SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'YSA'


List of Similar Pattern of Amino Acids


Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKO_A_EFZA999_1
(HIV-1 RT, A-CHAIN)
2pid TYROSYL-TRNA
SYNTHETASE

(Homo
sapiens)
5 / 10 LEU A 224
TYR A 177
GLY A 114
LEU A 119
TYR A 221
None
None
None
None
YSA  A 384 (-4.7A)
1.40A 1fkoA-2pidA:
undetectable
1fkoA-2pidA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HBP_A_RTLA184_0
(RETINOL BINDING
PROTEIN)
1vbm TYROSYL-TRNA
SYNTHETASE

(Escherichia
coli)
5 / 11 PHE A 114
ALA A 121
TYR A  37
LEU A 194
GLN A 195
None
None
YSA  A3001 (-4.7A)
None
YSA  A3001 (-4.4A)
1.23A 1hbpA-1vbmA:
undetectable
1hbpA-1vbmA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JZS_A_MRCA1301_1
(ISOLEUCYL-TRNA
SYNTHETASE)
1vbm TYROSYL-TRNA
SYNTHETASE

(Escherichia
coli)
6 / 11 GLY A  39
HIS A  48
HIS A  51
GLY A 198
ASP A 200
GLN A 201
YSA  A3001 (-3.1A)
SO4  A2003 (-3.9A)
YSA  A3001 ( 3.8A)
YSA  A3001 (-3.0A)
YSA  A3001 (-3.2A)
YSA  A3001 (-3.5A)
0.71A 1jzsA-1vbmA:
undetectable
1jzsA-1vbmA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JZS_A_MRCA1301_1
(ISOLEUCYL-TRNA
SYNTHETASE)
1vbm TYROSYL-TRNA
SYNTHETASE

(Escherichia
coli)
6 / 11 GLY A  39
HIS A  51
GLY A 198
ASP A 200
GLN A 201
ILE A 228
YSA  A3001 (-3.1A)
YSA  A3001 ( 3.8A)
YSA  A3001 (-3.0A)
YSA  A3001 (-3.2A)
YSA  A3001 (-3.5A)
YSA  A3001 (-4.1A)
0.78A 1jzsA-1vbmA:
undetectable
1jzsA-1vbmA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JZS_A_MRCA1301_1
(ISOLEUCYL-TRNA
SYNTHETASE)
2pid TYROSYL-TRNA
SYNTHETASE

(Homo
sapiens)
6 / 11 GLY A  79
HIS A  88
HIS A  91
GLY A 244
ASP A 246
GLN A 247
YSA  A 384 (-3.2A)
None
YSA  A 384 (-4.1A)
YSA  A 384 (-2.5A)
YSA  A 384 (-3.3A)
YSA  A 384 (-3.2A)
0.65A 1jzsA-2pidA:
undetectable
1jzsA-2pidA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JZS_A_MRCA1301_1
(ISOLEUCYL-TRNA
SYNTHETASE)
2pid TYROSYL-TRNA
SYNTHETASE

(Homo
sapiens)
6 / 11 GLY A  79
HIS A  91
GLY A 244
ASP A 246
GLN A 247
ILE A 274
YSA  A 384 (-3.2A)
YSA  A 384 (-4.1A)
YSA  A 384 (-2.5A)
YSA  A 384 (-3.3A)
YSA  A 384 (-3.2A)
YSA  A 384 (-4.4A)
0.57A 1jzsA-2pidA:
undetectable
1jzsA-2pidA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PG2_A_ADNA552_1
(METHIONYL-TRNA
SYNTHETASE)
1vbm TYROSYL-TRNA
SYNTHETASE

(Escherichia
coli)
5 / 11 HIS A  48
GLY A  50
HIS A  51
GLY A 198
ASP A 200
SO4  A2003 (-3.9A)
YSA  A3001 (-3.3A)
YSA  A3001 ( 3.8A)
YSA  A3001 (-3.0A)
YSA  A3001 (-3.2A)
0.36A 1pg2A-1vbmA:
9.3
1pg2A-1vbmA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PG2_A_ADNA552_1
(METHIONYL-TRNA
SYNTHETASE)
2pid TYROSYL-TRNA
SYNTHETASE

(Homo
sapiens)
5 / 11 HIS A  88
GLY A  90
HIS A  91
GLY A 244
ASP A 246
None
YSA  A 384 (-3.5A)
YSA  A 384 (-4.1A)
YSA  A 384 (-2.5A)
YSA  A 384 (-3.3A)
0.35A 1pg2A-2pidA:
8.4
1pg2A-2pidA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU2_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)
1vbm TYROSYL-TRNA
SYNTHETASE

(Escherichia
coli)
5 / 12 GLY A  50
HIS A  51
GLY A 198
ASP A 200
GLN A 201
YSA  A3001 (-3.3A)
YSA  A3001 ( 3.8A)
YSA  A3001 (-3.0A)
YSA  A3001 (-3.2A)
YSA  A3001 (-3.5A)
0.45A 1qu2A-1vbmA:
6.8
1qu2A-1vbmA:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU2_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)
2pid TYROSYL-TRNA
SYNTHETASE

(Homo
sapiens)
5 / 12 GLY A  90
HIS A  91
GLY A 244
ASP A 246
GLN A 247
YSA  A 384 (-3.5A)
YSA  A 384 (-4.1A)
YSA  A 384 (-2.5A)
YSA  A 384 (-3.3A)
YSA  A 384 (-3.2A)
0.57A 1qu2A-2pidA:
4.3
1qu2A-2pidA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU2_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)
2pid TYROSYL-TRNA
SYNTHETASE

(Homo
sapiens)
5 / 12 HIS A  88
GLY A  90
HIS A  91
GLY A 244
ASP A 246
None
YSA  A 384 (-3.5A)
YSA  A 384 (-4.1A)
YSA  A 384 (-2.5A)
YSA  A 384 (-3.3A)
0.85A 1qu2A-2pidA:
4.3
1qu2A-2pidA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU3_A_MRCA993_1
(ISOLEUCYL-TRNA
SYNTHETASE)
2pid TYROSYL-TRNA
SYNTHETASE

(Homo
sapiens)
5 / 12 HIS A  88
GLY A  90
HIS A  91
ASP A 246
GLN A 247
None
YSA  A 384 (-3.5A)
YSA  A 384 (-4.1A)
YSA  A 384 (-3.3A)
YSA  A 384 (-3.2A)
0.95A 1qu3A-2pidA:
5.6
1qu3A-2pidA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZX_A_TRPA601_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)
1vbm TYROSYL-TRNA
SYNTHETASE

(Escherichia
coli)
5 / 12 TYR A  37
GLY A  39
THR A  76
GLN A 179
GLN A 201
YSA  A3001 (-4.7A)
YSA  A3001 (-3.1A)
YSA  A3001 (-3.7A)
YSA  A3001 (-3.5A)
YSA  A3001 (-3.5A)
0.89A 2azxA-1vbmA:
20.5
2azxA-1vbmA:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_C_H4BC1290_1
(PTERIDINE REDUCTASE
1)
1vbm TYROSYL-TRNA
SYNTHETASE

(Escherichia
coli)
4 / 8 ASP A  41
TYR A 175
LEU A  71
LEU A 186
YSA  A3001 (-3.9A)
YSA  A3001 (-4.3A)
None
None
0.97A 2bfpC-1vbmA:
5.4
2bfpC-1vbmA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C49_B_ADNB1301_1
(SUGAR KINASE MJ0406)
1vbm TYROSYL-TRNA
SYNTHETASE

(Escherichia
coli)
4 / 7 ASP A  41
GLY A  73
GLY A  74
ASN A 126
YSA  A3001 (-3.9A)
YSA  A3001 ( 4.9A)
None
YSA  A3001 ( 4.9A)
0.76A 2c49B-1vbmA:
2.2
2c49B-1vbmA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C49_B_ADNB1301_1
(SUGAR KINASE MJ0406)
2pid TYROSYL-TRNA
SYNTHETASE

(Homo
sapiens)
4 / 7 ASP A  81
GLY A 113
GLY A 114
ASN A 173
YSA  A 384 (-3.9A)
YSA  A 384 ( 4.6A)
None
YSA  A 384 ( 4.8A)
0.69A 2c49B-2pidA:
undetectable
2c49B-2pidA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMM_A_SAMA301_0
(UPF0217 PROTEIN
AF_1056)
1vbm TYROSYL-TRNA
SYNTHETASE

(Escherichia
coli)
5 / 9 ILE A 196
GLY A 197
GLY A 198
LEU A  56
CYH A  57
None
YSA  A3001 (-3.6A)
YSA  A3001 (-3.0A)
None
None
1.13A 2qmmA-1vbmA:
undetectable
2qmmA-1vbmA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QWX_B_ML1B233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])
5usf TYROSYL-TRNA
SYNTHETASE, PUTATIVE

(Leishmania
donovani)
4 / 7 GLY A  50
GLY A 182
GLN A 180
PHE A  69
None
YSA  A 701 (-3.3A)
None
None
0.80A 2qwxA-5usfA:
undetectable
2qwxB-5usfA:
2.2
2qwxA-5usfA:
15.74
2qwxB-5usfA:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X1L_A_ADNA601_1
(METHIONYL-TRNA
SYNTHETASE)
1vbm TYROSYL-TRNA
SYNTHETASE

(Escherichia
coli)
5 / 11 HIS A  48
GLY A  50
HIS A  51
GLY A 198
ASP A 200
SO4  A2003 (-3.9A)
YSA  A3001 (-3.3A)
YSA  A3001 ( 3.8A)
YSA  A3001 (-3.0A)
YSA  A3001 (-3.2A)
0.46A 2x1lA-1vbmA:
8.2
2x1lA-1vbmA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X1L_A_ADNA601_1
(METHIONYL-TRNA
SYNTHETASE)
2pid TYROSYL-TRNA
SYNTHETASE

(Homo
sapiens)
5 / 11 HIS A  88
GLY A  90
HIS A  91
GLY A 244
ASP A 246
None
YSA  A 384 (-3.5A)
YSA  A 384 (-4.1A)
YSA  A 384 (-2.5A)
YSA  A 384 (-3.3A)
0.45A 2x1lA-2pidA:
8.8
2x1lA-2pidA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X1L_B_ADNB601_1
(METHIONYL-TRNA
SYNTHETASE)
1vbm TYROSYL-TRNA
SYNTHETASE

(Escherichia
coli)
5 / 12 HIS A  48
GLY A  50
HIS A  51
GLY A 198
ASP A 200
SO4  A2003 (-3.9A)
YSA  A3001 (-3.3A)
YSA  A3001 ( 3.8A)
YSA  A3001 (-3.0A)
YSA  A3001 (-3.2A)
0.45A 2x1lB-1vbmA:
7.5
2x1lB-1vbmA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X1L_B_ADNB601_1
(METHIONYL-TRNA
SYNTHETASE)
2pid TYROSYL-TRNA
SYNTHETASE

(Homo
sapiens)
5 / 12 HIS A  88
GLY A  90
HIS A  91
GLY A 244
ASP A 246
None
YSA  A 384 (-3.5A)
YSA  A 384 (-4.1A)
YSA  A 384 (-2.5A)
YSA  A 384 (-3.3A)
0.44A 2x1lB-2pidA:
8.4
2x1lB-2pidA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X1L_C_ADNC601_1
(METHIONYL-TRNA
SYNTHETASE)
1vbm TYROSYL-TRNA
SYNTHETASE

(Escherichia
coli)
5 / 11 HIS A  48
GLY A  50
HIS A  51
GLY A 198
ASP A 200
SO4  A2003 (-3.9A)
YSA  A3001 (-3.3A)
YSA  A3001 ( 3.8A)
YSA  A3001 (-3.0A)
YSA  A3001 (-3.2A)
0.49A 2x1lC-1vbmA:
7.6
2x1lC-1vbmA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X1L_C_ADNC601_1
(METHIONYL-TRNA
SYNTHETASE)
2pid TYROSYL-TRNA
SYNTHETASE

(Homo
sapiens)
5 / 11 HIS A  88
GLY A  90
HIS A  91
GLY A 244
ASP A 246
None
YSA  A 384 (-3.5A)
YSA  A 384 (-4.1A)
YSA  A 384 (-2.5A)
YSA  A 384 (-3.3A)
0.47A 2x1lC-2pidA:
9.0
2x1lC-2pidA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CSJ_B_CBLB211_0
(GLUTATHIONE
S-TRANSFERASE P)
2pid TYROSYL-TRNA
SYNTHETASE

(Homo
sapiens)
5 / 9 PRO A 272
VAL A 271
GLY A 243
ILE A  76
GLY A  97
None
None
YSA  A 384 (-3.1A)
None
None
1.44A 3csjB-2pidA:
undetectable
3csjB-2pidA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)
2pid TYROSYL-TRNA
SYNTHETASE

(Homo
sapiens)
4 / 7 GLN A 225
LEU A  98
VAL A 170
LEU A  87
YSA  A 384 (-3.3A)
None
None
None
0.86A 3g8iA-2pidA:
undetectable
3g8iA-2pidA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKD_A_CYZA266_2
(GLUTAMATE RECEPTOR 2)
1vbm TYROSYL-TRNA
SYNTHETASE

(Escherichia
coli)
4 / 5 ILE A 196
PRO A  54
SER A 199
GLY A 197
None
YSA  A3001 (-4.1A)
None
YSA  A3001 (-3.6A)
1.04A 3tkdB-1vbmA:
undetectable
3tkdB-1vbmA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKD_B_CYZB267_1
(GLUTAMATE RECEPTOR 2)
1vbm TYROSYL-TRNA
SYNTHETASE

(Escherichia
coli)
4 / 5 ILE A 196
PRO A  54
SER A 199
GLY A 197
None
YSA  A3001 (-4.1A)
None
YSA  A3001 (-3.6A)
1.04A 3tkdA-1vbmA:
undetectable
3tkdA-1vbmA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_B_ADNB401_2
(ADENOSINE KINASE,
PUTATIVE)
5usf TYROSYL-TRNA
SYNTHETASE, PUTATIVE

(Leishmania
donovani)
4 / 5 LEU A 181
GLY A 182
PHE A  39
ASN A  56
YSA  A 701 (-3.6A)
YSA  A 701 (-3.3A)
YSA  A 701 (-4.6A)
None
1.22A 3uq6B-5usfA:
undetectable
3uq6B-5usfA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7T_A_5FWA1002_1
(SUPEROXIDE DISMUTASE
[CU-ZN])
1vbm TYROSYL-TRNA
SYNTHETASE

(Escherichia
coli)
3 / 3 ASN A 126
TRP A 129
ASP A  41
YSA  A3001 ( 4.9A)
None
YSA  A3001 (-3.9A)
1.01A 4a7tA-1vbmA:
undetectable
4a7tF-1vbmA:
undetectable
4a7tA-1vbmA:
18.87
4a7tF-1vbmA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7T_A_5FWA1002_1
(SUPEROXIDE DISMUTASE
[CU-ZN])
2pid TYROSYL-TRNA
SYNTHETASE

(Homo
sapiens)
3 / 3 ASN A 173
TRP A 176
ASP A  81
YSA  A 384 ( 4.8A)
None
YSA  A 384 (-3.9A)
0.78A 4a7tA-2pidA:
undetectable
4a7tF-2pidA:
undetectable
4a7tA-2pidA:
17.61
4a7tF-2pidA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I1N_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)
2pid TYROSYL-TRNA
SYNTHETASE

(Homo
sapiens)
5 / 11 ILE A 269
ALA A  94
LEU A  47
PHE A  48
LEU A  38
None
YSA  A 384 ( 3.7A)
None
None
None
1.38A 4i1nA-2pidA:
undetectable
4i1nA-2pidA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWX_A_SAMA301_0
(GLYCINE SARCOSINE
N-METHYLTRANSFERASE)
2pid TYROSYL-TRNA
SYNTHETASE

(Homo
sapiens)
5 / 12 ALA A  94
GLY A 244
GLY A  79
HIS A  91
LEU A 292
YSA  A 384 ( 3.7A)
YSA  A 384 (-2.5A)
YSA  A 384 (-3.2A)
YSA  A 384 (-4.1A)
None
0.96A 5gwxA-2pidA:
2.5
5gwxA-2pidA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HG0_B_SAMB301_0
(PANTOTHENATE
SYNTHETASE)
1vbm TYROSYL-TRNA
SYNTHETASE

(Escherichia
coli)
5 / 12 HIS A  48
GLY A  50
HIS A  51
GLY A 198
ASP A 200
SO4  A2003 (-3.9A)
YSA  A3001 (-3.3A)
YSA  A3001 ( 3.8A)
YSA  A3001 (-3.0A)
YSA  A3001 (-3.2A)
1.00A 5hg0B-1vbmA:
7.8
5hg0B-1vbmA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HG0_B_SAMB301_0
(PANTOTHENATE
SYNTHETASE)
2pid TYROSYL-TRNA
SYNTHETASE

(Homo
sapiens)
5 / 12 HIS A  88
GLY A  90
HIS A  91
GLY A 244
ASP A 246
None
YSA  A 384 (-3.5A)
YSA  A 384 (-4.1A)
YSA  A 384 (-2.5A)
YSA  A 384 (-3.3A)
0.94A 5hg0B-2pidA:
7.2
5hg0B-2pidA:
21.22