SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'XK9'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M17_A_AQ4A999_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2xk9 CHECKPOINT KINASE 2
(Homo
sapiens) 		8 / 12 LEU A 226
ALA A 247
LYS A 249
LEU A 303
MET A 304
GLY A 307
LEU A 354
THR A 367
 XK9  A1511 (-3.8A)
XK9  A1511 ( 4.1A)
XK9  A1511 (-4.2A)
XK9  A1511 (-4.1A)
None
XK9  A1511 ( 3.7A)
XK9  A1511 (-4.6A)
XK9  A1511 (-3.7A)
 0.85A 1m17A-2xk9A:
21.3		 1m17A-2xk9A:
27.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_B_VIBB503_1
(YKOF)		 2xk9 CHECKPOINT KINASE 2
(Homo
sapiens) 		4 / 7 ILE A 251
ILE A 299
LYS A 249
THR A 367
 XK9  A1511 (-4.9A)
XK9  A1511 ( 4.9A)
XK9  A1511 (-4.2A)
XK9  A1511 (-3.7A)
 0.95A 1sbrB-2xk9A:
undetectable		 1sbrB-2xk9A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2xk9 CHECKPOINT KINASE 2
(Homo
sapiens) 		5 / 9 LEU A 226
VAL A 234
LYS A 249
LEU A 303
MET A 304
 XK9  A1511 (-3.8A)
XK9  A1511 (-4.8A)
XK9  A1511 (-4.2A)
XK9  A1511 (-4.1A)
None
 0.73A 1xkkA-2xk9A:
20.9		 1xkkA-2xk9A:
25.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ITO_A_IREA2020_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2xk9 CHECKPOINT KINASE 2
(Homo
sapiens) 		7 / 12 LEU A 226
ALA A 247
LYS A 249
GLY A 307
ASP A 311
LEU A 354
THR A 367
 XK9  A1511 (-3.8A)
XK9  A1511 ( 4.1A)
XK9  A1511 (-4.2A)
XK9  A1511 ( 3.7A)
None
XK9  A1511 (-4.6A)
XK9  A1511 (-3.7A)
 0.81A 2itoA-2xk9A:
15.3		 2itoA-2xk9A:
27.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ITZ_A_IREA2021_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2xk9 CHECKPOINT KINASE 2
(Homo
sapiens) 		8 / 12 LEU A 226
VAL A 234
ALA A 247
LYS A 249
GLY A 307
ASP A 311
LEU A 354
THR A 367
 XK9  A1511 (-3.8A)
XK9  A1511 (-4.8A)
XK9  A1511 ( 4.1A)
XK9  A1511 (-4.2A)
XK9  A1511 ( 3.7A)
None
XK9  A1511 (-4.6A)
XK9  A1511 (-3.7A)
 0.83A 2itzA-2xk9A:
21.5		 2itzA-2xk9A:
27.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XP2_A_VGHA9000_1
(TYROSINE-PROTEIN
KINASE RECEPTOR)		 2xk9 CHECKPOINT KINASE 2
(Homo
sapiens) 		8 / 9 LEU A 226
VAL A 234
ALA A 247
LEU A 301
MET A 304
GLY A 307
LEU A 354
ASP A 368
 XK9  A1511 (-3.8A)
XK9  A1511 (-4.8A)
XK9  A1511 ( 4.1A)
XK9  A1511 (-4.6A)
None
XK9  A1511 ( 3.7A)
XK9  A1511 (-4.6A)
XK9  A1511 (-3.6A)
 0.78A 2xp2A-2xk9A:
21.7		 2xp2A-2xk9A:
25.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2Y7J_A_B49A1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 2xk9 CHECKPOINT KINASE 2
(Homo
sapiens) 		8 / 12 VAL A 234
ALA A 247
ILE A 286
LEU A 303
MET A 304
GLY A 307
GLU A 308
LEU A 354
 XK9  A1511 (-4.8A)
XK9  A1511 ( 4.1A)
None
XK9  A1511 (-4.1A)
None
XK9  A1511 ( 3.7A)
None
XK9  A1511 (-4.6A)
 0.53A 2y7jA-2xk9A:
29.1		 2y7jA-2xk9A:
31.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2Y7J_B_B49B1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 2xk9 CHECKPOINT KINASE 2
(Homo
sapiens) 		7 / 10 VAL A 234
ALA A 247
ILE A 286
LEU A 303
MET A 304
GLY A 307
LEU A 354
 XK9  A1511 (-4.8A)
XK9  A1511 ( 4.1A)
None
XK9  A1511 (-4.1A)
None
XK9  A1511 ( 3.7A)
XK9  A1511 (-4.6A)
 0.37A 2y7jB-2xk9A:
29.5		 2y7jB-2xk9A:
31.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2Y7J_C_B49C1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 2xk9 CHECKPOINT KINASE 2
(Homo
sapiens) 		8 / 10 VAL A 234
ALA A 247
ILE A 286
LEU A 303
MET A 304
GLY A 307
ASP A 311
LEU A 354
 XK9  A1511 (-4.8A)
XK9  A1511 ( 4.1A)
None
XK9  A1511 (-4.1A)
None
XK9  A1511 ( 3.7A)
None
XK9  A1511 (-4.6A)
 0.40A 2y7jC-2xk9A:
29.2		 2y7jC-2xk9A:
31.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2Y7J_D_B49D1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 2xk9 CHECKPOINT KINASE 2
(Homo
sapiens) 		8 / 10 VAL A 234
ALA A 247
ILE A 286
LEU A 303
MET A 304
GLY A 307
ASP A 311
LEU A 354
 XK9  A1511 (-4.8A)
XK9  A1511 ( 4.1A)
None
XK9  A1511 (-4.1A)
None
XK9  A1511 ( 3.7A)
None
XK9  A1511 (-4.6A)
 0.42A 2y7jD-2xk9A:
29.5		 2y7jD-2xk9A:
31.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOX_A_EMHA901_1
(ALK TYROSINE KINASE
RECEPTOR)		 2xk9 CHECKPOINT KINASE 2
(Homo
sapiens) 		7 / 10 LEU A 226
ALA A 247
LEU A 301
LEU A 303
MET A 304
GLY A 307
LEU A 354
 XK9  A1511 (-3.8A)
XK9  A1511 ( 4.1A)
XK9  A1511 (-4.6A)
XK9  A1511 (-4.1A)
None
XK9  A1511 ( 3.7A)
XK9  A1511 (-4.6A)
 0.60A 3aoxA-2xk9A:
12.8		 3aoxA-2xk9A:
25.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_B_FMMB91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		 2xk9 CHECKPOINT KINASE 2
(Homo
sapiens) 		6 / 12 VAL A 234
ALA A 247
LEU A 303
GLY A 307
LEU A 354
THR A 367
 XK9  A1511 (-4.8A)
XK9  A1511 ( 4.1A)
XK9  A1511 (-4.1A)
XK9  A1511 ( 3.7A)
XK9  A1511 (-4.6A)
XK9  A1511 (-3.7A)
 0.58A 3bbtB-2xk9A:
20.6		 3bbtB-2xk9A:
26.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DVAC59_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 2xk9 CHECKPOINT KINASE 2
(Homo
sapiens) 		3 / 3 GLY A 232
GLY A 227
GLY A 229
 None
XK9  A1511 ( 4.5A)
None
 0.31A 3bogC-2xk9A:
undetectable		 3bogC-2xk9A:
12.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXZ_A_0LIA1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 2xk9 CHECKPOINT KINASE 2
(Homo
sapiens) 		5 / 9 LEU A 226
ILE A 299
MET A 304
LEU A 354
VAL A 353
 XK9  A1511 (-3.8A)
XK9  A1511 ( 4.9A)
None
XK9  A1511 (-4.6A)
None
 1.43A 3oxzA-2xk9A:
20.6		 3oxzA-2xk9A:
27.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXZ_A_0LIA1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 2xk9 CHECKPOINT KINASE 2
(Homo
sapiens) 		5 / 9 LEU A 226
LYS A 249
ILE A 299
MET A 304
VAL A 353
 XK9  A1511 (-3.8A)
XK9  A1511 (-4.2A)
XK9  A1511 ( 4.9A)
None
None
 1.16A 3oxzA-2xk9A:
20.6		 3oxzA-2xk9A:
27.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UE4_A_DB8A601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2xk9 CHECKPOINT KINASE 2
(Homo
sapiens) 		7 / 12 LEU A 226
ALA A 247
GLU A 273
ILE A 299
MET A 304
GLY A 307
LEU A 354
 XK9  A1511 (-3.8A)
XK9  A1511 ( 4.1A)
XK9  A1511 (-2.8A)
XK9  A1511 ( 4.9A)
None
XK9  A1511 ( 3.7A)
XK9  A1511 (-4.6A)
 1.07A 3ue4A-2xk9A:
21.7		 3ue4A-2xk9A:
27.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UE4_A_DB8A601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2xk9 CHECKPOINT KINASE 2
(Homo
sapiens) 		7 / 12 LEU A 226
ALA A 247
LYS A 249
ILE A 299
MET A 304
GLY A 307
LEU A 354
 XK9  A1511 (-3.8A)
XK9  A1511 ( 4.1A)
XK9  A1511 (-4.2A)
XK9  A1511 ( 4.9A)
None
XK9  A1511 ( 3.7A)
XK9  A1511 (-4.6A)
 0.84A 3ue4A-2xk9A:
21.7		 3ue4A-2xk9A:
27.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UG2_A_IREA1_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2xk9 CHECKPOINT KINASE 2
(Homo
sapiens) 		8 / 12 LEU A 226
VAL A 234
ALA A 247
LEU A 303
MET A 304
GLY A 307
ASP A 311
LEU A 354
 XK9  A1511 (-3.8A)
XK9  A1511 (-4.8A)
XK9  A1511 ( 4.1A)
XK9  A1511 (-4.1A)
None
XK9  A1511 ( 3.7A)
None
XK9  A1511 (-4.6A)
 0.75A 3ug2A-2xk9A:
20.9		 3ug2A-2xk9A:
27.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UG2_A_IREA1_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2xk9 CHECKPOINT KINASE 2
(Homo
sapiens) 		8 / 12 LEU A 226
VAL A 234
ALA A 247
LYS A 249
LEU A 303
MET A 304
GLY A 307
LEU A 354
 XK9  A1511 (-3.8A)
XK9  A1511 (-4.8A)
XK9  A1511 ( 4.1A)
XK9  A1511 (-4.2A)
XK9  A1511 (-4.1A)
None
XK9  A1511 ( 3.7A)
XK9  A1511 (-4.6A)
 0.94A 3ug2A-2xk9A:
20.9		 3ug2A-2xk9A:
27.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZBF_A_VGHA3000_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS)		 2xk9 CHECKPOINT KINASE 2
(Homo
sapiens) 		6 / 12 ALA A 247
LEU A 301
LEU A 303
MET A 304
GLY A 307
LEU A 354
 XK9  A1511 ( 4.1A)
XK9  A1511 (-4.6A)
XK9  A1511 (-4.1A)
None
XK9  A1511 ( 3.7A)
XK9  A1511 (-4.6A)
 0.57A 3zbfA-2xk9A:
22.8		 3zbfA-2xk9A:
26.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZBF_A_VGHA3000_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS)		 2xk9 CHECKPOINT KINASE 2
(Homo
sapiens) 		6 / 12 LEU A 226
ALA A 247
LEU A 301
LEU A 303
GLY A 307
LEU A 354
 XK9  A1511 (-3.8A)
XK9  A1511 ( 4.1A)
XK9  A1511 (-4.6A)
XK9  A1511 (-4.1A)
XK9  A1511 ( 3.7A)
XK9  A1511 (-4.6A)
 0.72A 3zbfA-2xk9A:
22.8		 3zbfA-2xk9A:
26.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ANQ_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 2xk9 CHECKPOINT KINASE 2
(Homo
sapiens) 		8 / 9 LEU A 226
VAL A 234
ALA A 247
LEU A 301
MET A 304
GLY A 307
LEU A 354
ASP A 368
 XK9  A1511 (-3.8A)
XK9  A1511 (-4.8A)
XK9  A1511 ( 4.1A)
XK9  A1511 (-4.6A)
None
XK9  A1511 ( 3.7A)
XK9  A1511 (-4.6A)
XK9  A1511 (-3.6A)
 0.80A 4anqA-2xk9A:
21.4		 4anqA-2xk9A:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ANS_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 2xk9 CHECKPOINT KINASE 2
(Homo
sapiens) 		7 / 9 LEU A 226
VAL A 234
ALA A 247
MET A 304
GLY A 307
LEU A 354
ASP A 368
 XK9  A1511 (-3.8A)
XK9  A1511 (-4.8A)
XK9  A1511 ( 4.1A)
None
XK9  A1511 ( 3.7A)
XK9  A1511 (-4.6A)
XK9  A1511 (-3.6A)
 0.76A 4ansA-2xk9A:
21.3		 4ansA-2xk9A:
24.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_A_0LIA1000_2
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 2xk9 CHECKPOINT KINASE 2
(Homo
sapiens) 		4 / 5 VAL A 234
ILE A 285
MET A 304
ILE A 366
 XK9  A1511 (-4.8A)
None
None
None
 0.65A 4c8bA-2xk9A:
21.9		 4c8bA-2xk9A:
26.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CKI_A_ADNA2022_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET)		 2xk9 CHECKPOINT KINASE 2
(Homo
sapiens) 		7 / 11 LEU A 226
GLY A 227
GLY A 229
VAL A 234
ALA A 247
GLY A 307
LEU A 354
 XK9  A1511 (-3.8A)
XK9  A1511 ( 4.5A)
None
XK9  A1511 (-4.8A)
XK9  A1511 ( 4.1A)
XK9  A1511 ( 3.7A)
XK9  A1511 (-4.6A)
 0.83A 4ckiA-2xk9A:
21.9		 4ckiA-2xk9A:
27.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HJO_A_AQ4A1001_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2xk9 CHECKPOINT KINASE 2
(Homo
sapiens) 		8 / 12 LEU A 226
VAL A 234
ALA A 247
LYS A 249
MET A 304
GLY A 307
LEU A 354
THR A 367
 XK9  A1511 (-3.8A)
XK9  A1511 (-4.8A)
XK9  A1511 ( 4.1A)
XK9  A1511 (-4.2A)
None
XK9  A1511 ( 3.7A)
XK9  A1511 (-4.6A)
XK9  A1511 (-3.7A)
 0.81A 4hjoA-2xk9A:
21.3		 4hjoA-2xk9A:
26.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I22_A_IREA9001_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2xk9 CHECKPOINT KINASE 2
(Homo
sapiens) 		9 / 12 LEU A 226
GLY A 227
VAL A 234
ALA A 247
LYS A 249
GLY A 307
ASP A 311
LEU A 354
THR A 367
 XK9  A1511 (-3.8A)
XK9  A1511 ( 4.5A)
XK9  A1511 (-4.8A)
XK9  A1511 ( 4.1A)
XK9  A1511 (-4.2A)
XK9  A1511 ( 3.7A)
None
XK9  A1511 (-4.6A)
XK9  A1511 (-3.7A)
 0.88A 4i22A-2xk9A:
20.6		 4i22A-2xk9A:
27.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9I_A_8PRA601_1
(RHODOPSIN KINASE)		 2xk9 CHECKPOINT KINASE 2
(Homo
sapiens) 		4 / 7 VAL A 234
ALA A 247
MET A 304
LEU A 354
 XK9  A1511 (-4.8A)
XK9  A1511 ( 4.1A)
None
XK9  A1511 (-4.6A)
 0.51A 4l9iA-2xk9A:
22.7		 4l9iA-2xk9A:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9I_B_8PRB601_1
(RHODOPSIN KINASE)		 2xk9 CHECKPOINT KINASE 2
(Homo
sapiens) 		5 / 8 GLY A 229
VAL A 234
ALA A 247
MET A 304
LEU A 354
 None
XK9  A1511 (-4.8A)
XK9  A1511 ( 4.1A)
None
XK9  A1511 (-4.6A)
 0.50A 4l9iB-2xk9A:
22.8		 4l9iB-2xk9A:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9I_B_8PRB601_1
(RHODOPSIN KINASE)		 2xk9 CHECKPOINT KINASE 2
(Homo
sapiens) 		5 / 8 GLY A 232
VAL A 234
ALA A 247
MET A 304
LEU A 354
 None
XK9  A1511 (-4.8A)
XK9  A1511 ( 4.1A)
None
XK9  A1511 (-4.6A)
 1.06A 4l9iB-2xk9A:
22.8		 4l9iB-2xk9A:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9I_B_8PRB601_1
(RHODOPSIN KINASE)		 2xk9 CHECKPOINT KINASE 2
(Homo
sapiens) 		5 / 8 VAL A 234
ALA A 247
LYS A 249
MET A 304
LEU A 354
 XK9  A1511 (-4.8A)
XK9  A1511 ( 4.1A)
XK9  A1511 (-4.2A)
None
XK9  A1511 (-4.6A)
 1.10A 4l9iB-2xk9A:
22.8		 4l9iB-2xk9A:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MKC_A_4MKA1503_1
(ALK TYROSINE KINASE
RECEPTOR)		 2xk9 CHECKPOINT KINASE 2
(Homo
sapiens) 		7 / 12 LEU A 226
VAL A 234
ALA A 247
LYS A 249
LEU A 303
GLY A 307
LEU A 354
 XK9  A1511 (-3.8A)
XK9  A1511 (-4.8A)
XK9  A1511 ( 4.1A)
XK9  A1511 (-4.2A)
XK9  A1511 (-4.1A)
XK9  A1511 ( 3.7A)
XK9  A1511 (-4.6A)
 1.13A 4mkcA-2xk9A:
21.4		 4mkcA-2xk9A:
25.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXX_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2xk9 CHECKPOINT KINASE 2
(Homo
sapiens) 		7 / 12 LEU A 226
VAL A 234
ALA A 247
MET A 304
GLY A 307
LEU A 354
THR A 367
 XK9  A1511 (-3.8A)
XK9  A1511 (-4.8A)
XK9  A1511 ( 4.1A)
None
XK9  A1511 ( 3.7A)
XK9  A1511 (-4.6A)
XK9  A1511 (-3.7A)
 0.82A 4mxxB-2xk9A:
20.7		 4mxxB-2xk9A:
28.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U5J_A_RXTA601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2xk9 CHECKPOINT KINASE 2
(Homo
sapiens) 		8 / 11 LEU A 226
GLY A 229
VAL A 234
ALA A 247
MET A 304
GLY A 307
ASN A 352
LEU A 354
 XK9  A1511 (-3.8A)
None
XK9  A1511 (-4.8A)
XK9  A1511 ( 4.1A)
None
XK9  A1511 ( 3.7A)
None
XK9  A1511 (-4.6A)
 0.70A 4u5jA-2xk9A:
22.8		 4u5jA-2xk9A:
28.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U5J_B_RXTB601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2xk9 CHECKPOINT KINASE 2
(Homo
sapiens) 		7 / 9 LEU A 226
VAL A 234
ALA A 247
MET A 304
GLY A 307
LEU A 354
ASP A 368
 XK9  A1511 (-3.8A)
XK9  A1511 (-4.8A)
XK9  A1511 ( 4.1A)
None
XK9  A1511 ( 3.7A)
XK9  A1511 (-4.6A)
XK9  A1511 (-3.6A)
 0.79A 4u5jB-2xk9A:
22.5		 4u5jB-2xk9A:
28.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UXQ_A_0LIA1752_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 2xk9 CHECKPOINT KINASE 2
(Homo
sapiens) 		4 / 7 VAL A 234
LYS A 249
ILE A 286
ILE A 366
 XK9  A1511 (-4.8A)
XK9  A1511 (-4.2A)
None
None
 0.82A 4uxqA-2xk9A:
19.7		 4uxqA-2xk9A:
25.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WA9_A_AXIA9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2xk9 CHECKPOINT KINASE 2
(Homo
sapiens) 		6 / 11 LEU A 226
ALA A 247
LYS A 249
MET A 304
GLY A 307
LEU A 354
 XK9  A1511 (-3.8A)
XK9  A1511 ( 4.1A)
XK9  A1511 (-4.2A)
None
XK9  A1511 ( 3.7A)
XK9  A1511 (-4.6A)
 0.80A 4wa9A-2xk9A:
19.3		 4wa9A-2xk9A:
27.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WA9_A_AXIA9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2xk9 CHECKPOINT KINASE 2
(Homo
sapiens) 		6 / 11 LEU A 226
ALA A 247
MET A 304
GLY A 307
ASN A 352
LEU A 354
 XK9  A1511 (-3.8A)
XK9  A1511 ( 4.1A)
None
XK9  A1511 ( 3.7A)
None
XK9  A1511 (-4.6A)
 0.58A 4wa9A-2xk9A:
19.3		 4wa9A-2xk9A:
27.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WBO_C_ANWC601_0
(RHODOPSIN KINASE)		 2xk9 CHECKPOINT KINASE 2
(Homo
sapiens) 		4 / 6 LEU A 226
ALA A 247
MET A 304
LEU A 354
 XK9  A1511 (-3.8A)
XK9  A1511 ( 4.1A)
None
XK9  A1511 (-4.6A)
 0.47A 4wboC-2xk9A:
22.4		 4wboC-2xk9A:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WKQ_A_IREA1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2xk9 CHECKPOINT KINASE 2
(Homo
sapiens) 		7 / 12 LEU A 226
ALA A 247
LEU A 303
GLY A 307
ASP A 311
LEU A 354
THR A 367
 XK9  A1511 (-3.8A)
XK9  A1511 ( 4.1A)
XK9  A1511 (-4.1A)
XK9  A1511 ( 3.7A)
None
XK9  A1511 (-4.6A)
XK9  A1511 (-3.7A)
 0.52A 4wkqA-2xk9A:
21.5		 4wkqA-2xk9A:
26.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WKQ_A_IREA1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2xk9 CHECKPOINT KINASE 2
(Homo
sapiens) 		7 / 12 LEU A 226
ALA A 247
LYS A 249
LEU A 303
GLY A 307
LEU A 354
THR A 367
 XK9  A1511 (-3.8A)
XK9  A1511 ( 4.1A)
XK9  A1511 (-4.2A)
XK9  A1511 (-4.1A)
XK9  A1511 ( 3.7A)
XK9  A1511 (-4.6A)
XK9  A1511 (-3.7A)
 0.90A 4wkqA-2xk9A:
21.5		 4wkqA-2xk9A:
26.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XEY_A_1N1A601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2xk9 CHECKPOINT KINASE 2
(Homo
sapiens) 		7 / 12 LEU A 226
VAL A 234
ALA A 247
LYS A 249
ILE A 299
GLY A 307
LEU A 354
 XK9  A1511 (-3.8A)
XK9  A1511 (-4.8A)
XK9  A1511 ( 4.1A)
XK9  A1511 (-4.2A)
XK9  A1511 ( 4.9A)
XK9  A1511 ( 3.7A)
XK9  A1511 (-4.6A)
 0.82A 4xeyA-2xk9A:
21.5		 4xeyA-2xk9A:
24.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XOY_A_DX4A401_0
(MITOGEN-ACTIVATED
PROTEIN KINASE 1)		 2xk9 CHECKPOINT KINASE 2
(Homo
sapiens) 		4 / 6 ALA A 247
LEU A 303
MET A 304
LEU A 354
 XK9  A1511 ( 4.1A)
XK9  A1511 (-4.1A)
None
XK9  A1511 (-4.6A)
 0.24A 4xoyA-2xk9A:
23.8		 4xoyA-2xk9A:
31.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XP3_A_DX4A401_0
(MITOGEN-ACTIVATED
PROTEIN KINASE 1)		 2xk9 CHECKPOINT KINASE 2
(Homo
sapiens) 		4 / 6 ALA A 247
LEU A 303
MET A 304
LEU A 354
 XK9  A1511 ( 4.1A)
XK9  A1511 (-4.1A)
None
XK9  A1511 (-4.6A)
 0.19A 4xp3A-2xk9A:
23.7		 4xp3A-2xk9A:
31.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AAA_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 2xk9 CHECKPOINT KINASE 2
(Homo
sapiens) 		7 / 9 LEU A 226
VAL A 234
ALA A 247
LEU A 301
MET A 304
GLY A 307
LEU A 354
 XK9  A1511 (-3.8A)
XK9  A1511 (-4.8A)
XK9  A1511 ( 4.1A)
XK9  A1511 (-4.6A)
None
XK9  A1511 ( 3.7A)
XK9  A1511 (-4.6A)
 0.76A 5aaaA-2xk9A:
21.6		 5aaaA-2xk9A:
25.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AAA_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 2xk9 CHECKPOINT KINASE 2
(Homo
sapiens) 		7 / 9 VAL A 234
ALA A 247
LEU A 301
MET A 304
GLY A 307
LEU A 354
ASP A 368
 XK9  A1511 (-4.8A)
XK9  A1511 ( 4.1A)
XK9  A1511 (-4.6A)
None
XK9  A1511 ( 3.7A)
XK9  A1511 (-4.6A)
XK9  A1511 (-3.6A)
 0.84A 5aaaA-2xk9A:
21.6		 5aaaA-2xk9A:
25.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AAB_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 2xk9 CHECKPOINT KINASE 2
(Homo
sapiens) 		8 / 10 LEU A 226
VAL A 234
ALA A 247
LYS A 249
LEU A 301
MET A 304
GLY A 307
LEU A 354
 XK9  A1511 (-3.8A)
XK9  A1511 (-4.8A)
XK9  A1511 ( 4.1A)
XK9  A1511 (-4.2A)
XK9  A1511 (-4.6A)
None
XK9  A1511 ( 3.7A)
XK9  A1511 (-4.6A)
 0.92A 5aabA-2xk9A:
21.5		 5aabA-2xk9A:
25.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AAC_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 2xk9 CHECKPOINT KINASE 2
(Homo
sapiens) 		9 / 10 LEU A 226
VAL A 234
ALA A 247
LYS A 249
LEU A 301
MET A 304
GLY A 307
LEU A 354
ASP A 368
 XK9  A1511 (-3.8A)
XK9  A1511 (-4.8A)
XK9  A1511 ( 4.1A)
XK9  A1511 (-4.2A)
XK9  A1511 (-4.6A)
None
XK9  A1511 ( 3.7A)
XK9  A1511 (-4.6A)
XK9  A1511 (-3.6A)
 0.90A 5aacA-2xk9A:
11.2		 5aacA-2xk9A:
25.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_A_1N1A501_1
(PROTEIN-TYROSINE
KINASE 6)		 2xk9 CHECKPOINT KINASE 2
(Homo
sapiens) 		6 / 12 LEU A 226
VAL A 234
ALA A 247
LEU A 303
GLY A 307
LEU A 354
 XK9  A1511 (-3.8A)
XK9  A1511 (-4.8A)
XK9  A1511 ( 4.1A)
XK9  A1511 (-4.1A)
XK9  A1511 ( 3.7A)
XK9  A1511 (-4.6A)
 0.59A 5h2uA-2xk9A:
21.0		 5h2uA-2xk9A:
29.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_B_1N1B501_1
(PROTEIN-TYROSINE
KINASE 6)		 2xk9 CHECKPOINT KINASE 2
(Homo
sapiens) 		7 / 12 LEU A 226
VAL A 234
ALA A 247
ILE A 299
LEU A 303
GLY A 307
LEU A 354
 XK9  A1511 (-3.8A)
XK9  A1511 (-4.8A)
XK9  A1511 ( 4.1A)
XK9  A1511 ( 4.9A)
XK9  A1511 (-4.1A)
XK9  A1511 ( 3.7A)
XK9  A1511 (-4.6A)
 0.72A 5h2uB-2xk9A:
14.4		 5h2uB-2xk9A:
29.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_D_1N1D504_1
(PROTEIN-TYROSINE
KINASE 6)		 2xk9 CHECKPOINT KINASE 2
(Homo
sapiens) 		6 / 12 LEU A 226
VAL A 234
ALA A 247
ILE A 299
LEU A 303
GLY A 307
 XK9  A1511 (-3.8A)
XK9  A1511 (-4.8A)
XK9  A1511 ( 4.1A)
XK9  A1511 ( 4.9A)
XK9  A1511 (-4.1A)
XK9  A1511 ( 3.7A)
 0.66A 5h2uD-2xk9A:
21.2		 5h2uD-2xk9A:
29.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_D_1N1D504_1
(PROTEIN-TYROSINE
KINASE 6)		 2xk9 CHECKPOINT KINASE 2
(Homo
sapiens) 		6 / 12 LEU A 226
VAL A 234
ALA A 247
LEU A 303
GLY A 307
LEU A 354
 XK9  A1511 (-3.8A)
XK9  A1511 (-4.8A)
XK9  A1511 ( 4.1A)
XK9  A1511 (-4.1A)
XK9  A1511 ( 3.7A)
XK9  A1511 (-4.6A)
 0.59A 5h2uD-2xk9A:
21.2		 5h2uD-2xk9A:
29.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IZJ_F_AZ1F2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR-DAR)		 2xk9 CHECKPOINT KINASE 2
(Homo
sapiens) 		4 / 7 GLY A 227
GLY A 229
GLY A 232
VAL A 234
 XK9  A1511 ( 4.5A)
None
None
XK9  A1511 (-4.8A)
 0.37A 5izjB-2xk9A:
23.6		 5izjB-2xk9A:
34.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LW1_B_ADNB401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 8)		 2xk9 CHECKPOINT KINASE 2
(Homo
sapiens) 		5 / 9 GLY A 227
VAL A 234
ALA A 247
ILE A 286
MET A 304
 XK9  A1511 ( 4.5A)
XK9  A1511 (-4.8A)
XK9  A1511 ( 4.1A)
None
None
 0.61A 5lw1B-2xk9A:
20.8		 5lw1B-2xk9A:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LW1_E_ADNE401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 8)		 2xk9 CHECKPOINT KINASE 2
(Homo
sapiens) 		6 / 10 GLY A 227
VAL A 234
ALA A 247
ILE A 286
LEU A 303
MET A 304
 XK9  A1511 ( 4.5A)
XK9  A1511 (-4.8A)
XK9  A1511 ( 4.1A)
None
XK9  A1511 (-4.1A)
None
 0.70A 5lw1E-2xk9A:
20.5		 5lw1E-2xk9A:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LW1_H_ADNH401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 8)		 2xk9 CHECKPOINT KINASE 2
(Homo
sapiens) 		5 / 9 GLY A 227
VAL A 234
ALA A 247
LEU A 303
MET A 304
 XK9  A1511 ( 4.5A)
XK9  A1511 (-4.8A)
XK9  A1511 ( 4.1A)
XK9  A1511 (-4.1A)
None
 0.53A 5lw1H-2xk9A:
14.9		 5lw1H-2xk9A:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5P9I_A_1E8A701_1
(TYROSINE-PROTEIN
KINASE BTK)		 2xk9 CHECKPOINT KINASE 2
(Homo
sapiens) 		6 / 12 VAL A 234
ALA A 247
LYS A 249
ILE A 299
GLY A 307
LEU A 354
 XK9  A1511 (-4.8A)
XK9  A1511 ( 4.1A)
XK9  A1511 (-4.2A)
XK9  A1511 ( 4.9A)
XK9  A1511 ( 3.7A)
XK9  A1511 (-4.6A)
 0.95A 5p9iA-2xk9A:
21.3		 5p9iA-2xk9A:
26.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_A_1E8A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2xk9 CHECKPOINT KINASE 2
(Homo
sapiens) 		7 / 12 LEU A 226
GLY A 227
VAL A 234
ALA A 247
LYS A 249
LEU A 354
THR A 367
 XK9  A1511 (-3.8A)
XK9  A1511 ( 4.5A)
XK9  A1511 (-4.8A)
XK9  A1511 ( 4.1A)
XK9  A1511 (-4.2A)
XK9  A1511 (-4.6A)
XK9  A1511 (-3.7A)
 0.81A 5yu9A-2xk9A:
15.8		 5yu9A-2xk9A:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_B_1E8B1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2xk9 CHECKPOINT KINASE 2
(Homo
sapiens) 		6 / 12 GLY A 227
VAL A 234
ALA A 247
ASP A 311
LEU A 354
THR A 367
 XK9  A1511 ( 4.5A)
XK9  A1511 (-4.8A)
XK9  A1511 ( 4.1A)
None
XK9  A1511 (-4.6A)
XK9  A1511 (-3.7A)
 0.58A 5yu9B-2xk9A:
21.0		 5yu9B-2xk9A:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_C_1E8C1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2xk9 CHECKPOINT KINASE 2
(Homo
sapiens) 		5 / 12 VAL A 234
ALA A 247
GLY A 307
ASP A 311
THR A 367
 XK9  A1511 (-4.8A)
XK9  A1511 ( 4.1A)
XK9  A1511 ( 3.7A)
None
XK9  A1511 (-3.7A)
 0.48A 5yu9C-2xk9A:
11.7		 5yu9C-2xk9A:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_C_1E8C1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2xk9 CHECKPOINT KINASE 2
(Homo
sapiens) 		5 / 12 VAL A 234
ALA A 247
LYS A 249
GLY A 307
ASP A 311
 XK9  A1511 (-4.8A)
XK9  A1511 ( 4.1A)
XK9  A1511 (-4.2A)
XK9  A1511 ( 3.7A)
None
 0.79A 5yu9C-2xk9A:
11.7		 5yu9C-2xk9A:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_D_1E8D1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2xk9 CHECKPOINT KINASE 2
(Homo
sapiens) 		6 / 12 VAL A 234
ALA A 247
GLY A 307
ASP A 311
LEU A 354
THR A 367
 XK9  A1511 (-4.8A)
XK9  A1511 ( 4.1A)
XK9  A1511 ( 3.7A)
None
XK9  A1511 (-4.6A)
XK9  A1511 (-3.7A)
 0.54A 5yu9D-2xk9A:
20.8		 5yu9D-2xk9A:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_D_1E8D1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2xk9 CHECKPOINT KINASE 2
(Homo
sapiens) 		6 / 12 VAL A 234
ALA A 247
LYS A 249
GLY A 307
ASP A 311
LEU A 354
 XK9  A1511 (-4.8A)
XK9  A1511 ( 4.1A)
XK9  A1511 (-4.2A)
XK9  A1511 ( 3.7A)
None
XK9  A1511 (-4.6A)
 0.85A 5yu9D-2xk9A:
20.8		 5yu9D-2xk9A:
14.85