SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'XYS'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHY_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 2cn3 BETA-1,4-XYLOGLUCAN
HYDROLASE
(Ruminiclostridiu
m
thermocellum) 		5 / 9 GLY A 153
GLY A 161
GLU A 102
ARG A 158
GLY A  54
 None
None
None
XYS  A1773 ( 3.3A)
CA  A1778 ( 4.8A)
 1.30A 1jhyA-2cn3A:
undetectable		 1jhyA-2cn3A:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L4N_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 2cn3 BETA-1,4-XYLOGLUCAN
HYDROLASE
(Ruminiclostridiu
m
thermocellum) 		5 / 9 GLY A 153
GLY A 161
GLU A 102
ARG A 158
GLY A  54
 None
None
None
XYS  A1773 ( 3.3A)
CA  A1778 ( 4.8A)
 1.34A 1l4nA-2cn3A:
undetectable		 1l4nA-2cn3A:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RI4_A_SAMA299_0
(MRNA CAPPING ENZYME)		 2cn3 BETA-1,4-XYLOGLUCAN
HYDROLASE
(Ruminiclostridiu
m
thermocellum) 		5 / 12 GLY A 119
GLY A 152
ALA A  70
SER A  97
TYR A  96
 None
None
GLC  A1769 (-3.5A)
None
XYS  A1774 ( 4.7A)
 1.21A 1ri4A-2cn3A:
undetectable		 1ri4A-2cn3A:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_P_CHDP4525_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE III)		 4w8b EXO-XYLOGLUCANASE
(uncultured
bacterium) 		4 / 7 LEU A 479
ASP A 475
THR A 473
HIS A 368
 XYS  A 618 ( 4.0A)
XYS  A 606 ( 4.1A)
BGC  A 602 ( 4.3A)
None
 1.21A 1v55C-4w8bA:
undetectable
1v55N-4w8bA:
undetectable
1v55P-4w8bA:
undetectable		 1v55C-4w8bA:
22.14
1v55N-4w8bA:
19.46
1v55P-4w8bA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_D_SAMD301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 5d9n B-1,4-ENDOGLUCANASE
(Prevotella
bryantii) 		3 / 3 LYS A 214
ASP A 253
ASP A 241
 XYS  A 408 ( 2.9A)
None
XYS  A 408 ( 3.4A)
 1.01A 2br4D-5d9nA:
undetectable		 2br4D-5d9nA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C49_A_ADNA1301_1
(SUGAR KINASE MJ0406)		 5oyd CELLULASE, PUTATIVE,
CEL5D
(Cellvibrio
japonicus) 		5 / 12 ASP A 433
GLY A 443
GLY A 436
ASN A 437
THR A 133
 None
None
XYS  A 505 ( 3.2A)
None
None
 1.16A 2c49A-5oydA:
undetectable		 2c49A-5oydA:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HKK_A_ALEA300_1
(CARBONIC ANHYDRASE 2)		 4w8b EXO-XYLOGLUCANASE
(uncultured
bacterium) 		4 / 6 ASN A 500
ASN A 447
ILE A 439
GLN A 443
 XYS  A 618 (-3.1A)
XYS  A 618 (-3.4A)
None
XYS  A 618 ( 4.2A)
 1.20A 2hkkA-4w8bA:
undetectable		 2hkkA-4w8bA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_2
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 5oyd CELLULASE, PUTATIVE,
CEL5D
(Cellvibrio
japonicus) 		4 / 6 PHE A 440
ARG A 395
ASN A 434
LEU A 388
 None
None
XYS  A 505 ( 4.1A)
None
 1.13A 2nyrA-5oydA:
undetectable		 2nyrA-5oydA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V3D_A_NBVA1503_1
(GLUCOSYLCERAMIDASE)		 5d9n B-1,4-ENDOGLUCANASE
(Prevotella
bryantii) 		5 / 12 ASN A 161
GLU A 162
HIS A 238
GLU A 280
TRP A 324
 None
XYS  A 408 ( 3.7A)
None
CA  A 401 ( 4.9A)
None
 0.60A 2v3dA-5d9nA:
7.4		 2v3dA-5d9nA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_A_DVAA8_0
(GRAMICIDIN A)		 1ur1 ENDOXYLANASE
(Cellvibrio
mixtus) 		3 / 3 VAL A 265
TRP A 328
TRP A 336
 None
XYS  A1376 ( 4.1A)
XYS  A1376 ( 3.9A)
 1.33A 2xdcA-1ur1A:
undetectable
2xdcB-1ur1A:
undetectable		 2xdcA-1ur1A:
5.46
2xdcB-1ur1A:
5.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_B_DVAB8_0
(GRAMICIDIN A)		 1ur1 ENDOXYLANASE
(Cellvibrio
mixtus) 		3 / 3 TRP A 336
VAL A 265
TRP A 328
 XYS  A1376 ( 3.9A)
None
XYS  A1376 ( 4.1A)
 1.34A 2xdcA-1ur1A:
undetectable
2xdcB-1ur1A:
undetectable		 2xdcA-1ur1A:
5.46
2xdcB-1ur1A:
5.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_C_DVAC8_0
(GRAMICIDIN A)		 1ur1 ENDOXYLANASE
(Cellvibrio
mixtus) 		3 / 3 VAL A 265
TRP A 328
TRP A 336
 None
XYS  A1376 ( 4.1A)
XYS  A1376 ( 3.9A)
 1.43A 2xdcC-1ur1A:
undetectable
2xdcD-1ur1A:
undetectable		 2xdcC-1ur1A:
5.46
2xdcD-1ur1A:
5.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y5M_A_DVAA8_0
(VAL-GRAMICIDIN A)		 1ur1 ENDOXYLANASE
(Cellvibrio
mixtus) 		3 / 3 VAL A 265
TRP A 328
TRP A 336
 None
XYS  A1376 ( 4.1A)
XYS  A1376 ( 3.9A)
 1.34A 2y5mA-1ur1A:
undetectable
2y5mB-1ur1A:
undetectable		 2y5mA-1ur1A:
5.46
2y5mB-1ur1A:
5.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y69_N_CHDN1517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4w8b EXO-XYLOGLUCANASE
(uncultured
bacterium) 		4 / 8 LEU A 479
ASP A 475
THR A 473
HIS A 368
 XYS  A 618 ( 4.0A)
XYS  A 606 ( 4.1A)
BGC  A 602 ( 4.3A)
None
 1.12A 2y69C-4w8bA:
undetectable
2y69N-4w8bA:
undetectable
2y69P-4w8bA:
undetectable		 2y69C-4w8bA:
22.14
2y69N-4w8bA:
19.46
2y69P-4w8bA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6N_A_DVAA8_0
(VAL-GRAMICIDIN A)		 1ur1 ENDOXYLANASE
(Cellvibrio
mixtus) 		3 / 3 VAL A 265
TRP A 328
TRP A 336
 None
XYS  A1376 ( 4.1A)
XYS  A1376 ( 3.9A)
 1.33A 2y6nA-1ur1A:
undetectable
2y6nB-1ur1A:
undetectable		 2y6nA-1ur1A:
5.46
2y6nB-1ur1A:
5.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6N_B_DVAB8_0
(VAL-GRAMICIDIN A)		 1ur1 ENDOXYLANASE
(Cellvibrio
mixtus) 		3 / 3 TRP A 336
VAL A 265
TRP A 328
 XYS  A1376 ( 3.9A)
None
XYS  A1376 ( 4.1A)
 1.33A 2y6nA-1ur1A:
undetectable
2y6nB-1ur1A:
undetectable		 2y6nA-1ur1A:
5.46
2y6nB-1ur1A:
5.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4w8b EXO-XYLOGLUCANASE
(uncultured
bacterium) 		4 / 8 ASP A 475
THR A 473
HIS A 368
LEU A 479
 XYS  A 606 ( 4.1A)
BGC  A 602 ( 4.3A)
None
XYS  A 618 ( 4.0A)
 1.14A 3ablA-4w8bA:
undetectable
3ablC-4w8bA:
undetectable
3ablP-4w8bA:
undetectable		 3ablA-4w8bA:
19.46
3ablC-4w8bA:
22.14
3ablP-4w8bA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4w8b EXO-XYLOGLUCANASE
(uncultured
bacterium) 		4 / 8 LEU A 479
ASP A 475
THR A 473
HIS A 368
 XYS  A 618 ( 4.0A)
XYS  A 606 ( 4.1A)
BGC  A 602 ( 4.3A)
None
 1.14A 3ablC-4w8bA:
undetectable
3ablN-4w8bA:
undetectable
3ablP-4w8bA:
undetectable		 3ablC-4w8bA:
22.14
3ablN-4w8bA:
19.46
3ablP-4w8bA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4w8b EXO-XYLOGLUCANASE
(uncultured
bacterium) 		4 / 8 ASP A 475
THR A 473
HIS A 368
LEU A 479
 XYS  A 606 ( 4.1A)
BGC  A 602 ( 4.3A)
None
XYS  A 618 ( 4.0A)
 1.13A 3abmA-4w8bA:
undetectable
3abmC-4w8bA:
undetectable
3abmP-4w8bA:
undetectable		 3abmA-4w8bA:
19.46
3abmC-4w8bA:
22.14
3abmP-4w8bA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4w8b EXO-XYLOGLUCANASE
(uncultured
bacterium) 		4 / 8 LEU A 479
ASP A 475
THR A 473
HIS A 368
 XYS  A 618 ( 4.0A)
XYS  A 606 ( 4.1A)
BGC  A 602 ( 4.3A)
None
 1.13A 3asnC-4w8bA:
undetectable
3asnN-4w8bA:
undetectable
3asnP-4w8bA:
undetectable		 3asnC-4w8bA:
22.14
3asnN-4w8bA:
19.46
3asnP-4w8bA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4w8b EXO-XYLOGLUCANASE
(uncultured
bacterium) 		4 / 8 ASP A 475
THR A 473
HIS A 368
LEU A 479
 XYS  A 606 ( 4.1A)
BGC  A 602 ( 4.3A)
None
XYS  A 618 ( 4.0A)
 1.17A 3asoA-4w8bA:
undetectable
3asoC-4w8bA:
undetectable
3asoP-4w8bA:
undetectable		 3asoA-4w8bA:
19.46
3asoC-4w8bA:
22.14
3asoP-4w8bA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4w8b EXO-XYLOGLUCANASE
(uncultured
bacterium) 		4 / 8 LEU A 479
ASP A 475
THR A 473
HIS A 368
 XYS  A 618 ( 4.0A)
XYS  A 606 ( 4.1A)
BGC  A 602 ( 4.3A)
None
 1.16A 3asoC-4w8bA:
undetectable
3asoN-4w8bA:
undetectable
3asoP-4w8bA:
undetectable		 3asoC-4w8bA:
22.14
3asoN-4w8bA:
19.46
3asoP-4w8bA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_D_SUED1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 1ur1 ENDOXYLANASE
(Cellvibrio
mixtus) 		5 / 12 GLY A 229
VAL A 154
ASP A 153
SER A 262
ALA A  39
 None
None
None
XYS  A1376 (-3.4A)
None
 1.02A 3sufD-1ur1A:
undetectable		 3sufD-1ur1A:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VT7_A_VDXA500_2
(VITAMIN D3 RECEPTOR)		 3zmr CELLULASE (GLYCOSYL
HYDROLASE FAMILY 5)
(Bacteroides
ovatus) 		4 / 4 LEU A 480
ILE A 380
TYR A 476
TYR A 431
 None
GLC  A1519 ( 3.9A)
XYS  A1524 (-3.9A)
None
 1.35A 3vt7A-3zmrA:
undetectable		 3vt7A-3zmrA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4w8b EXO-XYLOGLUCANASE
(uncultured
bacterium) 		4 / 8 ASP A 475
THR A 473
HIS A 368
LEU A 479
 XYS  A 606 ( 4.1A)
BGC  A 602 ( 4.3A)
None
XYS  A 618 ( 4.0A)
 1.13A 3wg7A-4w8bA:
undetectable
3wg7C-4w8bA:
undetectable
3wg7P-4w8bA:
undetectable		 3wg7A-4w8bA:
19.46
3wg7C-4w8bA:
22.14
3wg7P-4w8bA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4w8b EXO-XYLOGLUCANASE
(uncultured
bacterium) 		4 / 8 LEU A 479
ASP A 475
THR A 473
HIS A 368
 XYS  A 618 ( 4.0A)
XYS  A 606 ( 4.1A)
BGC  A 602 ( 4.3A)
None
 1.14A 3wg7C-4w8bA:
undetectable
3wg7N-4w8bA:
undetectable
3wg7P-4w8bA:
undetectable		 3wg7C-4w8bA:
22.14
3wg7N-4w8bA:
19.46
3wg7P-4w8bA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3X2Q_P_CHDP308_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4w8b EXO-XYLOGLUCANASE
(uncultured
bacterium) 		4 / 8 LEU A 479
ASP A 475
THR A 473
HIS A 368
 XYS  A 618 ( 4.0A)
XYS  A 606 ( 4.1A)
BGC  A 602 ( 4.3A)
None
 1.18A 3x2qC-4w8bA:
undetectable
3x2qN-4w8bA:
undetectable
3x2qP-4w8bA:
undetectable		 3x2qC-4w8bA:
22.14
3x2qN-4w8bA:
19.46
3x2qP-4w8bA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQ8_A_DVAA8_0
(VAL-GRAMICIDIN A)		 1ur1 ENDOXYLANASE
(Cellvibrio
mixtus) 		3 / 3 VAL A 265
TRP A 328
TRP A 336
 None
XYS  A1376 ( 4.1A)
XYS  A1376 ( 3.9A)
 1.29A 3zq8A-1ur1A:
undetectable
3zq8B-1ur1A:
undetectable		 3zq8A-1ur1A:
5.46
3zq8B-1ur1A:
5.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_B_FOLB301_1
(FOLATE RECEPTOR
ALPHA)		 1vbr ENDO-1,4-BETA-XYLANA
SE B
(Thermotoga
maritima) 		3 / 3 ASP A 651
TRP A 802
SER A 691
 None
XYS  A   1 ( 4.0A)
None
 1.04A 4lrhB-1vbrA:
undetectable		 4lrhB-1vbrA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R82_A_ACTA205_0
(OXIDOREDUCTASE)		 2cn3 BETA-1,4-XYLOGLUCAN
HYDROLASE
(Ruminiclostridiu
m
thermocellum) 		4 / 5 SER A 159
GLY A 157
ARG A 158
PHE A  51
 None
None
XYS  A1773 ( 3.3A)
None
 1.11A 4r82A-2cn3A:
undetectable
4r82B-2cn3A:
undetectable		 4r82A-2cn3A:
15.18
4r82B-2cn3A:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EAJ_B_FOLB201_1
(DIHYDROFOLATE
REDUCTASE)		 2cn3 BETA-1,4-XYLOGLUCAN
HYDROLASE
(Ruminiclostridiu
m
thermocellum) 		3 / 3 ASP A 213
ARG A 158
ARG A 179
 None
XYS  A1773 ( 3.3A)
None
 0.97A 5eajB-2cn3A:
undetectable		 5eajB-2cn3A:
12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FUK_A_SNPA1236_1
(MROUPO)		 5d9n B-1,4-ENDOGLUCANASE
(Prevotella
bryantii) 		5 / 7 ILE A 263
THR A 321
ILE A 278
SER A 319
LEU A 260
 XYS  A 410 ( 4.7A)
None
None
None
None
 1.15A 5fukA-5d9nA:
undetectable
5fukB-5d9nA:
undetectable		 5fukA-5d9nA:
22.78
5fukB-5d9nA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N8J_E_DVAE7_0
(GLY-DTY-GLY-DLE-DAL-
DSG-DVA-DAS-DGL-DSN-
DSN-GLY
STREPTAVIDIN)		 5e7g IPT/TIG
DOMAIN-CONTAINING
PROTEIN BACOVA_02650
(Bacteroides
ovatus) 		3 / 3 TYR A 466
SER A 368
TRP A 364
 XYS  A 504 ( 3.1A)
None
BGC  A 507 (-3.2A)
 1.02A 5n8jB-5e7gA:
undetectable		 5n8jB-5e7gA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N8J_O_DVAO7_0
(GLY-DTY-GLY-DLE-DAL-
DSG-DVA-DAS-DGL-DSN-
DSN-GLY
STREPTAVIDIN)		 5e7g IPT/TIG
DOMAIN-CONTAINING
PROTEIN BACOVA_02650
(Bacteroides
ovatus) 		3 / 3 TYR A 466
SER A 368
TRP A 364
 XYS  A 504 ( 3.1A)
None
BGC  A 507 (-3.2A)
 1.03A 5n8jA-5e7gA:
undetectable		 5n8jA-5e7gA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N8J_P_DVAP5_0
(GLY-DTY-GLY-DLE-DAL-
DSG-DVA-DAS-DGL-DSN-
DSN-GLY
STREPTAVIDIN)		 5e7g IPT/TIG
DOMAIN-CONTAINING
PROTEIN BACOVA_02650
(Bacteroides
ovatus) 		3 / 3 TYR A 466
SER A 368
TRP A 364
 XYS  A 504 ( 3.1A)
None
BGC  A 507 (-3.2A)
 1.05A 5n8jD-5e7gA:
undetectable		 5n8jD-5e7gA:
18.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UMW_F_RBFF201_1
(GLYOXALASE/BLEOMYCIN
RESISANCE
PROTEIN/DIOXYGENASE)		 2ypj ENDOGLUCANASE CEL5A
([Eubacterium]
cellulosolvens) 		4 / 7 LEU A 683
TRP A 646
GLU A 612
SER A 609
 None
BGC  A1712 (-3.9A)
XYS  A1715 ( 4.9A)
None
 1.27A 5umwA-2ypjA:
undetectable
5umwF-2ypjA:
undetectable		 5umwA-2ypjA:
30.46
5umwF-2ypjA:
30.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W97_C_CHDC302_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4w8b EXO-XYLOGLUCANASE
(uncultured
bacterium) 		4 / 7 LEU A 479
ASP A 475
THR A 473
HIS A 368
 XYS  A 618 ( 4.0A)
XYS  A 606 ( 4.1A)
BGC  A 602 ( 4.3A)
None
 1.22A 5w97C-4w8bA:
undetectable
5w97a-4w8bA:
undetectable
5w97c-4w8bA:
undetectable		 5w97C-4w8bA:
22.14
5w97a-4w8bA:
19.46
5w97c-4w8bA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_C_CHDC303_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4w8b EXO-XYLOGLUCANASE
(uncultured
bacterium) 		4 / 7 LEU A 479
ASP A 475
THR A 473
HIS A 368
 XYS  A 618 ( 4.0A)
XYS  A 606 ( 4.1A)
BGC  A 602 ( 4.3A)
None
 1.16A 5wauC-4w8bA:
undetectable
5waua-4w8bA:
undetectable
5wauc-4w8bA:
undetectable		 5wauC-4w8bA:
22.14
5waua-4w8bA:
19.46
5wauc-4w8bA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_C_CHDC305_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4w8b EXO-XYLOGLUCANASE
(uncultured
bacterium) 		4 / 8 ASP A 475
THR A 473
HIS A 368
LEU A 479
 XYS  A 606 ( 4.1A)
BGC  A 602 ( 4.3A)
None
XYS  A 618 ( 4.0A)
 1.14A 5x19A-4w8bA:
undetectable
5x19C-4w8bA:
undetectable
5x19P-4w8bA:
undetectable		 5x19A-4w8bA:
19.46
5x19C-4w8bA:
22.14
5x19P-4w8bA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_C_CHDC305_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4w8b EXO-XYLOGLUCANASE
(uncultured
bacterium) 		4 / 7 ASP A 475
THR A 473
HIS A 368
LEU A 479
 XYS  A 606 ( 4.1A)
BGC  A 602 ( 4.3A)
None
XYS  A 618 ( 4.0A)
 1.15A 5x1fA-4w8bA:
undetectable
5x1fC-4w8bA:
undetectable
5x1fP-4w8bA:
undetectable		 5x1fA-4w8bA:
19.46
5x1fC-4w8bA:
22.14
5x1fP-4w8bA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4w8b EXO-XYLOGLUCANASE
(uncultured
bacterium) 		4 / 8 ASP A 475
THR A 473
HIS A 368
LEU A 479
 XYS  A 606 ( 4.1A)
BGC  A 602 ( 4.3A)
None
XYS  A 618 ( 4.0A)
 1.15A 5xdqA-4w8bA:
undetectable
5xdqC-4w8bA:
undetectable
5xdqP-4w8bA:
undetectable		 5xdqA-4w8bA:
19.46
5xdqC-4w8bA:
22.14
5xdqP-4w8bA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4w8b EXO-XYLOGLUCANASE
(uncultured
bacterium) 		4 / 8 LEU A 479
ASP A 475
THR A 473
HIS A 368
 XYS  A 618 ( 4.0A)
XYS  A 606 ( 4.1A)
BGC  A 602 ( 4.3A)
None
 1.16A 5xdqC-4w8bA:
undetectable
5xdqN-4w8bA:
undetectable
5xdqP-4w8bA:
undetectable		 5xdqC-4w8bA:
22.14
5xdqN-4w8bA:
19.46
5xdqP-4w8bA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4w8b EXO-XYLOGLUCANASE
(uncultured
bacterium) 		4 / 8 LEU A 479
ASP A 475
THR A 473
HIS A 368
 XYS  A 618 ( 4.0A)
XYS  A 606 ( 4.1A)
BGC  A 602 ( 4.3A)
None
 1.20A 5xdxC-4w8bA:
undetectable
5xdxN-4w8bA:
undetectable
5xdxP-4w8bA:
undetectable		 5xdxC-4w8bA:
22.14
5xdxN-4w8bA:
19.46
5xdxP-4w8bA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4w8b EXO-XYLOGLUCANASE
(uncultured
bacterium) 		4 / 8 ASP A 475
THR A 473
HIS A 368
LEU A 479
 XYS  A 606 ( 4.1A)
BGC  A 602 ( 4.3A)
None
XYS  A 618 ( 4.0A)
 1.14A 5z84A-4w8bA:
undetectable
5z84C-4w8bA:
undetectable
5z84P-4w8bA:
undetectable		 5z84A-4w8bA:
19.46
5z84C-4w8bA:
22.14
5z84P-4w8bA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4w8b EXO-XYLOGLUCANASE
(uncultured
bacterium) 		4 / 7 LEU A 479
ASP A 475
THR A 473
HIS A 368
 XYS  A 618 ( 4.0A)
XYS  A 606 ( 4.1A)
BGC  A 602 ( 4.3A)
None
 1.17A 5z84C-4w8bA:
undetectable
5z84N-4w8bA:
undetectable
5z84P-4w8bA:
undetectable		 5z84C-4w8bA:
22.14
5z84N-4w8bA:
19.46
5z84P-4w8bA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z85_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4w8b EXO-XYLOGLUCANASE
(uncultured
bacterium) 		4 / 8 ASP A 475
THR A 473
HIS A 368
LEU A 479
 XYS  A 606 ( 4.1A)
BGC  A 602 ( 4.3A)
None
XYS  A 618 ( 4.0A)
 1.15A 5z85A-4w8bA:
undetectable
5z85C-4w8bA:
undetectable
5z85P-4w8bA:
undetectable		 5z85A-4w8bA:
19.46
5z85C-4w8bA:
22.14
5z85P-4w8bA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z85_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4w8b EXO-XYLOGLUCANASE
(uncultured
bacterium) 		4 / 7 LEU A 479
ASP A 475
THR A 473
HIS A 368
 XYS  A 618 ( 4.0A)
XYS  A 606 ( 4.1A)
BGC  A 602 ( 4.3A)
None
 1.16A 5z85C-4w8bA:
undetectable
5z85N-4w8bA:
undetectable
5z85P-4w8bA:
undetectable		 5z85C-4w8bA:
22.14
5z85N-4w8bA:
19.46
5z85P-4w8bA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4w8b EXO-XYLOGLUCANASE
(uncultured
bacterium) 		4 / 8 ASP A 475
THR A 473
HIS A 368
LEU A 479
 XYS  A 606 ( 4.1A)
BGC  A 602 ( 4.3A)
None
XYS  A 618 ( 4.0A)
 1.15A 5z86A-4w8bA:
undetectable
5z86C-4w8bA:
undetectable
5z86P-4w8bA:
undetectable		 5z86A-4w8bA:
19.46
5z86C-4w8bA:
22.14
5z86P-4w8bA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4w8b EXO-XYLOGLUCANASE
(uncultured
bacterium) 		4 / 8 LEU A 479
ASP A 475
THR A 473
HIS A 368
 XYS  A 618 ( 4.0A)
XYS  A 606 ( 4.1A)
BGC  A 602 ( 4.3A)
None
 1.17A 5z86C-4w8bA:
undetectable
5z86N-4w8bA:
undetectable
5z86P-4w8bA:
undetectable		 5z86C-4w8bA:
22.14
5z86N-4w8bA:
19.46
5z86P-4w8bA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4w8b EXO-XYLOGLUCANASE
(uncultured
bacterium) 		4 / 8 ASP A 475
THR A 473
HIS A 368
LEU A 479
 XYS  A 606 ( 4.1A)
BGC  A 602 ( 4.3A)
None
XYS  A 618 ( 4.0A)
 1.14A 5zcoA-4w8bA:
undetectable
5zcoC-4w8bA:
undetectable
5zcoP-4w8bA:
undetectable		 5zcoA-4w8bA:
19.46
5zcoC-4w8bA:
22.14
5zcoP-4w8bA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4w8b EXO-XYLOGLUCANASE
(uncultured
bacterium) 		4 / 8 LEU A 479
ASP A 475
THR A 473
HIS A 368
 XYS  A 618 ( 4.0A)
XYS  A 606 ( 4.1A)
BGC  A 602 ( 4.3A)
None
 1.14A 5zcoC-4w8bA:
undetectable
5zcoN-4w8bA:
undetectable
5zcoP-4w8bA:
undetectable		 5zcoC-4w8bA:
22.14
5zcoN-4w8bA:
19.46
5zcoP-4w8bA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4w8b EXO-XYLOGLUCANASE
(uncultured
bacterium) 		4 / 8 ASP A 475
THR A 473
HIS A 368
LEU A 479
 XYS  A 606 ( 4.1A)
BGC  A 602 ( 4.3A)
None
XYS  A 618 ( 4.0A)
 1.14A 5zcpA-4w8bA:
undetectable
5zcpC-4w8bA:
undetectable
5zcpP-4w8bA:
undetectable		 5zcpA-4w8bA:
19.46
5zcpC-4w8bA:
22.14
5zcpP-4w8bA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4w8b EXO-XYLOGLUCANASE
(uncultured
bacterium) 		4 / 8 LEU A 479
ASP A 475
THR A 473
HIS A 368
 XYS  A 618 ( 4.0A)
XYS  A 606 ( 4.1A)
BGC  A 602 ( 4.3A)
None
 1.14A 5zcpC-4w8bA:
undetectable
5zcpN-4w8bA:
undetectable
5zcpP-4w8bA:
undetectable		 5zcpC-4w8bA:
22.14
5zcpN-4w8bA:
19.46
5zcpP-4w8bA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4w8b EXO-XYLOGLUCANASE
(uncultured
bacterium) 		4 / 8 ASP A 475
THR A 473
HIS A 368
LEU A 479
 XYS  A 606 ( 4.1A)
BGC  A 602 ( 4.3A)
None
XYS  A 618 ( 4.0A)
 1.14A 5zcqA-4w8bA:
undetectable
5zcqC-4w8bA:
undetectable
5zcqP-4w8bA:
undetectable		 5zcqA-4w8bA:
19.46
5zcqC-4w8bA:
22.14
5zcqP-4w8bA:
22.14