SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'ZEN'


List of Similar Pattern of Amino Acids


Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1AQ7_B_AG2B4_1
(TRYPSIN
AERUGINOSIN 98-B)
1j17 TRYPSIN II, ANIONIC
(Rattus
norvegicus)
6 / 8 HIS T  57
ASP T 189
SER T 195
VAL T 213
GLY T 216
GLY T 226
SO4  T 600 (-3.8A)
ZEN  T   1 ( 3.8A)
SO4  T 600 ( 2.6A)
ZEN  T   1 (-4.1A)
ZEN  T   1 (-3.7A)
ZEN  T   1 (-3.7A)
0.46A 1aq7A-1j17T:
42.9
1aq7A-1j17T:
71.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1BCU_H_PRLH280_0
(ALPHA-THROMBIN)
1j17 TRYPSIN II, ANIONIC
(Rattus
norvegicus)
7 / 9 ASP T 189
ALA T 190
SER T 195
VAL T 213
TRP T 215
GLY T 216
GLY T 226
ZEN  T   1 ( 3.8A)
ZEN  T   1 (-3.8A)
SO4  T 600 ( 2.6A)
ZEN  T   1 (-4.1A)
ZEN  T   1 (-3.4A)
ZEN  T   1 (-3.7A)
ZEN  T   1 (-3.7A)
0.32A 1bcuH-1j17T:
18.7
1bcuH-1j17T:
37.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DWC_H_MITH1_1
(ALPHA-THROMBIN
(LARGE SUBUNIT))
1j17 TRYPSIN II, ANIONIC
(Rattus
norvegicus)
5 / 9 HIS T  57
ASP T 189
SER T 195
TRP T 215
GLY T 226
SO4  T 600 (-3.8A)
ZEN  T   1 ( 3.8A)
SO4  T 600 ( 2.6A)
ZEN  T   1 (-3.4A)
ZEN  T   1 (-3.7A)
0.37A 1dwcH-1j17T:
34.3
1dwcH-1j17T:
37.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ETR_H_MITH1_1
(EPSILON-THROMBIN)
1j17 TRYPSIN II, ANIONIC
(Rattus
norvegicus)
7 / 12 HIS T  57
ASP T 189
SER T 195
VAL T 213
TRP T 215
GLY T 216
GLY T 226
SO4  T 600 (-3.8A)
ZEN  T   1 ( 3.8A)
SO4  T 600 ( 2.6A)
ZEN  T   1 (-4.1A)
ZEN  T   1 (-3.4A)
ZEN  T   1 (-3.7A)
ZEN  T   1 (-3.7A)
0.49A 1etrH-1j17T:
34.4
1etrH-1j17T:
38.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1F5L_A_AMRA301_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)
1j17 TRYPSIN II, ANIONIC
(Rattus
norvegicus)
6 / 8 ASP T 189
GLN T 192
SER T 195
VAL T 213
GLY T 216
GLY T 226
ZEN  T   1 ( 3.8A)
None
SO4  T 600 ( 2.6A)
ZEN  T   1 (-4.1A)
ZEN  T   1 (-3.7A)
ZEN  T   1 (-3.7A)
0.50A 1f5lA-1j17T:
15.2
1f5lA-1j17T:
36.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TNL_A_TPAA900_1
(TRYPSIN)
1j17 TRYPSIN II, ANIONIC
(Rattus
norvegicus)
5 / 6 ASP T 189
SER T 195
VAL T 213
GLY T 216
GLY T 226
ZEN  T   1 ( 3.8A)
SO4  T 600 ( 2.6A)
ZEN  T   1 (-4.1A)
ZEN  T   1 (-3.7A)
ZEN  T   1 (-3.7A)
0.20A 1tnlA-1j17T:
43.0
1tnlA-1j17T:
71.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NMZ_B_ROCB401_1
(PROTEASE)
1j17 TRYPSIN II, ANIONIC
(Rattus
norvegicus)
6 / 12 LEU T 137
GLY T  19
ASP T 189
GLY T 142
PRO T 198
ILE T 138
None
None
ZEN  T   1 ( 3.8A)
None
None
None
1.21A 2nmzA-1j17T:
undetectable
2nmzA-1j17T:
17.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OTV_A_NCAA1301_0
(CATIONIC TRYPSIN)
1j17 TRYPSIN II, ANIONIC
(Rattus
norvegicus)
5 / 6 ASP T 189
SER T 195
VAL T 213
GLY T 216
GLY T 226
ZEN  T   1 ( 3.8A)
SO4  T 600 ( 2.6A)
ZEN  T   1 (-4.1A)
ZEN  T   1 (-3.7A)
ZEN  T   1 (-3.7A)
0.13A 2otvA-1j17T:
43.0
2otvA-1j17T:
71.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2P16_A_GG2A298_1
(COAGULATION FACTOR X
(EC 3.4.21.6)
(STUART FACTOR)
(STUART-PROWER
FACTOR))
1j17 TRYPSIN II, ANIONIC
(Rattus
norvegicus)
10 / 12 TYR T  99
PHE T 174
ASP T 189
ALA T 190
SER T 195
VAL T 213
TRP T 215
GLY T 216
GLY T 226
TYR T 228
ZEN  T   1 (-3.8A)
ZEN  T   1 (-3.8A)
ZEN  T   1 ( 3.8A)
ZEN  T   1 (-3.8A)
SO4  T 600 ( 2.6A)
ZEN  T   1 (-4.1A)
ZEN  T   1 (-3.4A)
ZEN  T   1 (-3.7A)
ZEN  T   1 (-3.7A)
ZEN  T   1 (-3.6A)
0.37A 2p16A-1j17T:
36.4
2p16A-1j17T:
39.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2VIN_A_505A1247_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR CHAIN B)
1j17 TRYPSIN II, ANIONIC
(Rattus
norvegicus)
6 / 8 ASP T 189
GLN T 192
SER T 195
VAL T 213
GLY T 216
GLY T 226
ZEN  T   1 ( 3.8A)
None
SO4  T 600 ( 2.6A)
ZEN  T   1 (-4.1A)
ZEN  T   1 (-3.7A)
ZEN  T   1 (-3.7A)
0.72A 2vinA-1j17T:
14.5
2vinA-1j17T:
36.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W26_A_RIVA1001_1
(ACTIVATED FACTOR XA
HEAVY CHAIN)
1j17 TRYPSIN II, ANIONIC
(Rattus
norvegicus)
11 / 12 TYR T  99
PHE T 174
ASP T 189
ALA T 190
SER T 195
VAL T 213
TRP T 215
GLY T 216
GLY T 219
GLY T 226
TYR T 228
ZEN  T   1 (-3.8A)
ZEN  T   1 (-3.8A)
ZEN  T   1 ( 3.8A)
ZEN  T   1 (-3.8A)
SO4  T 600 ( 2.6A)
ZEN  T   1 (-4.1A)
ZEN  T   1 (-3.4A)
ZEN  T   1 (-3.7A)
ZEN  T   1 (-4.5A)
ZEN  T   1 (-3.7A)
ZEN  T   1 (-3.6A)
0.40A 2w26A-1j17T:
14.3
2w26A-1j17T:
39.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GY3_A_PNTA246_0
(CATIONIC TRYPSIN)
1j17 TRYPSIN II, ANIONIC
(Rattus
norvegicus)
6 / 11 HIS T  57
ASP T 189
SER T 195
TRP T 215
GLY T 216
GLY T 226
SO4  T 600 (-3.8A)
ZEN  T   1 ( 3.8A)
SO4  T 600 ( 2.6A)
ZEN  T   1 (-3.4A)
ZEN  T   1 (-3.7A)
ZEN  T   1 (-3.7A)
0.29A 3gy3A-1j17T:
41.7
3gy3A-1j17T:
71.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_D_DVAD8_0
(GRAMICIDIN D)
1j17 TRYPSIN II, ANIONIC
(Rattus
norvegicus)
3 / 3 VAL T 227
VAL T 213
TRP T 215
None
ZEN  T   1 (-4.1A)
ZEN  T   1 (-3.4A)
0.95A 3l8lC-1j17T:
undetectable
3l8lD-1j17T:
undetectable
3l8lC-1j17T:
5.12
3l8lD-1j17T:
6.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MB5_A_SAMA301_0
(SAM-DEPENDENT
METHYLTRANSFERASE)
1j17 TRYPSIN II, ANIONIC
(Rattus
norvegicus)
5 / 12 ILE T 212
VAL T 213
GLY T  44
ALA T  55
ILE T  73
None
ZEN  T   1 (-4.1A)
None
None
None
0.97A 3mb5A-1j17T:
undetectable
3mb5A-1j17T:
21.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RXF_A_4APA9_1
(CATIONIC TRYPSIN)
1j17 TRYPSIN II, ANIONIC
(Rattus
norvegicus)
5 / 6 SER T 195
VAL T 213
TRP T 215
GLY T 216
GLY T 226
SO4  T 600 ( 2.6A)
ZEN  T   1 (-4.1A)
ZEN  T   1 (-3.4A)
ZEN  T   1 (-3.7A)
ZEN  T   1 (-3.7A)
0.18A 3rxfA-1j17T:
43.1
3rxfA-1j17T:
71.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RXH_A_HSMA7_1
(CATIONIC TRYPSIN)
1j17 TRYPSIN II, ANIONIC
(Rattus
norvegicus)
4 / 5 ASP T 189
SER T 195
VAL T 213
GLY T 226
ZEN  T   1 ( 3.8A)
SO4  T 600 ( 2.6A)
ZEN  T   1 (-4.1A)
ZEN  T   1 (-3.7A)
0.24A 3rxhA-1j17T:
43.1
3rxhA-1j17T:
71.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_B_VIVB301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)
1j17 TRYPSIN II, ANIONIC
(Rattus
norvegicus)
5 / 12 ILE T  89
VAL T 213
ILE T 242
ILE T  47
LEU T 209
None
ZEN  T   1 (-4.1A)
None
None
None
1.01A 3w67B-1j17T:
undetectable
3w67B-1j17T:
21.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4HFP_D_15UD402_1
(PROTHROMBIN)
1j17 TRYPSIN II, ANIONIC
(Rattus
norvegicus)
6 / 12 HIS T  57
ASP T 189
ALA T 190
VAL T 213
TRP T 215
GLY T 226
SO4  T 600 (-3.8A)
ZEN  T   1 ( 3.8A)
ZEN  T   1 (-3.8A)
ZEN  T   1 (-4.1A)
ZEN  T   1 (-3.4A)
ZEN  T   1 (-3.7A)
0.28A 4hfpD-1j17T:
34.3
4hfpD-1j17T:
37.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RN6_B_15UB301_1
(THROMBIN HEAVY CHAIN)
1j17 TRYPSIN II, ANIONIC
(Rattus
norvegicus)
6 / 12 HIS T  57
ALA T 190
VAL T 213
TRP T 215
GLY T 216
GLY T 226
SO4  T 600 (-3.8A)
ZEN  T   1 (-3.8A)
ZEN  T   1 (-4.1A)
ZEN  T   1 (-3.4A)
ZEN  T   1 (-3.7A)
ZEN  T   1 (-3.7A)
0.72A 4rn6B-1j17T:
28.7
4rn6B-1j17T:
37.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KBW_A_RBFA201_1
(RIBOFLAVIN
TRANSPORTER RIBU)
1j17 TRYPSIN II, ANIONIC
(Rattus
norvegicus)
5 / 12 LEU T 185
ASP T 189
GLY T 226
ASN T 224
ALA T 170
None
ZEN  T   1 ( 3.8A)
ZEN  T   1 (-3.7A)
None
None
1.42A 5kbwA-1j17T:
undetectable
5kbwA-1j17T:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC0_A_RBFA303_1
(RIBOFLAVIN
TRANSPORTER RIBU)
1j17 TRYPSIN II, ANIONIC
(Rattus
norvegicus)
5 / 12 LEU T 185
ASP T 189
GLY T 226
ASN T 224
ALA T 170
None
ZEN  T   1 ( 3.8A)
ZEN  T   1 (-3.7A)
None
None
1.41A 5kc0A-1j17T:
undetectable
5kc0A-1j17T:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_H_PCFH604_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 8
CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL)
1j17 TRYPSIN II, ANIONIC
(Rattus
norvegicus)
5 / 8 GLY T 216
VAL T 183
GLY T 193
SER T 195
ALA T  55
ZEN  T   1 (-3.7A)
None
SO4  T 600 (-3.8A)
SO4  T 600 ( 2.6A)
None
1.39A 6hu9H-1j17T:
undetectable
6hu9e-1j17T:
undetectable
6hu9H-1j17T:
14.69
6hu9e-1j17T:
22.87