SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'ZZU'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2JC9_A_ADNA1497_1 (CYTOSOLIC PURINE 5'-NUCLEOTIDASE)	2wbp	L-ARGININE BETA-HYDROXYLASE (Streptomyces vinaceus)	4 / 7	ASP A 268 THR A 169 ASN A 336 GLN A 137	ZZU A1359 (-3.0A) None None ZZU A1359 (-3.8A)	1.23A	2jc9A-2wbpA: undetectable	2jc9A-2wbpA: 20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2RK8_A_PPFA3969_1 (PHOSPHOENOLPYRUVATE CARBOXYKINASE, CYTOSOLIC [GTP])	2wbp	L-ARGININE BETA-HYDROXYLASE (Streptomyces vinaceus)	4 / 8	HIS A 225 SER A 224 ASP A 171 ARG A 334	None ZZU A1359 (-3.2A) ZZU A1359 ( 4.9A) ZZU A1359 ( 2.9A)	1.31A	2rk8A-2wbpA: undetectable	2rk8A-2wbpA: 20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2RK8_B_PPFB3969_1 (PHOSPHOENOLPYRUVATE CARBOXYKINASE, CYTOSOLIC [GTP])	2wbp	L-ARGININE BETA-HYDROXYLASE (Streptomyces vinaceus)	4 / 7	HIS A 225 SER A 224 ASP A 171 ARG A 334	None ZZU A1359 (-3.2A) ZZU A1359 ( 4.9A) ZZU A1359 ( 2.9A)	1.30A	2rk8B-2wbpA: undetectable	2rk8B-2wbpA: 20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3ILU_H_HFZH800_1 (GLUTAMATE RECEPTOR 2)	2wbp	L-ARGININE BETA-HYDROXYLASE (Streptomyces vinaceus)	4 / 5	PRO A 221 SER A 174 LEU A 226 SER A 224	None None None ZZU A1359 (-3.2A)	1.36A	3iluH-2wbpA: undetectable	3iluH-2wbpA: 20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4A99_D_MIYD392_1 (TETX2 PROTEIN)	2wbp	L-ARGININE BETA-HYDROXYLASE (Streptomyces vinaceus)	4 / 5	SER A 158 GLN A 138 SER A 224 VAL A 157	ZZU A1359 (-2.9A) None ZZU A1359 (-3.2A) ZZU A1359 (-3.1A)	1.39A	4a99D-2wbpA: undetectable	4a99D-2wbpA: 20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4XMF_A_HSMA202_1 (NITROPHORIN-7)	2wbp	L-ARGININE BETA-HYDROXYLASE (Streptomyces vinaceus)	3 / 3	ASP A 268 LEU A 165 GLY A 166	ZZU A1359 (-3.0A) SIN A1360 ( 4.7A) ZZU A1359 (-4.7A)	0.54A	4xmfA-2wbpA: undetectable	4xmfA-2wbpA: 16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4XQG_A_AG2A505_1 (HOMOSPERMIDINE SYNTHASE)	2wbp	L-ARGININE BETA-HYDROXYLASE (Streptomyces vinaceus)	4 / 8	ARG A 289 ARG A 220 PHE A 271 ASP A 270	None None ZZU A1359 (-4.8A) ZZU A1359 (-3.9A)	0.99A	4xqgA-2wbpA: undetectable	4xqgA-2wbpA: 23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4XQG_B_AG2B505_1 (HOMOSPERMIDINE SYNTHASE)	2wbp	L-ARGININE BETA-HYDROXYLASE (Streptomyces vinaceus)	4 / 8	ARG A 289 ARG A 220 PHE A 271 ASP A 270	None None ZZU A1359 (-4.8A) ZZU A1359 (-3.9A)	0.98A	4xqgB-2wbpA: undetectable	4xqgB-2wbpA: 23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6AG0_A_ACRA605_0 (ALPHA-AMYLASE)	2wbp	L-ARGININE BETA-HYDROXYLASE (Streptomyces vinaceus)	4 / 8	TYR A 180 GLY A 182 ILE A 335 ASP A 171	None None None ZZU A1359 ( 4.9A)	0.92A	6ag0A-2wbpA: undetectable	6ag0A-2wbpA: 11.86

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2JC9_A_ADNA1497_1","CYTOSOLIC PURINE 5'-NUCLEOTIDASE","2wbp","L-ARGININE BETA-HYDROXYLASE","Streptomyces vinaceus",4,"ASP A 268;THR A 169;ASN A 336;GLN A 137","ZZU A1359 (-3.0A);None;None;ZZU A1359 (-3.8A)","1.23A","2jc9A-2wbpA:undetectable",null],["2RK8_A_PPFA3969_1","PHOSPHOENOLPYRUVATE CARBOXYKINASE, CYTOSOLIC [GTP]","2wbp","L-ARGININE BETA-HYDROXYLASE","Streptomyces vinaceus",4,"HIS A 225;SER A 224;ASP A 171;ARG A 334","None;ZZU A1359 (-3.2A);ZZU A1359 ( 4.9A);ZZU A1359 ( 2.9A)","1.31A","2rk8A-2wbpA:undetectable","2jc9A-2wbpA:20.71"],["2RK8_B_PPFB3969_1","PHOSPHOENOLPYRUVATE CARBOXYKINASE, CYTOSOLIC [GTP]","2wbp","L-ARGININE BETA-HYDROXYLASE","Streptomyces vinaceus",4,"HIS A 225;SER A 224;ASP A 171;ARG A 334","None;ZZU A1359 (-3.2A);ZZU A1359 ( 4.9A);ZZU A1359 ( 2.9A)","1.30A","2rk8B-2wbpA:undetectable","2rk8A-2wbpA:20.03"],["3ILU_H_HFZH800_1","GLUTAMATE RECEPTOR 2","2wbp","L-ARGININE BETA-HYDROXYLASE","Streptomyces vinaceus",4,"PRO A 221;SER A 174;LEU A 226;SER A 224","None;None;None;ZZU A1359 (-3.2A)","1.36A","3iluH-2wbpA:undetectable","2rk8B-2wbpA:20.03"],["4A99_D_MIYD392_1","TETX2 PROTEIN","2wbp","L-ARGININE BETA-HYDROXYLASE","Streptomyces vinaceus",4,"SER A 158;GLN A 138;SER A 224;VAL A 157","ZZU A1359 (-2.9A);None;ZZU A1359 (-3.2A);ZZU A1359 (-3.1A)","1.39A","4a99D-2wbpA:undetectable","3iluH-2wbpA:20.50"],["4XMF_A_HSMA202_1","NITROPHORIN-7","2wbp","L-ARGININE BETA-HYDROXYLASE","Streptomyces vinaceus",3,"ASP A 268;LEU A 165;GLY A 166","ZZU A1359 (-3.0A);SIN A1360 ( 4.7A);ZZU A1359 (-4.7A)","0.54A","4xmfA-2wbpA:undetectable","4a99D-2wbpA:20.94"],["4XQG_A_AG2A505_1","HOMOSPERMIDINE SYNTHASE","2wbp","L-ARGININE BETA-HYDROXYLASE","Streptomyces vinaceus",4,"ARG A 289;ARG A 220;PHE A 271;ASP A 270","None;None;ZZU A1359 (-4.8A);ZZU A1359 (-3.9A)","0.99A","4xqgA-2wbpA:undetectable","4xmfA-2wbpA:16.99"],["4XQG_B_AG2B505_1","HOMOSPERMIDINE SYNTHASE","2wbp","L-ARGININE BETA-HYDROXYLASE","Streptomyces vinaceus",4,"ARG A 289;ARG A 220;PHE A 271;ASP A 270","None;None;ZZU A1359 (-4.8A);ZZU A1359 (-3.9A)","0.98A","4xqgB-2wbpA:undetectable","4xqgA-2wbpA:23.65"],["6AG0_A_ACRA605_0","ALPHA-AMYLASE","2wbp","L-ARGININE BETA-HYDROXYLASE","Streptomyces vinaceus",4,"TYR A 180;GLY A 182;ILE A 335;ASP A 171","None;None;None;ZZU A1359 ( 4.9A)","0.92A","6ag0A-2wbpA:undetectable","4xqgB-2wbpA:23.65"]]