DRUG BINDING INTERFACES MAPPED TO 'DB00773'

List of Binding Interfaces

(Click on the entry ID to view details of interfaces and pattern clusters)
(Note that ASSAM search use only 3-12 residue containing patterns)
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DrReposER ID PDB Ligand Organism Macromolecule Pfam Res. Interface HETATM
3QX3_A_EVPA1 3qx3 EVP

DB00773
(Etoposide)
Homo sapiens DNA TOPOISOMERASE
2-BETA
PF00521
(DNA_topoisoIV)
PF01751
(Toprim)
PF16898
(TOPRIM_C)
5 GLY A 478
ASP A 479
ARG A 503
GLN A 778
MET A 782
EVP A   1
3QX3_D_EVPD1 3qx3 EVP

DB00773
(Etoposide)
;
Homo sapiens
DNA TOPOISOMERASE
2-BETA
no annotation 5 GLY B 478
ASP B 479
ARG B 503
GLN B 778
MET B 782
EVP D   1
4LB9_A_EVPA605 4lb9 EVP

DB00773
(Etoposide)
Homo sapiens SERUM ALBUMIN PF00273
(Serum_albumin)
10 ASP A 108
HIS A 146
TYR A 148
SER A 193
ARG A 197
CYS A 200
ALA A 201
GLN A 204
HIS A 247
GLY A 248
EVP A 605
5CDN_G_EVPG2101 5cdn EVP

DB00773
(Etoposide)
Staphylococcus
aureus;
synthetic
construct
DNA GYRASE SUBUNIT
A;
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B
PF00521
(DNA_topoisoIV)
PF00986
(DNA_gyraseB_C)
PF01751
(Toprim)
no annotation
6 SER A  84
GLU A  88
GLY B 436
ASP B 437
ARG B 458
GLY B 459
EVP G2101
5CDN_N_EVPN2101 5cdn EVP

DB00773
(Etoposide)
Staphylococcus
aureus;
synthetic
construct
DNA GYRASE SUBUNIT
A;
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B
no annotation 6 SER R  84
GLU R  88
GLY S 436
ASP S 437
ARG S 458
GLY S 459
EVP N2101
5CDN_O_EVPO2101 5cdn EVP

DB00773
(Etoposide)
Staphylococcus
aureus;
synthetic
construct
DNA GYRASE SUBUNIT
A;
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B
no annotation 6 SER C  84
GLU C  88
GLY D 436
ASP D 437
ARG D 458
GLY D 459
EVP O2101
5CDN_P_EVPP2101 5cdn EVP

DB00773
(Etoposide)
Staphylococcus
aureus;
synthetic
construct
DNA GYRASE SUBUNIT
A;
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B
no annotation 6 SER T  84
GLU T  88
GLY U 436
ASP U 437
ARG U 458
GLY U 459
EVP P2101
5CDP_H_EVPH2101 5cdp EVP

DB00773
(Etoposide)
Staphylococcus
aureus;
synthetic
construct
DNA GYRASE SUBUNIT
A;
DNA GYRASE SUBUNIT B
PF00521
(DNA_topoisoIV)
PF00986
(DNA_gyraseB_C)
PF01751
(Toprim)
no annotation
6 SER A  84
GLU A  88
GLY B 436
ASP B 437
ARG B 458
GLY B 459
EVP H2101
5GWK_D_EVPD102 5gwk EVP

DB00773
(Etoposide)
Homo sapiens;
synthetic
construct
DNA TOPOISOMERASE
2-ALPHA
no annotation 4 GLY B 462
ASP B 463
ARG B 487
MET B 766
EVP D 102
5GWK_F_EVPF102 5gwk EVP

DB00773
(Etoposide)
Homo sapiens;
synthetic
construct
DNA TOPOISOMERASE
2-ALPHA
PF00521
(DNA_topoisoIV)
PF01751
(Toprim)
PF16898
(TOPRIM_C)
no annotation
5 GLY A 462
ASP A 463
ARG A 487
MET A 762
MET A 766
EVP F 102
5ZRF_D_EVPD101 5zrf EVP

DB00773
(Etoposide)
no annotation 5 GLY B 478
ASP B 479
ARG B 503
GLN B 778
MET B 782
EVP D 101
5ZRF_F_EVPF1301 5zrf EVP

DB00773
(Etoposide)
no annotation 4 GLY A 478
ASP A 479
ARG A 503
MET A 782
EVP F1301