DRUG BINDING INTERFACES MAPPED TO 'DB00145'

List of Binding Interfaces

(Click on the entry ID to view details of interfaces and pattern clusters)
(Note that ASSAM search use only 3-12 residue containing patterns)
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DrReposER ID PDB Ligand Organism Macromolecule Pfam Res. Interface HETATM
1EQB_A_GLYA1292 1eqb GLY

DB00145
(Glycine)
Escherichia coli SERINE
HYDROXYMETHYLTRANSFE
RASE
None
PF00464
(SHMT)
8 SER A  35
TYR B  55
PHE B  65
HIS A 126
SER A 175
HIS A 203
LYS A 229
ARG A 363
GLY A1292
1EQB_B_GLYB2292 1eqb GLY

DB00145
(Glycine)
Escherichia coli SERINE
HYDROXYMETHYLTRANSFE
RASE
None
PF00464
(SHMT)
8 SER B  35
TYR A  55
PHE A  65
HIS B 126
SER B 175
HIS B 203
LYS B 229
ARG B 363
GLY B2292
1EQB_C_GLYC3292 1eqb GLY

DB00145
(Glycine)
Escherichia coli SERINE
HYDROXYMETHYLTRANSFE
RASE
None 8 SER C  35
TYR D  55
PHE D  65
HIS C 126
SER C 175
HIS C 203
LYS C 229
ARG C 363
GLY C3292
1EQB_D_GLYD4292 1eqb GLY

DB00145
(Glycine)
Escherichia coli SERINE
HYDROXYMETHYLTRANSFE
RASE
None 8 SER D  35
TYR C  55
PHE C  65
HIS D 126
SER D 175
HIS D 203
LYS D 229
ARG D 363
GLY D4292
2RLC_A_GLYA333 2rlc GLY

DB00145
(Glycine)
Clostridium
perfringens
CHOLOYLGLYCINE
HYDROLASE
PF02275
(CBAH)
3 ASN A  82
ASN A 175
ARG A 228
GLY A 333
2VMY_A_GLYA502 2vmy GLY

DB00145
(Glycine)
Geobacillus
stearothermophilu
s
SERINE
HYDROXYMETHYLTRANSFE
RASE
None
PF00464
(SHMT)
7 SER A  31
TYR B  51
TYR B  61
HIS A 122
HIS A 200
LYS A 226
ARG A 357
GLY A 502
2VMY_B_GLYB502 2vmy GLY

DB00145
(Glycine)
Geobacillus
stearothermophilu
s
SERINE
HYDROXYMETHYLTRANSFE
RASE
None
PF00464
(SHMT)
8 SER B  31
TYR A  51
TYR A  61
HIS B 122
SER B 172
HIS B 200
LYS B 226
ARG B 357
GLY B 502
2YS6_A_GLYA431 2ys6 GLY

DB00145
(Glycine)
Geobacillus
kaustophilus
PHOSPHORIBOSYLGLYCIN
AMIDE SYNTHETASE
PF01071
(GARS_A)
PF02843
(GARS_C)
PF02844
(GARS_N)
8 ASP A 212
LYS A 214
TYR A 269
ASN A 285
ARG A 287
GLY A 289
PRO A 291
GLU A 292
GLY A 431
2Z0A_A_GLYA73 2z0a GLY

DB00145
(Glycine)
Influenza A virus NONSTRUCTURAL
PROTEIN 1
PF00600
(Flu_NS1)
5 GLN A  10
ALA A  60
GLN A  63
ILE A  64
ARG A  67
GLY A  73
2Z0A_A_GLYA74 2z0a GLY

DB00145
(Glycine)
Influenza A virus NONSTRUCTURAL
PROTEIN 1
PF00600
(Flu_NS1)
4 LYS A  20
LEU A  36
ARG A  37
GLN A  40
GLY A  74
2Z0A_C_GLYC73 2z0a GLY

DB00145
(Glycine)
Influenza A virus NONSTRUCTURAL
PROTEIN 1
None 4 ASP C  12
ASP C  39
SER C  42
ARG C  46
GLY C  73
2Z0A_D_GLYD73 2z0a GLY

DB00145
(Glycine)
Influenza A virus NONSTRUCTURAL
PROTEIN 1
None 4 ARG C  35
ASP D  39
SER D  42
ARG D  46
GLY D  73
2ZT7_A_GLYA1300 2zt7 GLY

DB00145
(Glycine)
Homo sapiens GLYCYL-TRNA
SYNTHETASE
PF00587
(HGTP_anticodon)
PF03129
(tRNA-synt_2b)
7 GLU A 245
ARG A 277
GLU A 296
TYR A 386
ARG A 410
GLU A 522
SER A 524
GLY A1300
3PGY_A_GLYA510 3pgy GLY

DB00145
(Glycine)
Staphylococcus
aureus
SERINE
HYDROXYMETHYLTRANSFE
RASE
None
PF00464
(SHMT)
6 GLU A  27
ILE A  29
GLU A  32
PHE A  34
ASN B  49
ALA A 363
GLY A 510
3PGY_B_GLYB509 3pgy GLY

DB00145
(Glycine)
Staphylococcus
aureus
SERINE
HYDROXYMETHYLTRANSFE
RASE
None 4 PHE B  34
THR B 366
LEU B 410
TYR B 411
GLY B 509
3PGY_B_GLYB511 3pgy GLY

DB00145
(Glycine)
Staphylococcus
aureus
SERINE
HYDROXYMETHYLTRANSFE
RASE
None 5 SER B 334
GLU B 391
LEU B 394
GLN B 395
LYS B 398
GLY B 511
3RGL_A_GLYA301 3rgl GLY

DB00145
(Glycine)
Campylobacter
jejuni
GLYCYL-TRNA
SYNTHETASE ALPHA
SUBUNIT
PF02091
(tRNA-synt_2e)
8 ALA A  31
GLY A  32
THR A  33
ARG A  58
GLN A  76
GLN A  78
GLU A 156
THR A 158
GLY A 301
4KR3_A_GLYA701 4kr3 GLY

DB00145
(Glycine)
Homo sapiens GLYCINE--TRNA LIGASE PF00587
(HGTP_anticodon)
PF03129
(tRNA-synt_2b)
6 GLU A 245
ARG A 277
GLU A 296
ARG A 410
GLU A 522
SER A 524
GLY A 701
4YSH_B_GLYB401 4ysh GLY

DB00145
(Glycine)
Geobacillus
kaustophilus
GLYCINE OXIDASE None 6 PHE B 247
LYS B 249
GLY B 251
TYR B 253
ALA B 266
ARG B 336
GLY B 401
4YSH_B_GLYB402 4ysh GLY

DB00145
(Glycine)
Geobacillus
kaustophilus
GLYCINE OXIDASE None 5 MET B  49
GLU B  55
TYR B 253
ARG B 309
ARG B 336
GLY B 402
4ZXI_A_GLYA1402 4zxi GLY

DB00145
(Glycine)
Acinetobacter
baumannii
TYROCIDINE
SYNTHETASE 3
PF00501
(PP-binding)
PF00550
(Thioesterase)
PF00668
(AMP-binding_C)
PF00975
(AMP-binding)
PF13193
(Condensation)
7 PHE A 669
ASP A 670
ILE A 671
GLY A 739
THR A 764
TRP A 769
LYS A 952
GLY A1402
5HHJ_A_GLYA403 5hhj GLY

DB00145
(Glycine)
Roseburia
intestinalis
RETRON-TYPE REVERSE
TRANSCRIPTASE
PF00078
(RVT_1)
4 LEU A  28
LEU A  56
GLY A  60
GLU A  61
GLY A 403
5HHJ_A_GLYA404 5hhj GLY

DB00145
(Glycine)
Roseburia
intestinalis
RETRON-TYPE REVERSE
TRANSCRIPTASE
PF00078
(RVT_1)
4 TYR A  55
ASN A  59
ILE A  63
GLN A  66
GLY A 404
5HHJ_B_GLYB404 5hhj GLY

DB00145
(Glycine)
Roseburia
intestinalis
RETRON-TYPE REVERSE
TRANSCRIPTASE
None 4 GLN B 104
ALA B 107
GLN B 108
THR B 111
GLY B 404
6AF6_A_GLYA507 6af6 GLY

DB00145
(Glycine)
Serratia sp. ATCC
39006
L-PROLYL-[PEPTIDYL-C
ARRIER PROTEIN]
DEHYDROGENASE
PF00441
(Acyl-CoA_dh_M)
PF02770
(Acyl-CoA_dh_1)
PF02771
(Acyl-CoA_dh_N)
3 TYR A 137
HIS A 238
MET A 241
GLY A 507
6DWD_A_GLYA715 6dwd GLY

DB00145
(Glycine)
Homo sapiens DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1
None
PF01966
(HD)
6 GLY A 357
ASN A 358
ASP A 361
SER C 368
ARG C 371
ARG C 372
GLY A 715
6DWD_A_GLYA717 6dwd GLY

DB00145
(Glycine)
Homo sapiens DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1
PF01966
(HD)
5 SER A 192
ARG A 194
ASP A 195
ARG A 290
LYS A 294
GLY A 717
6DWD_B_GLYB709 6dwd GLY

DB00145
(Glycine)
Homo sapiens DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1
None 5 GLY B 357
ASN B 358
ASP B 361
ARG D 371
ARG D 372
GLY B 709
6DWD_C_GLYC713 6dwd GLY

DB00145
(Glycine)
Homo sapiens DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1
None 3 GLN C 447
TYR C 450
ASN C 452
GLY C 713
6DWD_D_GLYD713 6dwd GLY

DB00145
(Glycine)
Homo sapiens DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1
None 3 ARG D 305
HIS D 517
ARG D 531
GLY D 713
6DWJ_B_GLYB710 6dwj GLY

DB00145
(Glycine)
Homo sapiens DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1
None 5 GLY D 357
ASN D 358
ASP D 361
ARG B 371
ARG B 372
GLY B 710
6MN8_A_GLYA607 6mn8 GLY

DB00145
(Glycine)
Onchocerca
volvulus
UNCHARACTERIZED
PROTEIN
PF00587
(HGTP_anticodon)
PF03129
(tRNA-synt_2b)
4 GLU A 379
ASP A 381
ARG A 383
TRP A 395
GLY A 607