SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'ZPE'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QO5_A_CHDA131_0
(LIVER-BASIC FATTY
ACID BINDING PROTEIN)		 5lc8 ARACHIDONATE
15-LIPOXYGENASE
(Pseudomonas
aeruginosa) 		5 / 12 ILE A 416
ILE A 113
THR A 109
LEU A 611
VAL A 189
 ZPE  A 703 (-4.8A)
ZPE  A 703 ( 4.6A)
ZPE  A 703 ( 4.4A)
ZPE  A 703 ( 4.9A)
None
 1.20A 2qo5A-5lc8A:
undetectable		 2qo5A-5lc8A:
10.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_C_VIVC301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 5lc8 ARACHIDONATE
15-LIPOXYGENASE
(Pseudomonas
aeruginosa) 		5 / 12 ILE A 685
VAL A  89
ILE A 608
LEU A 425
VAL A  86
 None
None
ZPE  A 703 ( 4.9A)
None
None
 0.99A 3w68C-5lc8A:
undetectable		 3w68C-5lc8A:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I41_A_MIXA501_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 5lc8 ARACHIDONATE
15-LIPOXYGENASE
(Pseudomonas
aeruginosa) 		5 / 12 ILE A 113
THR A 109
THR A 567
ILE A 608
GLU A 373
 ZPE  A 703 ( 4.6A)
ZPE  A 703 ( 4.4A)
None
ZPE  A 703 ( 4.9A)
ZPE  A 703 (-4.1A)
 1.16A 4i41A-5lc8A:
undetectable		 4i41A-5lc8A:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UY8_7_TRP71002_0
(TRYPTOPHANASE)		 5lc8 ARACHIDONATE
15-LIPOXYGENASE
(Pseudomonas
aeruginosa) 		4 / 4 ILE A 608
ASN A 607
ILE A 192
VAL A 189
 ZPE  A 703 ( 4.9A)
ZPE  A 703 ( 3.9A)
ZPE  A 703 ( 4.7A)
None
 1.18A 4uy87-5lc8A:
undetectable		 4uy87-5lc8A:
5.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TOA_B_ESTB601_1
(ESTROGEN RECEPTOR
BETA)		 5lc8 ARACHIDONATE
15-LIPOXYGENASE
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 107
LEU A 181
ILE A 117
LEU A 139
LEU A 611
 None
None
None
None
ZPE  A 703 ( 4.9A)
 1.17A 5toaB-5lc8A:
2.8		 5toaB-5lc8A:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_A_FFOA403_0
(THYMIDYLATE SYNTHASE)		 5lc8 ARACHIDONATE
15-LIPOXYGENASE
(Pseudomonas
aeruginosa) 		5 / 12 ILE A 192
ASN A 607
LEU A 116
LEU A 124
PHE A 132
 ZPE  A 703 ( 4.7A)
ZPE  A 703 ( 3.9A)
ZPE  A 703 ( 4.3A)
None
None
 1.31A 6r2eA-5lc8A:
undetectable		 6r2eA-5lc8A:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_G_FFOG403_0
(THYMIDYLATE SYNTHASE)		 5lc8 ARACHIDONATE
15-LIPOXYGENASE
(Pseudomonas
aeruginosa) 		5 / 11 ILE A 192
ASN A 607
LEU A 116
LEU A 124
PHE A 132
 ZPE  A 703 ( 4.7A)
ZPE  A 703 ( 3.9A)
ZPE  A 703 ( 4.3A)
None
None
 1.32A 6r2eG-5lc8A:
undetectable		 6r2eG-5lc8A:
18.20