SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'XYG'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RK8_A_PPFA3969_1
(PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP])		 2fl1 RED FLUORESCENT
PROTEIN ZOANRFP
(Zoanthus
sp.) 		4 / 8 LYS A  69
HIS A 122
ARG A  95
ALA A  63
 XYG  A  66 ( 3.6A)
XYG  A  66 ( 4.4A)
XYG  A  66 ( 3.0A)
XYG  A  66 ( 4.0A)
 1.32A 2rk8A-2fl1A:
undetectable		 2rk8A-2fl1A:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RK8_A_PPFA3969_1
(PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP])		 2pxs GFP-LIKE FLUORESCENT
CHROMOPROTEIN FP506
(Zoanthus
sp.) 		4 / 8 LYS A  69
HIS A 122
ARG A  95
ALA A  63
 DYG  A  66 ( 3.5A)
XYG  A  66 ( 3.8A)
XYG  A  66 ( 2.7A)
DYG  A  66 ( 3.8A)
 1.33A 2rk8A-2pxsA:
undetectable		 2rk8A-2pxsA:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_B_0LIB1000_2
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 2fl1 RED FLUORESCENT
PROTEIN ZOANRFP
(Zoanthus
sp.) 		3 / 3 TYR A 168
MET A 167
ILE A 200
 None
XYG  A  66 ( 3.2A)
None
 0.66A 4c8bB-2fl1A:
undetectable		 4c8bB-2fl1A:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_B_0LIB1000_2
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 2pxs GFP-LIKE FLUORESCENT
CHROMOPROTEIN FP506
(Zoanthus
sp.) 		3 / 3 TYR A 168
MET A 167
ILE A 200
 None
XYG  A  66 ( 3.1A)
None
 0.66A 4c8bB-2pxsA:
undetectable		 4c8bB-2pxsA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_A_SAMA301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 2fl1 RED FLUORESCENT
PROTEIN ZOANRFP
(Zoanthus
sp.) 		5 / 12 ALA A  63
ASP A 182
PHE A 181
GLY A 163
GLU A 150
 XYG  A  66 ( 4.0A)
None
None
None
XYG  A  66 ( 4.6A)
 1.19A 5hfjA-2fl1A:
undetectable		 5hfjA-2fl1A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_F_SAMF301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 2fl1 RED FLUORESCENT
PROTEIN ZOANRFP
(Zoanthus
sp.) 		5 / 12 ALA A  63
ASP A 182
PHE A 181
GLY A 163
GLU A 150
 XYG  A  66 ( 4.0A)
None
None
None
XYG  A  66 ( 4.6A)
 1.29A 5hfjF-2fl1A:
undetectable		 5hfjF-2fl1A:
18.18