SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'XAX'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EII_A_RTLA135_1
(CELLULAR
RETINOL-BINDING
PROTEIN II)		 2w55 XANTHINE
DEHYDROGENASE
(Rhodobacter
capsulatus) 		4 / 7 GLN B 234
THR B 339
SER B 337
GLN B 197
 None
None
None
XAX  B1778 (-3.5A)
 1.32A 1eiiA-2w55B:
undetectable		 1eiiA-2w55B:
10.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FO4_B_SALB4005_1
(XANTHINE
DEHYDROGENASE)		 2w55 XANTHINE
DEHYDROGENASE
(Rhodobacter
capsulatus) 		4 / 7 ARG B 310
PHE B 344
THR B 460
ALA B 528
 HPA  B1780 (-3.4A)
HPA  B1780 (-3.4A)
HPA  B1780 (-3.6A)
XAX  B1778 ( 3.2A)
 0.33A 1fo4B-2w55B:
35.1		 1fo4B-2w55B:
26.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG3_A_ADNA500_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 2w55 XANTHINE
DEHYDROGENASE
(Rhodobacter
capsulatus) 		5 / 11 GLY B 489
GLY B 491
GLU B 487
ARG B 223
GLY B 225
 XAX  B1778 (-3.4A)
None
None
None
None
 1.03A 1jg3A-2w55B:
undetectable		 1jg3A-2w55B:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG3_B_ADNB550_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 2w55 XANTHINE
DEHYDROGENASE
(Rhodobacter
capsulatus) 		5 / 11 GLY B 489
GLY B 491
GLU B 487
ARG B 223
GLY B 225
 XAX  B1778 (-3.4A)
None
None
None
None
 1.01A 1jg3B-2w55B:
undetectable		 1jg3B-2w55B:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N5X_A_TEIA3006_1
(XANTHINE
DEHYDROGENASE)		 2w55 XANTHINE
DEHYDROGENASE
(Rhodobacter
capsulatus) 		6 / 12 LEU B 303
ARG B 310
PHE B 344
THR B 460
ALA B 528
ALA B 529
 None
HPA  B1780 (-3.4A)
HPA  B1780 (-3.4A)
HPA  B1780 (-3.6A)
XAX  B1778 ( 3.2A)
HPA  B1780 ( 3.2A)
 0.34A 1n5xA-2w55B:
55.7		 1n5xA-2w55B:
26.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N5X_B_TEIB4006_1
(XANTHINE
DEHYDROGENASE)		 2w55 XANTHINE
DEHYDROGENASE
(Rhodobacter
capsulatus) 		6 / 12 LEU B 303
ARG B 310
PHE B 344
THR B 460
ALA B 528
ALA B 529
 None
HPA  B1780 (-3.4A)
HPA  B1780 (-3.4A)
HPA  B1780 (-3.6A)
XAX  B1778 ( 3.2A)
HPA  B1780 ( 3.2A)
 0.34A 1n5xB-2w55B:
55.8		 1n5xB-2w55B:
26.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WYG_A_SALA4005_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 2w55 XANTHINE
DEHYDROGENASE
(Rhodobacter
capsulatus) 		8 / 10 LEU B 303
ARG B 310
PHE B 344
PHE B 459
THR B 460
ALA B 528
ALA B 529
GLU B 730
 None
HPA  B1780 (-3.4A)
HPA  B1780 (-3.4A)
HPA  B1780 (-4.8A)
HPA  B1780 (-3.6A)
XAX  B1778 ( 3.2A)
HPA  B1780 ( 3.2A)
XAX  B1778 (-3.3A)
 0.51A 1wygA-2w55B:
48.4		 1wygA-2w55B:
26.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WYG_A_SALA4005_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 2w55 XANTHINE
DEHYDROGENASE
(Rhodobacter
capsulatus) 		5 / 10 LEU B 303
PHE B 344
PHE B 459
ALA B 528
GLU B 730
 None
HPA  B1780 (-3.4A)
HPA  B1780 (-4.8A)
XAX  B1778 ( 3.2A)
XAX  B1778 (-3.3A)
 1.48A 1wygA-2w55B:
48.4		 1wygA-2w55B:
26.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_P_ASDP1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 2w55 XANTHINE
DEHYDROGENASE
(Rhodobacter
capsulatus) 		4 / 8 LEU B 464
LEU B 461
ALA B 529
ALA B 340
 None
None
HPA  B1780 ( 3.2A)
XAX  B1778 ( 4.1A)
 0.80A 2vcvP-2w55B:
undetectable		 2vcvP-2w55B:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_A_2FAA500_2
(ADENOSYLHOMOCYSTEINA
SE)		 2w55 XANTHINE
DEHYDROGENASE
(Rhodobacter
capsulatus) 		4 / 5 GLN B 232
THR B 516
HIS B 483
LEU B 492
 HPA  B1780 ( 3.1A)
None
None
XAX  B1778 (-3.9A)
 1.24A 2zj0A-2w55B:
undetectable		 2zj0A-2w55B:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AX7_B_SALB1336_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 2w55 XANTHINE
DEHYDROGENASE
(Rhodobacter
capsulatus) 		6 / 9 ARG B 310
PHE B 344
THR B 460
LEU B 464
ALA B 528
ALA B 529
 HPA  B1780 (-3.4A)
HPA  B1780 (-3.4A)
HPA  B1780 (-3.6A)
None
XAX  B1778 ( 3.2A)
HPA  B1780 ( 3.2A)
 0.41A 3ax7B-2w55B:
51.4		 3ax7B-2w55B:
26.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AX9_B_SALB1340_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 2w55 XANTHINE
DEHYDROGENASE
(Rhodobacter
capsulatus) 		6 / 8 LEU B 303
ARG B 310
PHE B 344
THR B 460
ALA B 528
ALA B 529
 None
HPA  B1780 (-3.4A)
HPA  B1780 (-3.4A)
HPA  B1780 (-3.6A)
XAX  B1778 ( 3.2A)
HPA  B1780 ( 3.2A)
 0.29A 3ax9B-2w55B:
56.5		 3ax9B-2w55B:
26.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DHIC8_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 2w55 XANTHINE
DEHYDROGENASE
(Rhodobacter
capsulatus) 		3 / 3 SER B 195
GLY B 225
GLY B 227
 None
None
XAX  B1778 (-3.3A)
 0.53A 3bogA-2w55B:
undetectable
3bogC-2w55B:
undetectable		 3bogA-2w55B:
undetectable
3bogC-2w55B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_A_ADNA500_2
(ADENOSYLHOMOCYSTEINA
SE)		 2w55 XANTHINE
DEHYDROGENASE
(Rhodobacter
capsulatus) 		4 / 5 GLN B 232
THR B 516
HIS B 483
LEU B 492
 HPA  B1780 ( 3.1A)
None
None
XAX  B1778 (-3.9A)
 1.24A 3ce6A-2w55B:
undetectable		 3ce6A-2w55B:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_C_ADNC500_2
(ADENOSYLHOMOCYSTEINA
SE)		 2w55 XANTHINE
DEHYDROGENASE
(Rhodobacter
capsulatus) 		4 / 5 GLN B 232
THR B 516
HIS B 483
LEU B 492
 HPA  B1780 ( 3.1A)
None
None
XAX  B1778 (-3.9A)
 1.24A 3ce6C-2w55B:
undetectable		 3ce6C-2w55B:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_1
(CYTOCHROME P450 2R1)		 2w55 XANTHINE
DEHYDROGENASE
(Rhodobacter
capsulatus) 		5 / 12 THR B 527
VAL B 540
ALA B 469
VAL B 511
ILE B 513
 XAX  B1778 ( 4.9A)
None
None
None
None
 0.98A 3czhA-2w55B:
undetectable		 3czhA-2w55B:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DL9_A_V2HA602_0
(CYTOCHROME P450 2R1)		 2w55 XANTHINE
DEHYDROGENASE
(Rhodobacter
capsulatus) 		5 / 12 THR B 527
VAL B 540
ALA B 469
VAL B 511
ILE B 513
 XAX  B1778 ( 4.9A)
None
None
None
None
 0.99A 3dl9A-2w55B:
undetectable		 3dl9A-2w55B:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KKZ_A_SAMA301_0
(UNCHARACTERIZED
PROTEIN Q5LES9)		 2w55 XANTHINE
DEHYDROGENASE
(Rhodobacter
capsulatus) 		5 / 12 GLN B 197
GLY B 225
GLY B 227
LEU B 176
GLU B 487
 XAX  B1778 (-3.5A)
None
XAX  B1778 (-3.3A)
None
None
 1.07A 3kkzA-2w55B:
undetectable		 3kkzA-2w55B:
15.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3NS1_C_PM6C1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 2w55 XANTHINE
DEHYDROGENASE
(Rhodobacter
capsulatus) 		5 / 6 ARG B 310
PHE B 344
THR B 460
ALA B 528
ALA B 529
 HPA  B1780 (-3.4A)
HPA  B1780 (-3.4A)
HPA  B1780 (-3.6A)
XAX  B1778 ( 3.2A)
HPA  B1780 ( 3.2A)
 0.44A 3ns1C-2w55B:
55.5		 3ns1C-2w55B:
40.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 2w55 XANTHINE
DEHYDROGENASE
(Rhodobacter
capsulatus) 		6 / 8 ARG B 310
PHE B 344
THR B 460
LEU B 464
ALA B 528
ALA B 529
 HPA  B1780 (-3.4A)
HPA  B1780 (-3.4A)
HPA  B1780 (-3.6A)
None
XAX  B1778 ( 3.2A)
HPA  B1780 ( 3.2A)
 0.42A 3ns1L-2w55B:
48.9		 3ns1L-2w55B:
40.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QPK_A_CUA601_0
(LACCASE-1)		 2w55 XANTHINE
DEHYDROGENASE
(Rhodobacter
capsulatus) 		4 / 5 HIS B 483
ILE B 513
HIS B 493
LEU B 492
 None
None
None
XAX  B1778 (-3.9A)
 1.23A 3qpkA-2w55B:
undetectable		 3qpkA-2w55B:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_A_SAMA301_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 2w55 XANTHINE
DEHYDROGENASE
(Rhodobacter
capsulatus) 		3 / 3 SER B 530
ASP B 660
ASP B 714
 XAX  B1778 (-4.9A)
None
None
 0.90A 3uj7A-2w55B:
undetectable		 3uj7A-2w55B:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X2T_I_PEMI202_1
(HEMOGLOBIN SUBUNIT
ALPHA
HEMOGLOBIN SUBUNIT
BETA)		 2w55 XANTHINE
DEHYDROGENASE
(Rhodobacter
capsulatus) 		4 / 8 PRO B 306
THR B 460
TRP B 674
ALA B 528
 HPA  B1780 (-4.8A)
HPA  B1780 (-3.6A)
None
XAX  B1778 ( 3.2A)
 1.01A 5x2tI-2w55B:
undetectable
5x2tJ-2w55B:
undetectable
5x2tK-2w55B:
undetectable
5x2tL-2w55B:
undetectable		 5x2tI-2w55B:
11.04
5x2tJ-2w55B:
10.86
5x2tK-2w55B:
11.04
5x2tL-2w55B:
10.86