SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'Z99'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_K_KANK301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3sm9 METABOTROPIC
GLUTAMATE RECEPTOR 3
(Homo
sapiens) 		4 / 8 ASP A  38
ASP A 169
ASP A 276
GLU A 299
 None
Z99  A 485 ( 4.5A)
Z99  A 485 ( 3.8A)
None
 1.11A 4gkhC-3sm9A:
undetectable
4gkhK-3sm9A:
undetectable		 4gkhC-3sm9A:
19.62
4gkhK-3sm9A:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_G_KANG301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3sm9 METABOTROPIC
GLUTAMATE RECEPTOR 3
(Homo
sapiens) 		4 / 8 ASP A  38
ASP A 169
ASP A 276
GLU A 299
 None
Z99  A 485 ( 4.5A)
Z99  A 485 ( 3.8A)
None
 1.10A 4gkiE-3sm9A:
undetectable
4gkiG-3sm9A:
undetectable		 4gkiE-3sm9A:
19.62
4gkiG-3sm9A:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PL1_A_SAMA401_0
(DUAL-SPECIFICITY RNA
METHYLTRANSFERASE
RLMN)		 3mq4 METABOTROPIC
GLUTAMATE RECEPTOR 7
(Homo
sapiens) 		5 / 11 PHE A 195
PRO A  56
SER A 181
ILE A 163
ASN A 167
 None
None
Z99  A 514 (-4.6A)
None
None
 1.32A 4pl1A-3mq4A:
2.0		 4pl1A-3mq4A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PL1_A_SAMA401_0
(DUAL-SPECIFICITY RNA
METHYLTRANSFERASE
RLMN)		 3sm9 METABOTROPIC
GLUTAMATE RECEPTOR 3
(Homo
sapiens) 		5 / 11 PHE A 162
PRO A  21
SER A 148
ILE A 130
ASN A 134
 None
CL  A 486 ( 3.9A)
Z99  A 485 (-4.6A)
None
SO4  A 480 (-3.4A)
 1.36A 4pl1A-3sm9A:
1.9		 4pl1A-3sm9A:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGY_A_ERYA403_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 3sm9 METABOTROPIC
GLUTAMATE RECEPTOR 3
(Homo
sapiens) 		4 / 6 ASP A  38
ILE A 365
TYR A 146
TYR A 125
 None
None
None
Z99  A 485 ( 4.2A)
 1.30A 5igyA-3sm9A:
undetectable		 5igyA-3sm9A:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBV_D_FI8D1904_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 3sm9 METABOTROPIC
GLUTAMATE RECEPTOR 3
(Homo
sapiens) 		4 / 8 ASP A 276
ARG A  39
GLU A 362
VAL A 368
 Z99  A 485 ( 3.8A)
Z99  A 485 (-3.8A)
None
None
 1.27A 6fbvD-3sm9A:
0.0		 6fbvD-3sm9A:
16.18