SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'WYQ'
DrReposER ID / Desc. | Hit PDBID |
Hit Macromolecule |
Res. Matches |
Interface | HETATM | RMSD | Dali Z-score |
Seq. Identity (%) |
View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1UDU_B_CIAB2003_1 (CGMP-SPECIFIC3',5'-CYCLICPHOSPHODIESTERASE) |
3v94 | CYCLIC NUCLEOTIDESPECIFICPHOSPHODIESTERASE (Trypanosomacruzi) | 5 / 12 | TYR A 367ALA A 524PHE A 542GLN A 570PHE A 573 | WYQ A 701 (-4.5A)NoneWYQ A 701 (-4.7A)WYQ A 701 (-3.3A)WYQ A 701 (-3.4A) | 0.59A | 1uduB-3v94A:33.5 | 1uduB-3v94A:28.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1UHO_A_VDNA1000_1 (CGMP-SPECIFIC3',5'-CYCLICPHOSPHODIESTERASE) |
3v94 | CYCLIC NUCLEOTIDESPECIFICPHOSPHODIESTERASE (Trypanosomacruzi) | 5 / 10 | TYR A 367HIS A 368PHE A 542GLN A 570PHE A 573 | WYQ A 701 (-4.5A)NoneWYQ A 701 (-4.7A)WYQ A 701 (-3.3A)WYQ A 701 (-3.4A) | 0.41A | 1uhoA-3v94A:34.4 | 1uhoA-3v94A:28.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1XLX_A_CIOA101_1 (CAMP-SPECIFIC3',5'-CYCLICPHOSPHODIESTERASE 4B) |
3v94 | CYCLIC NUCLEOTIDESPECIFICPHOSPHODIESTERASE (Trypanosomacruzi) | 6 / 12 | TYR A 367HIS A 368HIS A 413ILE A 538GLN A 570PHE A 573 | WYQ A 701 (-4.5A)NoneNoneWYQ A 701 ( 4.1A)WYQ A 701 (-3.3A)WYQ A 701 (-3.4A) | 0.43A | 1xlxA-3v94A:40.1 | 1xlxA-3v94A:27.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1XLX_A_CIOA101_1 (CAMP-SPECIFIC3',5'-CYCLICPHOSPHODIESTERASE 4B) |
3v94 | CYCLIC NUCLEOTIDESPECIFICPHOSPHODIESTERASE (Trypanosomacruzi) | 6 / 12 | TYR A 367HIS A 413MET A 482ILE A 538GLN A 570PHE A 573 | WYQ A 701 (-4.5A)NoneWYQ A 701 (-4.5A)WYQ A 701 ( 4.1A)WYQ A 701 (-3.3A)WYQ A 701 (-3.4A) | 0.85A | 1xlxA-3v94A:40.1 | 1xlxA-3v94A:27.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1XLX_B_CIOB102_1 (CAMP-SPECIFIC3',5'-CYCLICPHOSPHODIESTERASE 4B) |
3v94 | CYCLIC NUCLEOTIDESPECIFICPHOSPHODIESTERASE (Trypanosomacruzi) | 8 / 12 | TYR A 367HIS A 368HIS A 413MET A 482ILE A 538PHE A 542GLN A 570PHE A 573 | WYQ A 701 (-4.5A)NoneNoneWYQ A 701 (-4.5A)WYQ A 701 ( 4.1A)WYQ A 701 (-4.7A)WYQ A 701 (-3.3A)WYQ A 701 (-3.4A) | 0.77A | 1xlxB-3v94A:39.9 | 1xlxB-3v94A:27.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1XMU_A_ROFA101_0 (CAMP-SPECIFIC3',5'-CYCLICPHOSPHODIESTERASE 4B) |
3v94 | CYCLIC NUCLEOTIDESPECIFICPHOSPHODIESTERASE (Trypanosomacruzi) | 7 / 12 | TYR A 367HIS A 368ASP A 521TRP A 535ILE A 538PHE A 542PHE A 573 | WYQ A 701 (-4.5A)None ZN A 702 (-1.9A)NoneWYQ A 701 ( 4.1A)WYQ A 701 (-4.7A)WYQ A 701 (-3.4A) | 0.77A | 1xmuA-3v94A:39.9 | 1xmuA-3v94A:27.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1XMU_A_ROFA101_0 (CAMP-SPECIFIC3',5'-CYCLICPHOSPHODIESTERASE 4B) |
3v94 | CYCLIC NUCLEOTIDESPECIFICPHOSPHODIESTERASE (Trypanosomacruzi) | 5 / 12 | TYR A 367TRP A 535PHE A 542SER A 569PHE A 573 | WYQ A 701 (-4.5A)NoneWYQ A 701 (-4.7A)NoneWYQ A 701 (-3.4A) | 0.94A | 1xmuA-3v94A:39.9 | 1xmuA-3v94A:27.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1XMU_B_ROFB102_0 (CAMP-SPECIFIC3',5'-CYCLICPHOSPHODIESTERASE 4B) |
3v94 | CYCLIC NUCLEOTIDESPECIFICPHOSPHODIESTERASE (Trypanosomacruzi) | 6 / 12 | TYR A 367HIS A 368ASP A 521TRP A 535ILE A 538PHE A 542 | WYQ A 701 (-4.5A)None ZN A 702 (-1.9A)NoneWYQ A 701 ( 4.1A)WYQ A 701 (-4.7A) | 0.61A | 1xmuB-3v94A:40.1 | 1xmuB-3v94A:27.11 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1XOM_A_CIOA603_1 (CAMP-SPECIFIC3',5'-CYCLICPHOSPHODIESTERASE 4D) |
3v94 | CYCLIC NUCLEOTIDESPECIFICPHOSPHODIESTERASE (Trypanosomacruzi) | 8 / 12 | TYR A 367HIS A 368MET A 482ASP A 521ILE A 538PHE A 542GLN A 570PHE A 573 | WYQ A 701 (-4.5A)NoneWYQ A 701 (-4.5A) ZN A 702 (-1.9A)WYQ A 701 ( 4.1A)WYQ A 701 (-4.7A)WYQ A 701 (-3.3A)WYQ A 701 (-3.4A) | 0.81A | 1xomA-3v94A:40.2 | 1xomA-3v94A:30.62 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1XOM_B_CIOB601_1 (CAMP-SPECIFIC3',5'-CYCLICPHOSPHODIESTERASE 4D) |
3v94 | CYCLIC NUCLEOTIDESPECIFICPHOSPHODIESTERASE (Trypanosomacruzi) | 7 / 12 | TYR A 367HIS A 368MET A 482ILE A 538PHE A 542GLN A 570PHE A 573 | WYQ A 701 (-4.5A)NoneWYQ A 701 (-4.5A)WYQ A 701 ( 4.1A)WYQ A 701 (-4.7A)WYQ A 701 (-3.3A)WYQ A 701 (-3.4A) | 0.81A | 1xomB-3v94A:40.2 | 1xomB-3v94A:30.62 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1XOQ_A_ROFA502_0 (CAMP-SPECIFIC3',5'-CYCLICPHOSPHODIESTERASE 4D) |
3v94 | CYCLIC NUCLEOTIDESPECIFICPHOSPHODIESTERASE (Trypanosomacruzi) | 5 / 12 | TYR A 367HIS A 368ILE A 538SER A 569PHE A 573 | WYQ A 701 (-4.5A)NoneWYQ A 701 ( 4.1A)NoneWYQ A 701 (-3.4A) | 0.77A | 1xoqA-3v94A:40.1 | 1xoqA-3v94A:30.62 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1XOQ_A_ROFA502_0 (CAMP-SPECIFIC3',5'-CYCLICPHOSPHODIESTERASE 4D) |
3v94 | CYCLIC NUCLEOTIDESPECIFICPHOSPHODIESTERASE (Trypanosomacruzi) | 6 / 12 | TYR A 367HIS A 368MET A 482ASP A 521ILE A 538PHE A 573 | WYQ A 701 (-4.5A)NoneWYQ A 701 (-4.5A) ZN A 702 (-1.9A)WYQ A 701 ( 4.1A)WYQ A 701 (-3.4A) | 0.76A | 1xoqA-3v94A:40.1 | 1xoqA-3v94A:30.62 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1XOQ_B_ROFB501_0 (CAMP-SPECIFIC3',5'-CYCLICPHOSPHODIESTERASE 4D) |
3v94 | CYCLIC NUCLEOTIDESPECIFICPHOSPHODIESTERASE (Trypanosomacruzi) | 6 / 12 | TYR A 367HIS A 368ASP A 521TRP A 535ILE A 538PHE A 573 | WYQ A 701 (-4.5A)None ZN A 702 (-1.9A)NoneWYQ A 701 ( 4.1A)WYQ A 701 (-3.4A) | 0.71A | 1xoqB-3v94A:40.0 | 1xoqB-3v94A:30.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1XOS_A_VIAA1_1 (CAMP-SPECIFIC3',5'-CYCLICPHOSPHODIESTERASE 4B) |
3v94 | CYCLIC NUCLEOTIDESPECIFICPHOSPHODIESTERASE (Trypanosomacruzi) | 5 / 12 | MET A 482ASP A 521PHE A 542GLN A 570PHE A 573 | WYQ A 701 (-4.5A) ZN A 702 (-1.9A)WYQ A 701 (-4.7A)WYQ A 701 (-3.3A)WYQ A 701 (-3.4A) | 0.97A | 1xosA-3v94A:40.0 | 1xosA-3v94A:27.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1XOS_A_VIAA1_1 (CAMP-SPECIFIC3',5'-CYCLICPHOSPHODIESTERASE 4B) |
3v94 | CYCLIC NUCLEOTIDESPECIFICPHOSPHODIESTERASE (Trypanosomacruzi) | 6 / 12 | TYR A 367HIS A 368ASP A 521PHE A 542GLN A 570PHE A 573 | WYQ A 701 (-4.5A)None ZN A 702 (-1.9A)WYQ A 701 (-4.7A)WYQ A 701 (-3.3A)WYQ A 701 (-3.4A) | 0.74A | 1xosA-3v94A:40.0 | 1xosA-3v94A:27.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1XOT_A_VDNA101_1 (CAMP-SPECIFIC3',5'-CYCLICPHOSPHODIESTERASE 4B) |
3v94 | CYCLIC NUCLEOTIDESPECIFICPHOSPHODIESTERASE (Trypanosomacruzi) | 5 / 12 | TYR A 367HIS A 368ILE A 538GLN A 570PHE A 573 | WYQ A 701 (-4.5A)NoneWYQ A 701 ( 4.1A)WYQ A 701 (-3.3A)WYQ A 701 (-3.4A) | 0.32A | 1xotA-3v94A:40.0 | 1xotA-3v94A:27.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1XOT_A_VDNA101_1 (CAMP-SPECIFIC3',5'-CYCLICPHOSPHODIESTERASE 4B) |
3v94 | CYCLIC NUCLEOTIDESPECIFICPHOSPHODIESTERASE (Trypanosomacruzi) | 5 / 12 | TYR A 367MET A 482ILE A 538GLN A 570PHE A 573 | WYQ A 701 (-4.5A)WYQ A 701 (-4.5A)WYQ A 701 ( 4.1A)WYQ A 701 (-3.3A)WYQ A 701 (-3.4A) | 0.76A | 1xotA-3v94A:40.0 | 1xotA-3v94A:27.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1XOT_B_VDNB102_1 (CAMP-SPECIFIC3',5'-CYCLICPHOSPHODIESTERASE 4B) |
3v94 | CYCLIC NUCLEOTIDESPECIFICPHOSPHODIESTERASE (Trypanosomacruzi) | 5 / 12 | TYR A 367HIS A 368ILE A 538GLN A 570PHE A 573 | WYQ A 701 (-4.5A)NoneWYQ A 701 ( 4.1A)WYQ A 701 (-3.3A)WYQ A 701 (-3.4A) | 0.34A | 1xotB-3v94A:40.1 | 1xotB-3v94A:27.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1XOT_B_VDNB102_1 (CAMP-SPECIFIC3',5'-CYCLICPHOSPHODIESTERASE 4B) |
3v94 | CYCLIC NUCLEOTIDESPECIFICPHOSPHODIESTERASE (Trypanosomacruzi) | 5 / 12 | TYR A 367MET A 482ILE A 538GLN A 570PHE A 573 | WYQ A 701 (-4.5A)WYQ A 701 (-4.5A)WYQ A 701 ( 4.1A)WYQ A 701 (-3.3A)WYQ A 701 (-3.4A) | 0.84A | 1xotB-3v94A:40.1 | 1xotB-3v94A:27.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1XOZ_A_CIAA501_1 (CGMP-SPECIFIC3',5'-CYCLICPHOSPHODIESTERASE) |
3v94 | CYCLIC NUCLEOTIDESPECIFICPHOSPHODIESTERASE (Trypanosomacruzi) | 5 / 12 | TYR A 367ALA A 524PHE A 542GLN A 570PHE A 573 | WYQ A 701 (-4.5A)NoneWYQ A 701 (-4.7A)WYQ A 701 (-3.3A)WYQ A 701 (-3.4A) | 0.68A | 1xozA-3v94A:37.1 | 1xozA-3v94A:27.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2H42_A_VIAA901_1 (CGMP-SPECIFIC3',5'-CYCLICPHOSPHODIESTERASE) |
3v94 | CYCLIC NUCLEOTIDESPECIFICPHOSPHODIESTERASE (Trypanosomacruzi) | 6 / 11 | TYR A 367HIS A 368ALA A 524PHE A 542GLN A 570PHE A 573 | WYQ A 701 (-4.5A)NoneNoneWYQ A 701 (-4.7A)WYQ A 701 (-3.3A)WYQ A 701 (-3.4A) | 0.78A | 2h42A-3v94A:34.4 | 2h42A-3v94A:27.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2H42_B_VIAB902_1 (CGMP-SPECIFIC3',5'-CYCLICPHOSPHODIESTERASE) |
3v94 | CYCLIC NUCLEOTIDESPECIFICPHOSPHODIESTERASE (Trypanosomacruzi) | 5 / 12 | TYR A 367HIS A 368ALA A 524GLN A 570PHE A 573 | WYQ A 701 (-4.5A)NoneNoneWYQ A 701 (-3.3A)WYQ A 701 (-3.4A) | 0.69A | 2h42B-3v94A:34.2 | 2h42B-3v94A:27.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2WEY_A_EV1A1771_1 (CAMP ANDCAMP-INHIBITED CGMP3', 5'-CYCLICPHOSPHODIESTERASE) |
3v94 | CYCLIC NUCLEOTIDESPECIFICPHOSPHODIESTERASE (Trypanosomacruzi) | 7 / 12 | TYR A 367HIS A 368ILE A 538GLU A 541PHE A 542GLN A 570PHE A 573 | WYQ A 701 (-4.5A)NoneWYQ A 701 ( 4.1A)NoneWYQ A 701 (-4.7A)WYQ A 701 (-3.3A)WYQ A 701 (-3.4A) | 0.89A | 2weyA-3v94A:37.8 | 2weyA-3v94A:25.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2WEY_B_EV1B1771_1 (CAMP ANDCAMP-INHIBITED CGMP3', 5'-CYCLICPHOSPHODIESTERASE) |
3v94 | CYCLIC NUCLEOTIDESPECIFICPHOSPHODIESTERASE (Trypanosomacruzi) | 4 / 8 | ILE A 538PHE A 542GLN A 570PHE A 573 | WYQ A 701 ( 4.1A)WYQ A 701 (-4.7A)WYQ A 701 (-3.3A)WYQ A 701 (-3.4A) | 0.74A | 2weyB-3v94A:37.6 | 2weyB-3v94A:25.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3B2R_A_VDNA1_1 (CGMP-SPECIFIC3',5'-CYCLICPHOSPHODIESTERASE) |
3v94 | CYCLIC NUCLEOTIDESPECIFICPHOSPHODIESTERASE (Trypanosomacruzi) | 6 / 12 | TYR A 367HIS A 368ALA A 524PHE A 542GLN A 570PHE A 573 | WYQ A 701 (-4.5A)NoneNoneWYQ A 701 (-4.7A)WYQ A 701 (-3.3A)WYQ A 701 (-3.4A) | 0.77A | 3b2rA-3v94A:30.3 | 3b2rA-3v94A:28.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3B2R_B_VDNB1_1 (CGMP-SPECIFIC3',5'-CYCLICPHOSPHODIESTERASE) |
3v94 | CYCLIC NUCLEOTIDESPECIFICPHOSPHODIESTERASE (Trypanosomacruzi) | 5 / 11 | TYR A 367HIS A 368ALA A 524GLN A 570PHE A 573 | WYQ A 701 (-4.5A)NoneNoneWYQ A 701 (-3.3A)WYQ A 701 (-3.4A) | 0.66A | 3b2rB-3v94A:30.2 | 3b2rB-3v94A:28.45 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3G4L_A_ROFA901_0 (CAMP-SPECIFIC3',5'-CYCLICPHOSPHODIESTERASE 4D) |
3v94 | CYCLIC NUCLEOTIDESPECIFICPHOSPHODIESTERASE (Trypanosomacruzi) | 6 / 12 | TYR A 367HIS A 368MET A 482TRP A 535ILE A 538PHE A 573 | WYQ A 701 (-4.5A)NoneWYQ A 701 (-4.5A)NoneWYQ A 701 ( 4.1A)WYQ A 701 (-3.4A) | 0.75A | 3g4lA-3v94A:39.7 | 3g4lA-3v94A:30.28 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3G4L_B_ROFB902_0 (CAMP-SPECIFIC3',5'-CYCLICPHOSPHODIESTERASE 4D) |
3v94 | CYCLIC NUCLEOTIDESPECIFICPHOSPHODIESTERASE (Trypanosomacruzi) | 7 / 12 | TYR A 367HIS A 368MET A 482ASP A 521TRP A 535ILE A 538PHE A 573 | WYQ A 701 (-4.5A)NoneWYQ A 701 (-4.5A) ZN A 702 (-1.9A)NoneWYQ A 701 ( 4.1A)WYQ A 701 (-3.4A) | 0.78A | 3g4lB-3v94A:39.8 | 3g4lB-3v94A:30.28 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3G4L_C_ROFC903_0 (CAMP-SPECIFIC3',5'-CYCLICPHOSPHODIESTERASE 4D) |
3v94 | CYCLIC NUCLEOTIDESPECIFICPHOSPHODIESTERASE (Trypanosomacruzi) | 6 / 12 | TYR A 367HIS A 368MET A 482ASP A 521TRP A 535ILE A 538 | WYQ A 701 (-4.5A)NoneWYQ A 701 (-4.5A) ZN A 702 (-1.9A)NoneWYQ A 701 ( 4.1A) | 0.63A | 3g4lC-3v94A:39.7 | 3g4lC-3v94A:30.28 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3G4L_C_ROFC903_1 (CAMP-SPECIFIC3',5'-CYCLICPHOSPHODIESTERASE 4D) |
3v94 | CYCLIC NUCLEOTIDESPECIFICPHOSPHODIESTERASE (Trypanosomacruzi) | 3 / 3 | SER A 569GLN A 570PHE A 573 | NoneWYQ A 701 (-3.3A)WYQ A 701 (-3.4A) | 0.56A | 3g4lC-3v94A:39.7 | 3g4lC-3v94A:30.28 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3G4L_D_ROFD904_0 (CAMP-SPECIFIC3',5'-CYCLICPHOSPHODIESTERASE 4D) |
3v94 | CYCLIC NUCLEOTIDESPECIFICPHOSPHODIESTERASE (Trypanosomacruzi) | 7 / 12 | TYR A 367HIS A 368MET A 482ASP A 521TRP A 535ILE A 538GLN A 570 | WYQ A 701 (-4.5A)NoneWYQ A 701 (-4.5A) ZN A 702 (-1.9A)NoneWYQ A 701 ( 4.1A)WYQ A 701 (-3.3A) | 0.73A | 3g4lD-3v94A:39.8 | 3g4lD-3v94A:30.28 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3IAK_A_EV1A415_1 (CAMP-SPECIFIC3',5'-CYCLICPHOSPHODIESTERASE 4D) |
3v94 | CYCLIC NUCLEOTIDESPECIFICPHOSPHODIESTERASE (Trypanosomacruzi) | 6 / 9 | TYR A 367MET A 482ILE A 538PHE A 542GLN A 570PHE A 573 | WYQ A 701 (-4.5A)WYQ A 701 (-4.5A)WYQ A 701 ( 4.1A)WYQ A 701 (-4.7A)WYQ A 701 (-3.3A)WYQ A 701 (-3.4A) | 0.52A | 3iakA-3v94A:39.9 | 3iakA-3v94A:30.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3JWQ_B_VIAB901_1 (CGMP-SPECIFIC3',5'-CYCLICPHOSPHODIESTERASECATALYTIC DOMAIN,CONE CGMP-SPECIFIC3',5'-CYCLICPHOSPHODIESTERASESUBUNIT ALPHACHIMERA) |
3v94 | CYCLIC NUCLEOTIDESPECIFICPHOSPHODIESTERASE (Trypanosomacruzi) | 5 / 11 | TYR A 367HIS A 368ALA A 524GLN A 570PHE A 573 | WYQ A 701 (-4.5A)NoneNoneWYQ A 701 (-3.3A)WYQ A 701 (-3.4A) | 0.71A | 3jwqB-3v94A:36.93jwqC-3v94A:37.0 | 3jwqB-3v94A:27.673jwqC-3v94A:27.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3JWQ_C_VIAC901_1 (CGMP-SPECIFIC3',5'-CYCLICPHOSPHODIESTERASECATALYTIC DOMAIN,CONE CGMP-SPECIFIC3',5'-CYCLICPHOSPHODIESTERASESUBUNIT ALPHACHIMERA) |
3v94 | CYCLIC NUCLEOTIDESPECIFICPHOSPHODIESTERASE (Trypanosomacruzi) | 4 / 7 | TYR A 367HIS A 368GLN A 570PHE A 573 | WYQ A 701 (-4.5A)NoneWYQ A 701 (-3.3A)WYQ A 701 (-3.4A) | 0.48A | 3jwqC-3v94A:37.0 | 3jwqC-3v94A:27.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3JWQ_D_VIAD901_1 (CGMP-SPECIFIC3',5'-CYCLICPHOSPHODIESTERASECATALYTIC DOMAIN,CONE CGMP-SPECIFIC3',5'-CYCLICPHOSPHODIESTERASESUBUNIT ALPHACHIMERA) |
3v94 | CYCLIC NUCLEOTIDESPECIFICPHOSPHODIESTERASE (Trypanosomacruzi) | 6 / 11 | TYR A 367HIS A 368ALA A 524PHE A 542GLN A 570PHE A 573 | WYQ A 701 (-4.5A)NoneNoneWYQ A 701 (-4.7A)WYQ A 701 (-3.3A)WYQ A 701 (-3.4A) | 0.74A | 3jwqA-3v94A:37.03jwqD-3v94A:36.8 | 3jwqA-3v94A:27.673jwqD-3v94A:27.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3RGL_A_GLYA301_0 (GLYCYL-TRNASYNTHETASE ALPHASUBUNIT) |
3v94 | CYCLIC NUCLEOTIDESPECIFICPHOSPHODIESTERASE (Trypanosomacruzi) | 4 / 8 | ALA A 419THR A 417GLN A 545THR A 557 | NoneWYQ A 701 (-4.5A)NoneNone | 0.83A | 3rglA-3v94A:undetectable | 3rglA-3v94A:23.32 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3TVX_B_PNXB902_1 (CAMP-SPECIFIC3',5'-CYCLICPHOSPHODIESTERASE 4A) |
3v94 | CYCLIC NUCLEOTIDESPECIFICPHOSPHODIESTERASE (Trypanosomacruzi) | 5 / 7 | TYR A 367ILE A 538PHE A 542GLN A 570PHE A 573 | WYQ A 701 (-4.5A)WYQ A 701 ( 4.1A)WYQ A 701 (-4.7A)WYQ A 701 (-3.3A)WYQ A 701 (-3.4A) | 0.55A | 3tvxB-3v94A:39.8 | 3tvxB-3v94A:30.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3UJ7_B_SAMB302_1 (PHOSPHOETHANOLAMINEN-METHYLTRANSFERASE) |
3v94 | CYCLIC NUCLEOTIDESPECIFICPHOSPHODIESTERASE (Trypanosomacruzi) | 4 / 5 | TYR A 367SER A 525ASP A 521ASP A 481 | WYQ A 701 (-4.5A)None ZN A 702 (-1.9A)None | 1.35A | 3uj7B-3v94A:undetectable | 3uj7B-3v94A:21.13 |