SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'X05'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2VZS_A_GCSA1902_1
(EXO-BETA-D-GLUCOSAMI
NIDASE)		 2x05 EXO-BETA-D-GLUCOSAMI
NIDASE
(Amycolatopsis
orientalis) 		11 / 12 ILE A 202
ASP A 203
GLU A 394
SER A 468
ASP A 469
MET A 512
TYR A 516
GLU A 541
TRP A 642
TRP A 653
TRP A 781
 X05  A1900 (-3.5A)
X05  A1900 (-2.7A)
X05  A1900 (-2.6A)
X05  A1900 (-3.6A)
X05  A1900 (-3.2A)
X05  A1900 (-3.4A)
X05  A1900 (-3.5A)
X05  A1900 (-2.5A)
X05  A1900 (-4.3A)
None
None
 0.35A 2vzsA-2x05A:
70.1		 2vzsA-2x05A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2VZS_B_GCSB1903_1
(EXO-BETA-D-GLUCOSAMI
NIDASE)		 2x05 EXO-BETA-D-GLUCOSAMI
NIDASE
(Amycolatopsis
orientalis) 		11 / 12 ILE A 202
ASP A 203
GLU A 394
SER A 468
ASP A 469
MET A 512
TYR A 516
GLU A 541
TRP A 642
TRP A 653
TRP A 781
 X05  A1900 (-3.5A)
X05  A1900 (-2.7A)
X05  A1900 (-2.6A)
X05  A1900 (-3.6A)
X05  A1900 (-3.2A)
X05  A1900 (-3.4A)
X05  A1900 (-3.5A)
X05  A1900 (-2.5A)
X05  A1900 (-4.3A)
None
None
 0.35A 2vzsB-2x05A:
69.7		 2vzsB-2x05A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2VZV_A_GCSA1899_1
(EXO-BETA-D-GLUCOSAMI
NIDASE)		 2x05 EXO-BETA-D-GLUCOSAMI
NIDASE
(Amycolatopsis
orientalis) 		10 / 11 ILE A 202
ASP A 203
TRP A 204
GLU A 394
ASP A 469
MET A 512
TYR A 516
TRP A 642
TRP A 653
TRP A 781
 X05  A1900 (-3.5A)
X05  A1900 (-2.7A)
X05  A1900 (-4.2A)
X05  A1900 (-2.6A)
X05  A1900 (-3.2A)
X05  A1900 (-3.4A)
X05  A1900 (-3.5A)
X05  A1900 (-4.3A)
None
None
 0.41A 2vzvA-2x05A:
69.1		 2vzvA-2x05A:
99.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2VZV_A_GCSA1900_1
(EXO-BETA-D-GLUCOSAMI
NIDASE)		 2x05 EXO-BETA-D-GLUCOSAMI
NIDASE
(Amycolatopsis
orientalis) 		5 / 6 GLU A 431
ASP A 469
MET A 512
TYR A 516
TRP A 781
 None
X05  A1900 (-3.2A)
X05  A1900 (-3.4A)
X05  A1900 (-3.5A)
None
 0.53A 2vzvA-2x05A:
69.1		 2vzvA-2x05A:
99.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2VZV_B_GCSB1899_1
(EXO-BETA-D-GLUCOSAMI
NIDASE)		 2x05 EXO-BETA-D-GLUCOSAMI
NIDASE
(Amycolatopsis
orientalis) 		10 / 11 ILE A 202
ASP A 203
TRP A 204
GLU A 394
ASP A 469
MET A 512
TYR A 516
TRP A 642
TRP A 653
TRP A 781
 X05  A1900 (-3.5A)
X05  A1900 (-2.7A)
X05  A1900 (-4.2A)
X05  A1900 (-2.6A)
X05  A1900 (-3.2A)
X05  A1900 (-3.4A)
X05  A1900 (-3.5A)
X05  A1900 (-4.3A)
None
None
 0.44A 2vzvB-2x05A:
69.4		 2vzvB-2x05A:
99.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2VZV_B_GCSB1900_1
(EXO-BETA-D-GLUCOSAMI
NIDASE)		 2x05 EXO-BETA-D-GLUCOSAMI
NIDASE
(Amycolatopsis
orientalis) 		5 / 6 GLU A 431
ASP A 469
MET A 512
TYR A 516
TRP A 781
 None
X05  A1900 (-3.2A)
X05  A1900 (-3.4A)
X05  A1900 (-3.5A)
None
 0.55A 2vzvB-2x05A:
69.4		 2vzvB-2x05A:
99.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OWX_B_XRAB233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2x05 EXO-BETA-D-GLUCOSAMI
NIDASE
(Amycolatopsis
orientalis) 		5 / 11 TRP A 201
GLY A 362
ASN A 645
GLU A 541
ILE A 640
 None
None
None
X05  A1900 (-2.5A)
None
 1.32A 3owxA-2x05A:
undetectable
3owxB-2x05A:
undetectable		 3owxA-2x05A:
12.67
3owxB-2x05A:
12.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_A_SAMA2409_1
(RNA-DIRECTED RNA
POLYMERASE L)		 2x05 EXO-BETA-D-GLUCOSAMI
NIDASE
(Amycolatopsis
orientalis) 		3 / 3 SER A 540
ASP A 473
ASP A 469
 None
None
X05  A1900 (-3.2A)
 0.82A 4uckA-2x05A:
undetectable		 4uckA-2x05A:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YMG_A_SAMA1001_0
(PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE)		 2x05 EXO-BETA-D-GLUCOSAMI
NIDASE
(Amycolatopsis
orientalis) 		5 / 12 GLY A 534
TYR A 516
TYR A 525
ALA A 535
ASN A 628
 None
X05  A1900 (-3.5A)
None
None
None
 1.16A 4ymgA-2x05A:
undetectable		 4ymgA-2x05A:
12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YMG_B_SAMB1001_0
(PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE)		 2x05 EXO-BETA-D-GLUCOSAMI
NIDASE
(Amycolatopsis
orientalis) 		5 / 12 GLY A 534
TYR A 516
TYR A 525
ALA A 535
ASN A 628
 None
X05  A1900 (-3.5A)
None
None
None
 1.18A 4ymgB-2x05A:
undetectable		 4ymgB-2x05A:
12.65