SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'XA2'
DrReposER ID / Desc. | Hit PDBID |
Hit Macromolecule |
Res. Matches |
Interface | HETATM | RMSD | Dali Z-score |
Seq. Identity (%) |
View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1V8B_A_ADNA502_1 (ADENOSYLHOMOCYSTEINASE) |
4q3r | ARGINASE (Schistosomamansoni) | 5 / 12 | HIS A 156ASP A 264THR A 274GLY A 172HIS A 171 | MN A 402 ( 3.3A) MN A 402 ( 2.1A)NoneXA2 A 407 ( 3.8A)XA2 A 407 (-3.2A) | 1.37A | 1v8bA-4q3rA:2.5 | 1v8bA-4q3rA:22.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1V8B_B_ADNB1502_1 (ADENOSYLHOMOCYSTEINASE) |
4q3r | ARGINASE (Schistosomamansoni) | 5 / 12 | HIS A 156ASP A 264THR A 274GLY A 172HIS A 171 | MN A 402 ( 3.3A) MN A 402 ( 2.1A)NoneXA2 A 407 ( 3.8A)XA2 A 407 (-3.2A) | 1.37A | 1v8bB-4q3rA:2.3 | 1v8bB-4q3rA:22.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1V8B_D_ADND3502_1 (ADENOSYLHOMOCYSTEINASE) |
4q3r | ARGINASE (Schistosomamansoni) | 5 / 12 | HIS A 156ASP A 264THR A 274GLY A 172HIS A 171 | MN A 402 ( 3.3A) MN A 402 ( 2.1A)NoneXA2 A 407 ( 3.8A)XA2 A 407 (-3.2A) | 1.36A | 1v8bD-4q3rA:undetectable | 1v8bD-4q3rA:22.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2CML_D_ZMRD4478_1 (NEURAMINIDASE) |
4q3r | ARGINASE (Schistosomamansoni) | 4 / 8 | SER A 167SER A 165ASN A 160LYS A 86 | XA2 A 407 (-2.7A)XA2 A 407 ( 4.4A)XA2 A 407 (-4.2A)None | 1.10A | 2cmlD-4q3rA:undetectable | 2cmlD-4q3rA:20.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2DU8_B_BEZB1352_0 (D-AMINO-ACID OXIDASE) |
4q3r | ARGINASE (Schistosomamansoni) | 4 / 6 | LEU A 209TYR A 206ILE A 220GLY A 172 | NoneNoneNoneXA2 A 407 ( 3.8A) | 0.89A | 2du8B-4q3rA:2.4 | 2du8B-4q3rA:22.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3C0Z_A_SHHA301_1 (HISTONE DEACETYLASE7A) |
4q3r | ARGINASE (Schistosomamansoni) | 4 / 5 | HIS A 171ASP A 158HIS A 156ASP A 154 | XA2 A 407 (-3.2A) MN A 401 ( 2.5A) MN A 402 ( 3.3A) MN A 401 (-2.6A) | 1.22A | 3c0zA-4q3rA:13.5 | 3c0zA-4q3rA:23.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3CE6_D_ADND500_1 (ADENOSYLHOMOCYSTEINASE) |
4q3r | ARGINASE (Schistosomamansoni) | 5 / 12 | HIS A 156ASP A 264THR A 274GLY A 172HIS A 171 | MN A 402 ( 3.3A) MN A 402 ( 2.1A)NoneXA2 A 407 ( 3.8A)XA2 A 407 (-3.2A) | 1.36A | 3ce6D-4q3rA:2.7 | 3ce6D-4q3rA:22.62 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3GN0_A_DMOA551_1 (ARGINASE-1) |
4q3r | ARGINASE (Schistosomamansoni) | 9 / 9 | HIS A 156ASP A 158ASN A 160SER A 167HIS A 171GLY A 172ASP A 213GLU A 216THR A 276 | MN A 402 ( 3.3A) MN A 401 ( 2.5A)XA2 A 407 (-4.2A)XA2 A 407 (-2.7A)XA2 A 407 (-3.2A)XA2 A 407 ( 3.8A)XA2 A 407 (-3.1A)XA2 A 407 ( 4.3A)XA2 A 407 (-3.6A) | 0.32A | 3gn0A-4q3rA:49.5 | 3gn0A-4q3rA:39.74 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3GN0_B_DMOB552_1 (ARGINASE-1) |
4q3r | ARGINASE (Schistosomamansoni) | 9 / 9 | HIS A 156ASP A 158ASN A 160SER A 167HIS A 171GLY A 172ASP A 213GLU A 216THR A 276 | MN A 402 ( 3.3A) MN A 401 ( 2.5A)XA2 A 407 (-4.2A)XA2 A 407 (-2.7A)XA2 A 407 (-3.2A)XA2 A 407 ( 3.8A)XA2 A 407 (-3.1A)XA2 A 407 ( 4.3A)XA2 A 407 (-3.6A) | 0.35A | 3gn0B-4q3rA:49.4 | 3gn0B-4q3rA:39.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3IV6_D_SAMD301_0 (PUTATIVEZN-DEPENDENT ALCOHOLDEHYDROGENASE) |
4q3r | ARGINASE (Schistosomamansoni) | 5 / 12 | GLY A 157SER A 176ILE A 220ASP A 211LEU A 212 | NoneNoneNoneXA2 A 407 (-3.8A)None | 1.07A | 3iv6D-4q3rA:3.8 | 3iv6D-4q3rA:22.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3N58_C_ADNC500_1 (ADENOSYLHOMOCYSTEINASE) |
4q3r | ARGINASE (Schistosomamansoni) | 5 / 12 | HIS A 156ASP A 264THR A 274GLY A 172HIS A 171 | MN A 402 ( 3.3A) MN A 402 ( 2.1A)NoneXA2 A 407 ( 3.8A)XA2 A 407 (-3.2A) | 1.36A | 3n58C-4q3rA:2.2 | 3n58C-4q3rA:24.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3OND_A_ADNA506_1 (ADENOSYLHOMOCYSTEINASE) |
4q3r | ARGINASE (Schistosomamansoni) | 5 / 12 | HIS A 156ASP A 264THR A 274GLY A 172HIS A 171 | MN A 402 ( 3.3A) MN A 402 ( 2.1A)NoneXA2 A 407 ( 3.8A)XA2 A 407 (-3.2A) | 1.38A | 3ondA-4q3rA:undetectable | 3ondA-4q3rA:23.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3OND_B_ADNB507_1 (ADENOSYLHOMOCYSTEINASE) |
4q3r | ARGINASE (Schistosomamansoni) | 5 / 12 | HIS A 156ASP A 264THR A 274GLY A 172HIS A 171 | MN A 402 ( 3.3A) MN A 402 ( 2.1A)NoneXA2 A 407 ( 3.8A)XA2 A 407 (-3.2A) | 1.38A | 3ondB-4q3rA:undetectable | 3ondB-4q3rA:23.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4TVT_A_ASCA301_0 (THAUMATIN-1) |
4q3r | ARGINASE (Schistosomamansoni) | 3 / 3 | THR A 161ASN A 164SER A 165 | NoneNoneXA2 A 407 ( 4.4A) | 0.70A | 4tvtA-4q3rA:undetectable | 4tvtA-4q3rA:18.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5AXD_A_RBVA502_1 (ADENOSYLHOMOCYSTEINASE) |
4q3r | ARGINASE (Schistosomamansoni) | 5 / 12 | HIS A 156ASP A 264THR A 274GLY A 172HIS A 171 | MN A 402 ( 3.3A) MN A 402 ( 2.1A)NoneXA2 A 407 ( 3.8A)XA2 A 407 (-3.2A) | 1.38A | 5axdA-4q3rA:2.2 | 5axdA-4q3rA:22.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5AXD_C_RBVC502_1 (ADENOSYLHOMOCYSTEINASE) |
4q3r | ARGINASE (Schistosomamansoni) | 5 / 12 | HIS A 156ASP A 264THR A 274GLY A 172HIS A 171 | MN A 402 ( 3.3A) MN A 402 ( 2.1A)NoneXA2 A 407 ( 3.8A)XA2 A 407 (-3.2A) | 1.38A | 5axdC-4q3rA:2.3 | 5axdC-4q3rA:22.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5IGI_A_ZITA402_1 (MACROLIDE2'-PHOSPHOTRANSFERASE) |
4q3r | ARGINASE (Schistosomamansoni) | 5 / 12 | ILE A 290ASP A 158ALA A 306GLY A 275THR A 276 | None MN A 401 ( 2.5A)NoneNoneXA2 A 407 (-3.6A) | 1.10A | 5igiA-4q3rA:undetectable | 5igiA-4q3rA:22.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5M5K_B_ADNB502_1 (ADENOSYLHOMOCYSTEINASE) |
4q3r | ARGINASE (Schistosomamansoni) | 5 / 12 | HIS A 156ASP A 264THR A 274GLY A 172HIS A 171 | MN A 402 ( 3.3A) MN A 402 ( 2.1A)NoneXA2 A 407 ( 3.8A)XA2 A 407 (-3.2A) | 1.33A | 5m5kB-4q3rA:undetectable | 5m5kB-4q3rA:21.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5M66_A_ADNA502_1 (ADENOSYLHOMOCYSTEINASE) |
4q3r | ARGINASE (Schistosomamansoni) | 5 / 12 | HIS A 156ASP A 264THR A 274GLY A 172HIS A 171 | MN A 402 ( 3.3A) MN A 402 ( 2.1A)NoneXA2 A 407 ( 3.8A)XA2 A 407 (-3.2A) | 1.38A | 5m66A-4q3rA:undetectable | 5m66A-4q3rA:21.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5M66_C_ADNC502_1 (ADENOSYLHOMOCYSTEINASE) |
4q3r | ARGINASE (Schistosomamansoni) | 5 / 12 | HIS A 156ASP A 264THR A 274GLY A 172HIS A 171 | MN A 402 ( 3.3A) MN A 402 ( 2.1A)NoneXA2 A 407 ( 3.8A)XA2 A 407 (-3.2A) | 1.36A | 5m66C-4q3rA:2.7 | 5m66C-4q3rA:21.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5UTU_F_ADNF503_1 (ADENOSYLHOMOCYSTEINASE) |
4q3r | ARGINASE (Schistosomamansoni) | 5 / 12 | HIS A 156ASP A 264THR A 274GLY A 172HIS A 171 | MN A 402 ( 3.3A) MN A 402 ( 2.1A)NoneXA2 A 407 ( 3.8A)XA2 A 407 (-3.2A) | 1.37A | 5utuF-4q3rA:undetectable | 5utuF-4q3rA:23.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6F3N_B_ADNB505_1 (-) |
4q3r | ARGINASE (Schistosomamansoni) | 5 / 12 | HIS A 156ASP A 264THR A 274GLY A 172HIS A 171 | MN A 402 ( 3.3A) MN A 402 ( 2.1A)NoneXA2 A 407 ( 3.8A)XA2 A 407 (-3.2A) | 1.34A | 6f3nB-4q3rA:2.1 | 6f3nB-4q3rA:20.78 |