SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'ZIO'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VQY_A_PARA1201_2
(AAC(6')-IB)		 2iya OLEANDOMYCIN
GLYCOSYLTRANSFERASE
(Streptomyces
antibioticus) 		3 / 3 TRP A 312
GLN A 311
TRP A  79
 UDP  A1424 (-3.6A)
None
ZIO  A1425 (-3.8A)
 1.28A 2vqyA-2iyaA:
undetectable		 2vqyA-2iyaA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCJ_A_THHA401_0
(PROBABLE
5'-PHOSPHORIBOSYLGLY
CINAMIDE
FORMYLTRANSFERASE
PURN)		 2iya OLEANDOMYCIN
GLYCOSYLTRANSFERASE
(Streptomyces
antibioticus) 		5 / 12 ILE A 360
LEU A 365
LEU A 396
THR A 139
THR A 334
 None
None
None
ZIO  A1425 (-3.7A)
None
 1.17A 3dcjA-2iyaA:
6.1
3dcjB-2iyaA:
6.8		 3dcjA-2iyaA:
23.66
3dcjB-2iyaA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEO_A_SAMA328_1
(MODIFICATION
METHYLASE HHAI)		 2iya OLEANDOMYCIN
GLYCOSYLTRANSFERASE
(Streptomyces
antibioticus) 		3 / 3 GLU A 352
SER A 137
VAL A 215
 ZIO  A1425 (-3.8A)
None
None
 0.84A 3eeoA-2iyaA:
5.3		 3eeoA-2iyaA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIO_A_HFGA801_1
(PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE))		 2iya OLEANDOMYCIN
GLYCOSYLTRANSFERASE
(Streptomyces
antibioticus) 		3 / 3 THR A 139
GLU A 352
HIS A 328
 ZIO  A1425 (-3.7A)
ZIO  A1425 (-3.8A)
UDP  A1424 (-4.0A)
 0.90A 5xioA-2iyaA:
4.9		 5xioA-2iyaA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_B_HFGB1002_1
(PROLYL-TRNA
SYNTHETASE (PRORS))		 2iya OLEANDOMYCIN
GLYCOSYLTRANSFERASE
(Streptomyces
antibioticus) 		3 / 3 THR A 139
GLU A 352
HIS A 328
 ZIO  A1425 (-3.7A)
ZIO  A1425 (-3.8A)
UDP  A1424 (-4.0A)
 0.91A 5xiqB-2iyaA:
3.9		 5xiqB-2iyaA:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_D_HFGD1002_1
(PROLYL-TRNA
SYNTHETASE (PRORS))		 2iya OLEANDOMYCIN
GLYCOSYLTRANSFERASE
(Streptomyces
antibioticus) 		3 / 3 THR A 139
GLU A 352
HIS A 328
 ZIO  A1425 (-3.7A)
ZIO  A1425 (-3.8A)
UDP  A1424 (-4.0A)
 0.89A 5xiqD-2iyaA:
3.1		 5xiqD-2iyaA:
23.83