SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'XFE'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1FMO_E_ADNE351_1
(CAMP-DEPENDENT
PROTEIN KINASE)		 3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		12 / 12 LEU A  49
GLY A  50
VAL A  57
ALA A  70
VAL A 104
VAL A 123
GLU A 127
ASN A 171
LEU A 173
THR A 183
ASP A 184
PHE A 327
 XFE  A 351 (-4.2A)
XFE  A 351 ( 4.0A)
XFE  A 351 ( 4.5A)
XFE  A 351 (-3.2A)
None
XFE  A 351 (-4.2A)
XFE  A 351 (-4.2A)
None
XFE  A 351 (-4.6A)
XFE  A 351 (-3.7A)
None
XFE  A 351 (-4.4A)
 0.47A 1fmoE-3mvjA:
54.0		 1fmoE-3mvjA:
98.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MUO_A_ADNA1_1
(AURORA-RELATED
KINASE 1)		 3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		6 / 9 LEU A  49
GLY A  50
VAL A  57
ALA A  70
TYR A 122
LEU A 173
 XFE  A 351 (-4.2A)
XFE  A 351 ( 4.0A)
XFE  A 351 ( 4.5A)
XFE  A 351 (-3.2A)
None
XFE  A 351 (-4.6A)
 0.73A 1muoA-3mvjA:
9.8		 1muoA-3mvjA:
28.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OPJ_A_STIA3_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		6 / 12 LEU A  49
VAL A  57
ALA A  70
GLU A  91
VAL A 104
LEU A 173
 XFE  A 351 (-4.2A)
XFE  A 351 ( 4.5A)
XFE  A 351 (-3.2A)
None
None
XFE  A 351 (-4.6A)
 0.74A 1opjA-3mvjA:
20.6		 1opjA-3mvjA:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T46_A_STIA3_1
(HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG)		 3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		9 / 12 LEU A  49
VAL A  57
ALA A  70
LYS A  72
GLU A  91
LEU A  95
VAL A 104
GLY A 126
LEU A 173
 XFE  A 351 (-4.2A)
XFE  A 351 ( 4.5A)
XFE  A 351 (-3.2A)
None
None
None
None
None
XFE  A 351 (-4.6A)
 0.75A 1t46A-3mvjA:
21.5		 1t46A-3mvjA:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XBB_A_STIA1_1
(TYROSINE-PROTEIN
KINASE SYK)		 3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		6 / 9 LEU A  49
VAL A  57
ALA A  70
MET A 120
GLY A 126
LEU A 173
 XFE  A 351 (-4.2A)
XFE  A 351 ( 4.5A)
XFE  A 351 (-3.2A)
XFE  A 351 ( 4.0A)
None
XFE  A 351 (-4.6A)
 0.82A 1xbbA-3mvjA:
23.7		 1xbbA-3mvjA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		 3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		7 / 12 VAL A  57
LYS A  72
VAL A 104
VAL A 123
ASN A 171
LEU A 173
ASP A 184
 XFE  A 351 ( 4.5A)
None
None
XFE  A 351 (-4.2A)
None
XFE  A 351 (-4.6A)
None
 0.68A 2eufB-3mvjA:
26.4		 2eufB-3mvjA:
25.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_A_MIXA539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		9 / 12 LEU A  49
GLY A  50
VAL A  57
ALA A  70
VAL A 123
ASP A 166
LYS A 168
ASN A 171
ASP A 184
 XFE  A 351 (-4.2A)
XFE  A 351 ( 4.0A)
XFE  A 351 ( 4.5A)
XFE  A 351 (-3.2A)
XFE  A 351 (-4.2A)
None
None
None
None
 0.67A 2fumA-3mvjA:
8.6		 2fumA-3mvjA:
28.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_B_MIXB1539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		10 / 12 LEU A  49
GLY A  50
VAL A  57
ALA A  70
MET A 120
TYR A 122
VAL A 123
LYS A 168
ASN A 171
ASP A 184
 XFE  A 351 (-4.2A)
XFE  A 351 ( 4.0A)
XFE  A 351 ( 4.5A)
XFE  A 351 (-3.2A)
XFE  A 351 ( 4.0A)
None
XFE  A 351 (-4.2A)
None
None
None
 0.71A 2fumB-3mvjA:
26.6		 2fumB-3mvjA:
28.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_C_MIXC2539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		8 / 12 LEU A  49
GLY A  50
VAL A  57
ALA A  70
MET A 120
TYR A 122
VAL A 123
ASN A 171
 XFE  A 351 (-4.2A)
XFE  A 351 ( 4.0A)
XFE  A 351 ( 4.5A)
XFE  A 351 (-3.2A)
XFE  A 351 ( 4.0A)
None
XFE  A 351 (-4.2A)
None
 0.51A 2fumC-3mvjA:
25.2		 2fumC-3mvjA:
28.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_D_MIXD3539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		7 / 12 GLY A  50
GLY A  52
VAL A  57
ALA A  70
LYS A 168
ASN A 171
ASP A 184
 XFE  A 351 ( 4.0A)
None
XFE  A 351 ( 4.5A)
XFE  A 351 (-3.2A)
None
None
None
 0.87A 2fumD-3mvjA:
25.2		 2fumD-3mvjA:
28.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_D_MIXD3539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		8 / 12 LEU A  49
GLY A  50
GLY A  52
VAL A  57
ALA A  70
MET A 120
LYS A 168
ASN A 171
 XFE  A 351 (-4.2A)
XFE  A 351 ( 4.0A)
None
XFE  A 351 ( 4.5A)
XFE  A 351 (-3.2A)
XFE  A 351 ( 4.0A)
None
None
 0.66A 2fumD-3mvjA:
25.2		 2fumD-3mvjA:
28.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_A_STIA600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		4 / 6 LEU A  49
LYS A  72
VAL A 104
ARG A 165
 XFE  A 351 (-4.2A)
None
None
TPO  A 197 ( 3.1A)
 1.01A 2hyyA-3mvjA:
20.8		 2hyyA-3mvjA:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IVU_A_ZD6A3015_0
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		 3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		7 / 12 LEU A  49
GLY A  50
VAL A  57
LYS A  72
GLU A  91
LEU A  95
ASP A 184
 XFE  A 351 (-4.2A)
XFE  A 351 ( 4.0A)
XFE  A 351 ( 4.5A)
None
None
None
None
 0.78A 2ivuA-3mvjA:
26.0		 2ivuA-3mvjA:
24.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IVU_A_ZD6A3015_0
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		 3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		7 / 12 LEU A  49
GLY A  50
VAL A  57
LYS A  72
GLU A  91
LEU A  95
TYR A 122
 XFE  A 351 (-4.2A)
XFE  A 351 ( 4.0A)
XFE  A 351 ( 4.5A)
None
None
None
None
 0.62A 2ivuA-3mvjA:
26.0		 2ivuA-3mvjA:
24.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_B_NILB600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		5 / 9 LEU A  49
VAL A  57
LYS A  72
VAL A 104
LEU A 173
 XFE  A 351 (-4.2A)
XFE  A 351 ( 4.5A)
None
None
XFE  A 351 (-4.6A)
 0.73A 3cs9B-3mvjA:
20.9		 3cs9B-3mvjA:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_D_NILD600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		4 / 6 LEU A  49
VAL A  57
LYS A  72
LEU A 173
 XFE  A 351 (-4.2A)
XFE  A 351 ( 4.5A)
None
XFE  A 351 (-4.6A)
 0.77A 3cs9D-3mvjA:
19.6		 3cs9D-3mvjA:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EYG_A_MI1A1_1
(TYROSINE-PROTEIN
KINASE)		 3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		11 / 12 LEU A  49
GLY A  50
GLY A  52
GLY A  55
VAL A  57
ALA A  70
LYS A  72
MET A 120
ASN A 171
LEU A 173
ASP A 184
 XFE  A 351 (-4.2A)
XFE  A 351 ( 4.0A)
None
None
XFE  A 351 ( 4.5A)
XFE  A 351 (-3.2A)
None
XFE  A 351 ( 4.0A)
None
XFE  A 351 (-4.6A)
None
 0.69A 3eygA-3mvjA:
24.0		 3eygA-3mvjA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUP_A_MI1A1_1
(TYROSINE-PROTEIN
KINASE JAK2)		 3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		10 / 12 LEU A  49
GLY A  50
GLY A  52
GLY A  55
VAL A  57
ALA A  70
MET A 120
TYR A 122
LEU A 173
ASP A 184
 XFE  A 351 (-4.2A)
XFE  A 351 ( 4.0A)
None
None
XFE  A 351 ( 4.5A)
XFE  A 351 (-3.2A)
XFE  A 351 ( 4.0A)
None
XFE  A 351 (-4.6A)
None
 0.80A 3fupA-3mvjA:
24.6		 3fupA-3mvjA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUP_A_MI1A1_1
(TYROSINE-PROTEIN
KINASE JAK2)		 3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		10 / 12 LEU A  49
GLY A  50
GLY A  55
VAL A  57
ALA A  70
LYS A  72
MET A 120
TYR A 122
LEU A 173
ASP A 184
 XFE  A 351 (-4.2A)
XFE  A 351 ( 4.0A)
None
XFE  A 351 ( 4.5A)
XFE  A 351 (-3.2A)
None
XFE  A 351 ( 4.0A)
None
XFE  A 351 (-4.6A)
None
 0.75A 3fupA-3mvjA:
24.6		 3fupA-3mvjA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUP_B_MI1B1_1
(TYROSINE-PROTEIN
KINASE JAK2)		 3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		8 / 12 GLY A  50
GLY A  52
VAL A  57
ALA A  70
LYS A  72
TYR A 122
LEU A 173
ASP A 184
 XFE  A 351 ( 4.0A)
None
XFE  A 351 ( 4.5A)
XFE  A 351 (-3.2A)
None
None
XFE  A 351 (-4.6A)
None
 0.64A 3fupB-3mvjA:
25.1		 3fupB-3mvjA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUP_B_MI1B1_1
(TYROSINE-PROTEIN
KINASE JAK2)		 3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		9 / 12 GLY A  50
GLY A  52
VAL A  57
ALA A  70
LYS A  72
VAL A 104
MET A 120
TYR A 122
ASP A 184
 XFE  A 351 ( 4.0A)
None
XFE  A 351 ( 4.5A)
XFE  A 351 (-3.2A)
None
None
XFE  A 351 ( 4.0A)
None
None
 0.52A 3fupB-3mvjA:
25.1		 3fupB-3mvjA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUP_B_MI1B1_1
(TYROSINE-PROTEIN
KINASE JAK2)		 3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		8 / 12 LEU A  49
GLY A  50
GLY A  52
VAL A  57
ALA A  70
LYS A  72
TYR A 122
LEU A 173
 XFE  A 351 (-4.2A)
XFE  A 351 ( 4.0A)
None
XFE  A 351 ( 4.5A)
XFE  A 351 (-3.2A)
None
None
XFE  A 351 (-4.6A)
 0.50A 3fupB-3mvjA:
25.1		 3fupB-3mvjA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUP_B_MI1B1_1
(TYROSINE-PROTEIN
KINASE JAK2)		 3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		9 / 12 LEU A  49
GLY A  50
GLY A  52
VAL A  57
ALA A  70
LYS A  72
VAL A 104
MET A 120
TYR A 122
 XFE  A 351 (-4.2A)
XFE  A 351 ( 4.0A)
None
XFE  A 351 ( 4.5A)
XFE  A 351 (-3.2A)
None
None
XFE  A 351 ( 4.0A)
None
 0.46A 3fupB-3mvjA:
25.1		 3fupB-3mvjA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0E_A_B49A9000_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		7 / 11 LEU A  49
VAL A  57
ALA A  70
VAL A 104
TYR A 122
GLY A 126
LEU A 173
 XFE  A 351 (-4.2A)
XFE  A 351 ( 4.5A)
XFE  A 351 (-3.2A)
None
None
None
XFE  A 351 (-4.6A)
 0.65A 3g0eA-3mvjA:
20.3		 3g0eA-3mvjA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0F_A_B49A9001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		6 / 11 LEU A  49
VAL A  57
ALA A  70
TYR A 122
GLY A 126
LEU A 173
 XFE  A 351 (-4.2A)
XFE  A 351 ( 4.5A)
XFE  A 351 (-3.2A)
None
None
XFE  A 351 (-4.6A)
 0.43A 3g0fA-3mvjA:
21.7		 3g0fA-3mvjA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0F_B_B49B9001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		6 / 10 LEU A  49
VAL A  57
ALA A  70
TYR A 122
GLY A 126
LEU A 173
 XFE  A 351 (-4.2A)
XFE  A 351 ( 4.5A)
XFE  A 351 (-3.2A)
None
None
XFE  A 351 (-4.6A)
 0.37A 3g0fB-3mvjA:
21.8		 3g0fB-3mvjA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G5D_B_1N1B1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		8 / 12 LEU A  49
VAL A  57
ALA A  70
LYS A  72
VAL A 104
TYR A 122
GLY A 126
LEU A 173
 XFE  A 351 (-4.2A)
XFE  A 351 ( 4.5A)
XFE  A 351 (-3.2A)
None
None
None
None
XFE  A 351 (-4.6A)
 0.78A 3g5dB-3mvjA:
22.3		 3g5dB-3mvjA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GVU_A_STIA1001_1
(TYROSINE-PROTEIN
KINASE ABL2)		 3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		6 / 12 LEU A  49
VAL A  57
ALA A  70
GLU A  91
VAL A 104
LEU A 173
 XFE  A 351 (-4.2A)
XFE  A 351 ( 4.5A)
XFE  A 351 (-3.2A)
None
None
XFE  A 351 (-4.6A)
 0.73A 3gvuA-3mvjA:
21.1		 3gvuA-3mvjA:
28.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXK_A_MI1A1125_1
(TYROSINE-PROTEIN
KINASE JAK3)		 3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		10 / 12 LEU A  49
GLY A  50
VAL A  57
ALA A  70
LYS A  72
VAL A 104
MET A 120
TYR A 122
LEU A 173
ASP A 184
 XFE  A 351 (-4.2A)
XFE  A 351 ( 4.0A)
XFE  A 351 ( 4.5A)
XFE  A 351 (-3.2A)
None
None
XFE  A 351 ( 4.0A)
None
XFE  A 351 (-4.6A)
None
 0.84A 3lxkA-3mvjA:
24.5		 3lxkA-3mvjA:
25.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXN_A_MI1A1_1
(NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2)		 3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		9 / 12 LEU A  49
GLY A  50
GLY A  52
VAL A  57
ALA A  70
TYR A 122
VAL A 123
LEU A 173
ASP A 184
 XFE  A 351 (-4.2A)
XFE  A 351 ( 4.0A)
None
XFE  A 351 ( 4.5A)
XFE  A 351 (-3.2A)
None
XFE  A 351 (-4.2A)
XFE  A 351 (-4.6A)
None
 0.69A 3lxnA-3mvjA:
25.1		 3lxnA-3mvjA:
26.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXN_A_MI1A1_1
(NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2)		 3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		9 / 12 LEU A  49
GLY A  50
VAL A  57
ALA A  70
LYS A  72
TYR A 122
VAL A 123
LEU A 173
ASP A 184
 XFE  A 351 (-4.2A)
XFE  A 351 ( 4.0A)
XFE  A 351 ( 4.5A)
XFE  A 351 (-3.2A)
None
None
XFE  A 351 (-4.2A)
XFE  A 351 (-4.6A)
None
 0.66A 3lxnA-3mvjA:
25.1		 3lxnA-3mvjA:
26.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M0W_E_P77E203_1
(PROTEIN S100-A4)		 3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		4 / 8 PHE A 314
PHE A 145
LEU A 173
ASP A 175
 None
None
XFE  A 351 (-4.6A)
None
 1.05A 3m0wE-3mvjA:
undetectable
3m0wF-3mvjA:
undetectable
3m0wG-3mvjA:
undetectable
3m0wH-3mvjA:
undetectable		 3m0wE-3mvjA:
14.45
3m0wF-3mvjA:
14.45
3m0wG-3mvjA:
14.45
3m0wH-3mvjA:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OCT_A_1N1A663_1
(TYROSINE-PROTEIN
KINASE BTK)		 3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		7 / 12 LEU A  49
VAL A  57
ALA A  70
LYS A  72
TYR A 122
GLY A 126
LEU A 173
 XFE  A 351 (-4.2A)
XFE  A 351 ( 4.5A)
XFE  A 351 (-3.2A)
None
None
None
XFE  A 351 (-4.6A)
 0.71A 3octA-3mvjA:
7.5		 3octA-3mvjA:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OEZ_A_STIA601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		7 / 12 VAL A  57
ALA A  70
GLU A  91
VAL A 104
TYR A 122
GLY A 126
LEU A 173
 XFE  A 351 ( 4.5A)
XFE  A 351 (-3.2A)
None
None
None
None
XFE  A 351 (-4.6A)
 0.88A 3oezA-3mvjA:
20.8		 3oezA-3mvjA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_B_1N1B1000_1
(P38A)		 3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		5 / 12 GLY A  50
VAL A  57
ALA A  70
LYS A  72
LEU A  95
 XFE  A 351 ( 4.0A)
XFE  A 351 ( 4.5A)
XFE  A 351 (-3.2A)
None
None
 0.49A 3ohtB-3mvjA:
5.3		 3ohtB-3mvjA:
28.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PYY_B_STIB4_1
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		6 / 12 LEU A  49
VAL A  57
ALA A  70
GLU A  91
VAL A 104
LEU A 173
 XFE  A 351 (-4.2A)
XFE  A 351 ( 4.5A)
XFE  A 351 (-3.2A)
None
None
XFE  A 351 (-4.6A)
 0.70A 3pyyB-3mvjA:
20.7		 3pyyB-3mvjA:
26.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QLG_A_1N1A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		8 / 12 LEU A  49
VAL A  57
ALA A  70
LYS A  72
VAL A 104
TYR A 122
GLY A 126
LEU A 173
 XFE  A 351 (-4.2A)
XFE  A 351 ( 4.5A)
XFE  A 351 (-3.2A)
None
None
None
None
XFE  A 351 (-4.6A)
 0.77A 3qlgA-3mvjA:
21.7		 3qlgA-3mvjA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UE4_A_DB8A601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		7 / 12 LEU A  49
ALA A  70
LYS A  72
GLU A  91
VAL A 104
GLY A 126
LEU A 173
 XFE  A 351 (-4.2A)
XFE  A 351 (-3.2A)
None
None
None
None
XFE  A 351 (-4.6A)
 0.97A 3ue4A-3mvjA:
23.8		 3ue4A-3mvjA:
25.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UE4_B_DB8B601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		7 / 12 LEU A  49
VAL A  57
ALA A  70
GLU A  91
VAL A 104
GLY A 126
LEU A 173
 XFE  A 351 (-4.2A)
XFE  A 351 ( 4.5A)
XFE  A 351 (-3.2A)
None
None
None
XFE  A 351 (-4.6A)
 0.85A 3ue4B-3mvjA:
23.4		 3ue4B-3mvjA:
25.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V5W_A_8PRA701_1
(G-PROTEIN COUPLED
RECEPTOR KINASE 2)		 3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		7 / 12 GLY A  52
GLY A  55
VAL A  57
ALA A  70
LYS A  72
LEU A  74
ASP A 184
 None
None
XFE  A 351 ( 4.5A)
XFE  A 351 (-3.2A)
None
None
None
 0.85A 3v5wA-3mvjA:
11.9		 3v5wA-3mvjA:
24.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V5W_A_8PRA701_1
(G-PROTEIN COUPLED
RECEPTOR KINASE 2)		 3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		7 / 12 GLY A  52
GLY A  55
VAL A  57
ALA A  70
LYS A  72
LEU A  74
VAL A 104
 None
None
XFE  A 351 ( 4.5A)
XFE  A 351 (-3.2A)
None
None
None
 0.79A 3v5wA-3mvjA:
11.9		 3v5wA-3mvjA:
24.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		5 / 12 LEU A  49
VAL A  57
ALA A  70
LEU A  95
GLY A 126
 XFE  A 351 (-4.2A)
XFE  A 351 ( 4.5A)
XFE  A 351 (-3.2A)
None
None
 0.43A 3wzdA-3mvjA:
15.9		 3wzdA-3mvjA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZE_A_BAXA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		7 / 12 LEU A  49
VAL A  57
ALA A  70
LYS A  72
GLU A  91
LEU A  95
LEU A 157
 XFE  A 351 (-4.2A)
XFE  A 351 ( 4.5A)
XFE  A 351 (-3.2A)
None
None
None
None
 0.58A 3wzeA-3mvjA:
14.0		 3wzeA-3mvjA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AG8_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		8 / 12 LEU A  49
VAL A  57
ALA A  70
LYS A  72
GLU A  91
VAL A 104
GLY A 126
LEU A 173
 XFE  A 351 (-4.2A)
XFE  A 351 ( 4.5A)
XFE  A 351 (-3.2A)
None
None
None
None
XFE  A 351 (-4.6A)
 0.65A 4ag8A-3mvjA:
21.2		 4ag8A-3mvjA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AGC_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		7 / 12 LEU A  49
VAL A  57
ALA A  70
GLU A  91
LEU A  95
GLY A 126
LEU A 173
 XFE  A 351 (-4.2A)
XFE  A 351 ( 4.5A)
XFE  A 351 (-3.2A)
None
None
None
XFE  A 351 (-4.6A)
 0.52A 4agcA-3mvjA:
20.8		 4agcA-3mvjA:
25.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AGC_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		6 / 12 LEU A  49
VAL A  57
ALA A  70
LYS A  72
GLU A  91
LEU A  95
 XFE  A 351 (-4.2A)
XFE  A 351 ( 4.5A)
XFE  A 351 (-3.2A)
None
None
None
 0.52A 4agcA-3mvjA:
20.8		 4agcA-3mvjA:
25.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ASD_A_BAXA1500_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		7 / 12 LEU A  49
VAL A  57
ALA A  70
LYS A  72
GLU A  91
LEU A  95
GLY A 126
 XFE  A 351 (-4.2A)
XFE  A 351 ( 4.5A)
XFE  A 351 (-3.2A)
None
None
None
None
 0.51A 4asdA-3mvjA:
21.0		 4asdA-3mvjA:
25.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BKJ_A_STIA1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		6 / 12 VAL A  57
ALA A  70
GLU A  91
ILE A  94
MET A 118
TYR A 122
 XFE  A 351 ( 4.5A)
XFE  A 351 (-3.2A)
None
None
None
None
 0.65A 4bkjA-3mvjA:
21.1		 4bkjA-3mvjA:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BKJ_B_STIB1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		6 / 12 VAL A  57
ALA A  70
GLU A  91
ILE A  94
MET A 118
LEU A 173
 XFE  A 351 ( 4.5A)
XFE  A 351 (-3.2A)
None
None
None
XFE  A 351 (-4.6A)
 1.01A 4bkjB-3mvjA:
21.2		 4bkjB-3mvjA:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CKI_A_ADNA2022_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET)		 3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		7 / 11 LEU A  49
GLY A  50
VAL A  57
ALA A  70
TYR A 122
GLY A 126
LEU A 173
 XFE  A 351 (-4.2A)
XFE  A 351 ( 4.0A)
XFE  A 351 ( 4.5A)
XFE  A 351 (-3.2A)
None
None
XFE  A 351 (-4.6A)
 0.69A 4ckiA-3mvjA:
25.7		 4ckiA-3mvjA:
24.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CKJ_A_ADNA2014_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET)		 3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		7 / 10 LEU A  49
GLY A  50
GLY A  52
VAL A  57
ALA A  70
TYR A 122
LEU A 173
 XFE  A 351 (-4.2A)
XFE  A 351 ( 4.0A)
None
XFE  A 351 ( 4.5A)
XFE  A 351 (-3.2A)
None
XFE  A 351 (-4.6A)
 0.64A 4ckjA-3mvjA:
25.7		 4ckjA-3mvjA:
24.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CSV_A_STIA1265_1
(SRC-ABL TYROSINE
KINASE ANCESTOR)		 3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		7 / 12 VAL A  57
ALA A  70
GLU A  91
ILE A  94
VAL A 104
TYR A 122
LEU A 173
 XFE  A 351 ( 4.5A)
XFE  A 351 (-3.2A)
None
None
None
None
XFE  A 351 (-4.6A)
 0.79A 4csvA-3mvjA:
21.7		 4csvA-3mvjA:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I22_A_IREA9001_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		9 / 12 LEU A  49
GLY A  50
VAL A  57
ALA A  70
LYS A  72
MET A 120
GLY A 126
LEU A 173
ASP A 184
 XFE  A 351 (-4.2A)
XFE  A 351 ( 4.0A)
XFE  A 351 ( 4.5A)
XFE  A 351 (-3.2A)
None
XFE  A 351 ( 4.0A)
None
XFE  A 351 (-4.6A)
None
 0.99A 4i22A-3mvjA:
21.5		 4i22A-3mvjA:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I22_A_IREA9001_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		9 / 12 LEU A  49
VAL A  57
ALA A  70
LYS A  72
MET A 120
GLY A 126
LEU A 173
THR A 183
ASP A 184
 XFE  A 351 (-4.2A)
XFE  A 351 ( 4.5A)
XFE  A 351 (-3.2A)
None
XFE  A 351 ( 4.0A)
None
XFE  A 351 (-4.6A)
XFE  A 351 (-3.7A)
None
 0.94A 4i22A-3mvjA:
21.5		 4i22A-3mvjA:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I41_A_MIXA500_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		7 / 12 VAL A  57
ALA A  70
ASP A 166
LYS A 168
ASN A 171
LEU A 173
ASP A 184
 XFE  A 351 ( 4.5A)
XFE  A 351 (-3.2A)
None
None
None
XFE  A 351 (-4.6A)
None
 0.59A 4i41A-3mvjA:
29.0		 4i41A-3mvjA:
25.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAA_A_RTZA401_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		6 / 11 VAL A  57
ALA A  70
LYS A  72
GLU A 170
LEU A 173
ASP A 184
 XFE  A 351 ( 4.5A)
XFE  A 351 (-3.2A)
None
None
XFE  A 351 (-4.6A)
None
 1.04A 4iaaA-3mvjA:
28.9		 4iaaA-3mvjA:
26.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9I_A_8PRA601_1
(RHODOPSIN KINASE)		 3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		4 / 7 VAL A  57
ALA A  70
LEU A  74
MET A 120
 XFE  A 351 ( 4.5A)
XFE  A 351 (-3.2A)
None
XFE  A 351 ( 4.0A)
 0.25A 4l9iA-3mvjA:
12.1		 4l9iA-3mvjA:
29.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9I_A_8PRA601_1
(RHODOPSIN KINASE)		 3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		4 / 7 VAL A  57
ALA A  70
MET A 120
LEU A 173
 XFE  A 351 ( 4.5A)
XFE  A 351 (-3.2A)
XFE  A 351 ( 4.0A)
XFE  A 351 (-4.6A)
 0.66A 4l9iA-3mvjA:
12.1		 4l9iA-3mvjA:
29.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MKC_A_4MKA1503_1
(ALK TYROSINE KINASE
RECEPTOR)		 3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		7 / 12 LEU A  49
VAL A  57
ALA A  70
GLY A 126
SER A 130
LEU A 173
ASP A 184
 XFE  A 351 (-4.2A)
XFE  A 351 ( 4.5A)
XFE  A 351 (-3.2A)
None
None
XFE  A 351 (-4.6A)
None
 0.94A 4mkcA-3mvjA:
23.1		 4mkcA-3mvjA:
25.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4O0W_A_ADNA501_1
(AURORA KINASE A)		 3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		5 / 6 LEU A  49
GLY A  50
VAL A  57
ALA A  70
LEU A 173
 XFE  A 351 (-4.2A)
XFE  A 351 ( 4.0A)
XFE  A 351 ( 4.5A)
XFE  A 351 (-3.2A)
XFE  A 351 (-4.6A)
 0.42A 4o0wA-3mvjA:
30.9		 4o0wA-3mvjA:
30.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_A_ADNA401_1
(CYCLIN-DEPENDENT
KINASE 9)		 3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		5 / 8 VAL A  57
ALA A  70
ASN A 171
LEU A 173
ASP A 184
 XFE  A 351 ( 4.5A)
XFE  A 351 (-3.2A)
None
XFE  A 351 (-4.6A)
None
 0.60A 4ogrA-3mvjA:
26.9		 4ogrA-3mvjA:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_E_ADNE401_1
(CYCLIN-DEPENDENT
KINASE 9)		 3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		5 / 7 GLY A  50
ALA A  70
ASN A 171
LEU A 173
ASP A 184
 XFE  A 351 ( 4.0A)
XFE  A 351 (-3.2A)
None
XFE  A 351 (-4.6A)
None
 0.76A 4ogrE-3mvjA:
26.1		 4ogrE-3mvjA:
23.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4OTI_A_MI1A1001_1
(SERINE/THREONINE-PRO
TEIN KINASE N1)		 3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		7 / 12 LEU A  49
GLY A  50
GLY A  52
GLY A  55
VAL A  57
ALA A  70
LEU A 173
 XFE  A 351 (-4.2A)
XFE  A 351 ( 4.0A)
None
None
XFE  A 351 ( 4.5A)
XFE  A 351 (-3.2A)
XFE  A 351 (-4.6A)
 0.41A 4otiA-3mvjA:
33.4		 4otiA-3mvjA:
34.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4OTI_A_MI1A1001_1
(SERINE/THREONINE-PRO
TEIN KINASE N1)		 3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		8 / 12 LEU A  49
GLY A  50
GLY A  52
GLY A  55
VAL A  57
ALA A  70
VAL A 104
PHE A 327
 XFE  A 351 (-4.2A)
XFE  A 351 ( 4.0A)
None
None
XFE  A 351 ( 4.5A)
XFE  A 351 (-3.2A)
None
XFE  A 351 (-4.4A)
 0.53A 4otiA-3mvjA:
33.4		 4otiA-3mvjA:
34.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4OTI_A_MI1A1001_1
(SERINE/THREONINE-PRO
TEIN KINASE N1)		 3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		7 / 12 LEU A  49
GLY A  50
GLY A  52
VAL A  57
ALA A  70
LYS A  72
LEU A 173
 XFE  A 351 (-4.2A)
XFE  A 351 ( 4.0A)
None
XFE  A 351 ( 4.5A)
XFE  A 351 (-3.2A)
None
XFE  A 351 (-4.6A)
 0.45A 4otiA-3mvjA:
33.4		 4otiA-3mvjA:
34.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4OTI_A_MI1A1001_1
(SERINE/THREONINE-PRO
TEIN KINASE N1)		 3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		8 / 12 LEU A  49
GLY A  50
GLY A  52
VAL A  57
ALA A  70
LYS A  72
VAL A 104
PHE A 327
 XFE  A 351 (-4.2A)
XFE  A 351 ( 4.0A)
None
XFE  A 351 ( 4.5A)
XFE  A 351 (-3.2A)
None
None
XFE  A 351 (-4.4A)
 0.58A 4otiA-3mvjA:
33.4		 4otiA-3mvjA:
34.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTW_A_DB8A1101_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3)		 3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		8 / 12 LEU A  49
VAL A  57
LYS A  72
VAL A 104
TYR A 122
GLY A 126
LEU A 173
ASP A 184
 XFE  A 351 (-4.2A)
XFE  A 351 ( 4.5A)
None
None
None
None
XFE  A 351 (-4.6A)
None
 1.01A 4otwA-3mvjA:
21.0		 4otwA-3mvjA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QMS_A_1N1A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		7 / 11 ALA A  70
LYS A  72
GLU A  91
MET A 120
TYR A 122
LEU A 173
ASP A 184
 XFE  A 351 (-3.2A)
None
None
XFE  A 351 ( 4.0A)
None
XFE  A 351 (-4.6A)
None
 0.97A 4qmsA-3mvjA:
29.9		 4qmsA-3mvjA:
27.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QMZ_A_B49A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		6 / 12 GLY A  50
VAL A  57
ALA A  70
MET A 120
TYR A 122
LEU A 173
 XFE  A 351 ( 4.0A)
XFE  A 351 ( 4.5A)
XFE  A 351 (-3.2A)
XFE  A 351 ( 4.0A)
None
XFE  A 351 (-4.6A)
 0.70A 4qmzA-3mvjA:
30.0		 4qmzA-3mvjA:
27.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7I_A_STIA1001_2
(MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR)		 3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		4 / 5 LEU A  49
VAL A 104
TYR A 122
ARG A 165
 XFE  A 351 (-4.2A)
None
None
TPO  A 197 ( 3.1A)
 0.75A 4r7iA-3mvjA:
15.1		 4r7iA-3mvjA:
26.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U5J_A_RXTA601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		9 / 11 LEU A  49
GLY A  52
VAL A  57
ALA A  70
TYR A 122
GLY A 126
ASN A 171
LEU A 173
ASP A 184
 XFE  A 351 (-4.2A)
None
XFE  A 351 ( 4.5A)
XFE  A 351 (-3.2A)
None
None
None
XFE  A 351 (-4.6A)
None
 0.86A 4u5jA-3mvjA:
24.3		 4u5jA-3mvjA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U5J_B_RXTB601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		6 / 9 LEU A  49
VAL A  57
ALA A  70
TYR A 122
GLY A 126
LEU A 173
 XFE  A 351 (-4.2A)
XFE  A 351 ( 4.5A)
XFE  A 351 (-3.2A)
None
None
XFE  A 351 (-4.6A)
 0.65A 4u5jB-3mvjA:
23.3		 4u5jB-3mvjA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V01_A_0LIA1776_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		6 / 9 LEU A  49
VAL A  57
LYS A  72
TYR A 122
ARG A 165
LEU A 173
 XFE  A 351 (-4.2A)
XFE  A 351 ( 4.5A)
None
None
TPO  A 197 ( 3.1A)
XFE  A 351 (-4.6A)
 0.92A 4v01A-3mvjA:
20.2		 4v01A-3mvjA:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V04_B_0LIB1771_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		6 / 10 LEU A  49
VAL A  57
LYS A  72
TYR A 122
ARG A 165
LEU A 173
 XFE  A 351 (-4.2A)
XFE  A 351 ( 4.5A)
None
None
TPO  A 197 ( 3.1A)
XFE  A 351 (-4.6A)
 1.02A 4v04B-3mvjA:
20.7		 4v04B-3mvjA:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WBO_C_ANWC601_0
(RHODOPSIN KINASE)		 3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		4 / 6 LEU A  49
ALA A  70
MET A 120
LEU A 173
 XFE  A 351 (-4.2A)
XFE  A 351 (-3.2A)
XFE  A 351 ( 4.0A)
XFE  A 351 (-4.6A)
 0.70A 4wboC-3mvjA:
33.8		 4wboC-3mvjA:
28.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		5 / 12 ALA A  70
LYS A  72
LEU A  95
ASP A 184
PHE A 185
 XFE  A 351 (-3.2A)
None
None
None
None
 0.97A 4xv2B-3mvjA:
22.0		 4xv2B-3mvjA:
27.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BVW_A_1N1A1009_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		8 / 12 LEU A  49
VAL A  57
ALA A  70
LYS A  72
GLU A  91
TYR A 122
GLY A 126
LEU A 173
 XFE  A 351 (-4.2A)
XFE  A 351 ( 4.5A)
XFE  A 351 (-3.2A)
None
None
None
None
XFE  A 351 (-4.6A)
 0.63A 5bvwA-3mvjA:
15.5		 5bvwA-3mvjA:
25.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IZF_E_AZ1E2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
6J9-ZEU-DAR-ACA-DAR-
NH2)		 3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		5 / 7 GLY A  50
GLY A  52
SER A  53
LEU A  74
GLU A 127
 XFE  A 351 ( 4.0A)
None
None
None
XFE  A 351 (-4.2A)
 1.12A 5izfA-3mvjA:
52.2		 5izfA-3mvjA:
94.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IZF_E_AZ1E2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
6J9-ZEU-DAR-ACA-DAR-
NH2)		 3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		5 / 7 GLY A  50
GLY A  52
SER A  53
PHE A  54
GLU A 127
 XFE  A 351 ( 4.0A)
None
None
None
XFE  A 351 (-4.2A)
 1.19A 5izfA-3mvjA:
52.2		 5izfA-3mvjA:
94.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IZF_E_AZ1E2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
6J9-ZEU-DAR-ACA-DAR-
NH2)		 3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		5 / 7 GLY A  50
SER A  53
LYS A  72
LEU A  74
GLU A 127
 XFE  A 351 ( 4.0A)
None
None
None
XFE  A 351 (-4.2A)
 1.13A 5izfA-3mvjA:
52.2		 5izfA-3mvjA:
94.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IZJ_F_AZ1F2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR-DAR)		 3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		5 / 7 GLY A  50
GLY A  52
GLY A  55
VAL A  57
LEU A  74
 XFE  A 351 ( 4.0A)
None
None
XFE  A 351 ( 4.5A)
None
 0.45A 5izjB-3mvjA:
46.1		 5izjB-3mvjA:
94.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IZJ_F_AZ1F2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR-DAR)		 3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		5 / 7 GLY A  50
GLY A  52
SER A  53
GLY A  55
VAL A  57
 XFE  A 351 ( 4.0A)
None
None
None
XFE  A 351 ( 4.5A)
 0.54A 5izjB-3mvjA:
46.1		 5izjB-3mvjA:
94.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IZJ_F_AZ1F2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR-DAR)		 3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		5 / 7 GLY A  50
GLY A  52
SER A  53
PHE A  54
GLY A  55
 XFE  A 351 ( 4.0A)
None
None
None
None
 1.00A 5izjB-3mvjA:
46.1		 5izjB-3mvjA:
94.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IZJ_G_AZ1G2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR)		 3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		5 / 7 GLY A  50
GLY A  52
SER A  53
VAL A  57
LYS A  72
 XFE  A 351 ( 4.0A)
None
None
XFE  A 351 ( 4.5A)
None
 0.69A 5izjA-3mvjA:
47.9		 5izjA-3mvjA:
94.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IZJ_G_AZ1G2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR)		 3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		5 / 7 GLY A  50
GLY A  52
VAL A  57
LYS A  72
LEU A  74
 XFE  A 351 ( 4.0A)
None
XFE  A 351 ( 4.5A)
None
None
 0.48A 5izjA-3mvjA:
47.9		 5izjA-3mvjA:
94.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5J5X_B_AZ1B2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAL-DAR-DAR-
DAR-DAR)		 3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		5 / 7 GLY A  50
GLY A  52
SER A  53
VAL A  57
LYS A  72
 XFE  A 351 ( 4.0A)
None
None
XFE  A 351 ( 4.5A)
None
 0.70A 5j5xA-3mvjA:
53.1		 5j5xA-3mvjA:
94.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5J5X_B_AZ1B2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAL-DAR-DAR-
DAR-DAR)		 3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		4 / 7 GLY A  50
VAL A  57
LYS A  72
ASP A 184
 XFE  A 351 ( 4.0A)
XFE  A 351 ( 4.5A)
None
None
 0.39A 5j5xA-3mvjA:
53.1		 5j5xA-3mvjA:
94.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5LVN_A_ADNA402_1
(3-PHOSPHOINOSITIDE-D
EPENDENT PROTEIN
KINASE 1)		 3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		6 / 11 LEU A  49
GLY A  50
VAL A  57
ALA A  70
VAL A 104
TYR A 122
 XFE  A 351 (-4.2A)
XFE  A 351 ( 4.0A)
XFE  A 351 ( 4.5A)
XFE  A 351 (-3.2A)
None
None
 0.42A 5lvnA-3mvjA:
35.3		 5lvnA-3mvjA:
36.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MAF_A_XINA403_1
(MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE)		 3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		8 / 12 GLY A  50
VAL A  57
ALA A  70
LYS A  72
GLU A  91
TYR A 122
GLY A 126
GLU A 127
 XFE  A 351 ( 4.0A)
XFE  A 351 ( 4.5A)
XFE  A 351 (-3.2A)
None
None
None
None
XFE  A 351 (-4.2A)
 0.87A 5mafA-3mvjA:
29.7		 5mafA-3mvjA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MO4_A_NILA601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		5 / 10 LEU A  49
VAL A  57
LYS A  72
GLU A  91
GLY A 126
 XFE  A 351 (-4.2A)
XFE  A 351 ( 4.5A)
None
None
None
 0.58A 5mo4A-3mvjA:
undetectable		 5mo4A-3mvjA:
22.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5N3H_A_NCAA401_0
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA)		 3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		10 / 10 LEU A  49
VAL A  57
ALA A  70
VAL A 104
MET A 120
TYR A 122
VAL A 123
LEU A 173
THR A 183
PHE A 327
 XFE  A 351 (-4.2A)
XFE  A 351 ( 4.5A)
XFE  A 351 (-3.2A)
None
XFE  A 351 ( 4.0A)
None
XFE  A 351 (-4.2A)
XFE  A 351 (-4.6A)
XFE  A 351 (-3.7A)
XFE  A 351 (-4.4A)
 0.54A 5n3hA-3mvjA:
53.3		 5n3hA-3mvjA:
93.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OWR_A_1N1A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		4 / 8 ALA A  70
GLU A  91
LEU A 173
ASP A 184
 XFE  A 351 (-3.2A)
None
XFE  A 351 (-4.6A)
None
 0.62A 5owrA-3mvjA:
23.0		 5owrA-3mvjA:
27.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE0_A_XINA401_1
(AP2-ASSOCIATED
PROTEIN KINASE 1)		 3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		6 / 12 LEU A  59
ALA A  70
GLU A  91
VAL A 104
GLY A 126
LEU A 173
 None
XFE  A 351 (-3.2A)
None
None
None
XFE  A 351 (-4.6A)
 0.64A 5te0A-3mvjA:
25.5		 5te0A-3mvjA:
25.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCV_A_1N1A404_1
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		5 / 12 LEU A  49
ALA A  70
LYS A  72
GLU A  91
VAL A 104
 XFE  A 351 (-4.2A)
XFE  A 351 (-3.2A)
None
None
None
 0.46A 5vcvA-3mvjA:
24.2		 5vcvA-3mvjA:
28.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W5V_A_ANWA701_0
(SERINE/THREONINE-PRO
TEIN KINASE TBK1)		 3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		6 / 9 LEU A  49
ALA A  70
VAL A 104
MET A 120
GLY A 126
THR A 183
 XFE  A 351 (-4.2A)
XFE  A 351 (-3.2A)
None
XFE  A 351 ( 4.0A)
None
XFE  A 351 (-3.7A)
 0.87A 5w5vA-3mvjA:
13.1		 5w5vA-3mvjA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		7 / 12 LEU A  49
VAL A  57
ALA A  70
LYS A  72
GLU A  91
GLY A 126
LEU A 173
 XFE  A 351 (-4.2A)
XFE  A 351 ( 4.5A)
XFE  A 351 (-3.2A)
None
None
None
XFE  A 351 (-4.6A)
 0.78A 5y7zA-3mvjA:
25.2		 5y7zA-3mvjA:
12.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		7 / 12 LEU A  49
VAL A  57
ALA A  70
LYS A  72
GLU A  91
GLY A 126
LEU A 173
 XFE  A 351 (-4.2A)
XFE  A 351 ( 4.5A)
XFE  A 351 (-3.2A)
None
None
None
XFE  A 351 (-4.6A)
 0.78A 5y7zA-3mvjA:
25.2		 5y7zA-3mvjA:
26.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_B_IREB401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		7 / 12 LEU A  49
ALA A  70
LYS A  72
GLU A  91
GLY A 126
LEU A 173
ASP A 184
 XFE  A 351 (-4.2A)
XFE  A 351 (-3.2A)
None
None
None
XFE  A 351 (-4.6A)
None
 0.69A 5y7zB-3mvjA:
17.7		 5y7zB-3mvjA:
12.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y80_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		8 / 12 LEU A  49
VAL A  57
ALA A  70
LYS A  72
GLU A  91
GLY A 126
LEU A 173
ASP A 184
 XFE  A 351 (-4.2A)
XFE  A 351 ( 4.5A)
XFE  A 351 (-3.2A)
None
None
None
XFE  A 351 (-4.6A)
None
 0.69A 5y80A-3mvjA:
24.0		 5y80A-3mvjA:
12.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		6 / 12 LEU A  49
VAL A  57
ALA A  70
GLU A  91
TYR A 122
GLY A 126
 XFE  A 351 (-4.2A)
XFE  A 351 ( 4.5A)
XFE  A 351 (-3.2A)
None
None
None
 0.44A 5zv2A-3mvjA:
20.5		 5zv2A-3mvjA:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		6 / 12 LEU A  49
VAL A  57
ALA A  70
LYS A  72
GLU A  91
GLY A 126
 XFE  A 351 (-4.2A)
XFE  A 351 ( 4.5A)
XFE  A 351 (-3.2A)
None
None
None
 0.36A 5zv2B-3mvjA:
20.5		 5zv2B-3mvjA:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSD_A_1N1A901_0
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		7 / 12 VAL A  57
ALA A  70
LYS A  72
GLU A  91
TYR A 122
GLY A 126
LEU A 173
 XFE  A 351 ( 4.5A)
XFE  A 351 (-3.2A)
None
None
None
None
XFE  A 351 (-4.6A)
 0.61A 6bsdA-3mvjA:
20.3		 6bsdA-3mvjA:
9.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_B_STIB601_0
(TYROSINE-PROTEIN
KINASE ABL1)		 3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens) 		7 / 12 LEU A  49
VAL A  57
ALA A  70
LYS A  72
GLU A  91
VAL A 104
LEU A 173
 XFE  A 351 (-4.2A)
XFE  A 351 ( 4.5A)
XFE  A 351 (-3.2A)
None
None
None
XFE  A 351 (-4.6A)
 0.86A 6hd6B-3mvjA:
20.3		 6hd6B-3mvjA:
14.53