SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'XPL'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 1l2q MONOMETHYLAMINE
METHYLTRANSFERASE
(Methanosarcina
barkeri) 		5 / 12 ILE A 135
GLY A 129
VAL A 143
SER A 365
SER A 369
 None
None
None
XPL  A 202 ( 2.7A)
None
 0.97A 1kiaA-1l2qA:
undetectable		 1kiaA-1l2qA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 1l2q MONOMETHYLAMINE
METHYLTRANSFERASE
(Methanosarcina
barkeri) 		5 / 12 ILE A 135
GLY A 129
VAL A 143
SER A 365
SER A 369
 None
None
None
XPL  A 202 ( 2.7A)
None
 0.96A 1nbhA-1l2qA:
undetectable		 1nbhA-1l2qA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_C_SAMC2293_0
(GLYCINE
N-METHYLTRANSFERASE)		 1l2q MONOMETHYLAMINE
METHYLTRANSFERASE
(Methanosarcina
barkeri) 		5 / 12 ILE A 135
GLY A 129
VAL A 143
SER A 365
SER A 369
 None
None
None
XPL  A 202 ( 2.7A)
None
 0.97A 1nbhC-1l2qA:
0.6		 1nbhC-1l2qA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)		 1l2q MONOMETHYLAMINE
METHYLTRANSFERASE
(Methanosarcina
barkeri) 		5 / 12 ILE A 135
GLY A 129
VAL A 143
SER A 365
SER A 369
 None
None
None
XPL  A 202 ( 2.7A)
None
 0.96A 1nbhD-1l2qA:
undetectable		 1nbhD-1l2qA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 1l2q MONOMETHYLAMINE
METHYLTRANSFERASE
(Methanosarcina
barkeri) 		5 / 12 ILE A 135
GLY A 129
VAL A 143
SER A 365
SER A 369
 None
None
None
XPL  A 202 ( 2.7A)
None
 0.96A 1nbiA-1l2qA:
undetectable		 1nbiA-1l2qA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 1l2q MONOMETHYLAMINE
METHYLTRANSFERASE
(Methanosarcina
barkeri) 		5 / 12 ILE A 187
GLY A 198
VAL A 201
ASP A 226
GLY A 221
 None
None
XPL  A 202 ( 2.9A)
None
None
 1.16A 1nbiA-1l2qA:
undetectable		 1nbiA-1l2qA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_B_SAMB1293_0
(GLYCINE
N-METHYLTRANSFERASE)		 1l2q MONOMETHYLAMINE
METHYLTRANSFERASE
(Methanosarcina
barkeri) 		5 / 12 ILE A 135
GLY A 129
VAL A 143
SER A 365
SER A 369
 None
None
None
XPL  A 202 ( 2.7A)
None
 0.97A 1nbiB-1l2qA:
undetectable		 1nbiB-1l2qA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_2_BO221405_1
(PROTEASOME COMPONENT
PRE3)		 1l2q MONOMETHYLAMINE
METHYLTRANSFERASE
(Methanosarcina
barkeri) 		5 / 11 THR A 378
SER A 365
GLY A 366
ALA A 383
SER A 133
 None
XPL  A 202 ( 2.7A)
None
None
None
 1.14A 2f162-1l2qA:
undetectable		 2f162-1l2qA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_N_BO2N1404_1
(PROTEASOME COMPONENT
PRE3)		 1l2q MONOMETHYLAMINE
METHYLTRANSFERASE
(Methanosarcina
barkeri) 		5 / 11 THR A 378
SER A 365
GLY A 366
ALA A 383
SER A 133
 None
XPL  A 202 ( 2.7A)
None
None
None
 1.14A 2f16N-1l2qA:
undetectable		 2f16N-1l2qA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PXC_A_SAMA500_0
(GENOME POLYPROTEIN
[CONTAINS: CAPSID
PROTEIN C (CORE
PROTEIN)
ENVELOPE PROTEIN M
(MATRIX PROTEIN)
MAJOR ENVELOPE
PROTEIN E
NON-STRUCTURAL
PROTEIN 1 (NS1)
NON-STRUCTURAL
PROTEIN 2A (NS2A)
FLAVIVIRIN PROTEASE
NS2B REGULATORY
SUBUNIT
FLAVIVIRIN PROTEASE
NS3 CATALYTIC
SUBUNIT
NON-STRUCTURAL
PROTEIN 4A (NS4A)
NON-STRUCTURAL
PROTEIN 4B (NS4B)
RNA-DIRECTED RNA
POLYMERASE (EC
2.7.7.48) (NS5)])		 1l2q MONOMETHYLAMINE
METHYLTRANSFERASE
(Methanosarcina
barkeri) 		5 / 12 GLY A 387
GLY A 129
GLY A 366
THR A 131
ILE A 156
 None
None
None
XPL  A 202 ( 4.5A)
None
 0.77A 2pxcA-1l2qA:
undetectable		 2pxcA-1l2qA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WA2_A_SAMA1248_0
(NON-STRUCTURAL
PROTEIN 5)		 1l2q MONOMETHYLAMINE
METHYLTRANSFERASE
(Methanosarcina
barkeri) 		5 / 12 GLY A 387
GLY A 129
GLY A 366
THR A 131
ILE A 156
 None
None
None
XPL  A 202 ( 4.5A)
None
 0.78A 2wa2A-1l2qA:
undetectable		 2wa2A-1l2qA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WA2_B_SAMB1267_0
(NON-STRUCTURAL
PROTEIN 5)		 1l2q MONOMETHYLAMINE
METHYLTRANSFERASE
(Methanosarcina
barkeri) 		5 / 12 GLY A 387
GLY A 129
GLY A 366
THR A 131
ILE A 156
 None
None
None
XPL  A 202 ( 4.5A)
None
 0.76A 2wa2B-1l2qA:
undetectable		 2wa2B-1l2qA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZG_B_NCAB302_0
(ADP-RIBOSYL CYCLASE
1)		 1l2q MONOMETHYLAMINE
METHYLTRANSFERASE
(Methanosarcina
barkeri) 		4 / 7 LEU A 295
GLU A 259
SER A 365
THR A 131
 XPL  A 202 ( 4.8A)
XPL  A 202 (-2.7A)
XPL  A 202 ( 2.7A)
XPL  A 202 ( 4.5A)
 1.33A 3dzgB-1l2qA:
undetectable		 3dzgB-1l2qA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELU_A_SAMA4633_0
(METHYLTRANSFERASE)		 1l2q MONOMETHYLAMINE
METHYLTRANSFERASE
(Methanosarcina
barkeri) 		5 / 12 GLY A 387
GLY A 129
GLY A 366
THR A 131
ILE A 156
 None
None
None
XPL  A 202 ( 4.5A)
None
 0.75A 3eluA-1l2qA:
undetectable		 3eluA-1l2qA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELW_A_SAMA4633_0
(METHYLTRANSFERASE)		 1l2q MONOMETHYLAMINE
METHYLTRANSFERASE
(Methanosarcina
barkeri) 		5 / 12 GLY A 387
GLY A 129
GLY A 366
THR A 131
ILE A 156
 None
None
None
XPL  A 202 ( 4.5A)
None
 0.72A 3elwA-1l2qA:
undetectable		 3elwA-1l2qA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EMB_A_SAMA4633_0
(METHYLTRANSFERASE)		 1l2q MONOMETHYLAMINE
METHYLTRANSFERASE
(Methanosarcina
barkeri) 		5 / 12 GLY A 387
GLY A 129
GLY A 366
THR A 131
ILE A 156
 None
None
None
XPL  A 202 ( 4.5A)
None
 0.71A 3embA-1l2qA:
undetectable		 3embA-1l2qA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GCZ_A_SAMA4633_0
(POLYPROTEIN)		 1l2q MONOMETHYLAMINE
METHYLTRANSFERASE
(Methanosarcina
barkeri) 		5 / 12 GLY A 387
GLY A 129
GLY A 366
THR A 131
ILE A 156
 None
None
None
XPL  A 202 ( 4.5A)
None
 0.77A 3gczA-1l2qA:
undetectable		 3gczA-1l2qA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_2_BO221405_1
(PROTEASOME COMPONENT
PRE3
PROTEASOME COMPONENT
PUP1)		 1l2q MONOMETHYLAMINE
METHYLTRANSFERASE
(Methanosarcina
barkeri) 		5 / 12 THR A 378
SER A 365
GLY A 366
ALA A 383
SER A 133
 None
XPL  A 202 ( 2.7A)
None
None
None
 1.11A 3mg02-1l2qA:
undetectable
3mg0V-1l2qA:
undetectable		 3mg02-1l2qA:
18.30
3mg0V-1l2qA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_N_BO2N1404_1
(PROTEASOME COMPONENT
PRE3)		 1l2q MONOMETHYLAMINE
METHYLTRANSFERASE
(Methanosarcina
barkeri) 		5 / 11 THR A 378
SER A 365
GLY A 366
ALA A 383
SER A 133
 None
XPL  A 202 ( 2.7A)
None
None
None
 1.10A 3mg0N-1l2qA:
undetectable		 3mg0N-1l2qA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_D_SAMD6735_0
(16S RRNA METHYLASE)		 1l2q MONOMETHYLAMINE
METHYLTRANSFERASE
(Methanosarcina
barkeri) 		5 / 12 GLY A 203
VAL A 160
ALA A 180
ALA A 216
SER A 365
 XPL  A 202 ( 2.4A)
None
None
None
XPL  A 202 ( 2.7A)
 0.87A 3p2kD-1l2qA:
undetectable		 3p2kD-1l2qA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P97_A_SAMA263_0
(NON-STRUCTURAL
PROTEIN 5)		 1l2q MONOMETHYLAMINE
METHYLTRANSFERASE
(Methanosarcina
barkeri) 		5 / 12 GLY A 387
GLY A 129
GLY A 366
THR A 131
ILE A 156
 None
None
None
XPL  A 202 ( 4.5A)
None
 0.79A 3p97A-1l2qA:
undetectable		 3p97A-1l2qA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P97_C_SAMC263_0
(NON-STRUCTURAL
PROTEIN 5)		 1l2q MONOMETHYLAMINE
METHYLTRANSFERASE
(Methanosarcina
barkeri) 		5 / 12 GLY A 387
GLY A 129
GLY A 366
THR A 131
ILE A 156
 None
None
None
XPL  A 202 ( 4.5A)
None
 0.75A 3p97C-1l2qA:
undetectable		 3p97C-1l2qA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROP_A_NCAA302_0
(ADP-RIBOSYL CYCLASE
1)		 1l2q MONOMETHYLAMINE
METHYLTRANSFERASE
(Methanosarcina
barkeri) 		4 / 6 LEU A 295
GLU A 259
SER A 365
THR A 131
 XPL  A 202 ( 4.8A)
XPL  A 202 (-2.7A)
XPL  A 202 ( 2.7A)
XPL  A 202 ( 4.5A)
 1.29A 3ropA-1l2qA:
undetectable		 3ropA-1l2qA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTJ_A_SAMA1263_0
(NON-STRUCTURAL
PROTEIN 5)		 1l2q MONOMETHYLAMINE
METHYLTRANSFERASE
(Methanosarcina
barkeri) 		5 / 12 GLY A 387
GLY A 129
GLY A 366
THR A 131
ILE A 156
 None
None
None
XPL  A 202 ( 4.5A)
None
 0.78A 4ctjA-1l2qA:
undetectable		 4ctjA-1l2qA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTJ_C_SAMC1263_0
(NON-STRUCTURAL
PROTEIN 5)		 1l2q MONOMETHYLAMINE
METHYLTRANSFERASE
(Methanosarcina
barkeri) 		5 / 12 GLY A 387
GLY A 129
GLY A 366
THR A 131
ILE A 156
 None
None
None
XPL  A 202 ( 4.5A)
None
 0.74A 4ctjC-1l2qA:
undetectable		 4ctjC-1l2qA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTK_A_SAMA1263_0
(POLYPROTEIN)		 1l2q MONOMETHYLAMINE
METHYLTRANSFERASE
(Methanosarcina
barkeri) 		5 / 12 GLY A 387
GLY A 129
GLY A 366
THR A 131
ILE A 156
 None
None
None
XPL  A 202 ( 4.5A)
None
 0.77A 4ctkA-1l2qA:
undetectable		 4ctkA-1l2qA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTK_C_SAMC1263_0
(POLYPROTEIN)		 1l2q MONOMETHYLAMINE
METHYLTRANSFERASE
(Methanosarcina
barkeri) 		5 / 12 GLY A 387
GLY A 129
GLY A 366
THR A 131
ILE A 156
 None
None
None
XPL  A 202 ( 4.5A)
None
 0.75A 4ctkC-1l2qA:
undetectable		 4ctkC-1l2qA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E9Q_A_SAMA301_0
(GENOME POLYPROTEIN)		 1l2q MONOMETHYLAMINE
METHYLTRANSFERASE
(Methanosarcina
barkeri) 		5 / 12 GLY A 387
GLY A 129
GLY A 366
THR A 131
ILE A 156
 None
None
None
XPL  A 202 ( 4.5A)
None
 0.77A 5e9qA-1l2qA:
undetectable		 5e9qA-1l2qA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E9Q_C_SAMC4000_0
(GENOME POLYPROTEIN)		 1l2q MONOMETHYLAMINE
METHYLTRANSFERASE
(Methanosarcina
barkeri) 		5 / 12 GLY A 387
GLY A 129
GLY A 366
THR A 131
ILE A 156
 None
None
None
XPL  A 202 ( 4.5A)
None
 0.75A 5e9qC-1l2qA:
0.0		 5e9qC-1l2qA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EC8_A_SAMA301_0
(GENOME POLYPROTEIN)		 1l2q MONOMETHYLAMINE
METHYLTRANSFERASE
(Methanosarcina
barkeri) 		5 / 12 GLY A 387
GLY A 129
GLY A 366
THR A 131
ILE A 156
 None
None
None
XPL  A 202 ( 4.5A)
None
 0.74A 5ec8A-1l2qA:
undetectable		 5ec8A-1l2qA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EC8_C_SAMC4000_0
(GENOME POLYPROTEIN)		 1l2q MONOMETHYLAMINE
METHYLTRANSFERASE
(Methanosarcina
barkeri) 		5 / 12 GLY A 387
GLY A 129
GLY A 366
THR A 131
ILE A 156
 None
None
None
XPL  A 202 ( 4.5A)
None
 0.73A 5ec8C-1l2qA:
undetectable		 5ec8C-1l2qA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EHG_A_SAMA301_0
(RNA-DIRECTED RNA
POLYMERASE NS5)		 1l2q MONOMETHYLAMINE
METHYLTRANSFERASE
(Methanosarcina
barkeri) 		5 / 12 GLY A 387
GLY A 129
GLY A 366
THR A 131
ILE A 156
 None
None
None
XPL  A 202 ( 4.5A)
None
 0.76A 5ehgA-1l2qA:
undetectable		 5ehgA-1l2qA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EHG_C_SAMC4001_0
(RNA-DIRECTED RNA
POLYMERASE NS5)		 1l2q MONOMETHYLAMINE
METHYLTRANSFERASE
(Methanosarcina
barkeri) 		5 / 12 GLY A 387
GLY A 129
GLY A 366
THR A 131
ILE A 156
 None
None
None
XPL  A 202 ( 4.5A)
None
 0.72A 5ehgC-1l2qA:
undetectable		 5ehgC-1l2qA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EHI_A_SAMA4001_0
(NS5
METHYLTRANSFERASE
DENGUE VIRUS)		 1l2q MONOMETHYLAMINE
METHYLTRANSFERASE
(Methanosarcina
barkeri) 		5 / 12 GLY A 387
GLY A 129
GLY A 366
THR A 131
ILE A 156
 None
None
None
XPL  A 202 ( 4.5A)
None
 0.77A 5ehiA-1l2qA:
undetectable		 5ehiA-1l2qA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EHI_C_SAMC4000_0
(NS5
METHYLTRANSFERASE
DENGUE VIRUS)		 1l2q MONOMETHYLAMINE
METHYLTRANSFERASE
(Methanosarcina
barkeri) 		5 / 12 GLY A 387
GLY A 129
GLY A 366
THR A 131
ILE A 156
 None
None
None
XPL  A 202 ( 4.5A)
None
 0.75A 5ehiC-1l2qA:
undetectable		 5ehiC-1l2qA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EIF_A_SAMA301_0
(GENOME POLYPROTEIN)		 1l2q MONOMETHYLAMINE
METHYLTRANSFERASE
(Methanosarcina
barkeri) 		5 / 12 GLY A 387
GLY A 129
GLY A 366
THR A 131
ILE A 156
 None
None
None
XPL  A 202 ( 4.5A)
None
 0.78A 5eifA-1l2qA:
undetectable		 5eifA-1l2qA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EIF_C_SAMC4000_0
(GENOME POLYPROTEIN)		 1l2q MONOMETHYLAMINE
METHYLTRANSFERASE
(Methanosarcina
barkeri) 		5 / 12 GLY A 387
GLY A 129
GLY A 366
THR A 131
ILE A 156
 None
None
None
XPL  A 202 ( 4.5A)
None
 0.75A 5eifC-1l2qA:
undetectable		 5eifC-1l2qA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EIW_A_SAMA301_0
(NS5
METHYLTRANSFERASE)		 1l2q MONOMETHYLAMINE
METHYLTRANSFERASE
(Methanosarcina
barkeri) 		5 / 12 GLY A 387
GLY A 129
GLY A 366
THR A 131
ILE A 156
 None
None
None
XPL  A 202 ( 4.5A)
None
 0.78A 5eiwA-1l2qA:
undetectable		 5eiwA-1l2qA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EIW_C_SAMC4000_0
(NS5
METHYLTRANSFERASE)		 1l2q MONOMETHYLAMINE
METHYLTRANSFERASE
(Methanosarcina
barkeri) 		5 / 12 GLY A 387
GLY A 129
GLY A 366
THR A 131
ILE A 156
 None
None
None
XPL  A 202 ( 4.5A)
None
 0.75A 5eiwC-1l2qA:
undetectable		 5eiwC-1l2qA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EKX_A_SAMA301_0
(NS5
METHYLTRANSFERASE)		 1l2q MONOMETHYLAMINE
METHYLTRANSFERASE
(Methanosarcina
barkeri) 		5 / 12 GLY A 387
GLY A 129
GLY A 366
THR A 131
ILE A 156
 None
None
None
XPL  A 202 ( 4.5A)
None
 0.75A 5ekxA-1l2qA:
undetectable		 5ekxA-1l2qA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EKX_B_SAMB4000_0
(NS5
METHYLTRANSFERASE)		 1l2q MONOMETHYLAMINE
METHYLTRANSFERASE
(Methanosarcina
barkeri) 		5 / 12 GLY A 387
GLY A 129
GLY A 366
THR A 131
ILE A 156
 None
None
None
XPL  A 202 ( 4.5A)
None
 0.74A 5ekxB-1l2qA:
undetectable		 5ekxB-1l2qA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKM_A_SAMA311_0
(NS5 METHYL
TRANSFERASE)		 1l2q MONOMETHYLAMINE
METHYLTRANSFERASE
(Methanosarcina
barkeri) 		5 / 12 GLY A 387
GLY A 129
GLY A 366
THR A 131
ILE A 156
 None
None
None
XPL  A 202 ( 4.5A)
None
 0.75A 5ikmA-1l2qA:
undetectable		 5ikmA-1l2qA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQR_A_SAMA301_0
(METHYLTRANSFERASE)		 1l2q MONOMETHYLAMINE
METHYLTRANSFERASE
(Methanosarcina
barkeri) 		5 / 12 GLY A 387
GLY A 129
GLY A 366
THR A 131
ILE A 156
 None
None
None
XPL  A 202 ( 4.5A)
None
 0.73A 5kqrA-1l2qA:
undetectable		 5kqrA-1l2qA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQS_A_SAMA307_0
(GENOME POLYPROTEIN)		 1l2q MONOMETHYLAMINE
METHYLTRANSFERASE
(Methanosarcina
barkeri) 		5 / 12 GLY A 387
GLY A 129
GLY A 366
THR A 131
ILE A 156
 None
None
None
XPL  A 202 ( 4.5A)
None
 0.73A 5kqsA-1l2qA:
undetectable		 5kqsA-1l2qA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_B_BO2B305_1
(PROTEASOME SUBUNIT
BETA TYPE-6)		 1l2q MONOMETHYLAMINE
METHYLTRANSFERASE
(Methanosarcina
barkeri) 		5 / 12 SER A 365
GLY A 366
ALA A 368
THR A 131
SER A 353
 XPL  A 202 ( 2.7A)
None
None
XPL  A 202 ( 4.5A)
None
 1.40A 5lf3b-1l2qA:
undetectable		 5lf3b-1l2qA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_B_BO2B305_1
(PROTEASOME SUBUNIT
BETA TYPE-6)		 1l2q MONOMETHYLAMINE
METHYLTRANSFERASE
(Methanosarcina
barkeri) 		5 / 12 THR A 378
SER A 365
GLY A 366
ALA A 383
SER A 133
 None
XPL  A 202 ( 2.7A)
None
None
None
 1.06A 5lf3b-1l2qA:
undetectable		 5lf3b-1l2qA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_N_BO2N304_1
(PROTEASOME SUBUNIT
BETA TYPE-6)		 1l2q MONOMETHYLAMINE
METHYLTRANSFERASE
(Methanosarcina
barkeri) 		5 / 12 THR A 378
SER A 365
GLY A 366
ALA A 383
SER A 133
 None
XPL  A 202 ( 2.7A)
None
None
None
 1.06A 5lf3N-1l2qA:
undetectable		 5lf3N-1l2qA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5B_A_SAMA1001_0
(NS5
METHYLTRANSFERASE)		 1l2q MONOMETHYLAMINE
METHYLTRANSFERASE
(Methanosarcina
barkeri) 		5 / 12 GLY A 387
GLY A 129
GLY A 366
THR A 131
ILE A 156
 None
None
None
XPL  A 202 ( 4.5A)
None
 0.72A 5m5bA-1l2qA:
undetectable		 5m5bA-1l2qA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NJV_A_SAMA301_0
(NS5)		 1l2q MONOMETHYLAMINE
METHYLTRANSFERASE
(Methanosarcina
barkeri) 		5 / 12 GLY A 387
GLY A 129
GLY A 366
THR A 131
ILE A 156
 None
None
None
XPL  A 202 ( 4.5A)
None
 0.74A 5njvA-1l2qA:
undetectable		 5njvA-1l2qA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NJV_B_SAMB301_0
(NS5)		 1l2q MONOMETHYLAMINE
METHYLTRANSFERASE
(Methanosarcina
barkeri) 		5 / 12 GLY A 387
GLY A 129
GLY A 366
THR A 131
ILE A 156
 None
None
None
XPL  A 202 ( 4.5A)
None
 0.74A 5njvB-1l2qA:
undetectable		 5njvB-1l2qA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NJV_C_SAMC301_0
(NS5)		 1l2q MONOMETHYLAMINE
METHYLTRANSFERASE
(Methanosarcina
barkeri) 		5 / 12 GLY A 387
GLY A 129
GLY A 366
THR A 131
ILE A 156
 None
None
None
XPL  A 202 ( 4.5A)
None
 0.81A 5njvC-1l2qA:
undetectable		 5njvC-1l2qA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NJV_D_SAMD301_0
(NS5)		 1l2q MONOMETHYLAMINE
METHYLTRANSFERASE
(Methanosarcina
barkeri) 		5 / 12 GLY A 387
GLY A 129
GLY A 366
THR A 131
ILE A 156
 None
None
None
XPL  A 202 ( 4.5A)
None
 0.74A 5njvD-1l2qA:
0.0		 5njvD-1l2qA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_B_SAMB601_0
(NS5
METHYLTRANSFERASE)		 1l2q MONOMETHYLAMINE
METHYLTRANSFERASE
(Methanosarcina
barkeri) 		5 / 12 GLY A 387
GLY A 129
GLY A 366
THR A 131
ILE A 156
 None
None
None
XPL  A 202 ( 4.5A)
None
 0.77A 5wz1B-1l2qA:
0.0		 5wz1B-1l2qA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ2_A_SAMA601_0
(NS5 MTASE)		 1l2q MONOMETHYLAMINE
METHYLTRANSFERASE
(Methanosarcina
barkeri) 		5 / 12 GLY A 387
GLY A 129
GLY A 366
THR A 131
ILE A 156
 None
None
None
XPL  A 202 ( 4.5A)
None
 0.76A 5wz2A-1l2qA:
undetectable		 5wz2A-1l2qA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ2_B_SAMB601_0
(NS5 MTASE)		 1l2q MONOMETHYLAMINE
METHYLTRANSFERASE
(Methanosarcina
barkeri) 		5 / 12 GLY A 387
GLY A 129
GLY A 366
THR A 131
ILE A 156
 None
None
None
XPL  A 202 ( 4.5A)
None
 0.79A 5wz2B-1l2qA:
undetectable		 5wz2B-1l2qA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ2_C_SAMC601_0
(NS5 MTASE)		 1l2q MONOMETHYLAMINE
METHYLTRANSFERASE
(Methanosarcina
barkeri) 		5 / 12 GLY A 387
GLY A 129
GLY A 366
THR A 131
ILE A 156
 None
None
None
XPL  A 202 ( 4.5A)
None
 0.77A 5wz2C-1l2qA:
undetectable		 5wz2C-1l2qA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_B_ACRB1471_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 1l2q MONOMETHYLAMINE
METHYLTRANSFERASE
(Methanosarcina
barkeri) 		5 / 12 ASP A 356
GLY A 331
LEU A 295
TYR A 334
THR A 131
 None
None
XPL  A 202 ( 4.8A)
None
XPL  A 202 ( 4.5A)
 1.42A 5x7pB-1l2qA:
0.3		 5x7pB-1l2qA:
18.02