SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'ZDR'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVD_B_SAMB601_1
(CATECHOL-O-METHYLTRA
NSFERASE)		 3ekm DIAMINOPIMELATE
EPIMERASE,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		3 / 3 SER A  94
GLU A 245
ASP A  38
 None
ZDR  A 500 (-3.0A)
None
 0.91A 2avdB-3ekmA:
undetectable		 2avdB-3ekmA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GAL_A_1GNA998_1
(GALECTIN-7)		 3ekm DIAMINOPIMELATE
EPIMERASE,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		4 / 6 HIS A 190
ASN A 227
ARG A 246
GLU A  97
 None
ZDR  A 500 (-3.0A)
ZDR  A 500 (-3.7A)
None
 1.40A 3galA-3ekmA:
undetectable		 3galA-3ekmA:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VHU_A_SNLA1001_1
(MINERALOCORTICOID
RECEPTOR)		 3ekm DIAMINOPIMELATE
EPIMERASE,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 12 ASN A  37
LEU A 261
MET A 297
CYH A  99
PHE A  39
 ZDR  A 500 (-3.4A)
None
None
ZDR  A 500 (-3.0A)
None
 1.46A 3vhuA-3ekmA:
undetectable		 3vhuA-3ekmA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A81_A_DXCA1161_0
(MAJOR POLLEN
ALLERGEN BET V 1-A)		 3ekm DIAMINOPIMELATE
EPIMERASE,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 12 ILE A 131
ILE A 286
VAL A 277
ASN A 101
ASN A  37
 None
None
None
ZDR  A 500 (-3.7A)
ZDR  A 500 (-3.4A)
 1.09A 4a81A-3ekmA:
undetectable		 4a81A-3ekmA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0V_D_MIXD101_1
(DNA TOPOISOMERASE
2-BETA)		 3ekm DIAMINOPIMELATE
EPIMERASE,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		4 / 6 ARG A 246
GLY A 247
ASN A  37
GLU A 245
 ZDR  A 500 (-3.7A)
None
ZDR  A 500 (-3.4A)
ZDR  A 500 (-3.0A)
 0.82A 4g0vB-3ekmA:
undetectable		 4g0vB-3ekmA:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0V_D_MIXD101_1
(DNA TOPOISOMERASE
2-BETA)		 3ekm DIAMINOPIMELATE
EPIMERASE,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		4 / 6 ARG A 246
GLY A 247
GLU A 245
GLN A  54
 ZDR  A 500 (-3.7A)
None
ZDR  A 500 (-3.0A)
None
 1.21A 4g0vB-3ekmA:
undetectable		 4g0vB-3ekmA:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L8F_B_MTXB301_1
(GAMMA-GLUTAMYL
HYDROLASE)		 3ekm DIAMINOPIMELATE
EPIMERASE,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 11 GLY A 257
GLY A 255
GLY A 100
GLU A 245
HIS A 190
 None
ZDR  A 500 (-3.6A)
ZDR  A 500 (-3.6A)
ZDR  A 500 (-3.0A)
None
 1.15A 4l8fB-3ekmA:
undetectable		 4l8fB-3ekmA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L8F_D_MTXD301_1
(GAMMA-GLUTAMYL
HYDROLASE)		 3ekm DIAMINOPIMELATE
EPIMERASE,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 11 GLY A 257
GLY A 255
GLY A 100
GLU A 245
HIS A 190
 None
ZDR  A 500 (-3.6A)
ZDR  A 500 (-3.6A)
ZDR  A 500 (-3.0A)
None
 1.14A 4l8fD-3ekmA:
undetectable		 4l8fD-3ekmA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O33_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)		 3ekm DIAMINOPIMELATE
EPIMERASE,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 12 GLY A 255
ALA A 258
GLY A 257
THR A 193
LEU A 261
 ZDR  A 500 (-3.6A)
None
None
None
None
 0.93A 4o33A-3ekmA:
undetectable		 4o33A-3ekmA:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O3F_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)		 3ekm DIAMINOPIMELATE
EPIMERASE,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 12 GLY A 255
ALA A 258
GLY A 257
THR A 193
LEU A 261
 ZDR  A 500 (-3.6A)
None
None
None
None
 0.82A 4o3fA-3ekmA:
undetectable		 4o3fA-3ekmA:
23.50