SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'Z69'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3C6G_B_VD3B700_1 (CYTOCHROME P450 2R1)	3mha	LIPOPROTEIN LPRG (Mycobacterium tuberculosis)	5 / 12	LEU A 80 PHE A 104 ALA A 126 VAL A 91 GLY A 78	Z69 A 1 ( 4.6A) Z69 A 1 (-4.1A) None Z69 A 1 (-4.8A) None	1.11A	3c6gB-3mhaA: undetectable	3c6gB-3mhaA: 17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4X1K_D_LOCD502_2 (TUBULIN BETA CHAIN)	3mha	LIPOPROTEIN LPRG (Mycobacterium tuberculosis)	5 / 12	LEU A 111 THR A 116 ALA A 102 VAL A 91 ILE A 100	Z69 A 1 ( 4.8A) None Z69 A 1 ( 4.9A) Z69 A 1 (-4.8A) None	1.00A	4x1kD-3mhaA: undetectable	4x1kD-3mhaA: 19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4X20_D_LOCD502_2 (TUBULIN BETA CHAIN)	3mha	LIPOPROTEIN LPRG (Mycobacterium tuberculosis)	5 / 11	LEU A 111 THR A 116 ALA A 102 VAL A 91 ILE A 100	Z69 A 1 ( 4.8A) None Z69 A 1 ( 4.9A) Z69 A 1 (-4.8A) None	0.97A	4x20D-3mhaA: undetectable	4x20D-3mhaA: 19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5UUN_A_ACTA305_0 (GLUTATHIONE S-TRANSFERASE-LIKE PROTEIN)	3mha	LIPOPROTEIN LPRG (Mycobacterium tuberculosis)	3 / 3	THR A 220 MET A 60 HIS A 59	None Z69 A 1 (-3.0A) None	0.89A	5uunA-3mhaA: undetectable	5uunA-3mhaA: 20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5XDH_B_DAHB60_1 (PUTATIVE CYTOCHROME C)	3mha	LIPOPROTEIN LPRG (Mycobacterium tuberculosis)	4 / 5	MET A 219 ASN A 215 VAL A 64 LEU A 62	Z69 A 1 (-4.2A) None None Z69 A 1 ( 4.8A)	1.32A	5xdhB-3mhaA: undetectable	5xdhB-3mhaA: 20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5XDH_D_DAHD60_1 (PUTATIVE CYTOCHROME C)	3mha	LIPOPROTEIN LPRG (Mycobacterium tuberculosis)	4 / 5	MET A 219 ASN A 215 VAL A 64 LEU A 62	Z69 A 1 (-4.2A) None None Z69 A 1 ( 4.8A)	1.15A	5xdhD-3mhaA: undetectable	5xdhD-3mhaA: 20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5ZJI_B_PQNB842_1 (PHOTOSYSTEM I P700 CHLOROPHYLL A APOPROTEIN A2)	3mha	LIPOPROTEIN LPRG (Mycobacterium tuberculosis)	5 / 10	ILE A 180 ILE A 160 ALA A 205 LEU A 204 ALA A 48	Z69 A 1 (-4.4A) None None None None	0.98A	5zjiB-3mhaA: undetectable	5zjiB-3mhaA: 17.73

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["3C6G_B_VD3B700_1","CYTOCHROME P450 2R1","3mha","LIPOPROTEIN LPRG","Mycobacterium tuberculosis",5,"LEU A  80;PHE A 104;ALA A 126;VAL A  91;GLY A  78","Z69 A   1 ( 4.6A);Z69 A   1 (-4.1A);None;Z69 A   1 (-4.8A);None","1.11A","3c6gB-3mhaA:undetectable",null],["4X1K_D_LOCD502_2","TUBULIN BETA CHAIN","3mha","LIPOPROTEIN LPRG","Mycobacterium tuberculosis",5,"LEU A 111;THR A 116;ALA A 102;VAL A  91;ILE A 100","Z69 A   1 ( 4.8A);None;Z69 A   1 ( 4.9A);Z69 A   1 (-4.8A);None","1.00A","4x1kD-3mhaA:undetectable","3c6gB-3mhaA:17.01"],["4X20_D_LOCD502_2","TUBULIN BETA CHAIN","3mha","LIPOPROTEIN LPRG","Mycobacterium tuberculosis",5,"LEU A 111;THR A 116;ALA A 102;VAL A  91;ILE A 100","Z69 A   1 ( 4.8A);None;Z69 A   1 ( 4.9A);Z69 A   1 (-4.8A);None","0.97A","4x20D-3mhaA:undetectable","4x1kD-3mhaA:19.33"],["5UUN_A_ACTA305_0","GLUTATHIONE S-TRANSFERASE-LIKE PROTEIN","3mha","LIPOPROTEIN LPRG","Mycobacterium tuberculosis",3,"THR A 220;MET A  60;HIS A  59","None;Z69 A   1 (-3.0A);None","0.89A","5uunA-3mhaA:undetectable","4x20D-3mhaA:19.33"],["5XDH_B_DAHB60_1","PUTATIVE CYTOCHROME C","3mha","LIPOPROTEIN LPRG","Mycobacterium tuberculosis",4,"MET A 219;ASN A 215;VAL A  64;LEU A  62","Z69 A   1 (-4.2A);None;None;Z69 A   1 ( 4.8A)","1.32A","5xdhB-3mhaA:undetectable","5uunA-3mhaA:20.88"],["5XDH_D_DAHD60_1","PUTATIVE CYTOCHROME C","3mha","LIPOPROTEIN LPRG","Mycobacterium tuberculosis",4,"MET A 219;ASN A 215;VAL A  64;LEU A  62","Z69 A   1 (-4.2A);None;None;Z69 A   1 ( 4.8A)","1.15A","5xdhD-3mhaA:undetectable","5xdhB-3mhaA:20.96"],["5ZJI_B_PQNB842_1","PHOTOSYSTEM I P700 CHLOROPHYLL A APOPROTEIN A2","3mha","LIPOPROTEIN LPRG","Mycobacterium tuberculosis",5,"ILE A 180;ILE A 160;ALA A 205;LEU A 204;ALA A  48","Z69 A   1 (-4.4A);None;None;None;None","0.98A","5zjiB-3mhaA:undetectable","5xdhD-3mhaA:20.96"]]