SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'XLF'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

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	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4AGA_A_ACTA1131_0 (LYSOZYME C)	3ctp	PERIPLASMIC BINDING PROTEIN/LACI TRANSCRIPTIONAL REGULATOR (Alkaliphilus metalliredigens)	3 / 3	ASN A 239 ASP A 213 ASN A 72	XLF A 401 (-3.8A) XLF A 401 ( 4.3A) XLF A 401 (-3.0A)	0.75A	4agaA-3ctpA: undetectable	4agaA-3ctpA: 17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4I13_A_FOLA201_1 (DIHYDROFOLATE REDUCTASE)	3ctp	PERIPLASMIC BINDING PROTEIN/LACI TRANSCRIPTIONAL REGULATOR (Alkaliphilus metalliredigens)	3 / 3	ASP A 240 ARG A 124 THR A 281	None XLF A 401 (-4.0A) None	0.80A	4i13A-3ctpA: undetectable	4i13A-3ctpA: 19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4P3R_A_FOLA201_1 (DIHYDROFOLATE REDUCTASE)	3ctp	PERIPLASMIC BINDING PROTEIN/LACI TRANSCRIPTIONAL REGULATOR (Alkaliphilus metalliredigens)	3 / 3	ASP A 240 ARG A 124 THR A 281	None XLF A 401 (-4.0A) None	0.80A	4p3rA-3ctpA: undetectable	4p3rA-3ctpA: 19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4XQE_A_AG2A506_1 (HOMOSPERMIDINE SYNTHASE)	3ctp	PERIPLASMIC BINDING PROTEIN/LACI TRANSCRIPTIONAL REGULATOR (Alkaliphilus metalliredigens)	4 / 6	ARG A 124 ARG A 190 ASP A 213 ASP A 267	XLF A 401 (-4.0A) XLF A 401 (-2.8A) XLF A 401 ( 4.3A) XLF A 401 (-2.8A)	1.08A	4xqeA-3ctpA: 3.4	4xqeA-3ctpA: 20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4XQE_B_AG2B505_1 (HOMOSPERMIDINE SYNTHASE)	3ctp	PERIPLASMIC BINDING PROTEIN/LACI TRANSCRIPTIONAL REGULATOR (Alkaliphilus metalliredigens)	4 / 6	ARG A 124 ARG A 190 ASP A 213 ASP A 267	XLF A 401 (-4.0A) XLF A 401 (-2.8A) XLF A 401 ( 4.3A) XLF A 401 (-2.8A)	1.09A	4xqeB-3ctpA: 2.2	4xqeB-3ctpA: 20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4XQG_A_AG2A505_1 (HOMOSPERMIDINE SYNTHASE)	3ctp	PERIPLASMIC BINDING PROTEIN/LACI TRANSCRIPTIONAL REGULATOR (Alkaliphilus metalliredigens)	4 / 8	ARG A 124 ARG A 190 ASP A 213 ASP A 267	XLF A 401 (-4.0A) XLF A 401 (-2.8A) XLF A 401 ( 4.3A) XLF A 401 (-2.8A)	1.10A	4xqgA-3ctpA: undetectable	4xqgA-3ctpA: 20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4XQG_B_AG2B505_1 (HOMOSPERMIDINE SYNTHASE)	3ctp	PERIPLASMIC BINDING PROTEIN/LACI TRANSCRIPTIONAL REGULATOR (Alkaliphilus metalliredigens)	4 / 8	ARG A 124 ARG A 190 ASP A 213 ASP A 267	XLF A 401 (-4.0A) XLF A 401 (-2.8A) XLF A 401 ( 4.3A) XLF A 401 (-2.8A)	1.11A	4xqgB-3ctpA: 3.0	4xqgB-3ctpA: 20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BQ4_A_ADNA401_1 (THERMOSPERMINE SYNTHASE ACAULIS PROTEIN)	3ctp	PERIPLASMIC BINDING PROTEIN/LACI TRANSCRIPTIONAL REGULATOR (Alkaliphilus metalliredigens)	6 / 12	ASP A 155 ILE A 312 VAL A 315 ASP A 310 LEU A 189 ALA A 186	None None None None None XLF A 401 ( 3.9A)	1.43A	6bq4A-3ctpA: 4.1	6bq4A-3ctpA: 14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BQ4_B_ADNB401_1 (THERMOSPERMINE SYNTHASE ACAULIS PROTEIN)	3ctp	PERIPLASMIC BINDING PROTEIN/LACI TRANSCRIPTIONAL REGULATOR (Alkaliphilus metalliredigens)	6 / 12	ASP A 155 ILE A 312 VAL A 315 ASP A 310 LEU A 189 ALA A 186	None None None None None XLF A 401 ( 3.9A)	1.43A	6bq4B-3ctpA: 3.1	6bq4B-3ctpA: 14.42

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["4AGA_A_ACTA1131_0","LYSOZYME C","3ctp","PERIPLASMIC BINDING PROTEIN\/LACI TRANSCRIPTIONAL REGULATOR","Alkaliphilus metalliredigens",3,"ASN A 239;ASP A 213;ASN A  72","XLF A 401 (-3.8A);XLF A 401 ( 4.3A);XLF A 401 (-3.0A)","0.75A","4agaA-3ctpA:undetectable",null],["4I13_A_FOLA201_1","DIHYDROFOLATE REDUCTASE","3ctp","PERIPLASMIC BINDING PROTEIN\/LACI TRANSCRIPTIONAL REGULATOR","Alkaliphilus metalliredigens",3,"ASP A 240;ARG A 124;THR A 281","None;XLF A 401 (-4.0A);None","0.80A","4i13A-3ctpA:undetectable","4agaA-3ctpA:17.52"],["4P3R_A_FOLA201_1","DIHYDROFOLATE REDUCTASE","3ctp","PERIPLASMIC BINDING PROTEIN\/LACI TRANSCRIPTIONAL REGULATOR","Alkaliphilus metalliredigens",3,"ASP A 240;ARG A 124;THR A 281","None;XLF A 401 (-4.0A);None","0.80A","4p3rA-3ctpA:undetectable","4i13A-3ctpA:19.50"],["4XQE_A_AG2A506_1","HOMOSPERMIDINE SYNTHASE","3ctp","PERIPLASMIC BINDING PROTEIN\/LACI TRANSCRIPTIONAL REGULATOR","Alkaliphilus metalliredigens",4,"ARG A 124;ARG A 190;ASP A 213;ASP A 267","XLF A 401 (-4.0A);XLF A 401 (-2.8A);XLF A 401 ( 4.3A);XLF A 401 (-2.8A)","1.08A","4xqeA-3ctpA:3.4","4p3rA-3ctpA:19.50"],["4XQE_B_AG2B505_1","HOMOSPERMIDINE SYNTHASE","3ctp","PERIPLASMIC BINDING PROTEIN\/LACI TRANSCRIPTIONAL REGULATOR","Alkaliphilus metalliredigens",4,"ARG A 124;ARG A 190;ASP A 213;ASP A 267","XLF A 401 (-4.0A);XLF A 401 (-2.8A);XLF A 401 ( 4.3A);XLF A 401 (-2.8A)","1.09A","4xqeB-3ctpA:2.2","4xqeA-3ctpA:20.88"],["4XQG_A_AG2A505_1","HOMOSPERMIDINE SYNTHASE","3ctp","PERIPLASMIC BINDING PROTEIN\/LACI TRANSCRIPTIONAL REGULATOR","Alkaliphilus metalliredigens",4,"ARG A 124;ARG A 190;ASP A 213;ASP A 267","XLF A 401 (-4.0A);XLF A 401 (-2.8A);XLF A 401 ( 4.3A);XLF A 401 (-2.8A)","1.10A","4xqgA-3ctpA:undetectable","4xqeB-3ctpA:20.88"],["4XQG_B_AG2B505_1","HOMOSPERMIDINE SYNTHASE","3ctp","PERIPLASMIC BINDING PROTEIN\/LACI TRANSCRIPTIONAL REGULATOR","Alkaliphilus metalliredigens",4,"ARG A 124;ARG A 190;ASP A 213;ASP A 267","XLF A 401 (-4.0A);XLF A 401 (-2.8A);XLF A 401 ( 4.3A);XLF A 401 (-2.8A)","1.11A","4xqgB-3ctpA:3.0","4xqgA-3ctpA:20.88"],["6BQ4_A_ADNA401_1","THERMOSPERMINE SYNTHASE ACAULIS PROTEIN","3ctp","PERIPLASMIC BINDING PROTEIN\/LACI TRANSCRIPTIONAL REGULATOR","Alkaliphilus metalliredigens",6,"ASP A 155;ILE A 312;VAL A 315;ASP A 310;LEU A 189;ALA A 186","None;None;None;None;None;XLF A 401 ( 3.9A)","1.43A","6bq4A-3ctpA:4.1","4xqgB-3ctpA:20.88"],["6BQ4_B_ADNB401_1","THERMOSPERMINE SYNTHASE ACAULIS PROTEIN","3ctp","PERIPLASMIC BINDING PROTEIN\/LACI TRANSCRIPTIONAL REGULATOR","Alkaliphilus metalliredigens",6,"ASP A 155;ILE A 312;VAL A 315;ASP A 310;LEU A 189;ALA A 186","None;None;None;None;None;XLF A 401 ( 3.9A)","1.43A","6bq4B-3ctpA:3.1","6bq4A-3ctpA:14.42"]]