SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'WYQ'


List of Similar Pattern of Amino Acids


Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_B_CIAB2003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)
3v94 CYCLIC NUCLEOTIDE
SPECIFIC
PHOSPHODIESTERASE

(Trypanosoma
cruzi)
5 / 12 TYR A 367
ALA A 524
PHE A 542
GLN A 570
PHE A 573
WYQ  A 701 (-4.5A)
None
WYQ  A 701 (-4.7A)
WYQ  A 701 (-3.3A)
WYQ  A 701 (-3.4A)
0.59A 1uduB-3v94A:
33.5
1uduB-3v94A:
28.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UHO_A_VDNA1000_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)
3v94 CYCLIC NUCLEOTIDE
SPECIFIC
PHOSPHODIESTERASE

(Trypanosoma
cruzi)
5 / 10 TYR A 367
HIS A 368
PHE A 542
GLN A 570
PHE A 573
WYQ  A 701 (-4.5A)
None
WYQ  A 701 (-4.7A)
WYQ  A 701 (-3.3A)
WYQ  A 701 (-3.4A)
0.41A 1uhoA-3v94A:
34.4
1uhoA-3v94A:
28.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLX_A_CIOA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)
3v94 CYCLIC NUCLEOTIDE
SPECIFIC
PHOSPHODIESTERASE

(Trypanosoma
cruzi)
6 / 12 TYR A 367
HIS A 368
HIS A 413
ILE A 538
GLN A 570
PHE A 573
WYQ  A 701 (-4.5A)
None
None
WYQ  A 701 ( 4.1A)
WYQ  A 701 (-3.3A)
WYQ  A 701 (-3.4A)
0.43A 1xlxA-3v94A:
40.1
1xlxA-3v94A:
27.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLX_A_CIOA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)
3v94 CYCLIC NUCLEOTIDE
SPECIFIC
PHOSPHODIESTERASE

(Trypanosoma
cruzi)
6 / 12 TYR A 367
HIS A 413
MET A 482
ILE A 538
GLN A 570
PHE A 573
WYQ  A 701 (-4.5A)
None
WYQ  A 701 (-4.5A)
WYQ  A 701 ( 4.1A)
WYQ  A 701 (-3.3A)
WYQ  A 701 (-3.4A)
0.85A 1xlxA-3v94A:
40.1
1xlxA-3v94A:
27.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLX_B_CIOB102_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)
3v94 CYCLIC NUCLEOTIDE
SPECIFIC
PHOSPHODIESTERASE

(Trypanosoma
cruzi)
8 / 12 TYR A 367
HIS A 368
HIS A 413
MET A 482
ILE A 538
PHE A 542
GLN A 570
PHE A 573
WYQ  A 701 (-4.5A)
None
None
WYQ  A 701 (-4.5A)
WYQ  A 701 ( 4.1A)
WYQ  A 701 (-4.7A)
WYQ  A 701 (-3.3A)
WYQ  A 701 (-3.4A)
0.77A 1xlxB-3v94A:
39.9
1xlxB-3v94A:
27.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XMU_A_ROFA101_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)
3v94 CYCLIC NUCLEOTIDE
SPECIFIC
PHOSPHODIESTERASE

(Trypanosoma
cruzi)
7 / 12 TYR A 367
HIS A 368
ASP A 521
TRP A 535
ILE A 538
PHE A 542
PHE A 573
WYQ  A 701 (-4.5A)
None
ZN  A 702 (-1.9A)
None
WYQ  A 701 ( 4.1A)
WYQ  A 701 (-4.7A)
WYQ  A 701 (-3.4A)
0.77A 1xmuA-3v94A:
39.9
1xmuA-3v94A:
27.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XMU_A_ROFA101_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)
3v94 CYCLIC NUCLEOTIDE
SPECIFIC
PHOSPHODIESTERASE

(Trypanosoma
cruzi)
5 / 12 TYR A 367
TRP A 535
PHE A 542
SER A 569
PHE A 573
WYQ  A 701 (-4.5A)
None
WYQ  A 701 (-4.7A)
None
WYQ  A 701 (-3.4A)
0.94A 1xmuA-3v94A:
39.9
1xmuA-3v94A:
27.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XMU_B_ROFB102_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)
3v94 CYCLIC NUCLEOTIDE
SPECIFIC
PHOSPHODIESTERASE

(Trypanosoma
cruzi)
6 / 12 TYR A 367
HIS A 368
ASP A 521
TRP A 535
ILE A 538
PHE A 542
WYQ  A 701 (-4.5A)
None
ZN  A 702 (-1.9A)
None
WYQ  A 701 ( 4.1A)
WYQ  A 701 (-4.7A)
0.61A 1xmuB-3v94A:
40.1
1xmuB-3v94A:
27.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOM_A_CIOA603_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)
3v94 CYCLIC NUCLEOTIDE
SPECIFIC
PHOSPHODIESTERASE

(Trypanosoma
cruzi)
8 / 12 TYR A 367
HIS A 368
MET A 482
ASP A 521
ILE A 538
PHE A 542
GLN A 570
PHE A 573
WYQ  A 701 (-4.5A)
None
WYQ  A 701 (-4.5A)
ZN  A 702 (-1.9A)
WYQ  A 701 ( 4.1A)
WYQ  A 701 (-4.7A)
WYQ  A 701 (-3.3A)
WYQ  A 701 (-3.4A)
0.81A 1xomA-3v94A:
40.2
1xomA-3v94A:
30.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOM_B_CIOB601_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)
3v94 CYCLIC NUCLEOTIDE
SPECIFIC
PHOSPHODIESTERASE

(Trypanosoma
cruzi)
7 / 12 TYR A 367
HIS A 368
MET A 482
ILE A 538
PHE A 542
GLN A 570
PHE A 573
WYQ  A 701 (-4.5A)
None
WYQ  A 701 (-4.5A)
WYQ  A 701 ( 4.1A)
WYQ  A 701 (-4.7A)
WYQ  A 701 (-3.3A)
WYQ  A 701 (-3.4A)
0.81A 1xomB-3v94A:
40.2
1xomB-3v94A:
30.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOQ_A_ROFA502_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)
3v94 CYCLIC NUCLEOTIDE
SPECIFIC
PHOSPHODIESTERASE

(Trypanosoma
cruzi)
5 / 12 TYR A 367
HIS A 368
ILE A 538
SER A 569
PHE A 573
WYQ  A 701 (-4.5A)
None
WYQ  A 701 ( 4.1A)
None
WYQ  A 701 (-3.4A)
0.77A 1xoqA-3v94A:
40.1
1xoqA-3v94A:
30.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOQ_A_ROFA502_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)
3v94 CYCLIC NUCLEOTIDE
SPECIFIC
PHOSPHODIESTERASE

(Trypanosoma
cruzi)
6 / 12 TYR A 367
HIS A 368
MET A 482
ASP A 521
ILE A 538
PHE A 573
WYQ  A 701 (-4.5A)
None
WYQ  A 701 (-4.5A)
ZN  A 702 (-1.9A)
WYQ  A 701 ( 4.1A)
WYQ  A 701 (-3.4A)
0.76A 1xoqA-3v94A:
40.1
1xoqA-3v94A:
30.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOQ_B_ROFB501_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)
3v94 CYCLIC NUCLEOTIDE
SPECIFIC
PHOSPHODIESTERASE

(Trypanosoma
cruzi)
6 / 12 TYR A 367
HIS A 368
ASP A 521
TRP A 535
ILE A 538
PHE A 573
WYQ  A 701 (-4.5A)
None
ZN  A 702 (-1.9A)
None
WYQ  A 701 ( 4.1A)
WYQ  A 701 (-3.4A)
0.71A 1xoqB-3v94A:
40.0
1xoqB-3v94A:
30.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOS_A_VIAA1_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)
3v94 CYCLIC NUCLEOTIDE
SPECIFIC
PHOSPHODIESTERASE

(Trypanosoma
cruzi)
5 / 12 MET A 482
ASP A 521
PHE A 542
GLN A 570
PHE A 573
WYQ  A 701 (-4.5A)
ZN  A 702 (-1.9A)
WYQ  A 701 (-4.7A)
WYQ  A 701 (-3.3A)
WYQ  A 701 (-3.4A)
0.97A 1xosA-3v94A:
40.0
1xosA-3v94A:
27.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOS_A_VIAA1_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)
3v94 CYCLIC NUCLEOTIDE
SPECIFIC
PHOSPHODIESTERASE

(Trypanosoma
cruzi)
6 / 12 TYR A 367
HIS A 368
ASP A 521
PHE A 542
GLN A 570
PHE A 573
WYQ  A 701 (-4.5A)
None
ZN  A 702 (-1.9A)
WYQ  A 701 (-4.7A)
WYQ  A 701 (-3.3A)
WYQ  A 701 (-3.4A)
0.74A 1xosA-3v94A:
40.0
1xosA-3v94A:
27.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOT_A_VDNA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)
3v94 CYCLIC NUCLEOTIDE
SPECIFIC
PHOSPHODIESTERASE

(Trypanosoma
cruzi)
5 / 12 TYR A 367
HIS A 368
ILE A 538
GLN A 570
PHE A 573
WYQ  A 701 (-4.5A)
None
WYQ  A 701 ( 4.1A)
WYQ  A 701 (-3.3A)
WYQ  A 701 (-3.4A)
0.32A 1xotA-3v94A:
40.0
1xotA-3v94A:
27.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOT_A_VDNA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)
3v94 CYCLIC NUCLEOTIDE
SPECIFIC
PHOSPHODIESTERASE

(Trypanosoma
cruzi)
5 / 12 TYR A 367
MET A 482
ILE A 538
GLN A 570
PHE A 573
WYQ  A 701 (-4.5A)
WYQ  A 701 (-4.5A)
WYQ  A 701 ( 4.1A)
WYQ  A 701 (-3.3A)
WYQ  A 701 (-3.4A)
0.76A 1xotA-3v94A:
40.0
1xotA-3v94A:
27.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOT_B_VDNB102_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)
3v94 CYCLIC NUCLEOTIDE
SPECIFIC
PHOSPHODIESTERASE

(Trypanosoma
cruzi)
5 / 12 TYR A 367
HIS A 368
ILE A 538
GLN A 570
PHE A 573
WYQ  A 701 (-4.5A)
None
WYQ  A 701 ( 4.1A)
WYQ  A 701 (-3.3A)
WYQ  A 701 (-3.4A)
0.34A 1xotB-3v94A:
40.1
1xotB-3v94A:
27.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOT_B_VDNB102_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)
3v94 CYCLIC NUCLEOTIDE
SPECIFIC
PHOSPHODIESTERASE

(Trypanosoma
cruzi)
5 / 12 TYR A 367
MET A 482
ILE A 538
GLN A 570
PHE A 573
WYQ  A 701 (-4.5A)
WYQ  A 701 (-4.5A)
WYQ  A 701 ( 4.1A)
WYQ  A 701 (-3.3A)
WYQ  A 701 (-3.4A)
0.84A 1xotB-3v94A:
40.1
1xotB-3v94A:
27.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOZ_A_CIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)
3v94 CYCLIC NUCLEOTIDE
SPECIFIC
PHOSPHODIESTERASE

(Trypanosoma
cruzi)
5 / 12 TYR A 367
ALA A 524
PHE A 542
GLN A 570
PHE A 573
WYQ  A 701 (-4.5A)
None
WYQ  A 701 (-4.7A)
WYQ  A 701 (-3.3A)
WYQ  A 701 (-3.4A)
0.68A 1xozA-3v94A:
37.1
1xozA-3v94A:
27.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_A_VIAA901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)
3v94 CYCLIC NUCLEOTIDE
SPECIFIC
PHOSPHODIESTERASE

(Trypanosoma
cruzi)
6 / 11 TYR A 367
HIS A 368
ALA A 524
PHE A 542
GLN A 570
PHE A 573
WYQ  A 701 (-4.5A)
None
None
WYQ  A 701 (-4.7A)
WYQ  A 701 (-3.3A)
WYQ  A 701 (-3.4A)
0.78A 2h42A-3v94A:
34.4
2h42A-3v94A:
27.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_B_VIAB902_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)
3v94 CYCLIC NUCLEOTIDE
SPECIFIC
PHOSPHODIESTERASE

(Trypanosoma
cruzi)
5 / 12 TYR A 367
HIS A 368
ALA A 524
GLN A 570
PHE A 573
WYQ  A 701 (-4.5A)
None
None
WYQ  A 701 (-3.3A)
WYQ  A 701 (-3.4A)
0.69A 2h42B-3v94A:
34.2
2h42B-3v94A:
27.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEY_A_EV1A1771_1
(CAMP AND
CAMP-INHIBITED CGMP
3', 5'-CYCLIC
PHOSPHODIESTERASE)
3v94 CYCLIC NUCLEOTIDE
SPECIFIC
PHOSPHODIESTERASE

(Trypanosoma
cruzi)
7 / 12 TYR A 367
HIS A 368
ILE A 538
GLU A 541
PHE A 542
GLN A 570
PHE A 573
WYQ  A 701 (-4.5A)
None
WYQ  A 701 ( 4.1A)
None
WYQ  A 701 (-4.7A)
WYQ  A 701 (-3.3A)
WYQ  A 701 (-3.4A)
0.89A 2weyA-3v94A:
37.8
2weyA-3v94A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEY_B_EV1B1771_1
(CAMP AND
CAMP-INHIBITED CGMP
3', 5'-CYCLIC
PHOSPHODIESTERASE)
3v94 CYCLIC NUCLEOTIDE
SPECIFIC
PHOSPHODIESTERASE

(Trypanosoma
cruzi)
4 / 8 ILE A 538
PHE A 542
GLN A 570
PHE A 573
WYQ  A 701 ( 4.1A)
WYQ  A 701 (-4.7A)
WYQ  A 701 (-3.3A)
WYQ  A 701 (-3.4A)
0.74A 2weyB-3v94A:
37.6
2weyB-3v94A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B2R_A_VDNA1_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)
3v94 CYCLIC NUCLEOTIDE
SPECIFIC
PHOSPHODIESTERASE

(Trypanosoma
cruzi)
6 / 12 TYR A 367
HIS A 368
ALA A 524
PHE A 542
GLN A 570
PHE A 573
WYQ  A 701 (-4.5A)
None
None
WYQ  A 701 (-4.7A)
WYQ  A 701 (-3.3A)
WYQ  A 701 (-3.4A)
0.77A 3b2rA-3v94A:
30.3
3b2rA-3v94A:
28.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B2R_B_VDNB1_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)
3v94 CYCLIC NUCLEOTIDE
SPECIFIC
PHOSPHODIESTERASE

(Trypanosoma
cruzi)
5 / 11 TYR A 367
HIS A 368
ALA A 524
GLN A 570
PHE A 573
WYQ  A 701 (-4.5A)
None
None
WYQ  A 701 (-3.3A)
WYQ  A 701 (-3.4A)
0.66A 3b2rB-3v94A:
30.2
3b2rB-3v94A:
28.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G4L_A_ROFA901_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)
3v94 CYCLIC NUCLEOTIDE
SPECIFIC
PHOSPHODIESTERASE

(Trypanosoma
cruzi)
6 / 12 TYR A 367
HIS A 368
MET A 482
TRP A 535
ILE A 538
PHE A 573
WYQ  A 701 (-4.5A)
None
WYQ  A 701 (-4.5A)
None
WYQ  A 701 ( 4.1A)
WYQ  A 701 (-3.4A)
0.75A 3g4lA-3v94A:
39.7
3g4lA-3v94A:
30.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G4L_B_ROFB902_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)
3v94 CYCLIC NUCLEOTIDE
SPECIFIC
PHOSPHODIESTERASE

(Trypanosoma
cruzi)
7 / 12 TYR A 367
HIS A 368
MET A 482
ASP A 521
TRP A 535
ILE A 538
PHE A 573
WYQ  A 701 (-4.5A)
None
WYQ  A 701 (-4.5A)
ZN  A 702 (-1.9A)
None
WYQ  A 701 ( 4.1A)
WYQ  A 701 (-3.4A)
0.78A 3g4lB-3v94A:
39.8
3g4lB-3v94A:
30.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G4L_C_ROFC903_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)
3v94 CYCLIC NUCLEOTIDE
SPECIFIC
PHOSPHODIESTERASE

(Trypanosoma
cruzi)
6 / 12 TYR A 367
HIS A 368
MET A 482
ASP A 521
TRP A 535
ILE A 538
WYQ  A 701 (-4.5A)
None
WYQ  A 701 (-4.5A)
ZN  A 702 (-1.9A)
None
WYQ  A 701 ( 4.1A)
0.63A 3g4lC-3v94A:
39.7
3g4lC-3v94A:
30.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G4L_C_ROFC903_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)
3v94 CYCLIC NUCLEOTIDE
SPECIFIC
PHOSPHODIESTERASE

(Trypanosoma
cruzi)
3 / 3 SER A 569
GLN A 570
PHE A 573
None
WYQ  A 701 (-3.3A)
WYQ  A 701 (-3.4A)
0.56A 3g4lC-3v94A:
39.7
3g4lC-3v94A:
30.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G4L_D_ROFD904_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)
3v94 CYCLIC NUCLEOTIDE
SPECIFIC
PHOSPHODIESTERASE

(Trypanosoma
cruzi)
7 / 12 TYR A 367
HIS A 368
MET A 482
ASP A 521
TRP A 535
ILE A 538
GLN A 570
WYQ  A 701 (-4.5A)
None
WYQ  A 701 (-4.5A)
ZN  A 702 (-1.9A)
None
WYQ  A 701 ( 4.1A)
WYQ  A 701 (-3.3A)
0.73A 3g4lD-3v94A:
39.8
3g4lD-3v94A:
30.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IAK_A_EV1A415_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)
3v94 CYCLIC NUCLEOTIDE
SPECIFIC
PHOSPHODIESTERASE

(Trypanosoma
cruzi)
6 / 9 TYR A 367
MET A 482
ILE A 538
PHE A 542
GLN A 570
PHE A 573
WYQ  A 701 (-4.5A)
WYQ  A 701 (-4.5A)
WYQ  A 701 ( 4.1A)
WYQ  A 701 (-4.7A)
WYQ  A 701 (-3.3A)
WYQ  A 701 (-3.4A)
0.52A 3iakA-3v94A:
39.9
3iakA-3v94A:
30.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWQ_B_VIAB901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
CATALYTIC DOMAIN,
CONE CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT ALPHA
CHIMERA)
3v94 CYCLIC NUCLEOTIDE
SPECIFIC
PHOSPHODIESTERASE

(Trypanosoma
cruzi)
5 / 11 TYR A 367
HIS A 368
ALA A 524
GLN A 570
PHE A 573
WYQ  A 701 (-4.5A)
None
None
WYQ  A 701 (-3.3A)
WYQ  A 701 (-3.4A)
0.71A 3jwqB-3v94A:
36.9
3jwqC-3v94A:
37.0
3jwqB-3v94A:
27.67
3jwqC-3v94A:
27.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWQ_C_VIAC901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
CATALYTIC DOMAIN,
CONE CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT ALPHA
CHIMERA)
3v94 CYCLIC NUCLEOTIDE
SPECIFIC
PHOSPHODIESTERASE

(Trypanosoma
cruzi)
4 / 7 TYR A 367
HIS A 368
GLN A 570
PHE A 573
WYQ  A 701 (-4.5A)
None
WYQ  A 701 (-3.3A)
WYQ  A 701 (-3.4A)
0.48A 3jwqC-3v94A:
37.0
3jwqC-3v94A:
27.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWQ_D_VIAD901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
CATALYTIC DOMAIN,
CONE CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT ALPHA
CHIMERA)
3v94 CYCLIC NUCLEOTIDE
SPECIFIC
PHOSPHODIESTERASE

(Trypanosoma
cruzi)
6 / 11 TYR A 367
HIS A 368
ALA A 524
PHE A 542
GLN A 570
PHE A 573
WYQ  A 701 (-4.5A)
None
None
WYQ  A 701 (-4.7A)
WYQ  A 701 (-3.3A)
WYQ  A 701 (-3.4A)
0.74A 3jwqA-3v94A:
37.0
3jwqD-3v94A:
36.8
3jwqA-3v94A:
27.67
3jwqD-3v94A:
27.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGL_A_GLYA301_0
(GLYCYL-TRNA
SYNTHETASE ALPHA
SUBUNIT)
3v94 CYCLIC NUCLEOTIDE
SPECIFIC
PHOSPHODIESTERASE

(Trypanosoma
cruzi)
4 / 8 ALA A 419
THR A 417
GLN A 545
THR A 557
None
WYQ  A 701 (-4.5A)
None
None
0.83A 3rglA-3v94A:
undetectable
3rglA-3v94A:
23.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TVX_B_PNXB902_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4A)
3v94 CYCLIC NUCLEOTIDE
SPECIFIC
PHOSPHODIESTERASE

(Trypanosoma
cruzi)
5 / 7 TYR A 367
ILE A 538
PHE A 542
GLN A 570
PHE A 573
WYQ  A 701 (-4.5A)
WYQ  A 701 ( 4.1A)
WYQ  A 701 (-4.7A)
WYQ  A 701 (-3.3A)
WYQ  A 701 (-3.4A)
0.55A 3tvxB-3v94A:
39.8
3tvxB-3v94A:
30.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_B_SAMB302_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)
3v94 CYCLIC NUCLEOTIDE
SPECIFIC
PHOSPHODIESTERASE

(Trypanosoma
cruzi)
4 / 5 TYR A 367
SER A 525
ASP A 521
ASP A 481
WYQ  A 701 (-4.5A)
None
ZN  A 702 (-1.9A)
None
1.35A 3uj7B-3v94A:
undetectable
3uj7B-3v94A:
21.13