SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'ZMA'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TT0_A_ACTA4901_0
(PYRANOSE OXIDASE)		 6aqf ADENOSINE RECEPTOR
A2A,SOLUBLE
CYTOCHROME
B562,ADENOSINE
RECEPTOR A2A
(Escherichia
coli;
Homo
sapiens) 		4 / 6 THR A  88
PHE A 242
HIS A 250
ASN A 181
 None
None
ZMA  A1201 (-3.9A)
None
 1.38A 1tt0A-6aqfA:
undetectable		 1tt0A-6aqfA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TT0_B_ACTB3901_0
(PYRANOSE OXIDASE)		 6aqf ADENOSINE RECEPTOR
A2A,SOLUBLE
CYTOCHROME
B562,ADENOSINE
RECEPTOR A2A
(Escherichia
coli;
Homo
sapiens) 		4 / 6 THR A  88
PHE A 242
HIS A 250
ASN A 181
 None
None
ZMA  A1201 (-3.9A)
None
 1.36A 1tt0B-6aqfA:
undetectable		 1tt0B-6aqfA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TT0_C_ACTC6901_0
(PYRANOSE OXIDASE)		 6aqf ADENOSINE RECEPTOR
A2A,SOLUBLE
CYTOCHROME
B562,ADENOSINE
RECEPTOR A2A
(Escherichia
coli;
Homo
sapiens) 		4 / 6 THR A  88
PHE A 242
HIS A 250
ASN A 181
 None
None
ZMA  A1201 (-3.9A)
None
 1.35A 1tt0C-6aqfA:
undetectable		 1tt0C-6aqfA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TT0_D_ACTD5901_0
(PYRANOSE OXIDASE)		 6aqf ADENOSINE RECEPTOR
A2A,SOLUBLE
CYTOCHROME
B562,ADENOSINE
RECEPTOR A2A
(Escherichia
coli;
Homo
sapiens) 		4 / 6 THR A  88
PHE A 242
HIS A 250
ASN A 181
 None
None
ZMA  A1201 (-3.9A)
None
 1.40A 1tt0D-6aqfA:
undetectable		 1tt0D-6aqfA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2YDO_A_ADNA400_1
(ADENOSINE RECEPTOR
A2A)		 6aqf ADENOSINE RECEPTOR
A2A,SOLUBLE
CYTOCHROME
B562,ADENOSINE
RECEPTOR A2A
(Escherichia
coli;
Homo
sapiens) 		11 / 12 LEU A  85
PHE A 168
GLU A 169
MET A 177
TRP A 246
LEU A 249
ASN A 253
MET A 270
ILE A 274
SER A 277
HIS A 278
 None
ZMA  A1201 (-3.5A)
ZMA  A1201 (-4.1A)
None
None
ZMA  A1201 (-4.1A)
ZMA  A1201 (-3.2A)
ZMA  A1201 (-4.8A)
ZMA  A1201 (-4.8A)
None
None
 0.76A 2ydoA-6aqfA:
33.6		 2ydoA-6aqfA:
83.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2YDO_A_ADNA400_1
(ADENOSINE RECEPTOR
A2A)		 6aqf ADENOSINE RECEPTOR
A2A,SOLUBLE
CYTOCHROME
B562,ADENOSINE
RECEPTOR A2A
(Escherichia
coli;
Homo
sapiens) 		11 / 12 LEU A  85
THR A  88
PHE A 168
GLU A 169
MET A 177
TRP A 246
LEU A 249
ASN A 253
MET A 270
ILE A 274
SER A 277
 None
None
ZMA  A1201 (-3.5A)
ZMA  A1201 (-4.1A)
None
None
ZMA  A1201 (-4.1A)
ZMA  A1201 (-3.2A)
ZMA  A1201 (-4.8A)
ZMA  A1201 (-4.8A)
None
 1.09A 2ydoA-6aqfA:
33.6		 2ydoA-6aqfA:
83.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RFM_A_CFFA330_1
(ADENOSINE RECEPTOR
A2A)		 6aqf ADENOSINE RECEPTOR
A2A,SOLUBLE
CYTOCHROME
B562,ADENOSINE
RECEPTOR A2A
(Escherichia
coli;
Homo
sapiens) 		5 / 7 PHE A 168
LEU A 249
ASN A 253
MET A 270
ILE A 274
 ZMA  A1201 (-3.5A)
ZMA  A1201 (-4.1A)
ZMA  A1201 (-3.2A)
ZMA  A1201 (-4.8A)
ZMA  A1201 (-4.8A)
 0.69A 3rfmA-6aqfA:
37.3		 3rfmA-6aqfA:
86.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RFM_A_CFFA330_1
(ADENOSINE RECEPTOR
A2A)		 6aqf ADENOSINE RECEPTOR
A2A,SOLUBLE
CYTOCHROME
B562,ADENOSINE
RECEPTOR A2A
(Escherichia
coli;
Homo
sapiens) 		6 / 7 VAL A  84
PHE A 168
MET A 177
LEU A 249
ASN A 253
ILE A 274
 None
ZMA  A1201 (-3.5A)
None
ZMA  A1201 (-4.1A)
ZMA  A1201 (-3.2A)
ZMA  A1201 (-4.8A)
 0.62A 3rfmA-6aqfA:
37.3		 3rfmA-6aqfA:
86.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MZJ_A_TEPA2401_1
(ADENOSINE RECEPTOR
A2A,SOLUBLE
CYTOCHROME
B562,ADENOSINE
RECEPTOR A2A)		 6aqf ADENOSINE RECEPTOR
A2A,SOLUBLE
CYTOCHROME
B562,ADENOSINE
RECEPTOR A2A
(Escherichia
coli;
Homo
sapiens) 		8 / 8 LEU A  85
PHE A 168
GLU A 169
MET A 177
LEU A 249
ASN A 253
MET A 270
ILE A 274
 None
ZMA  A1201 (-3.5A)
ZMA  A1201 (-4.1A)
None
ZMA  A1201 (-4.1A)
ZMA  A1201 (-3.2A)
ZMA  A1201 (-4.8A)
ZMA  A1201 (-4.8A)
 0.28A 5mzjA-6aqfA:
50.7		 5mzjA-6aqfA:
97.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MZP_A_CFFA2401_1
(ADENOSINE RECEPTOR
A2A,SOLUBLE
CYTOCHROME
B562,ADENOSINE
RECEPTOR A2A)		 6aqf ADENOSINE RECEPTOR
A2A,SOLUBLE
CYTOCHROME
B562,ADENOSINE
RECEPTOR A2A
(Escherichia
coli;
Homo
sapiens) 		9 / 9 ILE A  66
VAL A  84
PHE A 168
GLU A 169
MET A 177
LEU A 249
ASN A 253
MET A 270
ILE A 274
 None
None
ZMA  A1201 (-3.5A)
ZMA  A1201 (-4.1A)
None
ZMA  A1201 (-4.1A)
ZMA  A1201 (-3.2A)
ZMA  A1201 (-4.8A)
ZMA  A1201 (-4.8A)
 0.32A 5mzpA-6aqfA:
50.9		 5mzpA-6aqfA:
98.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D9H_R_ADNR400_1
(CHIMERA PROTEIN OF
MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4 AND
ADENOSINE RECEPTOR
A1)		 6aqf ADENOSINE RECEPTOR
A2A,SOLUBLE
CYTOCHROME
B562,ADENOSINE
RECEPTOR A2A
(Escherichia
coli;
Homo
sapiens) 		5 / 10 PHE A 168
GLU A 169
MET A 177
LEU A 249
ASN A 253
 ZMA  A1201 (-3.5A)
ZMA  A1201 (-4.1A)
None
ZMA  A1201 (-4.1A)
ZMA  A1201 (-3.2A)
 1.11A 6d9hR-6aqfA:
30.1		 6d9hR-6aqfA:
27.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D9H_R_ADNR400_1
(CHIMERA PROTEIN OF
MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4 AND
ADENOSINE RECEPTOR
A1)		 6aqf ADENOSINE RECEPTOR
A2A,SOLUBLE
CYTOCHROME
B562,ADENOSINE
RECEPTOR A2A
(Escherichia
coli;
Homo
sapiens) 		7 / 10 VAL A  84
PHE A 168
MET A 177
LEU A 249
ASN A 253
ILE A 274
HIS A 278
 None
ZMA  A1201 (-3.5A)
None
ZMA  A1201 (-4.1A)
ZMA  A1201 (-3.2A)
ZMA  A1201 (-4.8A)
None
 1.00A 6d9hR-6aqfA:
30.1		 6d9hR-6aqfA:
27.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D9H_R_ADNR400_1
(CHIMERA PROTEIN OF
MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4 AND
ADENOSINE RECEPTOR
A1)		 6aqf ADENOSINE RECEPTOR
A2A,SOLUBLE
CYTOCHROME
B562,ADENOSINE
RECEPTOR A2A
(Escherichia
coli;
Homo
sapiens) 		7 / 10 VAL A  84
THR A  88
PHE A 168
MET A 177
LEU A 249
ASN A 253
ILE A 274
 None
None
ZMA  A1201 (-3.5A)
None
ZMA  A1201 (-4.1A)
ZMA  A1201 (-3.2A)
ZMA  A1201 (-4.8A)
 1.08A 6d9hR-6aqfA:
30.1		 6d9hR-6aqfA:
27.27