SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'X2X'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_B_CCSB47_0
(GLUTATHIONE
S-TRANSFERASE)		 4p8b TRAP-TYPE
TRANSPORTER,
PERIPLASMIC
COMPONENT
(Cupriavidus
necator) 		4 / 7 LEU A  39
LEU A 278
GLY A  48
LEU A 244
 X2X  A 403 ( 4.5A)
None
None
None
 0.90A 1gtiB-4p8bA:
undetectable		 1gtiB-4p8bA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R30_A_SAMA501_0
(BIOTIN SYNTHASE)		 4oan TRAP DICARBOXYLATE
TRANSPORTER DCTP
SUBUNIT
(Rhodopseudomonas
palustris) 		5 / 12 GLY A 155
ASN A 218
ILE A 101
LEU A  84
LEU A  42
 None
X2X  A 402 (-2.8A)
None
None
None
 1.20A 1r30A-4oanA:
undetectable		 1r30A-4oanA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R30_B_SAMB501_0
(BIOTIN SYNTHASE)		 4oan TRAP DICARBOXYLATE
TRANSPORTER DCTP
SUBUNIT
(Rhodopseudomonas
palustris) 		5 / 12 GLY A 155
ASN A 218
ILE A 101
LEU A  84
LEU A  42
 None
X2X  A 402 (-2.8A)
None
None
None
 1.20A 1r30B-4oanA:
undetectable		 1r30B-4oanA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD3_B_CHDB504_0
(FERROCHELATASE)		 4oan TRAP DICARBOXYLATE
TRANSPORTER DCTP
SUBUNIT
(Rhodopseudomonas
palustris) 		4 / 6 MET A 188
ILE A 114
PRO A 180
SER A 198
 None
None
X2X  A 402 (-4.1A)
GOL  A 403 (-2.6A)
 1.48A 2qd3B-4oanA:
undetectable		 2qd3B-4oanA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 4p8b TRAP-TYPE
TRANSPORTER,
PERIPLASMIC
COMPONENT
(Cupriavidus
necator) 		5 / 12 VAL A 144
THR A  80
ASN A 100
GLY A  96
ALA A  94
 None
None
X2X  A 403 (-3.2A)
None
None
 1.21A 2x2iA-4p8bA:
undetectable		 2x2iA-4p8bA:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 4p8b TRAP-TYPE
TRANSPORTER,
PERIPLASMIC
COMPONENT
(Cupriavidus
necator) 		5 / 12 VAL A 144
THR A  80
ASN A 100
GLY A  96
ALA A  94
 None
None
X2X  A 403 (-3.2A)
None
None
 1.16A 2x2iC-4p8bA:
undetectable		 2x2iC-4p8bA:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_A_SAMA401_1
(O-METHYLTRANSFERASE)		 4oan TRAP DICARBOXYLATE
TRANSPORTER DCTP
SUBUNIT
(Rhodopseudomonas
palustris) 		4 / 4 ASP A  80
SER A  98
PHE A 245
SER A  74
 X2X  A 402 ( 4.8A)
X2X  A 402 ( 4.5A)
X2X  A 402 (-4.7A)
None
 1.48A 3i5uA-4oanA:
undetectable		 3i5uA-4oanA:
24.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWT_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4p8b TRAP-TYPE
TRANSPORTER,
PERIPLASMIC
COMPONENT
(Cupriavidus
necator) 		4 / 7 ARG A 155
VAL A  38
TRP A 199
TRP A  45
 X2X  A 403 (-3.0A)
X2X  A 403 ( 4.5A)
X2X  A 403 (-4.4A)
None
 1.49A 3jwtA-4p8bA:
0.7
3jwtB-4p8bA:
undetectable		 3jwtA-4p8bA:
20.81
3jwtB-4p8bA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWU_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4p8b TRAP-TYPE
TRANSPORTER,
PERIPLASMIC
COMPONENT
(Cupriavidus
necator) 		4 / 7 TRP A  45
ARG A 155
VAL A  38
TRP A 199
 None
X2X  A 403 (-3.0A)
X2X  A 403 ( 4.5A)
X2X  A 403 (-4.4A)
 1.49A 3jwuA-4p8bA:
undetectable
3jwuB-4p8bA:
undetectable		 3jwuA-4p8bA:
20.81
3jwuB-4p8bA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLK_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4p8b TRAP-TYPE
TRANSPORTER,
PERIPLASMIC
COMPONENT
(Cupriavidus
necator) 		4 / 7 TRP A  45
ARG A 155
VAL A  38
TRP A 199
 None
X2X  A 403 (-3.0A)
X2X  A 403 ( 4.5A)
X2X  A 403 (-4.4A)
 1.50A 3nlkA-4p8bA:
undetectable
3nlkB-4p8bA:
undetectable		 3nlkA-4p8bA:
20.81
3nlkB-4p8bA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLN_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4p8b TRAP-TYPE
TRANSPORTER,
PERIPLASMIC
COMPONENT
(Cupriavidus
necator) 		4 / 7 ARG A 155
VAL A  38
TRP A 199
TRP A  45
 X2X  A 403 (-3.0A)
X2X  A 403 ( 4.5A)
X2X  A 403 (-4.4A)
None
 1.50A 3nlnA-4p8bA:
undetectable
3nlnB-4p8bA:
undetectable		 3nlnA-4p8bA:
20.81
3nlnB-4p8bA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLN_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4p8b TRAP-TYPE
TRANSPORTER,
PERIPLASMIC
COMPONENT
(Cupriavidus
necator) 		4 / 7 TRP A  45
ARG A 155
VAL A  38
TRP A 199
 None
X2X  A 403 (-3.0A)
X2X  A 403 ( 4.5A)
X2X  A 403 (-4.4A)
 1.48A 3nlnA-4p8bA:
undetectable
3nlnB-4p8bA:
undetectable		 3nlnA-4p8bA:
20.81
3nlnB-4p8bA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFQ_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4p8b TRAP-TYPE
TRANSPORTER,
PERIPLASMIC
COMPONENT
(Cupriavidus
necator) 		4 / 7 TRP A  45
ARG A 155
VAL A  38
TRP A 199
 None
X2X  A 403 (-3.0A)
X2X  A 403 ( 4.5A)
X2X  A 403 (-4.4A)
 1.50A 3ufqA-4p8bA:
undetectable
3ufqB-4p8bA:
0.7		 3ufqA-4p8bA:
20.81
3ufqB-4p8bA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFR_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4p8b TRAP-TYPE
TRANSPORTER,
PERIPLASMIC
COMPONENT
(Cupriavidus
necator) 		4 / 6 ARG A 155
VAL A  38
TRP A 199
TRP A  45
 X2X  A 403 (-3.0A)
X2X  A 403 ( 4.5A)
X2X  A 403 (-4.4A)
None
 1.33A 3ufrA-4p8bA:
undetectable
3ufrB-4p8bA:
undetectable		 3ufrA-4p8bA:
20.81
3ufrB-4p8bA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFT_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4p8b TRAP-TYPE
TRANSPORTER,
PERIPLASMIC
COMPONENT
(Cupriavidus
necator) 		4 / 7 ARG A 155
VAL A  38
TRP A 199
TRP A  45
 X2X  A 403 (-3.0A)
X2X  A 403 ( 4.5A)
X2X  A 403 (-4.4A)
None
 1.50A 3uftA-4p8bA:
undetectable
3uftB-4p8bA:
undetectable		 3uftA-4p8bA:
20.81
3uftB-4p8bA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFT_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4p8b TRAP-TYPE
TRANSPORTER,
PERIPLASMIC
COMPONENT
(Cupriavidus
necator) 		4 / 7 TRP A  45
ARG A 155
VAL A  38
TRP A 199
 None
X2X  A 403 (-3.0A)
X2X  A 403 ( 4.5A)
X2X  A 403 (-4.4A)
 1.44A 3uftA-4p8bA:
undetectable
3uftB-4p8bA:
undetectable		 3uftA-4p8bA:
20.81
3uftB-4p8bA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTR_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4p8b TRAP-TYPE
TRANSPORTER,
PERIPLASMIC
COMPONENT
(Cupriavidus
necator) 		4 / 7 TRP A  45
ARG A 155
VAL A  38
TRP A 199
 None
X2X  A 403 (-3.0A)
X2X  A 403 ( 4.5A)
X2X  A 403 (-4.4A)
 1.47A 4ctrA-4p8bA:
undetectable
4ctrB-4p8bA:
undetectable		 4ctrA-4p8bA:
20.81
4ctrB-4p8bA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTT_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4p8b TRAP-TYPE
TRANSPORTER,
PERIPLASMIC
COMPONENT
(Cupriavidus
necator) 		4 / 7 TRP A  45
ARG A 155
VAL A  38
TRP A 199
 None
X2X  A 403 (-3.0A)
X2X  A 403 ( 4.5A)
X2X  A 403 (-4.4A)
 1.50A 4cttA-4p8bA:
undetectable
4cttB-4p8bA:
undetectable		 4cttA-4p8bA:
20.81
4cttB-4p8bA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IMW_A_H4BA805_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4p8b TRAP-TYPE
TRANSPORTER,
PERIPLASMIC
COMPONENT
(Cupriavidus
necator) 		4 / 7 TRP A  45
ARG A 155
VAL A  38
TRP A 199
 None
X2X  A 403 (-3.0A)
X2X  A 403 ( 4.5A)
X2X  A 403 (-4.4A)
 1.44A 4imwA-4p8bA:
undetectable
4imwB-4p8bA:
undetectable		 4imwA-4p8bA:
20.81
4imwB-4p8bA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K5F_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4p8b TRAP-TYPE
TRANSPORTER,
PERIPLASMIC
COMPONENT
(Cupriavidus
necator) 		4 / 7 TRP A  45
ARG A 155
VAL A  38
TRP A 199
 None
X2X  A 403 (-3.0A)
X2X  A 403 ( 4.5A)
X2X  A 403 (-4.4A)
 1.49A 4k5fA-4p8bA:
undetectable
4k5fB-4p8bA:
undetectable		 4k5fA-4p8bA:
20.81
4k5fB-4p8bA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCK_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4p8b TRAP-TYPE
TRANSPORTER,
PERIPLASMIC
COMPONENT
(Cupriavidus
necator) 		4 / 7 TRP A  45
ARG A 155
VAL A  38
TRP A 199
 None
X2X  A 403 (-3.0A)
X2X  A 403 ( 4.5A)
X2X  A 403 (-4.4A)
 1.47A 4kckA-4p8bA:
undetectable
4kckB-4p8bA:
undetectable		 4kckA-4p8bA:
20.81
4kckB-4p8bA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UH0_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4p8b TRAP-TYPE
TRANSPORTER,
PERIPLASMIC
COMPONENT
(Cupriavidus
necator) 		4 / 7 TRP A  45
ARG A 155
VAL A  38
TRP A 199
 None
X2X  A 403 (-3.0A)
X2X  A 403 ( 4.5A)
X2X  A 403 (-4.4A)
 1.49A 4uh0A-4p8bA:
undetectable
4uh0B-4p8bA:
undetectable		 4uh0A-4p8bA:
20.81
4uh0B-4p8bA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V32_B_EF2B151_1
(CEREBLON ISOFORM 4)		 4oan TRAP DICARBOXYLATE
TRANSPORTER DCTP
SUBUNIT
(Rhodopseudomonas
palustris) 		4 / 7 ASN A 218
PRO A 219
TRP A 185
PHE A 189
 X2X  A 402 (-2.8A)
None
None
None
 1.36A 4v32B-4oanA:
undetectable		 4v32B-4oanA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AD6_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4p8b TRAP-TYPE
TRANSPORTER,
PERIPLASMIC
COMPONENT
(Cupriavidus
necator) 		4 / 7 TRP A  45
ARG A 155
VAL A  38
TRP A 199
 None
X2X  A 403 (-3.0A)
X2X  A 403 ( 4.5A)
X2X  A 403 (-4.4A)
 1.49A 5ad6A-4p8bA:
undetectable
5ad6B-4p8bA:
undetectable		 5ad6A-4p8bA:
20.81
5ad6B-4p8bA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AD8_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4p8b TRAP-TYPE
TRANSPORTER,
PERIPLASMIC
COMPONENT
(Cupriavidus
necator) 		4 / 6 TRP A  45
ARG A 155
VAL A  38
TRP A 199
 None
X2X  A 403 (-3.0A)
X2X  A 403 ( 4.5A)
X2X  A 403 (-4.4A)
 1.49A 5ad8A-4p8bA:
undetectable
5ad8B-4p8bA:
undetectable		 5ad8A-4p8bA:
20.81
5ad8B-4p8bA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AD9_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4p8b TRAP-TYPE
TRANSPORTER,
PERIPLASMIC
COMPONENT
(Cupriavidus
necator) 		4 / 6 TRP A  45
ARG A 155
VAL A  38
TRP A 199
 None
X2X  A 403 (-3.0A)
X2X  A 403 ( 4.5A)
X2X  A 403 (-4.4A)
 1.48A 5ad9A-4p8bA:
undetectable
5ad9B-4p8bA:
undetectable		 5ad9A-4p8bA:
20.81
5ad9B-4p8bA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADA_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4p8b TRAP-TYPE
TRANSPORTER,
PERIPLASMIC
COMPONENT
(Cupriavidus
necator) 		4 / 7 TRP A  45
ARG A 155
VAL A  38
TRP A 199
 None
X2X  A 403 (-3.0A)
X2X  A 403 ( 4.5A)
X2X  A 403 (-4.4A)
 1.50A 5adaA-4p8bA:
undetectable
5adaB-4p8bA:
undetectable		 5adaA-4p8bA:
20.81
5adaB-4p8bA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADB_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4p8b TRAP-TYPE
TRANSPORTER,
PERIPLASMIC
COMPONENT
(Cupriavidus
necator) 		4 / 6 TRP A  45
ARG A 155
VAL A  38
TRP A 199
 None
X2X  A 403 (-3.0A)
X2X  A 403 ( 4.5A)
X2X  A 403 (-4.4A)
 1.49A 5adbA-4p8bA:
undetectable
5adbB-4p8bA:
undetectable		 5adbA-4p8bA:
20.81
5adbB-4p8bA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UNW_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4p8b TRAP-TYPE
TRANSPORTER,
PERIPLASMIC
COMPONENT
(Cupriavidus
necator) 		4 / 7 TRP A  45
ARG A 155
VAL A  38
TRP A 199
 None
X2X  A 403 (-3.0A)
X2X  A 403 ( 4.5A)
X2X  A 403 (-4.4A)
 1.46A 5unwA-4p8bA:
undetectable
5unwB-4p8bA:
undetectable		 5unwA-4p8bA:
20.81
5unwB-4p8bA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UNX_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4p8b TRAP-TYPE
TRANSPORTER,
PERIPLASMIC
COMPONENT
(Cupriavidus
necator) 		4 / 7 ARG A 155
VAL A  38
TRP A 199
TRP A  45
 X2X  A 403 (-3.0A)
X2X  A 403 ( 4.5A)
X2X  A 403 (-4.4A)
None
 1.49A 5unxA-4p8bA:
undetectable
5unxB-4p8bA:
undetectable		 5unxA-4p8bA:
20.81
5unxB-4p8bA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO0_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4p8b TRAP-TYPE
TRANSPORTER,
PERIPLASMIC
COMPONENT
(Cupriavidus
necator) 		4 / 6 ARG A 155
VAL A  38
TRP A 199
TRP A  45
 X2X  A 403 (-3.0A)
X2X  A 403 ( 4.5A)
X2X  A 403 (-4.4A)
None
 1.49A 5uo0A-4p8bA:
1.0
5uo0B-4p8bA:
undetectable		 5uo0A-4p8bA:
20.81
5uo0B-4p8bA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUL_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4p8b TRAP-TYPE
TRANSPORTER,
PERIPLASMIC
COMPONENT
(Cupriavidus
necator) 		4 / 7 TRP A  45
ARG A 155
VAL A  38
TRP A 199
 None
X2X  A 403 (-3.0A)
X2X  A 403 ( 4.5A)
X2X  A 403 (-4.4A)
 1.49A 5vulA-4p8bA:
undetectable
5vulB-4p8bA:
undetectable		 5vulA-4p8bA:
20.81
5vulB-4p8bA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUR_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4p8b TRAP-TYPE
TRANSPORTER,
PERIPLASMIC
COMPONENT
(Cupriavidus
necator) 		4 / 6 ARG A 155
VAL A  38
TRP A 199
TRP A  45
 X2X  A 403 (-3.0A)
X2X  A 403 ( 4.5A)
X2X  A 403 (-4.4A)
None
 1.49A 5vurA-4p8bA:
undetectable
5vurB-4p8bA:
0.0		 5vurA-4p8bA:
20.81
5vurB-4p8bA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUS_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4p8b TRAP-TYPE
TRANSPORTER,
PERIPLASMIC
COMPONENT
(Cupriavidus
necator) 		4 / 7 ARG A 155
VAL A  38
TRP A 199
TRP A  45
 X2X  A 403 (-3.0A)
X2X  A 403 ( 4.5A)
X2X  A 403 (-4.4A)
None
 1.49A 5vusA-4p8bA:
undetectable
5vusB-4p8bA:
undetectable		 5vusA-4p8bA:
20.81
5vusB-4p8bA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUS_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4p8b TRAP-TYPE
TRANSPORTER,
PERIPLASMIC
COMPONENT
(Cupriavidus
necator) 		4 / 7 TRP A  45
ARG A 155
VAL A  38
TRP A 199
 None
X2X  A 403 (-3.0A)
X2X  A 403 ( 4.5A)
X2X  A 403 (-4.4A)
 1.47A 5vusA-4p8bA:
undetectable
5vusB-4p8bA:
undetectable		 5vusA-4p8bA:
20.81
5vusB-4p8bA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUU_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4p8b TRAP-TYPE
TRANSPORTER,
PERIPLASMIC
COMPONENT
(Cupriavidus
necator) 		4 / 7 TRP A  45
ARG A 155
VAL A  38
TRP A 199
 None
X2X  A 403 (-3.0A)
X2X  A 403 ( 4.5A)
X2X  A 403 (-4.4A)
 1.49A 5vuuA-4p8bA:
undetectable
5vuuB-4p8bA:
undetectable		 5vuuA-4p8bA:
20.81
5vuuB-4p8bA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUY_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4p8b TRAP-TYPE
TRANSPORTER,
PERIPLASMIC
COMPONENT
(Cupriavidus
necator) 		4 / 7 ARG A 155
VAL A  38
TRP A 199
TRP A  45
 X2X  A 403 (-3.0A)
X2X  A 403 ( 4.5A)
X2X  A 403 (-4.4A)
None
 1.48A 5vuyA-4p8bA:
undetectable
5vuyB-4p8bA:
undetectable		 5vuyA-4p8bA:
20.87
5vuyB-4p8bA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUY_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4p8b TRAP-TYPE
TRANSPORTER,
PERIPLASMIC
COMPONENT
(Cupriavidus
necator) 		4 / 7 TRP A  45
ARG A 155
VAL A  38
TRP A 199
 None
X2X  A 403 (-3.0A)
X2X  A 403 ( 4.5A)
X2X  A 403 (-4.4A)
 1.44A 5vuyA-4p8bA:
undetectable
5vuyB-4p8bA:
undetectable		 5vuyA-4p8bA:
20.87
5vuyB-4p8bA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUZ_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4p8b TRAP-TYPE
TRANSPORTER,
PERIPLASMIC
COMPONENT
(Cupriavidus
necator) 		4 / 7 TRP A  45
ARG A 155
VAL A  38
TRP A 199
 None
X2X  A 403 (-3.0A)
X2X  A 403 ( 4.5A)
X2X  A 403 (-4.4A)
 1.50A 5vuzA-4p8bA:
undetectable
5vuzB-4p8bA:
undetectable		 5vuzA-4p8bA:
20.87
5vuzB-4p8bA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV0_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4p8b TRAP-TYPE
TRANSPORTER,
PERIPLASMIC
COMPONENT
(Cupriavidus
necator) 		4 / 6 TRP A  45
ARG A 155
VAL A  38
TRP A 199
 None
X2X  A 403 (-3.0A)
X2X  A 403 ( 4.5A)
X2X  A 403 (-4.4A)
 1.49A 5vv0A-4p8bA:
undetectable
5vv0B-4p8bA:
undetectable		 5vv0A-4p8bA:
20.87
5vv0B-4p8bA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV1_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4p8b TRAP-TYPE
TRANSPORTER,
PERIPLASMIC
COMPONENT
(Cupriavidus
necator) 		4 / 6 ARG A 155
VAL A  38
TRP A 199
TRP A  45
 X2X  A 403 (-3.0A)
X2X  A 403 ( 4.5A)
X2X  A 403 (-4.4A)
None
 1.49A 5vv1A-4p8bA:
undetectable
5vv1B-4p8bA:
undetectable		 5vv1A-4p8bA:
20.87
5vv1B-4p8bA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV1_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4p8b TRAP-TYPE
TRANSPORTER,
PERIPLASMIC
COMPONENT
(Cupriavidus
necator) 		4 / 6 TRP A  45
ARG A 155
VAL A  38
TRP A 199
 None
X2X  A 403 (-3.0A)
X2X  A 403 ( 4.5A)
X2X  A 403 (-4.4A)
 1.49A 5vv1A-4p8bA:
undetectable
5vv1B-4p8bA:
undetectable		 5vv1A-4p8bA:
20.87
5vv1B-4p8bA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV3_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4p8b TRAP-TYPE
TRANSPORTER,
PERIPLASMIC
COMPONENT
(Cupriavidus
necator) 		4 / 7 ARG A 155
VAL A  38
TRP A 199
TRP A  45
 X2X  A 403 (-3.0A)
X2X  A 403 ( 4.5A)
X2X  A 403 (-4.4A)
None
 1.49A 5vv3A-4p8bA:
undetectable
5vv3B-4p8bA:
undetectable		 5vv3A-4p8bA:
20.87
5vv3B-4p8bA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV3_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4p8b TRAP-TYPE
TRANSPORTER,
PERIPLASMIC
COMPONENT
(Cupriavidus
necator) 		4 / 7 TRP A  45
ARG A 155
VAL A  38
TRP A 199
 None
X2X  A 403 (-3.0A)
X2X  A 403 ( 4.5A)
X2X  A 403 (-4.4A)
 1.48A 5vv3A-4p8bA:
undetectable
5vv3B-4p8bA:
undetectable		 5vv3A-4p8bA:
20.87
5vv3B-4p8bA:
20.87