SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'ZPR'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DPM_A_SAMA300_0
(PROTEIN
(ADENINE-SPECIFIC
METHYLTRANSFERASE
DPNII 1))		 3muo PROLYL ENDOPEPTIDASE
(Aeromonas
caviae) 		5 / 12 GLY A 563
GLY A 540
GLY A 537
ALA A 561
ASP A 512
 None
None
ZPR  A 702 (-3.3A)
ZPR  A 702 ( 4.6A)
None
 1.08A 2dpmA-3muoA:
undetectable		 2dpmA-3muoA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q83_A_ADNA1_1
(YTAA PROTEIN)		 3muo PROLYL ENDOPEPTIDASE
(Aeromonas
caviae) 		4 / 7 ILE A 454
ILE A 438
LEU A 437
ILE A 439
 ZPR  A 702 ( 4.3A)
None
None
None
 0.90A 2q83A-3muoA:
undetectable		 2q83A-3muoA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJM_A_BJMA1_1
(DIPEPTIDYL PEPTIDASE
4)		 3muo PROLYL ENDOPEPTIDASE
(Aeromonas
caviae) 		5 / 12 TYR A 458
SER A 538
VAL A 564
VAL A 625
HIS A 657
 ZPR  A 701 (-4.4A)
ZPR  A 701 (-1.2A)
None
ZPR  A 701 (-4.9A)
ZPR  A 702 (-4.0A)
 0.28A 3bjmA-3muoA:
24.8		 3bjmA-3muoA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJM_B_BJMB2_1
(DIPEPTIDYL PEPTIDASE
4)		 3muo PROLYL ENDOPEPTIDASE
(Aeromonas
caviae) 		5 / 12 TYR A 458
SER A 538
VAL A 564
VAL A 625
HIS A 657
 ZPR  A 701 (-4.4A)
ZPR  A 701 (-1.2A)
None
ZPR  A 701 (-4.9A)
ZPR  A 702 (-4.0A)
 0.32A 3bjmB-3muoA:
24.4		 3bjmB-3muoA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_A_SAMA401_0
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 3muo PROLYL ENDOPEPTIDASE
(Aeromonas
caviae) 		5 / 12 LEU A 686
GLY A 481
TYR A 483
ALA A 533
LEU A 559
 None
None
ZPR  A 702 (-4.8A)
None
None
 1.23A 3tm4A-3muoA:
undetectable		 3tm4A-3muoA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_B_SAMB401_0
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 3muo PROLYL ENDOPEPTIDASE
(Aeromonas
caviae) 		5 / 12 LEU A 686
GLY A 481
TYR A 483
ALA A 533
LEU A 559
 None
None
ZPR  A 702 (-4.8A)
None
None
 1.24A 3tm4B-3muoA:
undetectable		 3tm4B-3muoA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W2T_A_LF7A801_1
(DIPEPTIDYL PEPTIDASE
4)		 3muo PROLYL ENDOPEPTIDASE
(Aeromonas
caviae) 		5 / 12 TYR A 458
SER A 538
VAL A 564
VAL A 625
HIS A 657
 ZPR  A 701 (-4.4A)
ZPR  A 701 (-1.2A)
None
ZPR  A 701 (-4.9A)
ZPR  A 702 (-4.0A)
 0.20A 3w2tA-3muoA:
25.8		 3w2tA-3muoA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W2T_B_LF7B801_1
(DIPEPTIDYL PEPTIDASE
4)		 3muo PROLYL ENDOPEPTIDASE
(Aeromonas
caviae) 		5 / 12 TYR A 458
SER A 538
VAL A 564
VAL A 625
HIS A 657
 ZPR  A 701 (-4.4A)
ZPR  A 701 (-1.2A)
None
ZPR  A 701 (-4.9A)
ZPR  A 702 (-4.0A)
 0.21A 3w2tB-3muoA:
25.7		 3w2tB-3muoA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_A_715A801_1
(DIPEPTIDYL PEPTIDASE
4)		 3muo PROLYL ENDOPEPTIDASE
(Aeromonas
caviae) 		5 / 12 TYR A 458
SER A 538
VAL A 564
VAL A 625
HIS A 657
 ZPR  A 701 (-4.4A)
ZPR  A 701 (-1.2A)
None
ZPR  A 701 (-4.9A)
ZPR  A 702 (-4.0A)
 0.44A 4ffwA-3muoA:
25.6		 4ffwA-3muoA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_B_715B801_1
(DIPEPTIDYL PEPTIDASE
4)		 3muo PROLYL ENDOPEPTIDASE
(Aeromonas
caviae) 		5 / 12 TYR A 458
SER A 538
VAL A 564
VAL A 625
HIS A 657
 ZPR  A 701 (-4.4A)
ZPR  A 701 (-1.2A)
None
ZPR  A 701 (-4.9A)
ZPR  A 702 (-4.0A)
 0.38A 4ffwB-3muoA:
23.3		 4ffwB-3muoA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDP_H_EVPH2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B)		 3muo PROLYL ENDOPEPTIDASE
(Aeromonas
caviae) 		4 / 6 GLU A 387
GLY A 540
ARG A 535
GLY A 457
 None
None
ZPR  A 702 (-4.1A)
None
 0.91A 5cdpA-3muoA:
undetectable
5cdpB-3muoA:
3.6		 5cdpA-3muoA:
21.13
5cdpB-3muoA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B1E_B_LF7B801_1
(DIPEPTIDYL PEPTIDASE
4)		 3muo PROLYL ENDOPEPTIDASE
(Aeromonas
caviae) 		5 / 12 TYR A 458
SER A 538
VAL A 564
VAL A 625
HIS A 657
 ZPR  A 701 (-4.4A)
ZPR  A 701 (-1.2A)
None
ZPR  A 701 (-4.9A)
ZPR  A 702 (-4.0A)
 0.22A 6b1eB-3muoA:
25.0		 6b1eB-3muoA:
22.04