SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'YSA'
DrReposER ID / Desc. | Hit PDBID |
Hit Macromolecule |
Res. Matches |
Interface | HETATM | RMSD | Dali Z-score |
Seq. Identity (%) |
View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1FKO_A_EFZA999_1 (HIV-1 RT, A-CHAIN) |
2pid | TYROSYL-TRNASYNTHETASE (Homosapiens) | 5 / 10 | LEU A 224TYR A 177GLY A 114LEU A 119TYR A 221 | NoneNoneNoneNoneYSA A 384 (-4.7A) | 1.40A | 1fkoA-2pidA:undetectable | 1fkoA-2pidA:20.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1HBP_A_RTLA184_0 (RETINOL BINDINGPROTEIN) |
1vbm | TYROSYL-TRNASYNTHETASE (Escherichiacoli) | 5 / 11 | PHE A 114ALA A 121TYR A 37LEU A 194GLN A 195 | NoneNoneYSA A3001 (-4.7A)NoneYSA A3001 (-4.4A) | 1.23A | 1hbpA-1vbmA:undetectable | 1hbpA-1vbmA:22.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1JZS_A_MRCA1301_1 (ISOLEUCYL-TRNASYNTHETASE) |
1vbm | TYROSYL-TRNASYNTHETASE (Escherichiacoli) | 6 / 11 | GLY A 39HIS A 48HIS A 51GLY A 198ASP A 200GLN A 201 | YSA A3001 (-3.1A)SO4 A2003 (-3.9A)YSA A3001 ( 3.8A)YSA A3001 (-3.0A)YSA A3001 (-3.2A)YSA A3001 (-3.5A) | 0.71A | 1jzsA-1vbmA:undetectable | 1jzsA-1vbmA:18.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1JZS_A_MRCA1301_1 (ISOLEUCYL-TRNASYNTHETASE) |
1vbm | TYROSYL-TRNASYNTHETASE (Escherichiacoli) | 6 / 11 | GLY A 39HIS A 51GLY A 198ASP A 200GLN A 201ILE A 228 | YSA A3001 (-3.1A)YSA A3001 ( 3.8A)YSA A3001 (-3.0A)YSA A3001 (-3.2A)YSA A3001 (-3.5A)YSA A3001 (-4.1A) | 0.78A | 1jzsA-1vbmA:undetectable | 1jzsA-1vbmA:18.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1JZS_A_MRCA1301_1 (ISOLEUCYL-TRNASYNTHETASE) |
2pid | TYROSYL-TRNASYNTHETASE (Homosapiens) | 6 / 11 | GLY A 79HIS A 88HIS A 91GLY A 244ASP A 246GLN A 247 | YSA A 384 (-3.2A)NoneYSA A 384 (-4.1A)YSA A 384 (-2.5A)YSA A 384 (-3.3A)YSA A 384 (-3.2A) | 0.65A | 1jzsA-2pidA:undetectable | 1jzsA-2pidA:18.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1JZS_A_MRCA1301_1 (ISOLEUCYL-TRNASYNTHETASE) |
2pid | TYROSYL-TRNASYNTHETASE (Homosapiens) | 6 / 11 | GLY A 79HIS A 91GLY A 244ASP A 246GLN A 247ILE A 274 | YSA A 384 (-3.2A)YSA A 384 (-4.1A)YSA A 384 (-2.5A)YSA A 384 (-3.3A)YSA A 384 (-3.2A)YSA A 384 (-4.4A) | 0.57A | 1jzsA-2pidA:undetectable | 1jzsA-2pidA:18.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1PG2_A_ADNA552_1 (METHIONYL-TRNASYNTHETASE) |
1vbm | TYROSYL-TRNASYNTHETASE (Escherichiacoli) | 5 / 11 | HIS A 48GLY A 50HIS A 51GLY A 198ASP A 200 | SO4 A2003 (-3.9A)YSA A3001 (-3.3A)YSA A3001 ( 3.8A)YSA A3001 (-3.0A)YSA A3001 (-3.2A) | 0.36A | 1pg2A-1vbmA:9.3 | 1pg2A-1vbmA:20.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1PG2_A_ADNA552_1 (METHIONYL-TRNASYNTHETASE) |
2pid | TYROSYL-TRNASYNTHETASE (Homosapiens) | 5 / 11 | HIS A 88GLY A 90HIS A 91GLY A 244ASP A 246 | NoneYSA A 384 (-3.5A)YSA A 384 (-4.1A)YSA A 384 (-2.5A)YSA A 384 (-3.3A) | 0.35A | 1pg2A-2pidA:8.4 | 1pg2A-2pidA:20.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1QU2_A_MRCA1993_1 (ISOLEUCYL-TRNASYNTHETASE) |
1vbm | TYROSYL-TRNASYNTHETASE (Escherichiacoli) | 5 / 12 | GLY A 50HIS A 51GLY A 198ASP A 200GLN A 201 | YSA A3001 (-3.3A)YSA A3001 ( 3.8A)YSA A3001 (-3.0A)YSA A3001 (-3.2A)YSA A3001 (-3.5A) | 0.45A | 1qu2A-1vbmA:6.8 | 1qu2A-1vbmA:16.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1QU2_A_MRCA1993_1 (ISOLEUCYL-TRNASYNTHETASE) |
2pid | TYROSYL-TRNASYNTHETASE (Homosapiens) | 5 / 12 | GLY A 90HIS A 91GLY A 244ASP A 246GLN A 247 | YSA A 384 (-3.5A)YSA A 384 (-4.1A)YSA A 384 (-2.5A)YSA A 384 (-3.3A)YSA A 384 (-3.2A) | 0.57A | 1qu2A-2pidA:4.3 | 1qu2A-2pidA:18.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1QU2_A_MRCA1993_1 (ISOLEUCYL-TRNASYNTHETASE) |
2pid | TYROSYL-TRNASYNTHETASE (Homosapiens) | 5 / 12 | HIS A 88GLY A 90HIS A 91GLY A 244ASP A 246 | NoneYSA A 384 (-3.5A)YSA A 384 (-4.1A)YSA A 384 (-2.5A)YSA A 384 (-3.3A) | 0.85A | 1qu2A-2pidA:4.3 | 1qu2A-2pidA:18.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1QU3_A_MRCA993_1 (ISOLEUCYL-TRNASYNTHETASE) |
2pid | TYROSYL-TRNASYNTHETASE (Homosapiens) | 5 / 12 | HIS A 88GLY A 90HIS A 91ASP A 246GLN A 247 | NoneYSA A 384 (-3.5A)YSA A 384 (-4.1A)YSA A 384 (-3.3A)YSA A 384 (-3.2A) | 0.95A | 1qu3A-2pidA:5.6 | 1qu3A-2pidA:18.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2AZX_A_TRPA601_0 (TRYPTOPHANYL-TRNASYNTHETASE) |
1vbm | TYROSYL-TRNASYNTHETASE (Escherichiacoli) | 5 / 12 | TYR A 37GLY A 39THR A 76GLN A 179GLN A 201 | YSA A3001 (-4.7A)YSA A3001 (-3.1A)YSA A3001 (-3.7A)YSA A3001 (-3.5A)YSA A3001 (-3.5A) | 0.89A | 2azxA-1vbmA:20.5 | 2azxA-1vbmA:24.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2BFP_C_H4BC1290_1 (PTERIDINE REDUCTASE1) |
1vbm | TYROSYL-TRNASYNTHETASE (Escherichiacoli) | 4 / 8 | ASP A 41TYR A 175LEU A 71LEU A 186 | YSA A3001 (-3.9A)YSA A3001 (-4.3A)NoneNone | 0.97A | 2bfpC-1vbmA:5.4 | 2bfpC-1vbmA:23.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2C49_B_ADNB1301_1 (SUGAR KINASE MJ0406) |
1vbm | TYROSYL-TRNASYNTHETASE (Escherichiacoli) | 4 / 7 | ASP A 41GLY A 73GLY A 74ASN A 126 | YSA A3001 (-3.9A)YSA A3001 ( 4.9A)NoneYSA A3001 ( 4.9A) | 0.76A | 2c49B-1vbmA:2.2 | 2c49B-1vbmA:23.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2C49_B_ADNB1301_1 (SUGAR KINASE MJ0406) |
2pid | TYROSYL-TRNASYNTHETASE (Homosapiens) | 4 / 7 | ASP A 81GLY A 113GLY A 114ASN A 173 | YSA A 384 (-3.9A)YSA A 384 ( 4.6A)NoneYSA A 384 ( 4.8A) | 0.69A | 2c49B-2pidA:undetectable | 2c49B-2pidA:20.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2QMM_A_SAMA301_0 (UPF0217 PROTEINAF_1056) |
1vbm | TYROSYL-TRNASYNTHETASE (Escherichiacoli) | 5 / 9 | ILE A 196GLY A 197GLY A 198LEU A 56CYH A 57 | NoneYSA A3001 (-3.6A)YSA A3001 (-3.0A)NoneNone | 1.13A | 2qmmA-1vbmA:undetectable | 2qmmA-1vbmA:21.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2QWX_B_ML1B233_1 (RIBOSYLDIHYDRONICOTINAMIDE DEHYDROGENASE[QUINONE]) |
5usf | TYROSYL-TRNASYNTHETASE, PUTATIVE (Leishmaniadonovani) | 4 / 7 | GLY A 50GLY A 182GLN A 180PHE A 69 | NoneYSA A 701 (-3.3A)NoneNone | 0.80A | 2qwxA-5usfA:undetectable2qwxB-5usfA:2.2 | 2qwxA-5usfA:15.742qwxB-5usfA:15.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2X1L_A_ADNA601_1 (METHIONYL-TRNASYNTHETASE) |
1vbm | TYROSYL-TRNASYNTHETASE (Escherichiacoli) | 5 / 11 | HIS A 48GLY A 50HIS A 51GLY A 198ASP A 200 | SO4 A2003 (-3.9A)YSA A3001 (-3.3A)YSA A3001 ( 3.8A)YSA A3001 (-3.0A)YSA A3001 (-3.2A) | 0.46A | 2x1lA-1vbmA:8.2 | 2x1lA-1vbmA:20.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2X1L_A_ADNA601_1 (METHIONYL-TRNASYNTHETASE) |
2pid | TYROSYL-TRNASYNTHETASE (Homosapiens) | 5 / 11 | HIS A 88GLY A 90HIS A 91GLY A 244ASP A 246 | NoneYSA A 384 (-3.5A)YSA A 384 (-4.1A)YSA A 384 (-2.5A)YSA A 384 (-3.3A) | 0.45A | 2x1lA-2pidA:8.8 | 2x1lA-2pidA:22.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2X1L_B_ADNB601_1 (METHIONYL-TRNASYNTHETASE) |
1vbm | TYROSYL-TRNASYNTHETASE (Escherichiacoli) | 5 / 12 | HIS A 48GLY A 50HIS A 51GLY A 198ASP A 200 | SO4 A2003 (-3.9A)YSA A3001 (-3.3A)YSA A3001 ( 3.8A)YSA A3001 (-3.0A)YSA A3001 (-3.2A) | 0.45A | 2x1lB-1vbmA:7.5 | 2x1lB-1vbmA:20.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2X1L_B_ADNB601_1 (METHIONYL-TRNASYNTHETASE) |
2pid | TYROSYL-TRNASYNTHETASE (Homosapiens) | 5 / 12 | HIS A 88GLY A 90HIS A 91GLY A 244ASP A 246 | NoneYSA A 384 (-3.5A)YSA A 384 (-4.1A)YSA A 384 (-2.5A)YSA A 384 (-3.3A) | 0.44A | 2x1lB-2pidA:8.4 | 2x1lB-2pidA:22.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2X1L_C_ADNC601_1 (METHIONYL-TRNASYNTHETASE) |
1vbm | TYROSYL-TRNASYNTHETASE (Escherichiacoli) | 5 / 11 | HIS A 48GLY A 50HIS A 51GLY A 198ASP A 200 | SO4 A2003 (-3.9A)YSA A3001 (-3.3A)YSA A3001 ( 3.8A)YSA A3001 (-3.0A)YSA A3001 (-3.2A) | 0.49A | 2x1lC-1vbmA:7.6 | 2x1lC-1vbmA:20.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2X1L_C_ADNC601_1 (METHIONYL-TRNASYNTHETASE) |
2pid | TYROSYL-TRNASYNTHETASE (Homosapiens) | 5 / 11 | HIS A 88GLY A 90HIS A 91GLY A 244ASP A 246 | NoneYSA A 384 (-3.5A)YSA A 384 (-4.1A)YSA A 384 (-2.5A)YSA A 384 (-3.3A) | 0.47A | 2x1lC-2pidA:9.0 | 2x1lC-2pidA:22.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3CSJ_B_CBLB211_0 (GLUTATHIONES-TRANSFERASE P) |
2pid | TYROSYL-TRNASYNTHETASE (Homosapiens) | 5 / 9 | PRO A 272VAL A 271GLY A 243ILE A 76GLY A 97 | NoneNoneYSA A 384 (-3.1A)NoneNone | 1.44A | 3csjB-2pidA:undetectable | 3csjB-2pidA:19.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3G8I_A_RO7A1_2 (PEROXISOMEPROLIFERATOR-ACTIVATED RECEPTOR ALPHA) |
2pid | TYROSYL-TRNASYNTHETASE (Homosapiens) | 4 / 7 | GLN A 225LEU A 98VAL A 170LEU A 87 | YSA A 384 (-3.3A)NoneNoneNone | 0.86A | 3g8iA-2pidA:undetectable | 3g8iA-2pidA:22.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3TKD_A_CYZA266_2 (GLUTAMATE RECEPTOR 2) |
1vbm | TYROSYL-TRNASYNTHETASE (Escherichiacoli) | 4 / 5 | ILE A 196PRO A 54SER A 199GLY A 197 | NoneYSA A3001 (-4.1A)NoneYSA A3001 (-3.6A) | 1.04A | 3tkdB-1vbmA:undetectable | 3tkdB-1vbmA:20.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3TKD_B_CYZB267_1 (GLUTAMATE RECEPTOR 2) |
1vbm | TYROSYL-TRNASYNTHETASE (Escherichiacoli) | 4 / 5 | ILE A 196PRO A 54SER A 199GLY A 197 | NoneYSA A3001 (-4.1A)NoneYSA A3001 (-3.6A) | 1.04A | 3tkdA-1vbmA:undetectable | 3tkdA-1vbmA:20.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3UQ6_B_ADNB401_2 (ADENOSINE KINASE,PUTATIVE) |
5usf | TYROSYL-TRNASYNTHETASE, PUTATIVE (Leishmaniadonovani) | 4 / 5 | LEU A 181GLY A 182PHE A 39ASN A 56 | YSA A 701 (-3.6A)YSA A 701 (-3.3A)YSA A 701 (-4.6A)None | 1.22A | 3uq6B-5usfA:undetectable | 3uq6B-5usfA:20.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4A7T_A_5FWA1002_1 (SUPEROXIDE DISMUTASE[CU-ZN]) |
1vbm | TYROSYL-TRNASYNTHETASE (Escherichiacoli) | 3 / 3 | ASN A 126TRP A 129ASP A 41 | YSA A3001 ( 4.9A)NoneYSA A3001 (-3.9A) | 1.01A | 4a7tA-1vbmA:undetectable4a7tF-1vbmA:undetectable | 4a7tA-1vbmA:18.874a7tF-1vbmA:18.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4A7T_A_5FWA1002_1 (SUPEROXIDE DISMUTASE[CU-ZN]) |
2pid | TYROSYL-TRNASYNTHETASE (Homosapiens) | 3 / 3 | ASN A 173TRP A 176ASP A 81 | YSA A 384 ( 4.8A)NoneYSA A 384 (-3.9A) | 0.78A | 4a7tA-2pidA:undetectable4a7tF-2pidA:undetectable | 4a7tA-2pidA:17.614a7tF-2pidA:17.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4I1N_A_FOLA201_0 (DIHYDROFOLATEREDUCTASE) |
2pid | TYROSYL-TRNASYNTHETASE (Homosapiens) | 5 / 11 | ILE A 269ALA A 94LEU A 47PHE A 48LEU A 38 | NoneYSA A 384 ( 3.7A)NoneNoneNone | 1.38A | 4i1nA-2pidA:undetectable | 4i1nA-2pidA:18.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5GWX_A_SAMA301_0 (GLYCINE SARCOSINEN-METHYLTRANSFERASE) |
2pid | TYROSYL-TRNASYNTHETASE (Homosapiens) | 5 / 12 | ALA A 94GLY A 244GLY A 79HIS A 91LEU A 292 | YSA A 384 ( 3.7A)YSA A 384 (-2.5A)YSA A 384 (-3.2A)YSA A 384 (-4.1A)None | 0.96A | 5gwxA-2pidA:2.5 | 5gwxA-2pidA:23.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5HG0_B_SAMB301_0 (PANTOTHENATESYNTHETASE) |
1vbm | TYROSYL-TRNASYNTHETASE (Escherichiacoli) | 5 / 12 | HIS A 48GLY A 50HIS A 51GLY A 198ASP A 200 | SO4 A2003 (-3.9A)YSA A3001 (-3.3A)YSA A3001 ( 3.8A)YSA A3001 (-3.0A)YSA A3001 (-3.2A) | 1.00A | 5hg0B-1vbmA:7.8 | 5hg0B-1vbmA:23.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5HG0_B_SAMB301_0 (PANTOTHENATESYNTHETASE) |
2pid | TYROSYL-TRNASYNTHETASE (Homosapiens) | 5 / 12 | HIS A 88GLY A 90HIS A 91GLY A 244ASP A 246 | NoneYSA A 384 (-3.5A)YSA A 384 (-4.1A)YSA A 384 (-2.5A)YSA A 384 (-3.3A) | 0.94A | 5hg0B-2pidA:7.2 | 5hg0B-2pidA:21.22 |