SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'ZIL'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XJ7_D_ADND303_1
(5'/3'-NUCLEOTIDASE
SURE)		 4u0g ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
(Mycobacterium
tuberculosis) 		5 / 10 LEU H 103
LEU H  32
GLY H 100
SER H  98
ALA H  76
 None
None
None
ZIL  H 301 ( 2.9A)
None
 1.12A 4xj7C-4u0gH:
undetectable
4xj7D-4u0gH:
undetectable		 4xj7C-4u0gH:
24.07
4xj7D-4u0gH:
24.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5DZK_O_BEZO801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 4u0g ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
(Mycobacterium
tuberculosis) 		5 / 6 PHE A  83
SER A 110
HIS A 135
PRO A 137
MET A 164
 ZIL  A 301 (-4.5A)
ZIL  A 301 ( 4.0A)
ZIL  A 301 (-3.7A)
ZIL  A 301 (-3.8A)
ZIL  A 301 ( 2.9A)
 0.49A 5dzka-4u0gA:
27.3
5dzko-4u0gA:
undetectable		 5dzka-4u0gA:
100.00
5dzko-4u0gA:
1.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5DZK_P_BEZP801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 4u0g ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
(Mycobacterium
tuberculosis) 		4 / 5 SER A 110
ALA A 111
HIS A 135
MET A 164
 ZIL  A 301 ( 4.0A)
ZIL  A 301 ( 4.0A)
ZIL  A 301 (-3.7A)
ZIL  A 301 ( 2.9A)
 0.41A 5dzkb-4u0gA:
27.7
5dzkp-4u0gA:
undetectable		 5dzkb-4u0gA:
100.00
5dzkp-4u0gA:
1.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5DZK_P_BEZP801_1
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 4u0g ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
(Mycobacterium
tuberculosis) 		5 / 6 PHE A  83
SER A 110
ALA A 111
HIS A 135
MET A 164
 ZIL  A 301 (-4.5A)
ZIL  A 301 ( 4.0A)
ZIL  A 301 ( 4.0A)
ZIL  A 301 (-3.7A)
ZIL  A 301 ( 2.9A)
 0.49A 5dzkB-4u0gA:
27.7
5dzkP-4u0gA:
undetectable		 5dzkB-4u0gA:
100.00
5dzkP-4u0gA:
1.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5DZK_Q_BEZQ801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 4u0g ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
(Mycobacterium
tuberculosis) 		4 / 5 SER A 110
ALA A 111
HIS A 135
MET A 164
 ZIL  A 301 ( 4.0A)
ZIL  A 301 ( 4.0A)
ZIL  A 301 (-3.7A)
ZIL  A 301 ( 2.9A)
 0.42A 5dzkc-4u0gA:
27.3
5dzkq-4u0gA:
undetectable		 5dzkc-4u0gA:
100.00
5dzkq-4u0gA:
1.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5DZK_R_BEZR801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 4u0g ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
(Mycobacterium
tuberculosis) 		6 / 7 PHE A  83
SER A 110
ALA A 111
HIS A 135
PRO A 137
MET A 164
 ZIL  A 301 (-4.5A)
ZIL  A 301 ( 4.0A)
ZIL  A 301 ( 4.0A)
ZIL  A 301 (-3.7A)
ZIL  A 301 (-3.8A)
ZIL  A 301 ( 2.9A)
 0.47A 5dzkD-4u0gA:
27.4
5dzkR-4u0gA:
undetectable		 5dzkD-4u0gA:
100.00
5dzkR-4u0gA:
1.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5DZK_R_BEZR801_1
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 4u0g ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
(Mycobacterium
tuberculosis) 		6 / 8 PHE A  83
SER A 110
ALA A 111
HIS A 135
PRO A 137
MET A 164
 ZIL  A 301 (-4.5A)
ZIL  A 301 ( 4.0A)
ZIL  A 301 ( 4.0A)
ZIL  A 301 (-3.7A)
ZIL  A 301 (-3.8A)
ZIL  A 301 ( 2.9A)
 0.47A 5dzkd-4u0gA:
27.4
5dzkr-4u0gA:
undetectable		 5dzkd-4u0gA:
100.00
5dzkr-4u0gA:
1.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5DZK_S_BEZS801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 4u0g ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
(Mycobacterium
tuberculosis) 		4 / 6 PHE A  83
SER A 110
HIS A 135
MET A 164
 ZIL  A 301 (-4.5A)
ZIL  A 301 ( 4.0A)
ZIL  A 301 (-3.7A)
ZIL  A 301 ( 2.9A)
 0.50A 5dzke-4u0gA:
27.6
5dzks-4u0gA:
undetectable		 5dzke-4u0gA:
100.00
5dzks-4u0gA:
1.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5DZK_T_BEZT801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 4u0g ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
(Mycobacterium
tuberculosis) 		4 / 5 SER A 110
ALA A 111
HIS A 135
MET A 164
 ZIL  A 301 ( 4.0A)
ZIL  A 301 ( 4.0A)
ZIL  A 301 (-3.7A)
ZIL  A 301 ( 2.9A)
 0.42A 5dzkf-4u0gA:
27.4
5dzkt-4u0gA:
undetectable		 5dzkf-4u0gA:
100.00
5dzkt-4u0gA:
1.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5DZK_T_BEZT801_1
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 4u0g ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
(Mycobacterium
tuberculosis) 		6 / 8 PHE A  83
SER A 110
ALA A 111
HIS A 135
PRO A 137
MET A 164
 ZIL  A 301 (-4.5A)
ZIL  A 301 ( 4.0A)
ZIL  A 301 ( 4.0A)
ZIL  A 301 (-3.7A)
ZIL  A 301 (-3.8A)
ZIL  A 301 ( 2.9A)
 0.46A 5dzkF-4u0gA:
27.4
5dzkT-4u0gA:
undetectable		 5dzkF-4u0gA:
100.00
5dzkT-4u0gA:
1.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5DZK_U_BEZU801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 4u0g ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
(Mycobacterium
tuberculosis) 		5 / 6 PHE A  83
SER A 110
ALA A 111
HIS A 135
MET A 164
 ZIL  A 301 (-4.5A)
ZIL  A 301 ( 4.0A)
ZIL  A 301 ( 4.0A)
ZIL  A 301 (-3.7A)
ZIL  A 301 ( 2.9A)
 0.49A 5dzkg-4u0gA:
27.4
5dzku-4u0gA:
undetectable		 5dzkg-4u0gA:
100.00
5dzku-4u0gA:
1.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5DZK_W_BEZW801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 4u0g ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
(Mycobacterium
tuberculosis;
Mycobacterium
tuberculosis) 		4 / 5 PHE A 147
ILE H  71
GLY H 127
ILE H 146
 ZIL  H 301 ( 4.8A)
ZIL  H 301 (-3.6A)
ZIL  H 301 ( 3.5A)
ZIL  H 301 ( 3.3A)
 0.38A 5dzkB-4u0gA:
27.7
5dzkI-4u0gA:
31.4
5dzkW-4u0gA:
undetectable		 5dzkB-4u0gA:
100.00
5dzkI-4u0gA:
41.58
5dzkW-4u0gA:
1.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5DZK_Y_BEZY801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 4u0g ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
(Mycobacterium
tuberculosis;
Mycobacterium
tuberculosis) 		4 / 5 PHE A 147
ILE H  71
GLY H 127
ILE H 146
 ZIL  H 301 ( 4.8A)
ZIL  H 301 (-3.6A)
ZIL  H 301 ( 3.5A)
ZIL  H 301 ( 3.3A)
 0.35A 5dzkd-4u0gA:
27.4
5dzkk-4u0gA:
31.4
5dzky-4u0gA:
undetectable		 5dzkd-4u0gA:
100.00
5dzkk-4u0gA:
41.58
5dzky-4u0gA:
1.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5K_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 4u0g ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
(Mycobacterium
tuberculosis) 		4 / 4 GLN A 136
THR A 183
THR A 167
LEU A  86
 None
None
None
ZIL  A 301 ( 4.3A)
 1.49A 5m5kA-4u0gA:
undetectable		 5m5kA-4u0gA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5K_C_ADNC502_2
(ADENOSYLHOMOCYSTEINA
SE)		 4u0g ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
(Mycobacterium
tuberculosis) 		4 / 4 GLN A 136
THR A 183
THR A 167
LEU A  86
 None
None
None
ZIL  A 301 ( 4.3A)
 1.49A 5m5kC-4u0gA:
undetectable		 5m5kC-4u0gA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M66_B_ADNB502_2
(ADENOSYLHOMOCYSTEINA
SE)		 4u0g ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
(Mycobacterium
tuberculosis) 		4 / 4 GLN A 136
THR A 183
THR A 167
LEU A  86
 None
None
None
ZIL  A 301 ( 4.3A)
 1.46A 5m66B-4u0gA:
undetectable		 5m66B-4u0gA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3M_B_ADNB502_2
(-)		 4u0g ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
(Mycobacterium
tuberculosis) 		4 / 4 GLN A 136
THR A 183
THR A 167
LEU A  86
 None
None
None
ZIL  A 301 ( 4.3A)
 1.47A 6f3mB-4u0gA:
undetectable		 6f3mB-4u0gA:
17.83