SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'X6K'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2PGZ_D_COCD401_1 (SOLUBLE ACETYLCHOLINE RECEPTOR)	2x6k	PHOSPHOTIDYLINOSITOL 3 KINASE 59F (Drosophila melanogaster)	4 / 6	TYR A 794 TYR A 732 GLN A 705 ILE A 709	None X6K A1951 ( 4.3A) None None	1.44A	2pgzD-2x6kA: undetectable 2pgzE-2x6kA: undetectable	2pgzD-2x6kA: 14.51 2pgzE-2x6kA: 14.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3ELZ_B_CHDB153_0 (ILEAL BILE ACID-BINDING PROTEIN)	2x6k	PHOSPHOTIDYLINOSITOL 3 KINASE 59F (Drosophila melanogaster)	4 / 6	THR A 814 LYS A 818 PHE A 820 TYR A 746	None None None X6K A1951 ( 4.6A)	0.92A	3elzB-2x6kA: undetectable	3elzB-2x6kA: 10.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4XE0_A_40LA1101_0 (PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM)	2x6k	PHOSPHOTIDYLINOSITOL 3 KINASE 59F (Drosophila melanogaster)	6 / 12	PRO A 679 ILE A 696 TYR A 732 VAL A 747 THR A 751 ILE A 822	None None X6K A1951 ( 4.3A) X6K A1951 (-4.1A) None X6K A1951 (-4.1A)	0.56A	4xe0A-2x6kA: 28.5	4xe0A-2x6kA: 26.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4ZE1_A_X2NA602_1 (LANOSTEROL 14-ALPHA DEMETHYLASE)	2x6k	PHOSPHOTIDYLINOSITOL 3 KINASE 59F (Drosophila melanogaster)	5 / 12	TYR A 732 LEU A 801 LEU A 708 PHE A 824 MET A 712	X6K A1951 ( 4.3A) None None None None	1.25A	4ze1A-2x6kA: undetectable	4ze1A-2x6kA: 21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6C2M_D_SUED1202_1 (NS3 PROTEASE)	2x6k	PHOSPHOTIDYLINOSITOL 3 KINASE 59F (Drosophila melanogaster)	4 / 9	PHE A 743 HIS A 699 LEU A 710 ASP A 823	None None None X6K A1951 (-3.5A)	0.96A	6c2mD-2x6kA: undetectable	6c2mD-2x6kA: 8.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6MKE_C_FK5C201_0 (PEPTIDYLPROLYL ISOMERASE)	2x6k	PHOSPHOTIDYLINOSITOL 3 KINASE 59F (Drosophila melanogaster)	4 / 4	ASP A 706 ILE A 713 PRO A 731 LEU A 710	X6K A1951 (-3.4A) None None None	1.44A	6mkeB-2x6kA: undetectable	6mkeB-2x6kA: 8.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6MKE_D_FK5D201_0 (PEPTIDYLPROLYL ISOMERASE)	2x6k	PHOSPHOTIDYLINOSITOL 3 KINASE 59F (Drosophila melanogaster)	4 / 4	ASP A 706 ILE A 713 PRO A 731 LEU A 710	X6K A1951 (-3.4A) None None None	1.40A	6mkeA-2x6kA: undetectable	6mkeA-2x6kA: 8.30

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2PGZ_D_COCD401_1","SOLUBLE ACETYLCHOLINE RECEPTOR;SOLUBLE ACETYLCHOLINE RECEPTOR","2x6k","PHOSPHOTIDYLINOSITOL 3 KINASE 59F","Drosophila melanogaster",4,"TYR A 794;TYR A 732;GLN A 705;ILE A 709","None;X6K A1951 ( 4.3A);None;None","1.44A","2pgzD-2x6kA:undetectable;2pgzE-2x6kA:undetectable",null],["3ELZ_B_CHDB153_0","ILEAL BILE ACID-BINDING PROTEIN","2x6k","PHOSPHOTIDYLINOSITOL 3 KINASE 59F","Drosophila melanogaster",4,"THR A 814;LYS A 818;PHE A 820;TYR A 746","None;None;None;X6K A1951 ( 4.6A)","0.92A","3elzB-2x6kA:undetectable","2pgzD-2x6kA:14.51;2pgzE-2x6kA:14.51"],["4XE0_A_40LA1101_0","PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM","2x6k","PHOSPHOTIDYLINOSITOL 3 KINASE 59F","Drosophila melanogaster",6,"PRO A 679;ILE A 696;TYR A 732;VAL A 747;THR A 751;ILE A 822","None;None;X6K A1951 ( 4.3A);X6K A1951 (-4.1A);None;X6K A1951 (-4.1A)","0.56A","4xe0A-2x6kA:28.5","3elzB-2x6kA:10.74"],["4ZE1_A_X2NA602_1","LANOSTEROL 14-ALPHA DEMETHYLASE","2x6k","PHOSPHOTIDYLINOSITOL 3 KINASE 59F","Drosophila melanogaster",5,"TYR A 732;LEU A 801;LEU A 708;PHE A 824;MET A 712","X6K A1951 ( 4.3A);None;None;None;None","1.25A","4ze1A-2x6kA:undetectable","4xe0A-2x6kA:26.15"],["6C2M_D_SUED1202_1","NS3 PROTEASE","2x6k","PHOSPHOTIDYLINOSITOL 3 KINASE 59F","Drosophila melanogaster",4,"PHE A 743;HIS A 699;LEU A 710;ASP A 823","None;None;None;X6K A1951 (-3.5A)","0.96A","6c2mD-2x6kA:undetectable","4ze1A-2x6kA:21.66"],["6MKE_C_FK5C201_0","PEPTIDYLPROLYL ISOMERASE","2x6k","PHOSPHOTIDYLINOSITOL 3 KINASE 59F","Drosophila melanogaster",4,"ASP A 706;ILE A 713;PRO A 731;LEU A 710","X6K A1951 (-3.4A);None;None;None","1.44A","6mkeB-2x6kA:undetectable","6c2mD-2x6kA:8.91"],["6MKE_D_FK5D201_0","PEPTIDYLPROLYL ISOMERASE","2x6k","PHOSPHOTIDYLINOSITOL 3 KINASE 59F","Drosophila melanogaster",4,"ASP A 706;ILE A 713;PRO A 731;LEU A 710","X6K A1951 (-3.4A);None;None;None","1.40A","6mkeA-2x6kA:undetectable","6mkeB-2x6kA:8.30"]]