SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'WCC'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AXW_A_MTXA732_1
(THYMIDYLATE SYNTHASE)		 3cf4 ACETYL-COA
DECARBOXYLASE/SYNTHA
SE ALPHA SUBUNIT
(Methanosarcina
barkeri) 		5 / 12 LYS A 637
ILE A 281
ASP A 320
GLY A 249
ALA A 253
 WCC  A 811 ( 3.6A)
None
None
None
None
 1.09A 1axwA-3cf4A:
undetectable		 1axwA-3cf4A:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T46_A_STIA3_2
(HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG)		 3cf4 ACETYL-COA
DECARBOXYLASE/SYNTHA
SE ALPHA SUBUNIT
(Methanosarcina
barkeri) 		4 / 7 VAL A 216
VAL A 252
ARG A 494
CYH A 587
 None
None
None
WCC  A 811 (-2.2A)
 1.04A 1t46A-3cf4A:
undetectable		 1t46A-3cf4A:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7P_A_SALA1001_1
(LYSR-TYPE REGULATORY
PROTEIN)		 3cf4 ACETYL-COA
DECARBOXYLASE/SYNTHA
SE ALPHA SUBUNIT
(Methanosarcina
barkeri) 		4 / 6 SER A 658
PRO A 524
GLY A 632
TRP A 631
 None
WCC  A 811 (-4.8A)
None
None
 1.39A 2y7pA-3cf4A:
3.6		 2y7pA-3cf4A:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7W_C_SALC1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 1jqk CARBON MONOXIDE
DEHYDROGENASE
(Rhodospirillum
rubrum) 		4 / 7 THR A 479
GLY A 480
HIS A  95
ILE A 572
 None
WCC  A 800 ( 4.4A)
None
None
 0.87A 2y7wC-1jqkA:
2.9		 2y7wC-1jqkA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCM_X_SAMX5452_0
(UNCHARACTERIZED
PROTEIN TM_1570)		 3cf4 ACETYL-COA
DECARBOXYLASE/SYNTHA
SE ALPHA SUBUNIT
(Methanosarcina
barkeri) 		6 / 11 THR A 549
ALA A 519
GLY A 553
GLY A 522
ILE A 518
VAL A 533
 None
None
None
WCC  A 811 (-3.6A)
None
None
 1.48A 3dcmX-3cf4A:
undetectable		 3dcmX-3cf4A:
12.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_B_SAMB301_1
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 1jqk CARBON MONOXIDE
DEHYDROGENASE
(Rhodospirillum
rubrum) 		4 / 7 GLY A 480
GLY A 450
GLU A 304
ALA A 483
 WCC  A 800 ( 4.4A)
WCC  A 800 (-4.1A)
None
None
 0.83A 3fpjB-1jqkA:
2.4		 3fpjB-1jqkA:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G9E_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3cf4 ACETYL-COA
DECARBOXYLASE/SYNTHA
SE ALPHA SUBUNIT
(Methanosarcina
barkeri) 		5 / 12 GLY A 585
HIS A 120
ILE A 593
LYS A 637
HIS A 250
 None
None
None
WCC  A 811 ( 3.6A)
FE  A 808 ( 3.2A)
 0.98A 3g9eA-3cf4A:
undetectable		 3g9eA-3cf4A:
15.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LOQ_A_ACTA278_0
(UNIVERSAL STRESS
PROTEIN)		 3cf4 ACETYL-COA
DECARBOXYLASE/SYNTHA
SE ALPHA SUBUNIT
(Methanosarcina
barkeri) 		3 / 3 SER A 640
GLY A 113
SER A 635
 None
None
WCC  A 811 (-3.2A)
 0.68A 3loqA-3cf4A:
2.3		 3loqA-3cf4A:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB513_1
(HEMOLYTIC LECTIN
CEL-III)		 1jqk CARBON MONOXIDE
DEHYDROGENASE
(Rhodospirillum
rubrum) 		4 / 6 THR A 315
ASN A 316
CYH A 299
ILE A 339
 None
None
WCC  A 800 ( 4.4A)
None
 1.21A 3w9tB-1jqkA:
0.0		 3w9tB-1jqkA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOG_D_C2FD302_0
(THYMIDYLATE SYNTHASE)		 3cf4 ACETYL-COA
DECARBOXYLASE/SYNTHA
SE ALPHA SUBUNIT
(Methanosarcina
barkeri) 		5 / 11 LYS A 637
ILE A 281
ASP A 320
GLY A 249
ALA A 253
 WCC  A 811 ( 3.6A)
None
None
None
None
 1.10A 4fogD-3cf4A:
undetectable		 4fogD-3cf4A:
15.00