SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'X8A'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 4hxq ARGINASE-1
(Homo
sapiens) 		5 / 12 HIS A 126
ASP A 234
THR A 244
GLY A 142
HIS A 141
 MN  A 902 ( 3.4A)
MN  A 902 ( 2.0A)
None
X8A  A 901 ( 3.7A)
X8A  A 901 (-3.4A)
 1.35A 1v8bA-4hxqA:
2.1		 1v8bA-4hxqA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_B_ADNB1502_1
(ADENOSYLHOMOCYSTEINA
SE)		 4hxq ARGINASE-1
(Homo
sapiens) 		5 / 12 HIS A 126
ASP A 234
THR A 244
GLY A 142
HIS A 141
 MN  A 902 ( 3.4A)
MN  A 902 ( 2.0A)
None
X8A  A 901 ( 3.7A)
X8A  A 901 (-3.4A)
 1.35A 1v8bB-4hxqA:
2.0		 1v8bB-4hxqA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_D_ADND3502_1
(ADENOSYLHOMOCYSTEINA
SE)		 4hxq ARGINASE-1
(Homo
sapiens) 		5 / 12 HIS A 126
ASP A 234
THR A 244
GLY A 142
HIS A 141
 MN  A 902 ( 3.4A)
MN  A 902 ( 2.0A)
None
X8A  A 901 ( 3.7A)
X8A  A 901 (-3.4A)
 1.33A 1v8bD-4hxqA:
undetectable		 1v8bD-4hxqA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUL_A_SAMA376_1
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 4hxq ARGINASE-1
(Homo
sapiens) 		3 / 3 SER A 137
GLU A 277
ASP A 274
 X8A  A 901 (-2.5A)
X8A  A 901 (-4.0A)
None
 0.81A 2zulA-4hxqA:
undetectable		 2zulA-4hxqA:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_D_ADND500_1
(ADENOSYLHOMOCYSTEINA
SE)		 4hxq ARGINASE-1
(Homo
sapiens) 		5 / 12 HIS A 126
ASP A 234
THR A 244
GLY A 142
HIS A 141
 MN  A 902 ( 3.4A)
MN  A 902 ( 2.0A)
None
X8A  A 901 ( 3.7A)
X8A  A 901 (-3.4A)
 1.34A 3ce6D-4hxqA:
undetectable		 3ce6D-4hxqA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DMH_A_SAMA384_1
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 4hxq ARGINASE-1
(Homo
sapiens) 		3 / 3 SER A 137
GLU A 277
ASP A 274
 X8A  A 901 (-2.5A)
X8A  A 901 (-4.0A)
None
 0.78A 3dmhA-4hxqA:
undetectable		 3dmhA-4hxqA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL5_B_1UNB201_2
(PROTEASE)		 4hxq ARGINASE-1
(Homo
sapiens) 		5 / 12 ASP A 274
VAL A 233
GLY A  99
THR A 244
THR A 246
 None
None
None
None
X8A  A 901 (-3.5A)
 0.88A 3el5B-4hxqA:
undetectable		 3el5B-4hxqA:
18.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GN0_A_DMOA551_1
(ARGINASE-1)		 4hxq ARGINASE-1
(Homo
sapiens) 		9 / 9 HIS A 126
ASP A 128
ASN A 130
SER A 137
HIS A 141
GLY A 142
ASP A 183
GLU A 186
THR A 246
 MN  A 902 ( 3.4A)
MN  A 903 ( 2.6A)
X8A  A 901 (-4.4A)
X8A  A 901 (-2.5A)
X8A  A 901 (-3.4A)
X8A  A 901 ( 3.7A)
X8A  A 901 (-3.0A)
X8A  A 901 ( 4.3A)
X8A  A 901 (-3.5A)
 0.21A 3gn0A-4hxqA:
58.5		 3gn0A-4hxqA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GN0_B_DMOB552_1
(ARGINASE-1)		 4hxq ARGINASE-1
(Homo
sapiens) 		9 / 9 HIS A 126
ASP A 128
ASN A 130
SER A 137
HIS A 141
GLY A 142
ASP A 183
GLU A 186
THR A 246
 MN  A 902 ( 3.4A)
MN  A 903 ( 2.6A)
X8A  A 901 (-4.4A)
X8A  A 901 (-2.5A)
X8A  A 901 (-3.4A)
X8A  A 901 ( 3.7A)
X8A  A 901 (-3.0A)
X8A  A 901 ( 4.3A)
X8A  A 901 (-3.5A)
 0.19A 3gn0B-4hxqA:
58.0		 3gn0B-4hxqA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OND_A_ADNA506_1
(ADENOSYLHOMOCYSTEINA
SE)		 4hxq ARGINASE-1
(Homo
sapiens) 		5 / 12 HIS A 126
ASP A 234
THR A 244
GLY A 142
HIS A 141
 MN  A 902 ( 3.4A)
MN  A 902 ( 2.0A)
None
X8A  A 901 ( 3.7A)
X8A  A 901 (-3.4A)
 1.36A 3ondA-4hxqA:
undetectable		 3ondA-4hxqA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OND_B_ADNB507_1
(ADENOSYLHOMOCYSTEINA
SE)		 4hxq ARGINASE-1
(Homo
sapiens) 		5 / 12 HIS A 126
ASP A 234
THR A 244
GLY A 142
HIS A 141
 MN  A 902 ( 3.4A)
MN  A 902 ( 2.0A)
None
X8A  A 901 ( 3.7A)
X8A  A 901 (-3.4A)
 1.35A 3ondB-4hxqA:
2.6		 3ondB-4hxqA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_J_KANJ301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4hxq ARGINASE-1
(Homo
sapiens) 		4 / 6 ASP A 183
ASP A 232
ASP A 128
GLU A 186
 X8A  A 901 (-3.0A)
MN  A 902 (-3.0A)
MN  A 903 ( 2.6A)
X8A  A 901 ( 4.3A)
 1.31A 4gkhJ-4hxqA:
undetectable		 4gkhJ-4hxqA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5K_B_ADNB502_1
(ADENOSYLHOMOCYSTEINA
SE)		 4hxq ARGINASE-1
(Homo
sapiens) 		5 / 12 HIS A 126
ASP A 234
THR A 244
GLY A 142
HIS A 141
 MN  A 902 ( 3.4A)
MN  A 902 ( 2.0A)
None
X8A  A 901 ( 3.7A)
X8A  A 901 (-3.4A)
 1.32A 5m5kB-4hxqA:
undetectable		 5m5kB-4hxqA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M66_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 4hxq ARGINASE-1
(Homo
sapiens) 		5 / 12 HIS A 126
ASP A 234
THR A 244
GLY A 142
HIS A 141
 MN  A 902 ( 3.4A)
MN  A 902 ( 2.0A)
None
X8A  A 901 ( 3.7A)
X8A  A 901 (-3.4A)
 1.37A 5m66A-4hxqA:
undetectable		 5m66A-4hxqA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M66_C_ADNC502_1
(ADENOSYLHOMOCYSTEINA
SE)		 4hxq ARGINASE-1
(Homo
sapiens) 		5 / 12 HIS A 126
ASP A 234
THR A 244
GLY A 142
HIS A 141
 MN  A 902 ( 3.4A)
MN  A 902 ( 2.0A)
None
X8A  A 901 ( 3.7A)
X8A  A 901 (-3.4A)
 1.35A 5m66C-4hxqA:
2.2		 5m66C-4hxqA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UTU_F_ADNF503_1
(ADENOSYLHOMOCYSTEINA
SE)		 4hxq ARGINASE-1
(Homo
sapiens) 		5 / 12 HIS A 126
ASP A 234
THR A 244
GLY A 142
HIS A 141
 MN  A 902 ( 3.4A)
MN  A 902 ( 2.0A)
None
X8A  A 901 ( 3.7A)
X8A  A 901 (-3.4A)
 1.34A 5utuF-4hxqA:
undetectable		 5utuF-4hxqA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIO_B_HFGB802_0
(PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE))		 4hxq ARGINASE-1
(Homo
sapiens) 		5 / 12 PRO A 247
THR A 246
GLU A 277
HIS A 141
THR A 127
 None
X8A  A 901 (-3.5A)
X8A  A 901 (-4.0A)
X8A  A 901 (-3.4A)
None
 1.32A 5xioB-4hxqA:
undetectable		 5xioB-4hxqA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3N_B_ADNB505_1
(-)		 4hxq ARGINASE-1
(Homo
sapiens) 		5 / 12 HIS A 126
ASP A 234
THR A 244
GLY A 142
HIS A 141
 MN  A 902 ( 3.4A)
MN  A 902 ( 2.0A)
None
X8A  A 901 ( 3.7A)
X8A  A 901 (-3.4A)
 1.32A 6f3nB-4hxqA:
2.5		 6f3nB-4hxqA:
21.21