SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'X48'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_B_CIAB2003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 4m5o POLYMERASE PA
(Influenza
A
virus) 		5 / 12 ALA A  17
ILE A  13
ILE A  38
LEU A 109
PHE A  46
 None
None
X48  A 306 ( 4.9A)
None
None
 0.97A 1uduB-4m5oA:
undetectable		 1uduB-4m5oA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOZ_A_CIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 4m5o POLYMERASE PA
(Influenza
A
virus) 		5 / 12 ALA A  17
ILE A  13
ILE A  38
LEU A 109
PHE A  46
 None
None
X48  A 306 ( 4.9A)
None
None
 1.00A 1xozA-4m5oA:
undetectable		 1xozA-4m5oA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XR2_B_C2FB1201_0
(5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE)		 4m5o POLYMERASE PA
(Influenza
A
virus) 		4 / 8 TRP A 188
SER A 194
ARG A 125
GLU A  26
 None
EDO  A 305 (-4.0A)
None
X48  A 308 (-3.5A)
 1.02A 1xr2B-4m5oA:
undetectable		 1xr2B-4m5oA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R0L_D_ACTD127_0
(PHOSPHOLIPASE A2 CB)		 4m5o POLYMERASE PA
(Influenza
A
virus) 		4 / 5 PHE A 148
ILE A 171
GLY A 121
HIS A 146
 None
None
X48  A 306 ( 4.7A)
None
 1.38A 3r0lD-4m5oA:
undetectable		 3r0lD-4m5oA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_E_9PLE1_1
(CYTOCHROME P450 2A13)		 4m5o POLYMERASE PA
(Influenza
A
virus) 		4 / 8 PHE A   4
PHE A   9
ASN A  33
ALA A  37
 None
None
SO4  A 304 (-3.7A)
X48  A 306 ( 3.7A)
 1.10A 3t3sE-4m5oA:
undetectable		 3t3sE-4m5oA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_F_9PLF1_1
(CYTOCHROME P450 2A13)		 4m5o POLYMERASE PA
(Influenza
A
virus) 		4 / 8 PHE A   4
PHE A   9
ASN A  33
ALA A  37
 None
None
SO4  A 304 (-3.7A)
X48  A 306 ( 3.7A)
 0.83A 3t3sF-4m5oA:
undetectable		 3t3sF-4m5oA:
17.02