SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'XYL'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GYX_A_BEZA1077_0
(HYPOTHETICAL PROTEIN
YDCE)		 4xwh ALPHA-N-ACETYLGLUCOS
AMINIDASE
(Homo
sapiens) 		4 / 7 PHE A 198
TRP A 649
TYR A 140
SER A 139
 None
XYL  A2015 ( 4.7A)
XYL  A2015 (-4.6A)
None
 1.21A 1gyxA-4xwhA:
undetectable
1gyxB-4xwhA:
undetectable		 1gyxA-4xwhA:
7.73
1gyxB-4xwhA:
7.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MOG_A_RBFA200_1
(DODECIN)		 4xwh ALPHA-N-ACETYLGLUCOS
AMINIDASE
(Homo
sapiens) 		3 / 3 PHE A 410
TRP A 352
GLU A 316
 None
GOL  A2011 ( 3.7A)
XYL  A2015 ( 2.9A)
 1.09A 1mogA-4xwhA:
undetectable		 1mogA-4xwhA:
9.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PJ7_A_FFOA2887_1
(N,N-DIMETHYLGLYCINE
OXIDASE)		 5y4j XYLOSE ISOMERASE
(Streptomyces
rubiginosus) 		3 / 3 ASP A  57
THR A  90
GLU A 181
 None
XYL  A 402 ( 4.1A)
XYL  A 402 ( 2.4A)
 0.79A 1pj7A-5y4jA:
undetectable		 1pj7A-5y4jA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q8J_B_C2FB802_0
(5-METHYLTETRAHYDROFO
LATE S-HOMOCYSTEINE
METHYLTRANSFERASE)		 4rs3 ABC TRANSPORTER,
CARBOHYDRATE UPTAKE
TRANSPORTER-2 (CUT2)
FAMILY, PERIPLASMIC
SUGAR-BINDING
PROTEIN
(Mycolicibacteriu
m
smegmatis) 		5 / 12 GLU A 144
GLY A 250
ASP A 137
SER A 168
ILE A 171
 None
None
XYL  A 401 ( 4.8A)
None
None
 1.19A 1q8jB-4rs3A:
2.0		 1q8jB-4rs3A:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q8J_B_C2FB802_0
(5-METHYLTETRAHYDROFO
LATE S-HOMOCYSTEINE
METHYLTRANSFERASE)		 4rs3 ABC TRANSPORTER,
CARBOHYDRATE UPTAKE
TRANSPORTER-2 (CUT2)
FAMILY, PERIPLASMIC
SUGAR-BINDING
PROTEIN
(Mycolicibacteriu
m
smegmatis) 		5 / 12 GLY A 250
ASP A 137
SER A 168
ILE A 171
GLY A 163
 None
XYL  A 401 ( 4.8A)
None
None
None
 1.11A 1q8jB-4rs3A:
2.0		 1q8jB-4rs3A:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TDN_A_LEUA487_0
(L-AMINO ACID OXIDASE)		 4xwh ALPHA-N-ACETYLGLUCOS
AMINIDASE
(Homo
sapiens) 		4 / 7 ASN A 413
HIS A 512
TYR A 140
ILE A 655
 None
None
XYL  A2015 (-4.6A)
XYL  A2015 ( 4.2A)
 1.40A 1tdnA-4xwhA:
undetectable		 1tdnA-4xwhA:
21.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XID_A_ASCA389_0
(D-XYLOSE ISOMERASE)		 5y4j XYLOSE ISOMERASE
(Streptomyces
rubiginosus) 		10 / 10 TRP A  16
HIS A  54
PHE A  94
TRP A 137
GLU A 181
GLU A 217
HIS A 220
ASP A 245
ASP A 287
LYS A 289
 XYL  A 402 (-4.1A)
XYL  A 402 (-3.8A)
XYL  A 402 ( 4.9A)
XYL  A 402 (-3.8A)
XYL  A 402 ( 2.4A)
MG  A 401 ( 2.8A)
XYL  A 402 (-4.2A)
MG  A 401 ( 3.0A)
XYL  A 402 ( 2.9A)
None
 0.24A 1xidA-5y4jA:
60.5		 1xidA-5y4jA:
99.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XID_A_ASCA389_0
(D-XYLOSE ISOMERASE)		 5y4j XYLOSE ISOMERASE
(Streptomyces
rubiginosus) 		5 / 10 TRP A 137
GLU A 181
GLU A 217
HIS A 220
ASP A 245
 XYL  A 402 (-3.8A)
XYL  A 402 ( 2.4A)
MG  A 401 ( 2.8A)
XYL  A 402 (-4.2A)
MG  A 401 ( 3.0A)
 1.28A 1xidA-5y4jA:
60.5		 1xidA-5y4jA:
99.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XIH_A_SORA389_0
(D-XYLOSE ISOMERASE)		 5y4j XYLOSE ISOMERASE
(Streptomyces
rubiginosus) 		6 / 12 HIS A  54
THR A  90
TRP A 137
GLU A 217
HIS A 220
ASP A 245
 XYL  A 402 (-3.8A)
XYL  A 402 ( 4.1A)
XYL  A 402 (-3.8A)
MG  A 401 ( 2.8A)
XYL  A 402 (-4.2A)
MG  A 401 ( 3.0A)
 1.33A 1xihA-5y4jA:
60.5		 1xihA-5y4jA:
99.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XIH_A_SORA389_0
(D-XYLOSE ISOMERASE)		 5y4j XYLOSE ISOMERASE
(Streptomyces
rubiginosus) 		12 / 12 TRP A  16
HIS A  54
THR A  90
PHE A  94
VAL A 135
TRP A 137
LYS A 183
GLU A 217
HIS A 220
ASP A 245
ASP A 255
ASP A 287
 XYL  A 402 (-4.1A)
XYL  A 402 (-3.8A)
XYL  A 402 ( 4.1A)
XYL  A 402 ( 4.9A)
None
XYL  A 402 (-3.8A)
XYL  A 402 (-2.8A)
MG  A 401 ( 2.8A)
XYL  A 402 (-4.2A)
MG  A 401 ( 3.0A)
XYL  A 402 ( 4.9A)
XYL  A 402 ( 2.9A)
 0.17A 1xihA-5y4jA:
60.5		 1xihA-5y4jA:
99.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_K_BEZK4387_0
(CES1 PROTEIN)		 4xwh ALPHA-N-ACETYLGLUCOS
AMINIDASE
(Homo
sapiens) 		3 / 3 TRP A 649
LEU A 646
LYS A 661
 XYL  A2015 ( 4.7A)
None
None
 1.46A 1yajK-4xwhA:
undetectable		 1yajK-4xwhA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOF_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 4rs3 ABC TRANSPORTER,
CARBOHYDRATE UPTAKE
TRANSPORTER-2 (CUT2)
FAMILY, PERIPLASMIC
SUGAR-BINDING
PROTEIN
(Mycolicibacteriu
m
smegmatis) 		4 / 5 ASP A 249
GLY A 163
ALA A 140
ILE A 248
 XYL  A 401 (-2.7A)
None
None
None
 0.85A 2aofA-4rs3A:
undetectable		 2aofA-4rs3A:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RCT_A_RTLA140_1
(RETINOL-BINDING
PROTEIN II, CELLULAR)		 4xwh ALPHA-N-ACETYLGLUCOS
AMINIDASE
(Homo
sapiens) 		3 / 3 GLN A 171
THR A 194
TRP A 201
 None
None
XYL  A2015 (-3.6A)
 1.06A 2rctA-4xwhA:
undetectable		 2rctA-4xwhA:
10.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2XIN_A_SORA397_0
(D-XYLOSE ISOMERASE)		 5y4j XYLOSE ISOMERASE
(Streptomyces
rubiginosus) 		7 / 12 HIS A  54
THR A  90
TRP A 137
GLU A 181
GLU A 217
HIS A 220
ASP A 287
 XYL  A 402 (-3.8A)
XYL  A 402 ( 4.1A)
XYL  A 402 (-3.8A)
XYL  A 402 ( 2.4A)
MG  A 401 ( 2.8A)
XYL  A 402 (-4.2A)
XYL  A 402 ( 2.9A)
 1.24A 2xinA-5y4jA:
57.1		 2xinA-5y4jA:
66.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2XIN_A_SORA397_0
(D-XYLOSE ISOMERASE)		 5y4j XYLOSE ISOMERASE
(Streptomyces
rubiginosus) 		8 / 12 HIS A  54
THR A  90
VAL A 135
TRP A 137
GLU A 181
GLU A 217
HIS A 220
ASP A 257
 XYL  A 402 (-3.8A)
XYL  A 402 ( 4.1A)
None
XYL  A 402 (-3.8A)
XYL  A 402 ( 2.4A)
MG  A 401 ( 2.8A)
XYL  A 402 (-4.2A)
None
 1.37A 2xinA-5y4jA:
57.1		 2xinA-5y4jA:
66.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2XIN_A_SORA397_0
(D-XYLOSE ISOMERASE)		 5y4j XYLOSE ISOMERASE
(Streptomyces
rubiginosus) 		12 / 12 TRP A  16
HIS A  54
THR A  90
VAL A 135
TRP A 137
GLU A 181
LYS A 183
GLU A 217
HIS A 220
ASP A 245
ASP A 255
ASP A 287
 XYL  A 402 (-4.1A)
XYL  A 402 (-3.8A)
XYL  A 402 ( 4.1A)
None
XYL  A 402 (-3.8A)
XYL  A 402 ( 2.4A)
XYL  A 402 (-2.8A)
MG  A 401 ( 2.8A)
XYL  A 402 (-4.2A)
MG  A 401 ( 3.0A)
XYL  A 402 ( 4.9A)
XYL  A 402 ( 2.9A)
 0.51A 2xinA-5y4jA:
57.1		 2xinA-5y4jA:
66.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2XIN_B_SORB397_0
(D-XYLOSE ISOMERASE)		 5y4j XYLOSE ISOMERASE
(Streptomyces
rubiginosus) 		8 / 12 HIS A  54
THR A  90
VAL A 135
TRP A 137
GLU A 181
GLU A 217
HIS A 220
ASP A 257
 XYL  A 402 (-3.8A)
XYL  A 402 ( 4.1A)
None
XYL  A 402 (-3.8A)
XYL  A 402 ( 2.4A)
MG  A 401 ( 2.8A)
XYL  A 402 (-4.2A)
None
 1.37A 2xinB-5y4jA:
57.0		 2xinB-5y4jA:
66.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2XIN_B_SORB397_0
(D-XYLOSE ISOMERASE)		 5y4j XYLOSE ISOMERASE
(Streptomyces
rubiginosus) 		6 / 12 THR A  90
TRP A 137
GLU A 181
GLU A 217
HIS A 220
ASP A 287
 XYL  A 402 ( 4.1A)
XYL  A 402 (-3.8A)
XYL  A 402 ( 2.4A)
MG  A 401 ( 2.8A)
XYL  A 402 (-4.2A)
XYL  A 402 ( 2.9A)
 1.22A 2xinB-5y4jA:
57.0		 2xinB-5y4jA:
66.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2XIN_B_SORB397_0
(D-XYLOSE ISOMERASE)		 5y4j XYLOSE ISOMERASE
(Streptomyces
rubiginosus) 		12 / 12 TRP A  16
HIS A  54
THR A  90
VAL A 135
TRP A 137
GLU A 181
LYS A 183
GLU A 217
HIS A 220
ASP A 245
ASP A 255
ASP A 287
 XYL  A 402 (-4.1A)
XYL  A 402 (-3.8A)
XYL  A 402 ( 4.1A)
None
XYL  A 402 (-3.8A)
XYL  A 402 ( 2.4A)
XYL  A 402 (-2.8A)
MG  A 401 ( 2.8A)
XYL  A 402 (-4.2A)
MG  A 401 ( 3.0A)
XYL  A 402 ( 4.9A)
XYL  A 402 ( 2.9A)
 0.49A 2xinB-5y4jA:
57.0		 2xinB-5y4jA:
66.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2XIN_C_SORC397_0
(D-XYLOSE ISOMERASE)		 5y4j XYLOSE ISOMERASE
(Streptomyces
rubiginosus) 		8 / 12 HIS A  54
THR A  90
VAL A 135
TRP A 137
GLU A 181
GLU A 217
HIS A 220
ASP A 257
 XYL  A 402 (-3.8A)
XYL  A 402 ( 4.1A)
None
XYL  A 402 (-3.8A)
XYL  A 402 ( 2.4A)
MG  A 401 ( 2.8A)
XYL  A 402 (-4.2A)
None
 1.39A 2xinC-5y4jA:
57.1		 2xinC-5y4jA:
66.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2XIN_C_SORC397_0
(D-XYLOSE ISOMERASE)		 5y4j XYLOSE ISOMERASE
(Streptomyces
rubiginosus) 		6 / 12 THR A  90
TRP A 137
GLU A 181
GLU A 217
HIS A 220
ASP A 287
 XYL  A 402 ( 4.1A)
XYL  A 402 (-3.8A)
XYL  A 402 ( 2.4A)
MG  A 401 ( 2.8A)
XYL  A 402 (-4.2A)
XYL  A 402 ( 2.9A)
 1.21A 2xinC-5y4jA:
57.1		 2xinC-5y4jA:
66.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2XIN_C_SORC397_0
(D-XYLOSE ISOMERASE)		 5y4j XYLOSE ISOMERASE
(Streptomyces
rubiginosus) 		12 / 12 TRP A  16
HIS A  54
THR A  90
VAL A 135
TRP A 137
GLU A 181
LYS A 183
GLU A 217
HIS A 220
ASP A 245
ASP A 255
ASP A 287
 XYL  A 402 (-4.1A)
XYL  A 402 (-3.8A)
XYL  A 402 ( 4.1A)
None
XYL  A 402 (-3.8A)
XYL  A 402 ( 2.4A)
XYL  A 402 (-2.8A)
MG  A 401 ( 2.8A)
XYL  A 402 (-4.2A)
MG  A 401 ( 3.0A)
XYL  A 402 ( 4.9A)
XYL  A 402 ( 2.9A)
 0.53A 2xinC-5y4jA:
57.1		 2xinC-5y4jA:
66.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2XIN_D_SORD397_0
(D-XYLOSE ISOMERASE)		 5y4j XYLOSE ISOMERASE
(Streptomyces
rubiginosus) 		8 / 12 HIS A  54
THR A  90
VAL A 135
TRP A 137
GLU A 181
GLU A 217
HIS A 220
ASP A 257
 XYL  A 402 (-3.8A)
XYL  A 402 ( 4.1A)
None
XYL  A 402 (-3.8A)
XYL  A 402 ( 2.4A)
MG  A 401 ( 2.8A)
XYL  A 402 (-4.2A)
None
 1.36A 2xinD-5y4jA:
52.2		 2xinD-5y4jA:
66.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2XIN_D_SORD397_0
(D-XYLOSE ISOMERASE)		 5y4j XYLOSE ISOMERASE
(Streptomyces
rubiginosus) 		12 / 12 TRP A  16
HIS A  54
THR A  90
VAL A 135
TRP A 137
GLU A 181
LYS A 183
GLU A 217
HIS A 220
ASP A 245
ASP A 255
ASP A 287
 XYL  A 402 (-4.1A)
XYL  A 402 (-3.8A)
XYL  A 402 ( 4.1A)
None
XYL  A 402 (-3.8A)
XYL  A 402 ( 2.4A)
XYL  A 402 (-2.8A)
MG  A 401 ( 2.8A)
XYL  A 402 (-4.2A)
MG  A 401 ( 3.0A)
XYL  A 402 ( 4.9A)
XYL  A 402 ( 2.9A)
 0.50A 2xinD-5y4jA:
52.2		 2xinD-5y4jA:
66.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CSJ_B_CBLB211_0
(GLUTATHIONE
S-TRANSFERASE P)		 4xwh ALPHA-N-ACETYLGLUCOS
AMINIDASE
(Homo
sapiens) 		5 / 9 PRO A 445
GLY A 511
ARG A 510
TYR A 658
GLY A 411
 None
None
None
XYL  A2015 (-3.4A)
None
 1.49A 3csjB-4xwhA:
undetectable		 3csjB-4xwhA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELU_A_SAMA4633_0
(METHYLTRANSFERASE)		 4rs3 ABC TRANSPORTER,
CARBOHYDRATE UPTAKE
TRANSPORTER-2 (CUT2)
FAMILY, PERIPLASMIC
SUGAR-BINDING
PROTEIN
(Mycolicibacteriu
m
smegmatis) 		5 / 12 GLY A 141
GLY A 163
GLY A 169
GLY A 174
ASN A  73
 None
None
XYL  A 401 ( 3.8A)
ACT  A 433 (-3.5A)
None
 0.94A 3eluA-4rs3A:
undetectable		 3eluA-4rs3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELW_A_SAMA4633_0
(METHYLTRANSFERASE)		 4rs3 ABC TRANSPORTER,
CARBOHYDRATE UPTAKE
TRANSPORTER-2 (CUT2)
FAMILY, PERIPLASMIC
SUGAR-BINDING
PROTEIN
(Mycolicibacteriu
m
smegmatis) 		5 / 12 GLY A 141
GLY A 163
GLY A 169
GLY A 174
ASN A  73
 None
None
XYL  A 401 ( 3.8A)
ACT  A 433 (-3.5A)
None
 0.88A 3elwA-4rs3A:
undetectable		 3elwA-4rs3A:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EMB_A_SAMA4633_0
(METHYLTRANSFERASE)		 4rs3 ABC TRANSPORTER,
CARBOHYDRATE UPTAKE
TRANSPORTER-2 (CUT2)
FAMILY, PERIPLASMIC
SUGAR-BINDING
PROTEIN
(Mycolicibacteriu
m
smegmatis) 		5 / 12 GLY A 141
GLY A 163
GLY A 169
GLY A 174
ASN A  73
 None
None
XYL  A 401 ( 3.8A)
ACT  A 433 (-3.5A)
None
 0.90A 3embA-4rs3A:
undetectable		 3embA-4rs3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_A_ADNA438_1
(ADENOSYLHOMOCYSTEINA
SE)		 5y4j XYLOSE ISOMERASE
(Streptomyces
rubiginosus) 		5 / 12 HIS A  54
ASN A 215
GLY A  14
HIS A 285
MET A  88
 XYL  A 402 (-3.8A)
None
None
None
None
 1.40A 3g1uA-5y4jA:
undetectable		 3g1uA-5y4jA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HRD_E_NIOE5660_1
(NICOTINATE
DEHYDROGENASE LARGE
MOLYBDOPTERIN
SUBUNIT
NICOTINATE
DEHYDROGENASE MEDIUM
MOLYBDOPTERIN
SUBUNIT)		 5y4j XYLOSE ISOMERASE
(Streptomyces
rubiginosus) 		3 / 3 GLU A 217
GLU A 181
TRP A  16
 MG  A 401 ( 2.8A)
XYL  A 402 ( 2.4A)
XYL  A 402 (-4.1A)
 1.30A 3hrdA-5y4jA:
undetectable
3hrdE-5y4jA:
undetectable
3hrdF-5y4jA:
undetectable		 3hrdA-5y4jA:
23.25
3hrdE-5y4jA:
23.25
3hrdF-5y4jA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PMZ_E_TUBE220_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4rs3 ABC TRANSPORTER,
CARBOHYDRATE UPTAKE
TRANSPORTER-2 (CUT2)
FAMILY, PERIPLASMIC
SUGAR-BINDING
PROTEIN
(Mycolicibacteriu
m
smegmatis) 		4 / 6 GLN A 269
MET A 299
SER A  45
SER A  46
 XYL  A 401 (-3.1A)
None
XYL  A 401 ( 4.8A)
CL  A 418 ( 4.3A)
 1.06A 3pmzD-4rs3A:
undetectable		 3pmzD-4rs3A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_A_SAMA501_1
(MNMC2)		 4xwh ALPHA-N-ACETYLGLUCOS
AMINIDASE
(Homo
sapiens) 		4 / 6 HIS A 512
GLU A 316
ASP A 312
ASN A 134
 None
XYL  A2015 ( 2.9A)
None
GOL  A2011 (-3.0A)
 1.24A 3vywA-4xwhA:
undetectable		 3vywA-4xwhA:
18.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3XIM_A_SORA397_0
(D-XYLOSE ISOMERASE)		 5y4j XYLOSE ISOMERASE
(Streptomyces
rubiginosus) 		7 / 12 HIS A  54
MET A  88
THR A  90
TRP A 137
GLU A 217
HIS A 220
ASP A 287
 XYL  A 402 (-3.8A)
None
XYL  A 402 ( 4.1A)
XYL  A 402 (-3.8A)
MG  A 401 ( 2.8A)
XYL  A 402 (-4.2A)
XYL  A 402 ( 2.9A)
 1.31A 3ximA-5y4jA:
57.2		 3ximA-5y4jA:
66.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3XIM_A_SORA397_0
(D-XYLOSE ISOMERASE)		 5y4j XYLOSE ISOMERASE
(Streptomyces
rubiginosus) 		6 / 12 HIS A  54
THR A  90
TRP A 137
HIS A 220
ASP A 287
ASP A 255
 XYL  A 402 (-3.8A)
XYL  A 402 ( 4.1A)
XYL  A 402 (-3.8A)
XYL  A 402 (-4.2A)
XYL  A 402 ( 2.9A)
XYL  A 402 ( 4.9A)
 1.33A 3ximA-5y4jA:
57.2		 3ximA-5y4jA:
66.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3XIM_A_SORA397_0
(D-XYLOSE ISOMERASE)		 5y4j XYLOSE ISOMERASE
(Streptomyces
rubiginosus) 		6 / 12 HIS A  54
THR A  90
VAL A 135
GLU A 217
ASP A 245
ASP A 257
 XYL  A 402 (-3.8A)
XYL  A 402 ( 4.1A)
None
MG  A 401 ( 2.8A)
MG  A 401 ( 3.0A)
None
 1.13A 3ximA-5y4jA:
57.2		 3ximA-5y4jA:
66.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3XIM_A_SORA397_0
(D-XYLOSE ISOMERASE)		 5y4j XYLOSE ISOMERASE
(Streptomyces
rubiginosus) 		7 / 12 HIS A  54
THR A  90
VAL A 135
TRP A 137
LYS A 183
HIS A 220
ASP A 255
 XYL  A 402 (-3.8A)
XYL  A 402 ( 4.1A)
None
XYL  A 402 (-3.8A)
XYL  A 402 (-2.8A)
XYL  A 402 (-4.2A)
XYL  A 402 ( 4.9A)
 0.70A 3ximA-5y4jA:
57.2		 3ximA-5y4jA:
66.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3XIM_A_SORA397_0
(D-XYLOSE ISOMERASE)		 5y4j XYLOSE ISOMERASE
(Streptomyces
rubiginosus) 		11 / 12 TRP A  16
HIS A  54
MET A  88
THR A  90
VAL A 135
TRP A 137
LYS A 183
GLU A 217
HIS A 220
ASP A 245
ASP A 287
 XYL  A 402 (-4.1A)
XYL  A 402 (-3.8A)
None
XYL  A 402 ( 4.1A)
None
XYL  A 402 (-3.8A)
XYL  A 402 (-2.8A)
MG  A 401 ( 2.8A)
XYL  A 402 (-4.2A)
MG  A 401 ( 3.0A)
XYL  A 402 ( 2.9A)
 0.21A 3ximA-5y4jA:
57.2		 3ximA-5y4jA:
66.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3XIM_B_SORB397_0
(D-XYLOSE ISOMERASE)		 5y4j XYLOSE ISOMERASE
(Streptomyces
rubiginosus) 		5 / 12 HIS A  54
THR A  90
GLU A 217
ASP A 257
ASP A 245
 XYL  A 402 (-3.8A)
XYL  A 402 ( 4.1A)
MG  A 401 ( 2.8A)
None
MG  A 401 ( 3.0A)
 1.50A 3ximB-5y4jA:
57.2		 3ximB-5y4jA:
66.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3XIM_B_SORB397_0
(D-XYLOSE ISOMERASE)		 5y4j XYLOSE ISOMERASE
(Streptomyces
rubiginosus) 		6 / 12 HIS A  54
THR A  90
TRP A 137
GLU A 217
HIS A 220
ASP A 245
 XYL  A 402 (-3.8A)
XYL  A 402 ( 4.1A)
XYL  A 402 (-3.8A)
MG  A 401 ( 2.8A)
XYL  A 402 (-4.2A)
MG  A 401 ( 3.0A)
 1.33A 3ximB-5y4jA:
57.2		 3ximB-5y4jA:
66.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3XIM_B_SORB397_0
(D-XYLOSE ISOMERASE)		 5y4j XYLOSE ISOMERASE
(Streptomyces
rubiginosus) 		7 / 12 HIS A  54
THR A  90
VAL A 135
GLU A 181
GLU A 217
ASP A 245
ASP A 257
 XYL  A 402 (-3.8A)
XYL  A 402 ( 4.1A)
None
XYL  A 402 ( 2.4A)
MG  A 401 ( 2.8A)
MG  A 401 ( 3.0A)
None
 1.14A 3ximB-5y4jA:
57.2		 3ximB-5y4jA:
66.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3XIM_B_SORB397_0
(D-XYLOSE ISOMERASE)		 5y4j XYLOSE ISOMERASE
(Streptomyces
rubiginosus) 		6 / 12 THR A  90
TRP A 137
GLU A 181
GLU A 217
HIS A 220
ASP A 287
 XYL  A 402 ( 4.1A)
XYL  A 402 (-3.8A)
XYL  A 402 ( 2.4A)
MG  A 401 ( 2.8A)
XYL  A 402 (-4.2A)
XYL  A 402 ( 2.9A)
 1.26A 3ximB-5y4jA:
57.2		 3ximB-5y4jA:
66.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3XIM_B_SORB397_0
(D-XYLOSE ISOMERASE)		 5y4j XYLOSE ISOMERASE
(Streptomyces
rubiginosus) 		6 / 12 THR A  90
TRP A 137
GLU A 181
HIS A 220
ASP A 287
ASP A 255
 XYL  A 402 ( 4.1A)
XYL  A 402 (-3.8A)
XYL  A 402 ( 2.4A)
XYL  A 402 (-4.2A)
XYL  A 402 ( 2.9A)
XYL  A 402 ( 4.9A)
 1.28A 3ximB-5y4jA:
57.2		 3ximB-5y4jA:
66.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3XIM_B_SORB397_0
(D-XYLOSE ISOMERASE)		 5y4j XYLOSE ISOMERASE
(Streptomyces
rubiginosus) 		11 / 12 TRP A  16
HIS A  54
THR A  90
VAL A 135
TRP A 137
GLU A 181
LYS A 183
GLU A 217
HIS A 220
ASP A 245
ASP A 287
 XYL  A 402 (-4.1A)
XYL  A 402 (-3.8A)
XYL  A 402 ( 4.1A)
None
XYL  A 402 (-3.8A)
XYL  A 402 ( 2.4A)
XYL  A 402 (-2.8A)
MG  A 401 ( 2.8A)
XYL  A 402 (-4.2A)
MG  A 401 ( 3.0A)
XYL  A 402 ( 2.9A)
 0.20A 3ximB-5y4jA:
57.2		 3ximB-5y4jA:
66.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3XIM_B_SORB397_0
(D-XYLOSE ISOMERASE)		 5y4j XYLOSE ISOMERASE
(Streptomyces
rubiginosus) 		9 / 12 TRP A  16
HIS A  54
THR A  90
VAL A 135
TRP A 137
GLU A 181
LYS A 183
HIS A 220
ASP A 255
 XYL  A 402 (-4.1A)
XYL  A 402 (-3.8A)
XYL  A 402 ( 4.1A)
None
XYL  A 402 (-3.8A)
XYL  A 402 ( 2.4A)
XYL  A 402 (-2.8A)
XYL  A 402 (-4.2A)
XYL  A 402 ( 4.9A)
 0.62A 3ximB-5y4jA:
57.2		 3ximB-5y4jA:
66.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3XIM_C_SORC397_0
(D-XYLOSE ISOMERASE)		 5y4j XYLOSE ISOMERASE
(Streptomyces
rubiginosus) 		6 / 12 MET A  88
THR A  90
GLU A 181
GLU A 217
HIS A 220
ASP A 287
 None
XYL  A 402 ( 4.1A)
XYL  A 402 ( 2.4A)
MG  A 401 ( 2.8A)
XYL  A 402 (-4.2A)
XYL  A 402 ( 2.9A)
 1.30A 3ximC-5y4jA:
56.8		 3ximC-5y4jA:
66.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3XIM_C_SORC397_0
(D-XYLOSE ISOMERASE)		 5y4j XYLOSE ISOMERASE
(Streptomyces
rubiginosus) 		6 / 12 MET A  88
THR A  90
GLU A 181
HIS A 220
ASP A 287
ASP A 255
 None
XYL  A 402 ( 4.1A)
XYL  A 402 ( 2.4A)
XYL  A 402 (-4.2A)
XYL  A 402 ( 2.9A)
XYL  A 402 ( 4.9A)
 1.41A 3ximC-5y4jA:
56.8		 3ximC-5y4jA:
66.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3XIM_C_SORC397_0
(D-XYLOSE ISOMERASE)		 5y4j XYLOSE ISOMERASE
(Streptomyces
rubiginosus) 		5 / 12 THR A  90
GLU A 181
GLU A 217
ASP A 257
ASP A 245
 XYL  A 402 ( 4.1A)
XYL  A 402 ( 2.4A)
MG  A 401 ( 2.8A)
None
MG  A 401 ( 3.0A)
 1.32A 3ximC-5y4jA:
56.8		 3ximC-5y4jA:
66.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3XIM_C_SORC397_0
(D-XYLOSE ISOMERASE)		 5y4j XYLOSE ISOMERASE
(Streptomyces
rubiginosus) 		6 / 12 THR A  90
TRP A 137
GLU A 181
GLU A 217
HIS A 220
ASP A 245
 XYL  A 402 ( 4.1A)
XYL  A 402 (-3.8A)
XYL  A 402 ( 2.4A)
MG  A 401 ( 2.8A)
XYL  A 402 (-4.2A)
MG  A 401 ( 3.0A)
 1.26A 3ximC-5y4jA:
56.8		 3ximC-5y4jA:
66.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3XIM_C_SORC397_0
(D-XYLOSE ISOMERASE)		 5y4j XYLOSE ISOMERASE
(Streptomyces
rubiginosus) 		6 / 12 THR A  90
VAL A 135
GLU A 181
GLU A 217
ASP A 245
ASP A 257
 XYL  A 402 ( 4.1A)
None
XYL  A 402 ( 2.4A)
MG  A 401 ( 2.8A)
MG  A 401 ( 3.0A)
None
 1.09A 3ximC-5y4jA:
56.8		 3ximC-5y4jA:
66.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3XIM_C_SORC397_0
(D-XYLOSE ISOMERASE)		 5y4j XYLOSE ISOMERASE
(Streptomyces
rubiginosus) 		11 / 12 TRP A  16
MET A  88
THR A  90
VAL A 135
TRP A 137
GLU A 181
LYS A 183
GLU A 217
HIS A 220
ASP A 245
ASP A 287
 XYL  A 402 (-4.1A)
None
XYL  A 402 ( 4.1A)
None
XYL  A 402 (-3.8A)
XYL  A 402 ( 2.4A)
XYL  A 402 (-2.8A)
MG  A 401 ( 2.8A)
XYL  A 402 (-4.2A)
MG  A 401 ( 3.0A)
XYL  A 402 ( 2.9A)
 0.22A 3ximC-5y4jA:
56.8		 3ximC-5y4jA:
66.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3XIM_C_SORC397_0
(D-XYLOSE ISOMERASE)		 5y4j XYLOSE ISOMERASE
(Streptomyces
rubiginosus) 		9 / 12 TRP A  16
MET A  88
THR A  90
VAL A 135
TRP A 137
GLU A 181
LYS A 183
HIS A 220
ASP A 255
 XYL  A 402 (-4.1A)
None
XYL  A 402 ( 4.1A)
None
XYL  A 402 (-3.8A)
XYL  A 402 ( 2.4A)
XYL  A 402 (-2.8A)
XYL  A 402 (-4.2A)
XYL  A 402 ( 4.9A)
 0.73A 3ximC-5y4jA:
56.8		 3ximC-5y4jA:
66.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3XIM_D_SORD397_0
(D-XYLOSE ISOMERASE)		 5y4j XYLOSE ISOMERASE
(Streptomyces
rubiginosus) 		6 / 12 HIS A  54
THR A  90
GLU A 181
GLU A 217
ASP A 257
ASP A 245
 XYL  A 402 (-3.8A)
XYL  A 402 ( 4.1A)
XYL  A 402 ( 2.4A)
MG  A 401 ( 2.8A)
None
MG  A 401 ( 3.0A)
 1.49A 3ximD-5y4jA:
57.3		 3ximD-5y4jA:
66.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3XIM_D_SORD397_0
(D-XYLOSE ISOMERASE)		 5y4j XYLOSE ISOMERASE
(Streptomyces
rubiginosus) 		7 / 12 HIS A  54
THR A  90
TRP A 137
GLU A 181
GLU A 217
HIS A 220
ASP A 245
 XYL  A 402 (-3.8A)
XYL  A 402 ( 4.1A)
XYL  A 402 (-3.8A)
XYL  A 402 ( 2.4A)
MG  A 401 ( 2.8A)
XYL  A 402 (-4.2A)
MG  A 401 ( 3.0A)
 1.23A 3ximD-5y4jA:
57.3		 3ximD-5y4jA:
66.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3XIM_D_SORD397_0
(D-XYLOSE ISOMERASE)		 5y4j XYLOSE ISOMERASE
(Streptomyces
rubiginosus) 		7 / 12 HIS A  54
THR A  90
VAL A 135
GLU A 181
GLU A 217
ASP A 245
ASP A 257
 XYL  A 402 (-3.8A)
XYL  A 402 ( 4.1A)
None
XYL  A 402 ( 2.4A)
MG  A 401 ( 2.8A)
MG  A 401 ( 3.0A)
None
 1.10A 3ximD-5y4jA:
57.3		 3ximD-5y4jA:
66.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3XIM_D_SORD397_0
(D-XYLOSE ISOMERASE)		 5y4j XYLOSE ISOMERASE
(Streptomyces
rubiginosus) 		11 / 12 TRP A  16
HIS A  54
THR A  90
VAL A 135
TRP A 137
GLU A 181
LYS A 183
GLU A 217
HIS A 220
ASP A 245
ASP A 287
 XYL  A 402 (-4.1A)
XYL  A 402 (-3.8A)
XYL  A 402 ( 4.1A)
None
XYL  A 402 (-3.8A)
XYL  A 402 ( 2.4A)
XYL  A 402 (-2.8A)
MG  A 401 ( 2.8A)
XYL  A 402 (-4.2A)
MG  A 401 ( 3.0A)
XYL  A 402 ( 2.9A)
 0.20A 3ximD-5y4jA:
57.3		 3ximD-5y4jA:
66.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3XIM_D_SORD397_0
(D-XYLOSE ISOMERASE)		 5y4j XYLOSE ISOMERASE
(Streptomyces
rubiginosus) 		7 / 12 TRP A  16
HIS A  54
THR A  90
VAL A 135
TRP A 137
LYS A 183
ASP A 255
 XYL  A 402 (-4.1A)
XYL  A 402 (-3.8A)
XYL  A 402 ( 4.1A)
None
XYL  A 402 (-3.8A)
XYL  A 402 (-2.8A)
XYL  A 402 ( 4.9A)
 0.75A 3ximD-5y4jA:
57.3		 3ximD-5y4jA:
66.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DVO_A_SORA404_0
(XYLOSE ISOMERASE)		 5y4j XYLOSE ISOMERASE
(Streptomyces
rubiginosus) 		7 / 12 HIS A  54
THR A  90
VAL A 135
ASN A 215
GLU A 217
ASP A 245
ASP A 257
 XYL  A 402 (-3.8A)
XYL  A 402 ( 4.1A)
None
None
MG  A 401 ( 2.8A)
MG  A 401 ( 3.0A)
None
 1.20A 4dvoA-5y4jA:
60.5		 4dvoA-5y4jA:
99.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DVO_A_SORA404_0
(XYLOSE ISOMERASE)		 5y4j XYLOSE ISOMERASE
(Streptomyces
rubiginosus) 		6 / 12 MET A  88
THR A  90
TRP A 137
GLU A 217
HIS A 220
ASP A 287
 None
XYL  A 402 ( 4.1A)
XYL  A 402 (-3.8A)
MG  A 401 ( 2.8A)
XYL  A 402 (-4.2A)
XYL  A 402 ( 2.9A)
 1.39A 4dvoA-5y4jA:
60.5		 4dvoA-5y4jA:
99.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DVO_A_SORA404_0
(XYLOSE ISOMERASE)		 5y4j XYLOSE ISOMERASE
(Streptomyces
rubiginosus) 		6 / 12 MET A  88
THR A  90
TRP A 137
HIS A 220
ASP A 287
ASP A 255
 None
XYL  A 402 ( 4.1A)
XYL  A 402 (-3.8A)
XYL  A 402 (-4.2A)
XYL  A 402 ( 2.9A)
XYL  A 402 ( 4.9A)
 1.45A 4dvoA-5y4jA:
60.5		 4dvoA-5y4jA:
99.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DVO_A_SORA404_0
(XYLOSE ISOMERASE)		 5y4j XYLOSE ISOMERASE
(Streptomyces
rubiginosus) 		11 / 12 TRP A  16
HIS A  54
MET A  88
THR A  90
VAL A 135
TRP A 137
LYS A 183
ASN A 215
GLU A 217
HIS A 220
ASP A 245
 XYL  A 402 (-4.1A)
XYL  A 402 (-3.8A)
None
XYL  A 402 ( 4.1A)
None
XYL  A 402 (-3.8A)
XYL  A 402 (-2.8A)
None
MG  A 401 ( 2.8A)
XYL  A 402 (-4.2A)
MG  A 401 ( 3.0A)
 0.22A 4dvoA-5y4jA:
60.5		 4dvoA-5y4jA:
99.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DVO_A_SORA404_0
(XYLOSE ISOMERASE)		 5y4j XYLOSE ISOMERASE
(Streptomyces
rubiginosus) 		10 / 12 TRP A  16
HIS A  54
MET A  88
THR A  90
VAL A 135
TRP A 137
LYS A 183
ASN A 215
HIS A 220
ASP A 255
 XYL  A 402 (-4.1A)
XYL  A 402 (-3.8A)
None
XYL  A 402 ( 4.1A)
None
XYL  A 402 (-3.8A)
XYL  A 402 (-2.8A)
None
XYL  A 402 (-4.2A)
XYL  A 402 ( 4.9A)
 0.68A 4dvoA-5y4jA:
60.5		 4dvoA-5y4jA:
99.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGK_A_0TXA304_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4rs3 ABC TRANSPORTER,
CARBOHYDRATE UPTAKE
TRANSPORTER-2 (CUT2)
FAMILY, PERIPLASMIC
SUGAR-BINDING
PROTEIN
(Mycolicibacteriu
m
smegmatis) 		5 / 10 GLY A 167
GLY A 166
ASN A 121
VAL A  96
GLN A  78
 None
None
XYL  A 401 (-3.0A)
None
None
 1.18A 4fgkA-4rs3A:
4.7
4fgkB-4rs3A:
3.7		 4fgkA-4rs3A:
23.96
4fgkB-4rs3A:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_D_SAMD601_1
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 5y4j XYLOSE ISOMERASE
(Streptomyces
rubiginosus) 		3 / 3 ASN A  92
ASP A  57
ASP A 287
 None
None
XYL  A 402 ( 2.9A)
 0.88A 4obwD-5y4jA:
undetectable		 4obwD-5y4jA:
20.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XIA_A_SORA400_0
(D-XYLOSE ISOMERASE)		 5y4j XYLOSE ISOMERASE
(Streptomyces
rubiginosus) 		6 / 12 HIS A  54
THR A  90
TRP A 137
GLU A 217
HIS A 220
ASP A 245
 XYL  A 402 (-3.8A)
XYL  A 402 ( 4.1A)
XYL  A 402 (-3.8A)
MG  A 401 ( 2.8A)
XYL  A 402 (-4.2A)
MG  A 401 ( 3.0A)
 1.30A 4xiaA-5y4jA:
57.1		 4xiaA-5y4jA:
65.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XIA_A_SORA400_0
(D-XYLOSE ISOMERASE)		 5y4j XYLOSE ISOMERASE
(Streptomyces
rubiginosus) 		6 / 12 MET A  88
THR A  90
TRP A 137
GLU A 217
HIS A 220
ASP A 287
 None
XYL  A 402 ( 4.1A)
XYL  A 402 (-3.8A)
MG  A 401 ( 2.8A)
XYL  A 402 (-4.2A)
XYL  A 402 ( 2.9A)
 1.41A 4xiaA-5y4jA:
57.1		 4xiaA-5y4jA:
65.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XIA_A_SORA400_0
(D-XYLOSE ISOMERASE)		 5y4j XYLOSE ISOMERASE
(Streptomyces
rubiginosus) 		12 / 12 TRP A  16
HIS A  54
MET A  88
THR A  90
VAL A 135
TRP A 137
LYS A 183
GLU A 217
HIS A 220
ASP A 245
ASP A 255
ASP A 287
 XYL  A 402 (-4.1A)
XYL  A 402 (-3.8A)
None
XYL  A 402 ( 4.1A)
None
XYL  A 402 (-3.8A)
XYL  A 402 (-2.8A)
MG  A 401 ( 2.8A)
XYL  A 402 (-4.2A)
MG  A 401 ( 3.0A)
XYL  A 402 ( 4.9A)
XYL  A 402 ( 2.9A)
 0.19A 4xiaA-5y4jA:
57.1		 4xiaA-5y4jA:
65.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XIA_B_SORB400_0
(D-XYLOSE ISOMERASE)		 5y4j XYLOSE ISOMERASE
(Streptomyces
rubiginosus) 		8 / 12 HIS A  54
MET A  88
THR A  90
TRP A 137
GLU A 181
GLU A 217
HIS A 220
ASP A 287
 XYL  A 402 (-3.8A)
None
XYL  A 402 ( 4.1A)
XYL  A 402 (-3.8A)
XYL  A 402 ( 2.4A)
MG  A 401 ( 2.8A)
XYL  A 402 (-4.2A)
XYL  A 402 ( 2.9A)
 1.24A 4xiaB-5y4jA:
57.0		 4xiaB-5y4jA:
65.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XIA_B_SORB400_0
(D-XYLOSE ISOMERASE)		 5y4j XYLOSE ISOMERASE
(Streptomyces
rubiginosus) 		12 / 12 TRP A  16
HIS A  54
MET A  88
THR A  90
VAL A 135
TRP A 137
GLU A 181
LYS A 183
GLU A 217
HIS A 220
ASP A 245
ASP A 287
 XYL  A 402 (-4.1A)
XYL  A 402 (-3.8A)
None
XYL  A 402 ( 4.1A)
None
XYL  A 402 (-3.8A)
XYL  A 402 ( 2.4A)
XYL  A 402 (-2.8A)
MG  A 401 ( 2.8A)
XYL  A 402 (-4.2A)
MG  A 401 ( 3.0A)
XYL  A 402 ( 2.9A)
 0.17A 4xiaB-5y4jA:
57.0		 4xiaB-5y4jA:
65.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KGP_A_GCSA407_1
(PREDICTED
ACETYLTRANSFERASE)		 5y4j XYLOSE ISOMERASE
(Streptomyces
rubiginosus) 		4 / 8 TRP A 137
GLU A 181
ASP A 257
TRP A  16
 XYL  A 402 (-3.8A)
XYL  A 402 ( 2.4A)
None
XYL  A 402 (-4.1A)
 1.07A 5kgpA-5y4jA:
0.9		 5kgpA-5y4jA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KGP_B_GCSB405_1
(PREDICTED
ACETYLTRANSFERASE)		 5y4j XYLOSE ISOMERASE
(Streptomyces
rubiginosus) 		4 / 8 TRP A 137
GLU A 181
ASP A 257
TRP A  16
 XYL  A 402 (-3.8A)
XYL  A 402 ( 2.4A)
None
XYL  A 402 (-4.1A)
 1.09A 5kgpB-5y4jA:
undetectable		 5kgpB-5y4jA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NHA_A_SORA503_0
(XYLOSE ISOMERASE)		 5y4j XYLOSE ISOMERASE
(Streptomyces
rubiginosus) 		6 / 9 HIS A  54
TRP A 137
GLU A 181
GLU A 217
HIS A 220
ASP A 287
 XYL  A 402 (-3.8A)
XYL  A 402 (-3.8A)
XYL  A 402 ( 2.4A)
MG  A 401 ( 2.8A)
XYL  A 402 (-4.2A)
XYL  A 402 ( 2.9A)
 1.34A 5nhaA-5y4jA:
40.0		 5nhaA-5y4jA:
29.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NHA_A_SORA503_0
(XYLOSE ISOMERASE)		 5y4j XYLOSE ISOMERASE
(Streptomyces
rubiginosus) 		8 / 9 TRP A  16
HIS A  54
TRP A 137
GLU A 181
GLU A 217
HIS A 220
ASP A 245
ASP A 287
 XYL  A 402 (-4.1A)
XYL  A 402 (-3.8A)
XYL  A 402 (-3.8A)
XYL  A 402 ( 2.4A)
MG  A 401 ( 2.8A)
XYL  A 402 (-4.2A)
MG  A 401 ( 3.0A)
XYL  A 402 ( 2.9A)
 0.28A 5nhaA-5y4jA:
40.0		 5nhaA-5y4jA:
29.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NHA_B_SORB503_0
(XYLOSE ISOMERASE)		 5y4j XYLOSE ISOMERASE
(Streptomyces
rubiginosus) 		6 / 9 HIS A  54
TRP A 137
GLU A 181
GLU A 217
HIS A 220
ASP A 287
 XYL  A 402 (-3.8A)
XYL  A 402 (-3.8A)
XYL  A 402 ( 2.4A)
MG  A 401 ( 2.8A)
XYL  A 402 (-4.2A)
XYL  A 402 ( 2.9A)
 1.34A 5nhaB-5y4jA:
40.0		 5nhaB-5y4jA:
29.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NHA_B_SORB503_0
(XYLOSE ISOMERASE)		 5y4j XYLOSE ISOMERASE
(Streptomyces
rubiginosus) 		8 / 9 TRP A  16
HIS A  54
TRP A 137
GLU A 181
GLU A 217
HIS A 220
ASP A 245
ASP A 287
 XYL  A 402 (-4.1A)
XYL  A 402 (-3.8A)
XYL  A 402 (-3.8A)
XYL  A 402 ( 2.4A)
MG  A 401 ( 2.8A)
XYL  A 402 (-4.2A)
MG  A 401 ( 3.0A)
XYL  A 402 ( 2.9A)
 0.28A 5nhaB-5y4jA:
40.0		 5nhaB-5y4jA:
29.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NHA_C_SORC503_0
(XYLOSE ISOMERASE)		 5y4j XYLOSE ISOMERASE
(Streptomyces
rubiginosus) 		6 / 9 HIS A  54
TRP A 137
GLU A 181
GLU A 217
HIS A 220
ASP A 287
 XYL  A 402 (-3.8A)
XYL  A 402 (-3.8A)
XYL  A 402 ( 2.4A)
MG  A 401 ( 2.8A)
XYL  A 402 (-4.2A)
XYL  A 402 ( 2.9A)
 1.34A 5nhaC-5y4jA:
39.8		 5nhaC-5y4jA:
29.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NHA_C_SORC503_0
(XYLOSE ISOMERASE)		 5y4j XYLOSE ISOMERASE
(Streptomyces
rubiginosus) 		8 / 9 TRP A  16
HIS A  54
TRP A 137
GLU A 181
GLU A 217
HIS A 220
ASP A 245
ASP A 287
 XYL  A 402 (-4.1A)
XYL  A 402 (-3.8A)
XYL  A 402 (-3.8A)
XYL  A 402 ( 2.4A)
MG  A 401 ( 2.8A)
XYL  A 402 (-4.2A)
MG  A 401 ( 3.0A)
XYL  A 402 ( 2.9A)
 0.28A 5nhaC-5y4jA:
39.8		 5nhaC-5y4jA:
29.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NHA_D_SORD503_0
(XYLOSE ISOMERASE)		 5y4j XYLOSE ISOMERASE
(Streptomyces
rubiginosus) 		6 / 9 HIS A  54
TRP A 137
GLU A 181
GLU A 217
HIS A 220
ASP A 287
 XYL  A 402 (-3.8A)
XYL  A 402 (-3.8A)
XYL  A 402 ( 2.4A)
MG  A 401 ( 2.8A)
XYL  A 402 (-4.2A)
XYL  A 402 ( 2.9A)
 1.34A 5nhaD-5y4jA:
40.0		 5nhaD-5y4jA:
29.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NHA_D_SORD503_0
(XYLOSE ISOMERASE)		 5y4j XYLOSE ISOMERASE
(Streptomyces
rubiginosus) 		8 / 9 TRP A  16
HIS A  54
TRP A 137
GLU A 181
GLU A 217
HIS A 220
ASP A 245
ASP A 287
 XYL  A 402 (-4.1A)
XYL  A 402 (-3.8A)
XYL  A 402 (-3.8A)
XYL  A 402 ( 2.4A)
MG  A 401 ( 2.8A)
XYL  A 402 (-4.2A)
MG  A 401 ( 3.0A)
XYL  A 402 ( 2.9A)
 0.28A 5nhaD-5y4jA:
40.0		 5nhaD-5y4jA:
29.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_E_CVIE301_1
(REGULATORY PROTEIN
TETR)		 4rs3 ABC TRANSPORTER,
CARBOHYDRATE UPTAKE
TRANSPORTER-2 (CUT2)
FAMILY, PERIPLASMIC
SUGAR-BINDING
PROTEIN
(Mycolicibacteriu
m
smegmatis) 		4 / 7 GLY A  51
GLN A  78
TRP A  68
ASP A 249
 None
None
None
XYL  A 401 (-2.7A)
 1.09A 5vlmE-4rs3A:
undetectable		 5vlmE-4rs3A:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_H_CVIH301_1
(REGULATORY PROTEIN
TETR)		 4rs3 ABC TRANSPORTER,
CARBOHYDRATE UPTAKE
TRANSPORTER-2 (CUT2)
FAMILY, PERIPLASMIC
SUGAR-BINDING
PROTEIN
(Mycolicibacteriu
m
smegmatis) 		4 / 8 GLY A  51
GLN A  78
TRP A  68
ASP A 249
 None
None
None
XYL  A 401 (-2.7A)
 1.01A 5vlmH-4rs3A:
undetectable		 5vlmH-4rs3A:
22.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5XIM_A_SORA397_0
(D-XYLOSE ISOMERASE)		 5y4j XYLOSE ISOMERASE
(Streptomyces
rubiginosus) 		7 / 12 HIS A  54
THR A  90
VAL A 135
GLU A 181
GLU A 217
ASP A 245
ASP A 257
 XYL  A 402 (-3.8A)
XYL  A 402 ( 4.1A)
None
XYL  A 402 ( 2.4A)
MG  A 401 ( 2.8A)
MG  A 401 ( 3.0A)
None
 1.14A 5ximA-5y4jA:
57.3		 5ximA-5y4jA:
66.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5XIM_A_SORA397_0
(D-XYLOSE ISOMERASE)		 5y4j XYLOSE ISOMERASE
(Streptomyces
rubiginosus) 		6 / 12 THR A  90
TRP A 137
GLU A 181
GLU A 217
HIS A 220
ASP A 287
 XYL  A 402 ( 4.1A)
XYL  A 402 (-3.8A)
XYL  A 402 ( 2.4A)
MG  A 401 ( 2.8A)
XYL  A 402 (-4.2A)
XYL  A 402 ( 2.9A)
 1.30A 5ximA-5y4jA:
57.3		 5ximA-5y4jA:
66.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5XIM_A_SORA397_0
(D-XYLOSE ISOMERASE)		 5y4j XYLOSE ISOMERASE
(Streptomyces
rubiginosus) 		6 / 12 THR A  90
TRP A 137
GLU A 181
HIS A 220
ASP A 287
ASP A 255
 XYL  A 402 ( 4.1A)
XYL  A 402 (-3.8A)
XYL  A 402 ( 2.4A)
XYL  A 402 (-4.2A)
XYL  A 402 ( 2.9A)
XYL  A 402 ( 4.9A)
 1.32A 5ximA-5y4jA:
57.3		 5ximA-5y4jA:
66.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5XIM_A_SORA397_0
(D-XYLOSE ISOMERASE)		 5y4j XYLOSE ISOMERASE
(Streptomyces
rubiginosus) 		11 / 12 TRP A  16
HIS A  54
THR A  90
VAL A 135
TRP A 137
GLU A 181
LYS A 183
GLU A 217
HIS A 220
ASP A 245
ASP A 287
 XYL  A 402 (-4.1A)
XYL  A 402 (-3.8A)
XYL  A 402 ( 4.1A)
None
XYL  A 402 (-3.8A)
XYL  A 402 ( 2.4A)
XYL  A 402 (-2.8A)
MG  A 401 ( 2.8A)
XYL  A 402 (-4.2A)
MG  A 401 ( 3.0A)
XYL  A 402 ( 2.9A)
 0.21A 5ximA-5y4jA:
57.3		 5ximA-5y4jA:
66.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5XIM_A_SORA397_0
(D-XYLOSE ISOMERASE)		 5y4j XYLOSE ISOMERASE
(Streptomyces
rubiginosus) 		9 / 12 TRP A  16
HIS A  54
THR A  90
VAL A 135
TRP A 137
GLU A 181
LYS A 183
HIS A 220
ASP A 255
 XYL  A 402 (-4.1A)
XYL  A 402 (-3.8A)
XYL  A 402 ( 4.1A)
None
XYL  A 402 (-3.8A)
XYL  A 402 ( 2.4A)
XYL  A 402 (-2.8A)
XYL  A 402 (-4.2A)
XYL  A 402 ( 4.9A)
 0.68A 5ximA-5y4jA:
57.3		 5ximA-5y4jA:
66.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5XIM_B_SORB397_0
(D-XYLOSE ISOMERASE)		 5y4j XYLOSE ISOMERASE
(Streptomyces
rubiginosus) 		6 / 12 HIS A  54
THR A  90
TRP A 137
GLU A 217
HIS A 220
ASP A 245
 XYL  A 402 (-3.8A)
XYL  A 402 ( 4.1A)
XYL  A 402 (-3.8A)
MG  A 401 ( 2.8A)
XYL  A 402 (-4.2A)
MG  A 401 ( 3.0A)
 1.31A 5ximB-5y4jA:
57.3		 5ximB-5y4jA:
66.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5XIM_B_SORB397_0
(D-XYLOSE ISOMERASE)		 5y4j XYLOSE ISOMERASE
(Streptomyces
rubiginosus) 		6 / 12 HIS A  54
THR A  90
VAL A 135
TRP A 137
GLU A 217
ASP A 257
 XYL  A 402 (-3.8A)
XYL  A 402 ( 4.1A)
None
XYL  A 402 (-3.8A)
MG  A 401 ( 2.8A)
None
 1.38A 5ximB-5y4jA:
57.3		 5ximB-5y4jA:
66.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5XIM_B_SORB397_0
(D-XYLOSE ISOMERASE)		 5y4j XYLOSE ISOMERASE
(Streptomyces
rubiginosus) 		6 / 12 MET A  88
THR A  90
TRP A 137
GLU A 217
HIS A 220
ASP A 287
 None
XYL  A 402 ( 4.1A)
XYL  A 402 (-3.8A)
MG  A 401 ( 2.8A)
XYL  A 402 (-4.2A)
XYL  A 402 ( 2.9A)
 1.34A 5ximB-5y4jA:
57.3		 5ximB-5y4jA:
66.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5XIM_B_SORB397_0
(D-XYLOSE ISOMERASE)		 5y4j XYLOSE ISOMERASE
(Streptomyces
rubiginosus) 		6 / 12 MET A  88
THR A  90
TRP A 137
HIS A 220
ASP A 287
ASP A 255
 None
XYL  A 402 ( 4.1A)
XYL  A 402 (-3.8A)
XYL  A 402 (-4.2A)
XYL  A 402 ( 2.9A)
XYL  A 402 ( 4.9A)
 1.42A 5ximB-5y4jA:
57.3		 5ximB-5y4jA:
66.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5XIM_B_SORB397_0
(D-XYLOSE ISOMERASE)		 5y4j XYLOSE ISOMERASE
(Streptomyces
rubiginosus) 		11 / 12 TRP A  16
HIS A  54
MET A  88
THR A  90
VAL A 135
TRP A 137
LYS A 183
GLU A 217
HIS A 220
ASP A 245
ASP A 287
 XYL  A 402 (-4.1A)
XYL  A 402 (-3.8A)
None
XYL  A 402 ( 4.1A)
None
XYL  A 402 (-3.8A)
XYL  A 402 (-2.8A)
MG  A 401 ( 2.8A)
XYL  A 402 (-4.2A)
MG  A 401 ( 3.0A)
XYL  A 402 ( 2.9A)
 0.20A 5ximB-5y4jA:
57.3		 5ximB-5y4jA:
66.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5XIM_B_SORB397_0
(D-XYLOSE ISOMERASE)		 5y4j XYLOSE ISOMERASE
(Streptomyces
rubiginosus) 		10 / 12 TRP A  16
HIS A  54
MET A  88
THR A  90
VAL A 135
TRP A 137
LYS A 183
HIS A 220
ASP A 255
ASP A 287
 XYL  A 402 (-4.1A)
XYL  A 402 (-3.8A)
None
XYL  A 402 ( 4.1A)
None
XYL  A 402 (-3.8A)
XYL  A 402 (-2.8A)
XYL  A 402 (-4.2A)
XYL  A 402 ( 4.9A)
XYL  A 402 ( 2.9A)
 0.59A 5ximB-5y4jA:
57.3		 5ximB-5y4jA:
66.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5XIM_C_SORC397_0
(D-XYLOSE ISOMERASE)		 5y4j XYLOSE ISOMERASE
(Streptomyces
rubiginosus) 		8 / 12 HIS A  54
THR A  90
VAL A 135
TRP A 137
GLU A 181
GLU A 217
HIS A 220
ASP A 257
 XYL  A 402 (-3.8A)
XYL  A 402 ( 4.1A)
None
XYL  A 402 (-3.8A)
XYL  A 402 ( 2.4A)
MG  A 401 ( 2.8A)
XYL  A 402 (-4.2A)
None
 1.28A 5ximC-5y4jA:
57.2		 5ximC-5y4jA:
66.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5XIM_C_SORC397_0
(D-XYLOSE ISOMERASE)		 5y4j XYLOSE ISOMERASE
(Streptomyces
rubiginosus) 		6 / 12 THR A  90
TRP A 137
GLU A 181
GLU A 217
HIS A 220
ASP A 287
 XYL  A 402 ( 4.1A)
XYL  A 402 (-3.8A)
XYL  A 402 ( 2.4A)
MG  A 401 ( 2.8A)
XYL  A 402 (-4.2A)
XYL  A 402 ( 2.9A)
 1.27A 5ximC-5y4jA:
57.2		 5ximC-5y4jA:
66.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5XIM_C_SORC397_0
(D-XYLOSE ISOMERASE)		 5y4j XYLOSE ISOMERASE
(Streptomyces
rubiginosus) 		6 / 12 THR A  90
TRP A 137
GLU A 181
HIS A 220
ASP A 287
ASP A 255
 XYL  A 402 ( 4.1A)
XYL  A 402 (-3.8A)
XYL  A 402 ( 2.4A)
XYL  A 402 (-4.2A)
XYL  A 402 ( 2.9A)
XYL  A 402 ( 4.9A)
 1.33A 5ximC-5y4jA:
57.2		 5ximC-5y4jA:
66.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5XIM_C_SORC397_0
(D-XYLOSE ISOMERASE)		 5y4j XYLOSE ISOMERASE
(Streptomyces
rubiginosus) 		11 / 12 TRP A  16
HIS A  54
THR A  90
VAL A 135
TRP A 137
GLU A 181
LYS A 183
GLU A 217
HIS A 220
ASP A 245
ASP A 287
 XYL  A 402 (-4.1A)
XYL  A 402 (-3.8A)
XYL  A 402 ( 4.1A)
None
XYL  A 402 (-3.8A)
XYL  A 402 ( 2.4A)
XYL  A 402 (-2.8A)
MG  A 401 ( 2.8A)
XYL  A 402 (-4.2A)
MG  A 401 ( 3.0A)
XYL  A 402 ( 2.9A)
 0.17A 5ximC-5y4jA:
57.2		 5ximC-5y4jA:
66.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5XIM_C_SORC397_0
(D-XYLOSE ISOMERASE)		 5y4j XYLOSE ISOMERASE
(Streptomyces
rubiginosus) 		10 / 12 TRP A  16
HIS A  54
THR A  90
VAL A 135
TRP A 137
GLU A 181
LYS A 183
HIS A 220
ASP A 255
ASP A 287
 XYL  A 402 (-4.1A)
XYL  A 402 (-3.8A)
XYL  A 402 ( 4.1A)
None
XYL  A 402 (-3.8A)
XYL  A 402 ( 2.4A)
XYL  A 402 (-2.8A)
XYL  A 402 (-4.2A)
XYL  A 402 ( 4.9A)
XYL  A 402 ( 2.9A)
 0.58A 5ximC-5y4jA:
57.2		 5ximC-5y4jA:
66.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5XIM_D_SORD397_0
(D-XYLOSE ISOMERASE)		 5y4j XYLOSE ISOMERASE
(Streptomyces
rubiginosus) 		7 / 12 MET A  88
THR A  90
TRP A 137
GLU A 181
GLU A 217
HIS A 220
ASP A 287
 None
XYL  A 402 ( 4.1A)
XYL  A 402 (-3.8A)
XYL  A 402 ( 2.4A)
MG  A 401 ( 2.8A)
XYL  A 402 (-4.2A)
XYL  A 402 ( 2.9A)
 1.28A 5ximD-5y4jA:
57.3		 5ximD-5y4jA:
66.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5XIM_D_SORD397_0
(D-XYLOSE ISOMERASE)		 5y4j XYLOSE ISOMERASE
(Streptomyces
rubiginosus) 		7 / 12 MET A  88
THR A  90
TRP A 137
GLU A 181
HIS A 220
ASP A 287
ASP A 255
 None
XYL  A 402 ( 4.1A)
XYL  A 402 (-3.8A)
XYL  A 402 ( 2.4A)
XYL  A 402 (-4.2A)
XYL  A 402 ( 2.9A)
XYL  A 402 ( 4.9A)
 1.37A 5ximD-5y4jA:
57.3		 5ximD-5y4jA:
66.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5XIM_D_SORD397_0
(D-XYLOSE ISOMERASE)		 5y4j XYLOSE ISOMERASE
(Streptomyces
rubiginosus) 		5 / 12 THR A  90
GLU A 181
GLU A 217
ASP A 257
ASP A 245
 XYL  A 402 ( 4.1A)
XYL  A 402 ( 2.4A)
MG  A 401 ( 2.8A)
None
MG  A 401 ( 3.0A)
 1.30A 5ximD-5y4jA:
57.3		 5ximD-5y4jA:
66.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5XIM_D_SORD397_0
(D-XYLOSE ISOMERASE)		 5y4j XYLOSE ISOMERASE
(Streptomyces
rubiginosus) 		5 / 12 THR A  90
VAL A 135
GLU A 181
GLU A 217
ASP A 257
 XYL  A 402 ( 4.1A)
None
XYL  A 402 ( 2.4A)
MG  A 401 ( 2.8A)
None
 1.11A 5ximD-5y4jA:
57.3		 5ximD-5y4jA:
66.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5XIM_D_SORD397_0
(D-XYLOSE ISOMERASE)		 5y4j XYLOSE ISOMERASE
(Streptomyces
rubiginosus) 		11 / 12 TRP A  16
MET A  88
THR A  90
VAL A 135
TRP A 137
GLU A 181
LYS A 183
GLU A 217
HIS A 220
ASP A 245
ASP A 287
 XYL  A 402 (-4.1A)
None
XYL  A 402 ( 4.1A)
None
XYL  A 402 (-3.8A)
XYL  A 402 ( 2.4A)
XYL  A 402 (-2.8A)
MG  A 401 ( 2.8A)
XYL  A 402 (-4.2A)
MG  A 401 ( 3.0A)
XYL  A 402 ( 2.9A)
 0.19A 5ximD-5y4jA:
57.3		 5ximD-5y4jA:
66.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5XIM_D_SORD397_0
(D-XYLOSE ISOMERASE)		 5y4j XYLOSE ISOMERASE
(Streptomyces
rubiginosus) 		9 / 12 TRP A  16
MET A  88
THR A  90
VAL A 135
TRP A 137
GLU A 181
LYS A 183
HIS A 220
ASP A 255
 XYL  A 402 (-4.1A)
None
XYL  A 402 ( 4.1A)
None
XYL  A 402 (-3.8A)
XYL  A 402 ( 2.4A)
XYL  A 402 (-2.8A)
XYL  A 402 (-4.2A)
XYL  A 402 ( 4.9A)
 0.65A 5ximD-5y4jA:
57.3		 5ximD-5y4jA:
66.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F7L_B_ACTB505_0
(AMINE OXIDASE LKCE)		 5y4j XYLOSE ISOMERASE
(Streptomyces
rubiginosus) 		3 / 3 HIS A  54
ASN A  92
LEU A  93
 XYL  A 402 (-3.8A)
None
None
 0.88A 6f7lB-5y4jA:
undetectable		 6f7lB-5y4jA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_B_AM2B301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 5y4j XYLOSE ISOMERASE
(Streptomyces
rubiginosus) 		4 / 8 TRP A  20
ASP A  57
ASP A 287
GLU A 181
 None
None
XYL  A 402 ( 2.9A)
XYL  A 402 ( 2.4A)
 1.23A 6mn4B-5y4jA:
undetectable		 6mn4B-5y4jA:
24.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_C_AM2C301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 5y4j XYLOSE ISOMERASE
(Streptomyces
rubiginosus) 		4 / 8 TRP A  20
ASP A  57
ASP A 287
GLU A 181
 None
None
XYL  A 402 ( 2.9A)
XYL  A 402 ( 2.4A)
 1.03A 6mn4C-5y4jA:
undetectable		 6mn4C-5y4jA:
24.74