SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'ZQU'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3NMU_J_SAMJ228_0 (FIBRILLARIN-LIKE RRNA/TRNA 2'-O-METHYLTRANSFERA SE NOP5/NOP56 RELATED PROTEIN)	6fn1	HUMAN-MOUSE CHIMERIC ABCB1 (ABCBHM) (Homo sapiens)	5 / 11	ALA A 868 ILE A 980 PHE A 982 ALA A 979 GLN A 724	None None ZQU A1305 ( 4.6A) None ZQU A1304 (-4.2A)	1.24A	3nmuB-6fn1A: 3.4 3nmuJ-6fn1A: undetectable	3nmuB-6fn1A: undetectable 3nmuJ-6fn1A: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5FSA_A_X2NA590_1 (CYP51 VARIANT1)	6fn1	HUMAN-MOUSE CHIMERIC ABCB1 (ABCBHM) (Homo sapiens)	5 / 12	PHE A 313 ILE A 734 PHE A 335 PHE A 982 PHE A 977	None None ZQU A1304 ( 3.8A) ZQU A1305 ( 4.6A) None	1.08A	5fsaA-6fn1A: undetectable	5fsaA-6fn1A: 10.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5V5Z_A_1YNA602_1 (LANOSTEROL 14-ALPHA DEMETHYLASE)	6fn1	HUMAN-MOUSE CHIMERIC ABCB1 (ABCBHM) (Homo sapiens)	5 / 12	PHE A 313 ILE A 734 PHE A 335 PHE A 982 PHE A 977	None None ZQU A1304 ( 3.8A) ZQU A1305 ( 4.6A) None	1.20A	5v5zA-6fn1A: undetectable	5v5zA-6fn1A: 9.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5ZRF_D_EVPD101_1 ()	6fn1	HUMAN-MOUSE CHIMERIC ABCB1 (ABCBHM) (Homo sapiens)	4 / 5	GLY A 190 ASP A 187 GLN A 945 MET A 948	None None ZQU A1305 (-3.8A) ZQU A1305 (-3.4A)	1.30A	5zrfB-6fn1A: undetectable	5zrfB-6fn1A: 8.86

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["3NMU_J_SAMJ228_0","FIBRILLARIN-LIKE RRNA\/TRNA 2'-O-METHYLTRANSFERASE;NOP5\/NOP56 RELATED PROTEIN","6fn1","HUMAN-MOUSE CHIMERIC ABCB1 (ABCBHM)","Homo sapiens",5,"ALA A 868;ILE A 980;PHE A 982;ALA A 979;GLN A 724","None;None;ZQU A1305 ( 4.6A);None;ZQU A1304 (-4.2A)","1.24A","3nmuB-6fn1A:3.4;3nmuJ-6fn1A:undetectable",null],["5FSA_A_X2NA590_1","CYP51 VARIANT1","6fn1","HUMAN-MOUSE CHIMERIC ABCB1 (ABCBHM)","Homo sapiens",5,"PHE A 313;ILE A 734;PHE A 335;PHE A 982;PHE A 977","None;None;ZQU A1304 ( 3.8A);ZQU A1305 ( 4.6A);None","1.08A","5fsaA-6fn1A:undetectable","3nmuB-6fn1A:undetectable;3nmuJ-6fn1A:undetectable"],["5V5Z_A_1YNA602_1","LANOSTEROL 14-ALPHA DEMETHYLASE","6fn1","HUMAN-MOUSE CHIMERIC ABCB1 (ABCBHM)","Homo sapiens",5,"PHE A 313;ILE A 734;PHE A 335;PHE A 982;PHE A 977","None;None;ZQU A1304 ( 3.8A);ZQU A1305 ( 4.6A);None","1.20A","5v5zA-6fn1A:undetectable","5fsaA-6fn1A:10.52"],["5ZRF_D_EVPD101_1",";","6fn1","HUMAN-MOUSE CHIMERIC ABCB1 (ABCBHM)","Homo sapiens",4,"GLY A 190;ASP A 187;GLN A 945;MET A 948","None;None;ZQU A1305 (-3.8A);ZQU A1305 (-3.4A)","1.30A","5zrfB-6fn1A:undetectable","5v5zA-6fn1A:9.49"]]