)	12	TYR A 26 ASP A 37 PHE A 46 GLN A 53 GLU A 54 VAL A 55 ILE A 56 TRP A 59 TYR A 82 HIS A 87 ILE A 90 PHE A 99	RAP A 108
1FKL_A_RAPA108	1fkl	RAP DB00877 (Sirolimus)	Bos taurus	FK506 BINDING PROTEIN	PF00254 (FKBP_C)	12	TYR A 26 ASP A 37 PHE A 46 GLU A 54 VAL A 55 ILE A 56 TRP A 59 TYR A 82 HIS A 87 ILE A 90 ILE A 91 PHE A 99	RAP A 108
1PBK_A_RAPA225	1pbk	RAP DB00877 (Sirolimus)	Homo sapiens	FKBP25	PF00254 (FKBP_C)	12	TYR A 135 ASP A 146 LEU A 162 GLY A 169 LYS A 170 VAL A 171 ILE A 172 TRP A 175 TYR A 198 ALA A 206 ILE A 208 PHE A 216	RAP A 225
2DG3_A_RAPA501	2dg3	RAP DB00877 (Sirolimus)	Homo sapiens	FK506-BINDING PROTEIN 1A	PF00254 (FKBP_C)	11	TYR A 26 ASP A 37 PHE A 46 GLU A 54 VAL A 55 ILE A 56 TRP A 59 TYR A 82 HIS A 87 ILE A 90 PHE A 99	RAP A 501
2DG4_A_RAPA501	2dg4	RAP DB00877 (Sirolimus)	Homo sapiens	FK506-BINDING PROTEIN 1A	PF00254 (FKBP_C)	11	TYR A 26 ASP A 37 PHE A 46 GLU A 54 VAL A 55 ILE A 56 PHE A 59 TYR A 82 HIS A 87 ILE A 90 PHE A 99	RAP A 501
2DG9_A_RAPA501	2dg9	RAP DB00877 (Sirolimus)	Homo sapiens	FK506-BINDING PROTEIN 1A	PF00254 (FKBP_C)	11	TYR A 26 ASP A 37 PHE A 46 GLU A 54 VAL A 55 ILE A 56 LEU A 59 TYR A 82 HIS A 87 ILE A 90 PHE A 99	RAP A 501
2VCD_A_RAPA138	2vcd	RAP DB00877 (Sirolimus)	Legionella pneumophila	OUTER MEMBRANE PROTEIN MIP	PF00254 (FKBP_C) PF01346 (FKBP_N)	11	TYR A 55 PHE A 65 ASP A 66 PHE A 77 GLN A 81 VAL A 82 ILE A 83 PRO A 84 TRP A 86 TYR A 109 VAL A 114	RAP A 138
3KZ7_A_RAPA225	3kz7	RAP DB00877 (Sirolimus)	Mus musculus	FK506-BINDING PROTEIN 3	PF00254 (FKBP_C)	10	TYR A 135 ASP A 146 LEU A 162 LYS A 170 VAL A 171 ILE A 172 TRP A 175 TYR A 198 ILE A 208 PHE A 216	RAP A 225
4DRH_A_RAPA201	4drh	RAP DB00877 (Sirolimus)	Homo sapiens	PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP5; SERINE/THREONINE-PRO TEIN KINASE MTOR	PF00254 (FKBP_C) PF08771 (FRB_dom)	21	TYR A 57 ASP A 68 HIS A 71 PHE A 77 GLN A 85 VAL A 86 ILE A 87 TRP A 90 TYR A 113 LYS A 121 ILE A 122 PHE A 130 LEU B2031 SER B2035 ARG B2036 PHE B2039 THR B2098 TRP B2101 ASP B2102 TYR B2105 PHE B2108	RAP A 201
4DRH_D_RAPD201	4drh	RAP DB00877 (Sirolimus)	Homo sapiens	PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP5; SERINE/THREONINE-PRO TEIN KINASE MTOR	PF08771 (FRB_dom) no annotation	22	TYR D 57 ASP D 68 HIS D 71 PHE D 77 GLN D 85 VAL D 86 ILE D 87 TRP D 90 TYR D 113 PRO D 120 ILE D 122 PHE D 130 GLU B2022 LEU E2031 SER E2035 ARG E2036 PHE E2039 THR E2098 TRP E2101 ASP E2102 TYR E2105 PHE E2108	RAP D 201
4DRI_A_RAPA201	4dri	RAP DB00877 (Sirolimus)	Homo sapiens	PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP5; SERINE/THREONINE-PRO TEIN KINASE MTOR	PF00254 (FKBP_C) PF08771 (FRB_dom)	21	TYR A 57 ASP A 68 ARG A 73 PHE A 77 GLN A 85 VAL A 86 ILE A 87 TRP A 90 TYR A 113 ILE A 122 PHE A 130 LEU B2031 GLU B2032 SER B2035 ARG B2036 PHE B2039 THR B2098 TRP B2101 ASP B2102 TYR B2105 PHE B2108	RAP A 201
4DRJ_A_RAPA201	4drj	RAP DB00877 (Sirolimus)	Homo sapiens	PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP4; SERINE/THREONINE-PRO TEIN KINASE MTOR	PF00254 (FKBP_C) PF08771 (FRB_dom)	19	TYR A 57 ASP A 68 PHE A 77 GLU A 85 VAL A 86 ILE A 87 TRP A 90 TYR A 113 LYS A 121 ILE A 122 PHE A 130 LEU B2031 SER B2035 PHE B2039 THR B2098 TRP B2101 ASP B2102 TYR B2105 PHE B2108	RAP A 201
4QT2_A_RAPA202	4qt2	RAP DB00877 (Sirolimus)	Plasmodium falciparum	FK506-BINDING PROTEIN (FKBP)-TYPE PEPTIDYL-PROPYL ISOMERASE	PF00254 (FKBP_C)	10	TYR A 44 ASP A 56 PHE A 65 GLU A 73 VAL A 74 ILE A 75 TRP A 78 TYR A 101 ILE A 110 PHE A 118	RAP A 202
4QT3_A_RAPA202	4qt3	RAP DB00877 (Sirolimus)	Plasmodium falciparum	FK506-BINDING PROTEIN (FKBP)-TYPE PEPTIDYL-PROPYL ISOMERASE	PF00254 (FKBP_C)	10	TYR A 44 ASP A 56 PHE A 65 GLU A 73 VAL A 74 ILE A 75 TRP A 78 TYR A 101 ILE A 110 PHE A 118	RAP A 202
5FLC_C_RAPC999	5flc	RAP DB00877 (Sirolimus)	Homo sapiens; Spodoptera frugiperda	FKBP; SERINE/THREONINE-PRO TEIN KINASE MTOR	PF00454 (PI3_PI4_kinase) PF02259 (FAT) PF02260 (FATC) PF08771 (FRB_dom) no annotation	8	GLU B2032 SER B2035 PHE B2039 GLY B2040 THR B2098 TRP B2101 TYR B2105 PHE B2108	RAP C 999
5FLC_G_RAPG999	5flc	RAP DB00877 (Sirolimus)	Homo sapiens; Spodoptera frugiperda	FKBP; SERINE/THREONINE-PRO TEIN KINASE MTOR	no annotation	8	GLU F2032 SER F2035 PHE F2039 GLY F2040 THR F2098 TRP F2101 TYR F2105 PHE F2108	RAP G 999
5GPG_A_RAPA301	5gpg	RAP DB00877 (Sirolimus)	Homo sapiens	PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP3; SERINE/THREONINE-PRO TEIN KINASE MTOR	PF00254 (FKBP_C) PF08771 (FRB_dom)	20	TYR A 135 ASP A 146 LEU A 162 LYS A 170 VAL A 171 ILE A 172 TRP A 175 TYR A 198 ALA A 206 ILE A 208 PHE A 216 LEU B2031 SER B2035 ARG B2036 PHE B2039 THR B2098 TRP B2101 ASP B2102 TYR B2105 PHE B2108	RAP A 301
5HKG_A_RAPA201	5hkg	RAP DB00877 (Sirolimus)	Homo sapiens	PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP1B	PF00254 (FKBP_C)	13	TYR A 26 ASP A 37 PHE A 46 GLN A 53 GLU A 54 VAL A 55 ILE A 56 PHE A 59 TYR A 82 HIS A 87 VAL A 90 ILE A 91 PHE A 99	RAP A 201

[["1C9H_A_RAPA108","1c9h","RAP","DB00877(Sirolimus)","Homo sapiens","FKBP12.6","PF00254(FKBP_C)",13,"TYR A  26;ASP A  37;PHE A  46;GLN A  53;GLU A  54;VAL A  55;ILE A  56;PHE A  59;TYR A  82;HIS A  87;VAL A  90;ILE A  91;PHE A  99","RAP A 108\r"],["1FAP_A_RAPA108","1fap","RAP","DB00877(Sirolimus)","Homo sapiens","FK506-BINDING PROTEIN;FRAP","PF00254(FKBP_C);PF08771(FRB_dom)",20,"TYR A  26;ASP A  37;PHE A  46;GLN A  53;GLU A  54;VAL A  55;ILE A  56;TRP A  59;TYR A  82;ILE A  90;ILE A  91;PHE A  99;LEU B2031;SER B2035;ARG B2036;PHE B2039;GLY B2040;TRP B2101;TYR B2105;PHE B2108","RAP A 108\r"],["1FKB_A_RAPA108","1fkb","RAP","DB00877(Sirolimus)","Homo sapiens","FK506 BINDING PROTEIN","PF00254(FKBP_C)",12,"TYR A  26;ASP A  37;PHE A  46;GLN A  53;GLU A  54;VAL A  55;ILE A  56;TRP A  59;TYR A  82;HIS A  87;ILE A  90;PHE A  99","RAP A 108\r"],["1FKL_A_RAPA108","1fkl","RAP","DB00877(Sirolimus)","Bos taurus","FK506 BINDING PROTEIN","PF00254(FKBP_C)",12,"TYR A  26;ASP A  37;PHE A  46;GLU A  54;VAL A  55;ILE A  56;TRP A  59;TYR A  82;HIS A  87;ILE A  90;ILE A  91;PHE A  99","RAP A 108\r"],["1PBK_A_RAPA225","1pbk","RAP","DB00877(Sirolimus)","Homo sapiens","FKBP25","PF00254(FKBP_C)",12,"TYR A 135;ASP A 146;LEU A 162;GLY A 169;LYS A 170;VAL A 171;ILE A 172;TRP A 175;TYR A 198;ALA A 206;ILE A 208;PHE A 216","RAP A 225\r"],["2DG3_A_RAPA501","2dg3","RAP","DB00877(Sirolimus)","Homo sapiens","FK506-BINDING PROTEIN 1A","PF00254(FKBP_C)",11,"TYR A  26;ASP A  37;PHE A  46;GLU A  54;VAL A  55;ILE A  56;TRP A  59;TYR A  82;HIS A  87;ILE A  90;PHE A  99","RAP A 501\r"],["2DG4_A_RAPA501","2dg4","RAP","DB00877(Sirolimus)","Homo sapiens","FK506-BINDING PROTEIN 1A","PF00254(FKBP_C)",11,"TYR A  26;ASP A  37;PHE A  46;GLU A  54;VAL A  55;ILE A  56;PHE A  59;TYR A  82;HIS A  87;ILE A  90;PHE A  99","RAP A 501\r"],["2DG9_A_RAPA501","2dg9","RAP","DB00877(Sirolimus)","Homo sapiens","FK506-BINDING PROTEIN 1A","PF00254(FKBP_C)",11,"TYR A  26;ASP A  37;PHE A  46;GLU A  54;VAL A  55;ILE A  56;LEU A  59;TYR A  82;HIS A  87;ILE A  90;PHE A  99","RAP A 501\r"],["2VCD_A_RAPA138","2vcd","RAP","DB00877(Sirolimus)","Legionella pneumophila","OUTER MEMBRANE PROTEIN MIP","PF00254(FKBP_C);PF01346(FKBP_N)",11,"TYR A  55;PHE A  65;ASP A  66;PHE A  77;GLN A  81;VAL A  82;ILE A  83;PRO A  84;TRP A  86;TYR A 109;VAL A 114","RAP A 138\r"],["3KZ7_A_RAPA225","3kz7","RAP","DB00877(Sirolimus)","Mus musculus","FK506-BINDING PROTEIN 3","PF00254(FKBP_C)",10,"TYR A 135;ASP A 146;LEU A 162;LYS A 170;VAL A 171;ILE A 172;TRP A 175;TYR A 198;ILE A 208;PHE A 216","RAP A 225\r"],["4DRH_A_RAPA201","4drh","RAP","DB00877(Sirolimus)","Homo sapiens","PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP5;SERINE\/THREONINE-PROTEIN KINASE MTOR","PF00254(FKBP_C);PF08771(FRB_dom)",21,"TYR A  57;ASP A  68;HIS A  71;PHE A  77;GLN A  85;VAL A  86;ILE A  87;TRP A  90;TYR A 113;LYS A 121;ILE A 122;PHE A 130;LEU B2031;SER B2035;ARG B2036;PHE B2039;THR B2098;TRP B2101;ASP B2102;TYR B2105;PHE B2108","RAP A 201\r"],["4DRH_D_RAPD201","4drh","RAP","DB00877(Sirolimus)","Homo sapiens","PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP5;SERINE\/THREONINE-PROTEIN KINASE MTOR","PF08771(FRB_dom);no annotation",22,"TYR D  57;ASP D  68;HIS D  71;PHE D  77;GLN D  85;VAL D  86;ILE D  87;TRP D  90;TYR D 113;PRO D 120;ILE D 122;PHE D 130;GLU B2022;LEU E2031;SER E2035;ARG E2036;PHE E2039;THR E2098;TRP E2101;ASP E2102;TYR E2105;PHE E2108","RAP D 201\r"],["4DRI_A_RAPA201","4dri","RAP","DB00877(Sirolimus)","Homo sapiens","PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP5;SERINE\/THREONINE-PROTEIN KINASE MTOR","PF00254(FKBP_C);PF08771(FRB_dom)",21,"TYR A  57;ASP A  68;ARG A  73;PHE A  77;GLN A  85;VAL A  86;ILE A  87;TRP A  90;TYR A 113;ILE A 122;PHE A 130;LEU B2031;GLU B2032;SER B2035;ARG B2036;PHE B2039;THR B2098;TRP B2101;ASP B2102;TYR B2105;PHE B2108","RAP A 201\r"],["4DRJ_A_RAPA201","4drj","RAP","DB00877(Sirolimus)","Homo sapiens","PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP4;SERINE\/THREONINE-PROTEIN KINASE MTOR","PF00254(FKBP_C);PF08771(FRB_dom)",19,"TYR A  57;ASP A  68;PHE A  77;GLU A  85;VAL A  86;ILE A  87;TRP A  90;TYR A 113;LYS A 121;ILE A 122;PHE A 130;LEU B2031;SER B2035;PHE B2039;THR B2098;TRP B2101;ASP B2102;TYR B2105;PHE B2108","RAP A 201\r"],["4QT2_A_RAPA202","4qt2","RAP","DB00877(Sirolimus)","Plasmodium falciparum","FK506-BINDING PROTEIN (FKBP)-TYPE PEPTIDYL-PROPYL ISOMERASE","PF00254(FKBP_C)",10,"TYR A  44;ASP A  56;PHE A  65;GLU A  73;VAL A  74;ILE A  75;TRP A  78;TYR A 101;ILE A 110;PHE A 118","RAP A 202\r"],["4QT3_A_RAPA202","4qt3","RAP","DB00877(Sirolimus)","Plasmodium falciparum","FK506-BINDING PROTEIN (FKBP)-TYPE PEPTIDYL-PROPYL ISOMERASE","PF00254(FKBP_C)",10,"TYR A  44;ASP A  56;PHE A  65;GLU A  73;VAL A  74;ILE A  75;TRP A  78;TYR A 101;ILE A 110;PHE A 118","RAP A 202\r"],["5FLC_C_RAPC999","5flc","RAP","DB00877(Sirolimus)","Homo sapiens;Spodoptera frugiperda","FKBP;SERINE\/THREONINE-PROTEIN KINASE MTOR","PF00454(PI3_PI4_kinase);PF02259(FAT);PF02260(FATC);PF08771(FRB_dom);no annotation",8,"GLU B2032;SER B2035;PHE B2039;GLY B2040;THR B2098;TRP B2101;TYR B2105;PHE B2108","RAP C 999\r"],["5FLC_G_RAPG999","5flc","RAP","DB00877(Sirolimus)","Homo sapiens;Spodoptera frugiperda","FKBP;SERINE\/THREONINE-PROTEIN KINASE MTOR","no annotation",8,"GLU F2032;SER F2035;PHE F2039;GLY F2040;THR F2098;TRP F2101;TYR F2105;PHE F2108","RAP G 999\r"],["5GPG_A_RAPA301","5gpg","RAP","DB00877(Sirolimus)","Homo sapiens","PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP3;SERINE\/THREONINE-PROTEIN KINASE MTOR","PF00254(FKBP_C);PF08771(FRB_dom)",20,"TYR A 135;ASP A 146;LEU A 162;LYS A 170;VAL A 171;ILE A 172;TRP A 175;TYR A 198;ALA A 206;ILE A 208;PHE A 216;LEU B2031;SER B2035;ARG B2036;PHE B2039;THR B2098;TRP B2101;ASP B2102;TYR B2105;PHE B2108","RAP A 301\r"],["5HKG_A_RAPA201","5hkg","RAP","DB00877(Sirolimus)","Homo sapiens","PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP1B","PF00254(FKBP_C)",13,"TYR A  26;ASP A  37;PHE A  46;GLN A  53;GLU A  54;VAL A  55;ILE A  56;PHE A  59;TYR A  82;HIS A  87;VAL A  90;ILE A  91;PHE A  99","RAP A 201\r"]]