SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'ZYC'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1GTN_G_TRPG81_0 (TRP RNA-BINDING ATTENUATION PROTEIN)	3qm1	CINNAMOYL ESTERASE (Lactobacillus johnsonii)	4 / 7	GLY A 104 HIS A 105 THR A 239 ILE A 30	None ZYC A 245 ( 4.4A) None None	0.95A	1gtnF-3qm1A: undetectable 1gtnG-3qm1A: undetectable	1gtnF-3qm1A: 14.06 1gtnG-3qm1A: 14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1IE9_A_VDXA500_1 (VITAMIN D3 RECEPTOR)	3qm1	CINNAMOYL ESTERASE (Lactobacillus johnsonii)	5 / 12	LEU A 191 SER A 113 VAL A 200 HIS A 225 HIS A 105	None CL A 292 (-4.9A) None ZYC A 245 ( 3.9A) ZYC A 245 ( 4.4A)	1.35A	1ie9A-3qm1A: undetectable	1ie9A-3qm1A: 18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1S8F_B_BEZB1503_0 (RAS-RELATED PROTEIN RAB-9A)	3qm1	CINNAMOYL ESTERASE (Lactobacillus johnsonii)	4 / 6	VAL A 147 THR A 144 LEU A 158 PHE A 160	NA A 287 ( 4.0A) ZYC A 245 (-3.8A) None None	0.99A	1s8fB-3qm1A: 4.8	1s8fB-3qm1A: 21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1UKB_A_BEZA1300_0 (2-HYDROXY-6-OXO-7-ME THYLOCTA-2,4-DIENOAT E HYDROLASE)	3qm1	CINNAMOYL ESTERASE (Lactobacillus johnsonii)	5 / 11	GLY A 33 ALA A 106 VAL A 199 VAL A 200 HIS A 225	ZYC A 245 (-3.4A) ZYC A 245 (-3.0A) NA A 249 ( 4.0A) None ZYC A 245 ( 3.9A)	0.39A	1ukbA-3qm1A: 21.9	1ukbA-3qm1A: 24.22

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1GTN_G_TRPG81_0","TRP RNA-BINDING ATTENUATION PROTEIN","3qm1","CINNAMOYL ESTERASE","Lactobacillus johnsonii",4,"GLY A 104;HIS A 105;THR A 239;ILE A  30","None;ZYC A 245 ( 4.4A);None;None","0.95A","1gtnF-3qm1A:undetectable;1gtnG-3qm1A:undetectable",null],["1IE9_A_VDXA500_1","VITAMIN D3 RECEPTOR","3qm1","CINNAMOYL ESTERASE","Lactobacillus johnsonii",5,"LEU A 191;SER A 113;VAL A 200;HIS A 225;HIS A 105","None; CL A 292 (-4.9A);None;ZYC A 245 ( 3.9A);ZYC A 245 ( 4.4A)","1.35A","1ie9A-3qm1A:undetectable","1gtnF-3qm1A:14.06;1gtnG-3qm1A:14.06"],["1S8F_B_BEZB1503_0","RAS-RELATED PROTEIN RAB-9A","3qm1","CINNAMOYL ESTERASE","Lactobacillus johnsonii",4,"VAL A 147;THR A 144;LEU A 158;PHE A 160"," NA A 287 ( 4.0A);ZYC A 245 (-3.8A);None;None","0.99A","1s8fB-3qm1A:4.8","1ie9A-3qm1A:18.64"],["1UKB_A_BEZA1300_0","2-HYDROXY-6-OXO-7-METHYLOCTA-2,4-DIENOATE HYDROLASE","3qm1","CINNAMOYL ESTERASE","Lactobacillus johnsonii",5,"GLY A  33;ALA A 106;VAL A 199;VAL A 200;HIS A 225","ZYC A 245 (-3.4A);ZYC A 245 (-3.0A); NA A 249 ( 4.0A);None;ZYC A 245 ( 3.9A)","0.39A","1ukbA-3qm1A:21.9","1s8fB-3qm1A:21.76"]]