SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'XDM'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3U5K_A_08JA1_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 5lpk HISTONE
ACETYLTRANSFERASE
P300
(Homo
sapiens) 		4 / 8 PRO A1074
VAL A1079
LEU A1084
ASN A1132
 XDM  A1201 (-3.9A)
XDM  A1201 (-4.7A)
XDM  A1201 ( 4.4A)
XDM  A1201 (-3.1A)
 0.60A 3u5kA-5lpkA:
17.2		 3u5kA-5lpkA:
31.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3U5K_B_08JB2_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 5lpk HISTONE
ACETYLTRANSFERASE
P300
(Homo
sapiens) 		4 / 7 PRO A1074
VAL A1079
LEU A1084
ASN A1132
 XDM  A1201 (-3.9A)
XDM  A1201 (-4.7A)
XDM  A1201 ( 4.4A)
XDM  A1201 (-3.1A)
 0.46A 3u5kB-5lpkA:
17.1		 3u5kB-5lpkA:
31.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3U5K_C_08JC3_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 5lpk HISTONE
ACETYLTRANSFERASE
P300
(Homo
sapiens) 		4 / 8 PRO A1074
VAL A1079
LEU A1084
ASN A1132
 XDM  A1201 (-3.9A)
XDM  A1201 (-4.7A)
XDM  A1201 ( 4.4A)
XDM  A1201 (-3.1A)
 0.65A 3u5kC-5lpkA:
17.1		 3u5kC-5lpkA:
31.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3U5K_D_08JD4_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 5lpk HISTONE
ACETYLTRANSFERASE
P300
(Homo
sapiens) 		4 / 8 PRO A1074
VAL A1079
LEU A1084
ASN A1132
 XDM  A1201 (-3.9A)
XDM  A1201 (-4.7A)
XDM  A1201 ( 4.4A)
XDM  A1201 (-3.1A)
 0.68A 3u5kD-5lpkA:
17.3		 3u5kD-5lpkA:
31.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4A9K_A_TYLA2200_1
(CREB-BINDING PROTEIN)		 5lpk HISTONE
ACETYLTRANSFERASE
P300
(Homo
sapiens) 		6 / 6 VAL A1079
LEU A1084
ILE A1086
TYR A1131
ASN A1132
VAL A1138
 XDM  A1201 (-4.7A)
XDM  A1201 ( 4.4A)
None
XDM  A1201 (-4.4A)
XDM  A1201 (-3.1A)
None
 0.49A 4a9kA-5lpkA:
22.5		 4a9kA-5lpkA:
91.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4A9K_B_TYLB2198_1
(CREB-BINDING PROTEIN)		 5lpk HISTONE
ACETYLTRANSFERASE
P300
(Homo
sapiens) 		5 / 5 VAL A1079
LEU A1084
ILE A1086
ASN A1132
VAL A1138
 XDM  A1201 (-4.7A)
XDM  A1201 ( 4.4A)
None
XDM  A1201 (-3.1A)
None
 0.49A 4a9kB-5lpkA:
22.1		 4a9kB-5lpkA:
91.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4C66_A_H4CA1168_0
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 5lpk HISTONE
ACETYLTRANSFERASE
P300
(Homo
sapiens) 		5 / 9 PRO A1074
GLN A1077
VAL A1079
LEU A1084
ASN A1132
 XDM  A1201 (-3.9A)
None
XDM  A1201 (-4.7A)
XDM  A1201 ( 4.4A)
XDM  A1201 (-3.1A)
 0.49A 4c66A-5lpkA:
17.1		 4c66A-5lpkA:
31.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5PBE_A_TYLA2001_1
(BROMODOMAIN ADJACENT
TO ZINC FINGER
DOMAIN PROTEIN 2B)		 5lpk HISTONE
ACETYLTRANSFERASE
P300
(Homo
sapiens) 		4 / 6 PRO A1074
VAL A1079
TYR A1089
ASN A1132
 XDM  A1201 (-3.9A)
XDM  A1201 (-4.7A)
XDM  A1201 ( 4.7A)
XDM  A1201 (-3.1A)
 0.53A 5pbeA-5lpkA:
17.5		 5pbeA-5lpkA:
27.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5Y1Y_A_HNQA201_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 5lpk HISTONE
ACETYLTRANSFERASE
P300
(Homo
sapiens) 		5 / 8 PRO A1074
VAL A1079
LEU A1084
TYR A1131
ASN A1132
 XDM  A1201 (-3.9A)
XDM  A1201 (-4.7A)
XDM  A1201 ( 4.4A)
XDM  A1201 (-4.4A)
XDM  A1201 (-3.1A)
 0.61A 5y1yA-5lpkA:
17.0		 5y1yA-5lpkA:
31.82