SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'YNE'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		 2yne GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE
(Plasmodium
vivax) 		4 / 7 LEU A 317
VAL A  96
LEU A 388
LEU A 116
 None
NHW  A1000 ( 4.0A)
YNE  A1001 (-4.2A)
None
 0.92A 3g8iA-2yneA:
undetectable		 3g8iA-2yneA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP1_A_LDPA708_1
(DOPAMINE
TRANSPORTER, ISOFORM
B)		 2yne GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE
(Plasmodium
vivax) 		5 / 10 PHE A 103
VAL A 363
ASP A 362
PHE A 226
SER A 319
 None
None
None
None
YNE  A1001 (-3.5A)
 1.06A 4xp1A-2yneA:
undetectable		 4xp1A-2yneA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP4_A_COCA706_1
(DOPAMINE TRANSPORTER)		 2yne GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE
(Plasmodium
vivax) 		5 / 11 PHE A 103
VAL A 363
ASP A 362
PHE A 226
SER A 319
 None
None
None
None
YNE  A1001 (-3.5A)
 1.16A 4xp4A-2yneA:
undetectable		 4xp4A-2yneA:
21.55