SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'WSA'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FFY_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 2yy5 TRYPTOPHANYL-TRNA
SYNTHETASE
(Mycoplasma
pneumoniae) 		5 / 12 HIS A  16
GLY A  18
GLY A 152
ASP A 154
GLN A 155
 SO4  A1362 ( 4.1A)
WSA  A1350 (-3.5A)
WSA  A1350 (-3.2A)
WSA  A1350 (-2.7A)
SO4  A1363 ( 3.2A)
 0.69A 1ffyA-2yy5A:
5.8		 1ffyA-2yy5A:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JZS_A_MRCA1301_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 2yy5 TRYPTOPHANYL-TRNA
SYNTHETASE
(Mycoplasma
pneumoniae) 		5 / 11 GLY A   8
HIS A  16
GLY A 152
ASP A 154
GLN A 155
 WSA  A1350 (-3.7A)
SO4  A1362 ( 4.1A)
WSA  A1350 (-3.2A)
WSA  A1350 (-2.7A)
SO4  A1363 ( 3.2A)
 0.81A 1jzsA-2yy5A:
undetectable		 1jzsA-2yy5A:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JZS_A_MRCA1301_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 2yy5 TRYPTOPHANYL-TRNA
SYNTHETASE
(Mycoplasma
pneumoniae) 		5 / 11 GLY A   8
HIS A  16
GLY A 152
GLN A 155
ILE A 191
 WSA  A1350 (-3.7A)
SO4  A1362 ( 4.1A)
WSA  A1350 (-3.2A)
SO4  A1363 ( 3.2A)
WSA  A1350 (-3.7A)
 0.89A 1jzsA-2yy5A:
undetectable		 1jzsA-2yy5A:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU2_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 2yy5 TRYPTOPHANYL-TRNA
SYNTHETASE
(Mycoplasma
pneumoniae) 		5 / 12 HIS A  16
GLY A  18
GLY A 152
ASP A 154
GLN A 155
 SO4  A1362 ( 4.1A)
WSA  A1350 (-3.5A)
WSA  A1350 (-3.2A)
WSA  A1350 (-2.7A)
SO4  A1363 ( 3.2A)
 0.69A 1qu2A-2yy5A:
5.8		 1qu2A-2yy5A:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y0X_X_T44X500_1
(THYROID HORMONE
RECEPTOR BETA-1)		 2yy5 TRYPTOPHANYL-TRNA
SYNTHETASE
(Mycoplasma
pneumoniae) 		5 / 12 ILE A 225
ALA A 228
MET A 249
LEU A  17
ILE A 191
 None
None
None
None
WSA  A1350 (-3.7A)
 1.35A 1y0xX-2yy5A:
undetectable		 1y0xX-2yy5A:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_D_X2ND1479_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 2yy5 TRYPTOPHANYL-TRNA
SYNTHETASE
(Mycoplasma
pneumoniae) 		5 / 12 PHE A  79
ALA A 323
ALA A 327
THR A 330
MET A 137
 None
None
None
None
WSA  A1350 (-3.9A)
 1.39A 2x2nD-2yy5A:
undetectable		 2x2nD-2yy5A:
21.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FHJ_A_TRPA1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2yy5 TRYPTOPHANYL-TRNA
SYNTHETASE
(Mycoplasma
pneumoniae) 		9 / 10 GLY A   8
GLN A  10
HIS A  44
MET A 137
ASP A 140
ILE A 141
VAL A 149
VAL A 151
GLN A 155
 WSA  A1350 (-3.7A)
WSA  A1350 (-3.6A)
WSA  A1350 (-3.5A)
WSA  A1350 (-3.9A)
WSA  A1350 (-4.1A)
WSA  A1350 ( 4.9A)
None
WSA  A1350 ( 3.7A)
SO4  A1363 ( 3.2A)
 0.52A 3fhjA-2yy5A:
35.6		 3fhjA-2yy5A:
40.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FHJ_B_TRPB1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2yy5 TRYPTOPHANYL-TRNA
SYNTHETASE
(Mycoplasma
pneumoniae) 		9 / 10 GLY A   8
GLN A  10
HIS A  44
MET A 137
ASP A 140
ILE A 141
VAL A 149
VAL A 151
GLN A 155
 WSA  A1350 (-3.7A)
WSA  A1350 (-3.6A)
WSA  A1350 (-3.5A)
WSA  A1350 (-3.9A)
WSA  A1350 (-4.1A)
WSA  A1350 ( 4.9A)
None
WSA  A1350 ( 3.7A)
SO4  A1363 ( 3.2A)
 0.61A 3fhjB-2yy5A:
33.8		 3fhjB-2yy5A:
40.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FHJ_C_TRPC1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2yy5 TRYPTOPHANYL-TRNA
SYNTHETASE
(Mycoplasma
pneumoniae) 		9 / 10 GLY A   8
GLN A  10
HIS A  44
MET A 137
ASP A 140
ILE A 141
VAL A 149
VAL A 151
GLN A 155
 WSA  A1350 (-3.7A)
WSA  A1350 (-3.6A)
WSA  A1350 (-3.5A)
WSA  A1350 (-3.9A)
WSA  A1350 (-4.1A)
WSA  A1350 ( 4.9A)
None
WSA  A1350 ( 3.7A)
SO4  A1363 ( 3.2A)
 0.58A 3fhjC-2yy5A:
33.6		 3fhjC-2yy5A:
40.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FHJ_D_TRPD1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2yy5 TRYPTOPHANYL-TRNA
SYNTHETASE
(Mycoplasma
pneumoniae) 		8 / 9 GLY A   8
HIS A  44
MET A 137
ASP A 140
ILE A 141
VAL A 149
VAL A 151
GLN A 155
 WSA  A1350 (-3.7A)
WSA  A1350 (-3.5A)
WSA  A1350 (-3.9A)
WSA  A1350 (-4.1A)
WSA  A1350 ( 4.9A)
None
WSA  A1350 ( 3.7A)
SO4  A1363 ( 3.2A)
 0.45A 3fhjD-2yy5A:
34.4		 3fhjD-2yy5A:
40.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FHJ_E_TRPE1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2yy5 TRYPTOPHANYL-TRNA
SYNTHETASE
(Mycoplasma
pneumoniae) 		9 / 10 GLY A   8
GLN A  10
HIS A  44
MET A 137
ASP A 140
ILE A 141
VAL A 149
VAL A 151
GLN A 155
 WSA  A1350 (-3.7A)
WSA  A1350 (-3.6A)
WSA  A1350 (-3.5A)
WSA  A1350 (-3.9A)
WSA  A1350 (-4.1A)
WSA  A1350 ( 4.9A)
None
WSA  A1350 ( 3.7A)
SO4  A1363 ( 3.2A)
 0.56A 3fhjE-2yy5A:
34.6		 3fhjE-2yy5A:
40.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FHJ_F_TRPF1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2yy5 TRYPTOPHANYL-TRNA
SYNTHETASE
(Mycoplasma
pneumoniae) 		8 / 9 GLY A   8
HIS A  44
MET A 137
ASP A 140
ILE A 141
VAL A 149
VAL A 151
GLN A 155
 WSA  A1350 (-3.7A)
WSA  A1350 (-3.5A)
WSA  A1350 (-3.9A)
WSA  A1350 (-4.1A)
WSA  A1350 ( 4.9A)
None
WSA  A1350 ( 3.7A)
SO4  A1363 ( 3.2A)
 0.44A 3fhjF-2yy5A:
35.8		 3fhjF-2yy5A:
40.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FI0_A_TRPA1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2yy5 TRYPTOPHANYL-TRNA
SYNTHETASE
(Mycoplasma
pneumoniae) 		8 / 9 GLY A   8
GLN A  10
HIS A  44
ASP A 140
ILE A 141
VAL A 149
VAL A 151
GLN A 155
 WSA  A1350 (-3.7A)
WSA  A1350 (-3.6A)
WSA  A1350 (-3.5A)
WSA  A1350 (-4.1A)
WSA  A1350 ( 4.9A)
None
WSA  A1350 ( 3.7A)
SO4  A1363 ( 3.2A)
 0.59A 3fi0A-2yy5A:
35.2		 3fi0A-2yy5A:
40.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FI0_B_TRPB1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2yy5 TRYPTOPHANYL-TRNA
SYNTHETASE
(Mycoplasma
pneumoniae) 		7 / 8 GLY A   8
HIS A  44
ASP A 140
ILE A 141
VAL A 149
VAL A 151
GLN A 155
 WSA  A1350 (-3.7A)
WSA  A1350 (-3.5A)
WSA  A1350 (-4.1A)
WSA  A1350 ( 4.9A)
None
WSA  A1350 ( 3.7A)
SO4  A1363 ( 3.2A)
 0.53A 3fi0B-2yy5A:
34.5		 3fi0B-2yy5A:
40.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FI0_C_TRPC1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2yy5 TRYPTOPHANYL-TRNA
SYNTHETASE
(Mycoplasma
pneumoniae) 		8 / 9 GLY A   8
GLN A  10
HIS A  44
ASP A 140
ILE A 141
VAL A 149
VAL A 151
GLN A 155
 WSA  A1350 (-3.7A)
WSA  A1350 (-3.6A)
WSA  A1350 (-3.5A)
WSA  A1350 (-4.1A)
WSA  A1350 ( 4.9A)
None
WSA  A1350 ( 3.7A)
SO4  A1363 ( 3.2A)
 0.63A 3fi0C-2yy5A:
35.5		 3fi0C-2yy5A:
40.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FI0_D_TRPD1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2yy5 TRYPTOPHANYL-TRNA
SYNTHETASE
(Mycoplasma
pneumoniae) 		8 / 9 GLY A   8
GLN A  10
HIS A  44
ASP A 140
ILE A 141
VAL A 149
VAL A 151
GLN A 155
 WSA  A1350 (-3.7A)
WSA  A1350 (-3.6A)
WSA  A1350 (-3.5A)
WSA  A1350 (-4.1A)
WSA  A1350 ( 4.9A)
None
WSA  A1350 ( 3.7A)
SO4  A1363 ( 3.2A)
 0.61A 3fi0D-2yy5A:
35.7		 3fi0D-2yy5A:
40.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FI0_E_TRPE1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2yy5 TRYPTOPHANYL-TRNA
SYNTHETASE
(Mycoplasma
pneumoniae) 		5 / 7 GLY A   8
HIS A  44
ASP A 140
ILE A 141
VAL A 149
 WSA  A1350 (-3.7A)
WSA  A1350 (-3.5A)
WSA  A1350 (-4.1A)
WSA  A1350 ( 4.9A)
None
 0.35A 3fi0E-2yy5A:
33.9		 3fi0E-2yy5A:
40.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FI0_E_TRPE1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2yy5 TRYPTOPHANYL-TRNA
SYNTHETASE
(Mycoplasma
pneumoniae) 		5 / 7 HIS A  44
ASP A 140
ILE A 141
VAL A 149
GLN A 155
 WSA  A1350 (-3.5A)
WSA  A1350 (-4.1A)
WSA  A1350 ( 4.9A)
None
SO4  A1363 ( 3.2A)
 0.49A 3fi0E-2yy5A:
33.9		 3fi0E-2yy5A:
40.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FI0_F_TRPF1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2yy5 TRYPTOPHANYL-TRNA
SYNTHETASE
(Mycoplasma
pneumoniae) 		8 / 9 GLY A   8
GLN A  10
HIS A  44
ASP A 140
ILE A 141
VAL A 149
VAL A 151
GLN A 155
 WSA  A1350 (-3.7A)
WSA  A1350 (-3.6A)
WSA  A1350 (-3.5A)
WSA  A1350 (-4.1A)
WSA  A1350 ( 4.9A)
None
WSA  A1350 ( 3.7A)
SO4  A1363 ( 3.2A)
 0.69A 3fi0F-2yy5A:
34.5		 3fi0F-2yy5A:
40.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FI0_G_TRPG1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2yy5 TRYPTOPHANYL-TRNA
SYNTHETASE
(Mycoplasma
pneumoniae) 		7 / 8 GLY A   8
HIS A  44
ASP A 140
ILE A 141
VAL A 149
VAL A 151
GLN A 155
 WSA  A1350 (-3.7A)
WSA  A1350 (-3.5A)
WSA  A1350 (-4.1A)
WSA  A1350 ( 4.9A)
None
WSA  A1350 ( 3.7A)
SO4  A1363 ( 3.2A)
 0.45A 3fi0G-2yy5A:
35.7		 3fi0G-2yy5A:
40.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FI0_H_TRPH1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2yy5 TRYPTOPHANYL-TRNA
SYNTHETASE
(Mycoplasma
pneumoniae) 		8 / 9 GLY A   8
GLN A  10
HIS A  44
ASP A 140
ILE A 141
VAL A 149
VAL A 151
GLN A 155
 WSA  A1350 (-3.7A)
WSA  A1350 (-3.6A)
WSA  A1350 (-3.5A)
WSA  A1350 (-4.1A)
WSA  A1350 ( 4.9A)
None
WSA  A1350 ( 3.7A)
SO4  A1363 ( 3.2A)
 0.60A 3fi0H-2yy5A:
35.2		 3fi0H-2yy5A:
40.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_I_TRPI1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2yy5 TRYPTOPHANYL-TRNA
SYNTHETASE
(Mycoplasma
pneumoniae) 		7 / 8 GLY A   8
HIS A  44
ASP A 140
ILE A 141
VAL A 149
VAL A 151
GLN A 155
 WSA  A1350 (-3.7A)
WSA  A1350 (-3.5A)
WSA  A1350 (-4.1A)
WSA  A1350 ( 4.9A)
None
WSA  A1350 ( 3.7A)
SO4  A1363 ( 3.2A)
 0.46A 3fi0I-2yy5A:
35.3		 3fi0I-2yy5A:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FI0_J_TRPJ1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2yy5 TRYPTOPHANYL-TRNA
SYNTHETASE
(Mycoplasma
pneumoniae) 		8 / 9 GLY A   8
GLN A  10
HIS A  44
ASP A 140
ILE A 141
VAL A 149
VAL A 151
GLN A 155
 WSA  A1350 (-3.7A)
WSA  A1350 (-3.6A)
WSA  A1350 (-3.5A)
WSA  A1350 (-4.1A)
WSA  A1350 ( 4.9A)
None
WSA  A1350 ( 3.7A)
SO4  A1363 ( 3.2A)
 0.62A 3fi0J-2yy5A:
35.7		 3fi0J-2yy5A:
40.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FI0_K_TRPK1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2yy5 TRYPTOPHANYL-TRNA
SYNTHETASE
(Mycoplasma
pneumoniae) 		8 / 9 GLY A   8
GLN A  10
HIS A  44
ASP A 140
ILE A 141
VAL A 149
VAL A 151
GLN A 155
 WSA  A1350 (-3.7A)
WSA  A1350 (-3.6A)
WSA  A1350 (-3.5A)
WSA  A1350 (-4.1A)
WSA  A1350 ( 4.9A)
None
WSA  A1350 ( 3.7A)
SO4  A1363 ( 3.2A)
 0.64A 3fi0K-2yy5A:
34.8		 3fi0K-2yy5A:
40.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FI0_L_TRPL1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2yy5 TRYPTOPHANYL-TRNA
SYNTHETASE
(Mycoplasma
pneumoniae) 		8 / 9 GLY A   8
GLN A  10
HIS A  44
ASP A 140
ILE A 141
VAL A 149
VAL A 151
GLN A 155
 WSA  A1350 (-3.7A)
WSA  A1350 (-3.6A)
WSA  A1350 (-3.5A)
WSA  A1350 (-4.1A)
WSA  A1350 ( 4.9A)
None
WSA  A1350 ( 3.7A)
SO4  A1363 ( 3.2A)
 0.50A 3fi0L-2yy5A:
35.6		 3fi0L-2yy5A:
40.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FI0_M_TRPM1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2yy5 TRYPTOPHANYL-TRNA
SYNTHETASE
(Mycoplasma
pneumoniae) 		8 / 9 GLY A   8
GLN A  10
HIS A  44
ASP A 140
ILE A 141
VAL A 149
VAL A 151
GLN A 155
 WSA  A1350 (-3.7A)
WSA  A1350 (-3.6A)
WSA  A1350 (-3.5A)
WSA  A1350 (-4.1A)
WSA  A1350 ( 4.9A)
None
WSA  A1350 ( 3.7A)
SO4  A1363 ( 3.2A)
 0.62A 3fi0M-2yy5A:
35.0		 3fi0M-2yy5A:
40.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FI0_N_TRPN1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2yy5 TRYPTOPHANYL-TRNA
SYNTHETASE
(Mycoplasma
pneumoniae) 		8 / 9 GLY A   8
GLN A  10
HIS A  44
ASP A 140
ILE A 141
VAL A 149
VAL A 151
GLN A 155
 WSA  A1350 (-3.7A)
WSA  A1350 (-3.6A)
WSA  A1350 (-3.5A)
WSA  A1350 (-4.1A)
WSA  A1350 ( 4.9A)
None
WSA  A1350 ( 3.7A)
SO4  A1363 ( 3.2A)
 0.63A 3fi0N-2yy5A:
35.6		 3fi0N-2yy5A:
40.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FI0_O_TRPO1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2yy5 TRYPTOPHANYL-TRNA
SYNTHETASE
(Mycoplasma
pneumoniae) 		8 / 9 GLY A   8
GLN A  10
HIS A  44
ASP A 140
ILE A 141
VAL A 149
VAL A 151
GLN A 155
 WSA  A1350 (-3.7A)
WSA  A1350 (-3.6A)
WSA  A1350 (-3.5A)
WSA  A1350 (-4.1A)
WSA  A1350 ( 4.9A)
None
WSA  A1350 ( 3.7A)
SO4  A1363 ( 3.2A)
 0.56A 3fi0O-2yy5A:
35.2		 3fi0O-2yy5A:
40.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FI0_P_TRPP1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2yy5 TRYPTOPHANYL-TRNA
SYNTHETASE
(Mycoplasma
pneumoniae) 		6 / 7 GLY A   8
GLN A  10
HIS A  44
ASP A 140
ILE A 141
GLN A 155
 WSA  A1350 (-3.7A)
WSA  A1350 (-3.6A)
WSA  A1350 (-3.5A)
WSA  A1350 (-4.1A)
WSA  A1350 ( 4.9A)
SO4  A1363 ( 3.2A)
 0.70A 3fi0P-2yy5A:
34.7		 3fi0P-2yy5A:
40.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FI0_Q_TRPQ1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2yy5 TRYPTOPHANYL-TRNA
SYNTHETASE
(Mycoplasma
pneumoniae) 		7 / 8 GLY A   8
GLN A  10
HIS A  44
ASP A 140
ILE A 141
VAL A 149
VAL A 151
 WSA  A1350 (-3.7A)
WSA  A1350 (-3.6A)
WSA  A1350 (-3.5A)
WSA  A1350 (-4.1A)
WSA  A1350 ( 4.9A)
None
WSA  A1350 ( 3.7A)
 0.70A 3fi0Q-2yy5A:
35.2		 3fi0Q-2yy5A:
40.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FI0_R_TRPR1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2yy5 TRYPTOPHANYL-TRNA
SYNTHETASE
(Mycoplasma
pneumoniae) 		8 / 9 GLY A   8
GLN A  10
HIS A  44
ASP A 140
ILE A 141
VAL A 149
VAL A 151
GLN A 155
 WSA  A1350 (-3.7A)
WSA  A1350 (-3.6A)
WSA  A1350 (-3.5A)
WSA  A1350 (-4.1A)
WSA  A1350 ( 4.9A)
None
WSA  A1350 ( 3.7A)
SO4  A1363 ( 3.2A)
 0.60A 3fi0R-2yy5A:
33.8		 3fi0R-2yy5A:
40.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_A_RITA600_1
(CYTOCHROME P450 3A4)		 2yy5 TRYPTOPHANYL-TRNA
SYNTHETASE
(Mycoplasma
pneumoniae) 		5 / 12 LEU A 273
PHE A 277
ALA A 255
ILE A 191
GLY A 245
 None
None
None
WSA  A1350 (-3.7A)
None
 1.05A 3nxuA-2yy5A:
undetectable		 3nxuA-2yy5A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_C_D16C301_1
(THYMIDYLATE SYNTHASE)		 2yy5 TRYPTOPHANYL-TRNA
SYNTHETASE
(Mycoplasma
pneumoniae) 		5 / 11 SER A  98
LEU A 331
ASP A 140
LEU A 136
GLY A 139
 None
None
WSA  A1350 (-4.1A)
None
None
 1.48A 4foxC-2yy5A:
undetectable		 4foxC-2yy5A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LUF_A_ACTA605_0
(SERUM ALBUMIN)		 2yy5 TRYPTOPHANYL-TRNA
SYNTHETASE
(Mycoplasma
pneumoniae) 		4 / 4 ALA A  41
HIS A  87
PHE A  39
LEU A  80
 WSA  A1350 ( 3.8A)
None
WSA  A1350 (-4.8A)
None
 1.46A 4lufA-2yy5A:
0.0		 4lufA-2yy5A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LUH_A_ACTA609_0
(SERUM ALBUMIN)		 2yy5 TRYPTOPHANYL-TRNA
SYNTHETASE
(Mycoplasma
pneumoniae) 		4 / 4 ALA A  41
HIS A  87
PHE A  39
LEU A  80
 WSA  A1350 ( 3.8A)
None
WSA  A1350 (-4.8A)
None
 1.50A 4luhA-2yy5A:
0.3		 4luhA-2yy5A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8F_A_BRLA501_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2yy5 TRYPTOPHANYL-TRNA
SYNTHETASE
(Mycoplasma
pneumoniae) 		4 / 5 GLY A  18
ILE A 212
LEU A 256
LEU A  27
 WSA  A1350 (-3.5A)
None
None
None
 0.78A 4o8fA-2yy5A:
undetectable		 4o8fA-2yy5A:
23.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5V0I_A_TRPA402_0
(TRYPTOPHAN--TRNA
LIGASE)		 2yy5 TRYPTOPHANYL-TRNA
SYNTHETASE
(Mycoplasma
pneumoniae) 		8 / 9 GLY A   8
GLN A  10
HIS A  44
MET A 137
ASP A 140
ILE A 141
VAL A 149
GLN A 155
 WSA  A1350 (-3.7A)
WSA  A1350 (-3.6A)
WSA  A1350 (-3.5A)
WSA  A1350 (-3.9A)
WSA  A1350 (-4.1A)
WSA  A1350 ( 4.9A)
None
SO4  A1363 ( 3.2A)
 0.59A 5v0iA-2yy5A:
36.6		 5v0iA-2yy5A:
38.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5V0I_B_TRPB402_0
(TRYPTOPHAN--TRNA
LIGASE)		 2yy5 TRYPTOPHANYL-TRNA
SYNTHETASE
(Mycoplasma
pneumoniae) 		8 / 9 GLY A   8
GLN A  10
HIS A  44
MET A 137
ASP A 140
ILE A 141
VAL A 149
GLN A 155
 WSA  A1350 (-3.7A)
WSA  A1350 (-3.6A)
WSA  A1350 (-3.5A)
WSA  A1350 (-3.9A)
WSA  A1350 (-4.1A)
WSA  A1350 ( 4.9A)
None
SO4  A1363 ( 3.2A)
 0.56A 5v0iB-2yy5A:
37.3		 5v0iB-2yy5A:
38.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM0_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 2yy5 TRYPTOPHANYL-TRNA
SYNTHETASE
(Mycoplasma
pneumoniae) 		5 / 10 LEU A  62
LEU A 316
ASP A  83
ILE A   9
GLY A   8
 None
None
None
WSA  A1350 ( 4.3A)
WSA  A1350 (-3.7A)
 1.24A 6dm0B-2yy5A:
undetectable
6dm0C-2yy5A:
undetectable		 6dm0B-2yy5A:
13.18
6dm0C-2yy5A:
13.18