SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'X9X'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_A_ASDA1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 4wt7 ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (RIBOSE)
(Agrobacterium
vitis) 		4 / 7 ALA A 299
LEU A 295
ALA A  67
PHE A  63
 None
None
None
X9X  A 401 (-3.5A)
 1.00A 2vcvA-4wt7A:
undetectable		 2vcvA-4wt7A:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_G_ASDG1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 4wt7 ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (RIBOSE)
(Agrobacterium
vitis) 		4 / 7 ALA A 299
LEU A 295
ALA A  67
PHE A  63
 None
None
None
X9X  A 401 (-3.5A)
 0.99A 2vcvG-4wt7A:
3.0		 2vcvG-4wt7A:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_L_ASDL1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 4wt7 ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (RIBOSE)
(Agrobacterium
vitis) 		4 / 7 ALA A 299
LEU A 295
ALA A  67
PHE A  63
 None
None
None
X9X  A 401 (-3.5A)
 0.91A 2vcvL-4wt7A:
3.0		 2vcvL-4wt7A:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UY4_A_PAUA302_0
(PANTOTHENATE
SYNTHETASE)		 4wt7 ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (RIBOSE)
(Agrobacterium
vitis) 		4 / 8 GLN A 247
VAL A 273
VAL A 277
ASP A 268
 None
None
None
X9X  A 401 (-2.7A)
 1.08A 3uy4A-4wt7A:
undetectable		 3uy4A-4wt7A:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJF_B_C2FB300_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 4wt7 ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (RIBOSE)
(Agrobacterium
vitis) 		5 / 12 ASP A 137
ASN A 151
ILE A 186
GLY A 139
SER A 143
 X9X  A 401 (-3.0A)
None
None
None
None
 1.50A 4djfB-4wt7A:
undetectable		 4djfB-4wt7A:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_C_SAMC902_0
(MRNA CAPPING ENZYME
P5)		 4wt7 ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (RIBOSE)
(Agrobacterium
vitis) 		5 / 12 LEU A  98
GLY A 114
PRO A 183
PHE A 178
THR A 115
 None
None
None
X9X  A 401 ( 4.6A)
None
 1.33A 5x6yC-4wt7A:
2.7		 5x6yC-4wt7A:
16.89